Full Text Journal Articles by
Author Ayan Hussein


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Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.

Ayan Hussein, Christopher A Guevara, Pamela Del Valle, Swati Gupta, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211011979]

Cited: 0 times

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Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation.

Deanna L Benson, Bridget A Matikainen-Ankney, Ayan Hussein, George W Huntley,

<i>LRRK2</i> mutation is the most common inherited, autosomal dominant cause of Parkinson's disease (PD) and has also been observed in sporadic cases. Most mutations result in increased LRRK2 kinase activity. LRRK2 is highly expressed in brain regions that receive dense, convergent innervation by dopaminergic and glutamatergic axons, and its levels ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2018, 46(6):1697-1705]

Cited: 4 times

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Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.

Noreen Bukhari, Poromendro N Burman, Ayan Hussein, Michael P Demars, Masato Sadahiro, Daniel M Brady, Stella E Tsirka, Scott J Russo, Hirofumi Morishita,

<h4>Unlabelled</h4>Experience-dependent cortical plasticity declines with age. At the molecular level, experience-dependent proteolytic activity of tissue plasminogen activator (tPA) becomes restricted in the adult brain if mice are raised in standard cages. Understanding the mechanism for the loss of permissive proteolytic activity is therefore a key link for improving function in ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(37):12693-12702]

Cited: 18 times

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