Full Text Journal Articles by
Author Aziz Gauhar

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Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro.

Aziz Gauhar, Cyril V Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J Kungl, Frank S Walsh, J Lynn Rutkowski, Pawel Stocki,

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the severe acute respiratory syndrome coronavirus 2 spike ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21970]

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Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1.

Pawel Stocki, Jaroslaw Szary, Charlotte L M Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S Walsh, J Lynn Rutkowski,

Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. A ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21172]

Cited: 6 times

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Blood-brain barrier transport using a high-affinity, brain-selective VNAR (Variable Domain of New Antigen Receptor) antibody targeting transferrin receptor 1

Pawel Stocki, Jaroslaw Szary, Charlotte LM Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank Walsh, Lynn Rutkowski,

<h4>ABSTRACT</h4> Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high-affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. <h4>Methods</h4> ... Read more >>

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Mathematical model of early Reelin-induced Src family kinase-mediated signaling.

Helge Hass, Friederike Kipkeew, Aziz Gauhar, Elisabeth Bouché, Petra May, Jens Timmer, Hans H Bock,

Reelin is a large glycoprotein with a dual role in the mammalian brain. It regulates the positioning and differentiation of postmitotic neurons during brain development and modulates neurotransmission and memory formation in the adult brain. Alterations in the Reelin signaling pathway have been described in different psychiatric disorders. Reelin mainly ... Read more >>

PLoS One (PloS one)
[2017, 12(10):e0186927]

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Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

Burkhard Jakob, Gaga Kochlamazashvili, Maria Jäpel, Aziz Gauhar, Hans H Bock, Tanja Maritzen, Volker Haucke,

Brain development and function depend on the directed and coordinated migration of neurons from proliferative zones to their final position. The secreted glycoprotein Reelin is an important factor directing neuronal migration. Loss of Reelin function results in the severe developmental disorder lissencephaly and is associated with neurological diseases in humans. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(21):5533-5538]

Cited: 12 times

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Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.

Hamed Shaykhalishahi, Aziz Gauhar, Michael M Wördehoff, Clara S R Grüning, Antonia N Klein, Oliver Bannach, Matthias Stoldt, Dieter Willbold, Torleif Härd, Wolfgang Hoyer,

Conversion of the intrinsically disordered protein α-synuclein (α-syn) into amyloid aggregates is a key process in Parkinson's disease. The sequence region 35-59 contains β-strand segments β1 and β2 of α-syn amyloid fibril models and most disease-related mutations. β1 and β2 frequently engage in transient interactions in monomeric α-syn. The consequences ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2015, 54(30):8837-8840]

Cited: 13 times

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A β-hairpin-binding protein for three different disease-related amyloidogenic proteins.

Hamed Shaykhalishahi, Ewa A Mirecka, Aziz Gauhar, Clara S R Grüning, Dieter Willbold, Torleif Härd, Matthias Stoldt, Wolfgang Hoyer,

Amyloidogenic proteins share a propensity to convert to the β-structure-rich amyloid state that is associated with the progression of several protein-misfolding disorders. Here we show that a single engineered β-hairpin-binding protein, the β-wrapin AS10, binds monomers of three different amyloidogenic proteins, that is, amyloid-β peptide, α-synuclein, and islet amyloid polypeptide, ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2015, 16(3):411-414]

Cited: 8 times

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Sequestration of a β-hairpin for control of α-synuclein aggregation.

Ewa A Mirecka, Hamed Shaykhalishahi, Aziz Gauhar, Şerife Akgül, Justin Lecher, Dieter Willbold, Matthias Stoldt, Wolfgang Hoyer,

The misfolding and aggregation of the protein α-synuclein (α-syn), which results in the formation of amyloid fibrils, is involved in the pathogenesis of Parkinson's disease and other synucleinopathies. The emergence of amyloid toxicity is associated with the formation of partially folded aggregation intermediates. Here, we engineered a class of binding ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2014, 53(16):4227-4230]

Cited: 39 times

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Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein.

Aziz Gauhar, Hamed Shaykhalishahi, Lothar Gremer, Ewa A Mirecka, Wolfgang Hoyer,

Aggregation of the protein α-synuclein (α-syn) has been implicated in Parkinson's disease and other neurodegenerative disorders, collectively referred to as synucleinopathies. The β-wrapin AS69 is a small engineered binding protein to α-syn that stabilizes a β-hairpin conformation of monomeric α-syn and inhibits α-syn aggregation at substoichiometric concentrations. AS69 is a ... Read more >>

Protein Eng Des Sel (Protein engineering, design & selection : PEDS)
[2014, 27(12):473-479]

Cited: 6 times

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Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger.

Mamta Jaiswal, Radovan Dvorsky, Ehsan Amin, Sarah L Risse, Eyad K Fansa, Si-Cai Zhang, Mohamed S Taha, Aziz R Gauhar, Saeideh Nakhaei-Rad, Claus Kordes, Katja T Koessmeier, Ion C Cirstea, Monilola A Olayioye, Dieter Häussinger, Mohammad R Ahmadian,

The three deleted in liver cancer genes (DLC1-3) encode Rho-specific GTPase-activating proteins (RhoGAPs). Their expression is frequently silenced in a variety of cancers. The RhoGAP activity, which is required for full DLC-dependent tumor suppressor activity, can be inhibited by the Src homology 3 (SH3) domain of a Ras-specific GAP (p120RasGAP). ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2014, 289(10):6839-6849]

Cited: 19 times

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