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Author Axel Heidenreich

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Ureterolyse, Intraperitonealisierung, Ureter-Ileum-Interponat und pyelovesikaler Bypass (Detour) bei Morbus Ormond oder langstreckiger Ureterstriktur.

Axel Heidenreich,

Aktuelle Urol (Aktuelle Urologie)
[2021, 52(5):490-500]

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Late toxicities and recurrences in patients with clinical stage I non-seminomatous germ cell tumours after 1 cycle of adjuvant bleomycin, etoposide and cisplatin versus primary retroperitoneal lymph node dissection - A 13-year follow-up analysis of a phase III trial cohort.

Andreas Hiester, Anna Fingerhut, Günter Niegisch, Roswitha Siener, Susanne Krege, Hans-Ulrich Schmelz, Klaus-Peter Dieckmann, Axel Heidenreich, Peter Kwasny, Maik Pechoel, Jan Lehmann, Sabine Kliesch, Kai-Uwe Köhrmann, Rolf Fimmers, Volker Loy, Christian Wittekind, Michael Hartmann, Peter Albers,

<h4>Background</h4>One cycle of adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) has shown superiority in recurrence-free survival over retroperitoneal lymph node dissection (RPLND) in patients with clinical stage (CS) I non-seminomatous germ cell tumours (NSGCTs) of the testis in the setting of a phase III trial. We report the recurrences ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 155:64-72]

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[Pelvic exenteration in patients with locally advanced, symptomatic castration-resistant prostate cancer].

Saskia Kanzelmeyer, Mark Bludau, David Johannes Karl Paul Pfister, Axel Heidenreich,

<h4>Goal</h4>The retrospective evaluation of clinical outcomes after palliative pelvic exenteration (PPE) in patients with subvesical and supravesical complications due to symptomatic locally advanced castration-resistant prostate cancer (CRPC).<h4>Patients and methods</h4>In all, 84 patients with locally advanced and symptomatic CRPC underwent radical cystoprostatectomy (n = 71, 83.3%) or anterior and posterior exenteration (n = 13, 16.7%). ... Read more >>

Urologe A (Der Urologe. Ausg. A)
[2021, :]

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Reply by Authors.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

J Urol (The Journal of urology)
[2021, 206(4):969]

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Manual kidney stone size measurements in computed tomography are most accurate using multiplanar image reformatations and bone window settings.

Robert Peter Reimer, Konstantin Klein, Miriam Rinneburger, David Zopfs, Simon Lennartz, Johannes Salem, Axel Heidenreich, David Maintz, Stefan Haneder, Nils Große Hokamp,

Computed tomography in suspected urolithiasis provides information about the presence, location and size of stones. Particularly stone size is a key parameter in treatment decision; however, data on impact of reformatation and measurement strategies is sparse. This study aimed to investigate the influence of different image reformatations, slice thicknesses and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16437]

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Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response.

Bernhard Grubmüller, Victoria Jahrreiss, Stephan Brönimann, Fahad Quhal, Keiichiro Mori, Axel Heidenreich, Alberto Briganti, Derya Tilki, Shahrokh F Shariat,

A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(4):2881-2892]

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Intermediate-risk Prostate Cancer-A Sheep in Wolf's Clothing?

Isabel Heidegger, Freddie C Hamdy, Roderick C N van den Bergh, Axel Heidenreich, Michiel Sedelaar, Morgan Roupret, ,

This case-based discussion describes a 65-year-old man newly diagnosed with International Society of Urological Pathology (ISUP) grade 2 prostate cancer (PCa). According to the European Association of Urology classification system, the patient harbors an intermediate-risk cancer. In step-by step discussion, we elaborate guideline-based treatment modalities for intermediate-risk PCa focused on ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Perioperative Outcomes of Transurethral Resection, Open Prostatectomy, and Laser Therapy in the Surgical Treatment of Benign Prostatic Obstruction: A "Real-World" Data Analysis from the URO-Cert Prostate Centers.

Jan Herden, Thomas Ebert, Daniel Schlager, Jana Pretzer, Daniel Porres, Wolfgang Schafhauser, Martin Kriegmair, Miguel Garcia Schürmann, Florian Distler, Frank Oberpenning, Michael Reimann, Gerald Haupt, Sebastian Schmidt, Sven Laabs, Bernhard Planz, Maximilian Cohausz, Eckart Gronau, Guido Platz, Stephan Buse, Jon Jones, Michael Waldner, Axel Heidenreich, Herbert Ruebben, Juergen Zumbe, Alexander Goell, Ehsan Khaljani, Winfried Czempiel, Wolfgang Schultze-Seemann, Peter Weib,

<h4>Introduction</h4>The aim of the study is to compare length of hospital stay, transfusion rates, and re-intervention rates during hospitalization for transurethral resection of the prostate (TUR-P), open prostatectomy (OP), and laser therapy (LT) for surgical treatment of benign prostatic obstruction (BPO).<h4>Methods</h4>URO-Cert is an organization, in which clinical data of prostatic ... Read more >>

Urol Int (Urologia internationalis)
[2021, 105(9-10):869-874]

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Dietary interventions to improve body composition in men treated with androgen deprivation therapy for prostate cancer: a solution for the growing problem?

Lisa Umlauff, Manuel Weber, Nils Freitag, Ciaran M Fairman, Axel Heidenreich, Wilhelm Bloch, Moritz Schumann,

<h4>Background</h4>Androgen deprivation therapy (ADT) has adverse effects on body composition, including muscle wasting and body fat accumulation, which may be attenuated by nutrition therapy. This systematic review summarises available evidence on the effects of dietary interventions on lean mass, fat mass and body mass index (BMI) in men treated with ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Definition and Impact on Oncologic Outcomes of Persistently Elevated Prostate-specific Antigen After Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer After Radical Prostatectomy: Clinical Implications for Multimodal Therapy.

Carlo A Bravi, Matteo Droghetti, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Vito Cucchiara, Simone Scuderi, Francesco Barletta, Riccardo Schiavina, Daniar Osmonov, Klaus-Peter Juenemann, Luca Boeri, R Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh F Shariat, Axel Heidenreich, David Pfister, Derya Tilki, Markus Graefen, Inderbir S Gill, Alexandre Mottrie, Pierre I Karakiewicz, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The optimal definition and prognostic significance of persistently elevated prostate-specific antigen (PSA) after salvage lymph node dissection (sLND) for node-only recurrent prostate cancer (PCa) remain unknown.<h4>Objective</h4>To assess the definition and clinical implications of persistently elevated PSA after sLND for node-only recurrent PCa after radical prostatectomy.<h4>Design, setting, and participants</h4>The study included ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Oligometastatic prostate cancer: definition and the role of local and systemic therapy: a narrative review.

Samy Mahjoub, Axel Heidenreich,

The definition of oligometastatic prostate cancer (OMPC) includes a heterogenous group of disease states, mostly defined by the number and site of metastases, which seems to be biologically different to widespread tumors. Evidence suggests a substantial survival benefit for this subgroup of limited metastatic burden which is currently seen as ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(7):3167-3175]

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Health-related quality of life in bladder cancer patients: bladder cancer-specific instruments and domains. Part 2.

Kristin Zimmermann, Hadi Mostafaei, Axel Heidenreich, Hans U Schmelz, Shahrokh F Shariat, Keiichiro Mori,

<h4>Purpose of review</h4>Several instruments have been designed to evaluate health-related quality of life (HRQoL) in patients with bladder cancer (BC). However, they vary in purpose, domains, and quality. To identify QoL instruments that have been validated for BC patients and to critically assess their domains and limitations.<h4>Recent findings</h4>Of the 11 ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):304-314]

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Management of Late Relapses in Metastatic Testicular Germ Cell Tumors: Still a Challenge.

Axel Heidenreich,

Eur Urol Open Sci (European urology open science)
[2021, 30:11-12]

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Health-related quality of life in bladder cancer patients: general and cancer-specific instruments. Part 1.

Kristin Zimmermann, Hadi Mostafaei, Axel Heidenreich, Hans U Schmelz, Shahrokh F Shariat, Keiichiro Mori,

<h4>Purpose of review</h4>Although survival outcomes are the primary outcomes to determine the effectiveness of treatment options, quality of life (QoL) is gaining in importance in addition to classic oncological outcomes. The present review aims to state and critically assess the challenges in health-related QoL (HRQoL) assessment especially in bladder cancer ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):297-303]

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Teratomatous Elements in Orchiectomy Specimens Are Associated with a Reduced Relapse-Free Survival in Metastasized Testicular Germ Cell Tumors.

Pia Paffenholz, Tim Nestler, Yasmine Maatoug, Melanie von Brandenstein, Barbara Köditz, Sven H Loosen, Nicolas Fischer, David Pfister, Axel Heidenreich,

<h4>Introduction</h4>The impact of teratomatous elements in orchiectomy specimens of metastasized testicular germ cell tumors (TGCT) regarding oncological outcome is still unclear.<h4>Methods</h4>We performed a retrospective analysis including 146 patients with metastasized TGCT analysing patient characteristics.<h4>Results</h4>Twenty-six (18%) of all patients showed teratomatous elements in the orchiectomy specimens. TGCT with teratomatous elements showed ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-7]

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Re: Sophie Knipper, Luigi Ascalone, Benjamin Ziegler, et al. Salvage Surgery in Patients with Local Recurrence After Radical Prostatectomy. Eur Urol 2021;79:537-44.

David Pfister, Florian Hartmann, Axel Heidenreich,

Eur Urol (European urology)
[2021, 80(2):e61]

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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer.

Fahad Quhal, Pawel Rajwa, Keiichiro Mori, Ekaterina Laukhtina, Nico C Grossmann, Victor M Schuettfort, Frederik König, Abdulmajeed Aydh, Reza S Motlagh, Satoshi Katayama, Hadi Mostafai, Benjamin Pradere, Giancarlo Marra, Paolo Gontero, Romain Mathieu, Pierre I Karakiewicz, Alberto Briganti, Shahrokh F Shariat, Axel Heidenreich,

<h4>Purpose</h4>To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).<h4>Material and methods</h4>We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of ... Read more >>

Prostate (The Prostate)
[2021, 81(11):765-771]

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Patterns of Recurrence following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Purpose</h4>Our primary objective is to detail the incidence, site, and timing of penile squamous cell carcinoma (pSCC) recurrence after inguinal lymph node dissection (ILND).<h4>Materials and methods</h4>We performed a retrospective analysis of 551 patients who underwent ILND for pSCC from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. ... Read more >>

J Urol (The Journal of urology)
[2021, 206(4):960-969]

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Non-invasive urine markers for the differentiation between RCCs and oncocytoma.

Melanie von Brandenstein, Jan Herden, Barbara Köditz, Manuel Huerta, Tim Nestler, Axel Heidenreich, Jochen W U Fries,

<h4>Background</h4>Recently, our group showed that Vim3 is overexpressed in tissue samples of renal oncocytomas and Mxi-2 in clear cell renal carcinoma (ccRCC). The mechanism leading to the truncation of both proteins is known and involves with two miRs, both detectable in urine. Since the analysis of miRs is time-consuming, our ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2021, 35(5):e23762]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Safety and mid-term surgical results of anterior urethroplasty with the tissue-engineered oral mucosa graft MukoCell® : A single-center experience.

Leonidas Karapanos, Ilgar Akbarov, Vahudin Zugor, Ruud Kokx, Anna Hagemeier, Axel Heidenreich,

<h4>Objective</h4>To assess the mid-term efficacy and safety of anterior urethroplasty using an autologous tissue-engineered oral mucosa graft (MukoCell<sup>®</sup> ).<h4>Methods</h4>The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell<sup>®</sup> at a tertiary center from June 2016 to May 2019 were analyzed. Patients' characteristics, pre- and postoperative diagnostics, perioperative ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, 28(9):936-942]

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Preoperative Parameters to Predict the Development of Symptomatic Lymphoceles after Radical Prostatectomy.

Samy Mahjoub, Marius Hennecken, David Pfister, Florian Hartmann, Patricia John, Maximilian Schmautz, Axel Heidenreich,

<h4>Introduction</h4>Symptomatic lymphoceles (SLs) represent the most common complication after radical prostatectomy (RP) and pelvic lymph node dissection (PLND). To date, preoperative risk factors are missing.<h4>Methods</h4>Clinical and pathological data of 592 patients who underwent RP and PLND were evaluated. Included parameters were age, BMI, prostate-specific antigen (PSA), PSA ratio, PSA density, ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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Editorial: Salvage therapy in uro-oncology.

Axel Heidenreich, R Jeffrey Karnes,

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):177]

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The current landscape of salvage therapies for patients with bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer.

Vignesh T Packiam, Jordan Richards, Maximilian Schmautz, Axel Heidenreich, Stephen A Boorjian,

<h4>Purpose of review</h4>Although radical cystectomy represents the gold standard treatment for patients with high-risk nonmuscle invasive bladder cancer (NMIBC) whose disease does not respond to bacillus Calmette-Guérin (BCG), many patients are unable or unwilling to undergo surgery. The need remains for effective bladder-preserving therapies. This review aims to describe existing ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):178-187]

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Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy.

Pawel Rajwa, Victor M Schuettfort, Fahad Quhal, Keiichiro Mori, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Andreas Aulitzky, Andrzej Paradysz, Pierre I Karakiewicz, Harun Fajkovic, Kristin Zimmermann, Axel Heidenreich, Paolo Gontero, Shahrokh F Shariat,

<h4>Purpose</h4>To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).<h4>Materials and methods</h4>This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils × ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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