Full Text Journal Articles by
Author Axel Dost

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

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Undertreatment of cardiovascular risk factors in the type 1 diabetes exchange clinic network (United States) and the prospective diabetes follow-up (Germany/Austria) registries.

Viral N Shah, Julia M Grimsmann, Nicole C Foster, Axel Dost, Kellee M Miller, Marianne Pavel, Ruth S Weinstock, Wolfram Karges, David M Maahs, Reinhard W Holl,

<h4>Aim</h4>To examine the control of cardiovascular risk factors in type 1 diabetes (T1D) registries from the United States and Germany/Austria.<h4>Materials and methods</h4>Data on individuals aged ≥12 years with T1D for ≥1 year, from the T1D Exchange Clinic Network (T1DX, United States) and the Prospective Diabetes Follow-up Registry (DPV, Germany/Austria) from 1 ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2020, 22(9):1577-1585]

Cited: 0 times

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2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes.

Axel Dost, Susanne Bechtold, Katharina Fink, Walter Bonfig, Dagobert Wiemann, Thomas M Kapellen, Michael Witsch, Karl O Schwab, Reinhard W Holl, ,

<h4>Objective</h4>In 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(6):1311-1318]

Cited: 0 times

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Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(S 01):S39-S72]

Cited: 1 time

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Diagnosis, Therapy and Follow-up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(6):341-352]

Cited: 1 time

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Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg.

Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl, ,

OBJECTIVE:To investigate differences in cardiovascular risk factors and metabolic control in girls with type 1 diabetes with or without use of oral contraceptives (OC) from the multicenter "diabetes prospective follow-up" (DPV) registry. METHODS:Twenty-four thousand eleven adolescent girls (13 to < 18 years of age) from Germany, Austria or Luxembourg with type ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(5):937-944]

Cited: 0 times

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Factors contributing to partial remission in type 1 diabetes: analysis based on the insulin dose-adjusted HbA1c in 3657 children and adolescents from Germany and Austria.

Katrin Nagl, Julia M Hermann, Michaela Plamper, Carmen Schröder, Axel Dost, Olga Kordonouri, Birgit Rami-Merhar, Reinhard W Holl,

<h4>Objective</h4>Insulin dose-adjusted hemoglobin A1c (HbA1C, IDAA1c) correlates well with stimulated C-peptide levels, but has not yet been evaluated in a large cohort of patients with Type 1 diabetes (T1D).<h4>Methods</h4>We investigated prevalence of partial remission (PREM) defined by IDAA1c ≤9 in 3657 in children with new-onset T1D who were continuously followed ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2017, 18(6):428-434]

Cited: 22 times

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Seasonal Variation in Blood Pressure in 162,135 Patients With Type 1 or Type 2 Diabetes Mellitus.

Julia M Hermann, Joachim Rosenbauer, Axel Dost, Claudia Steigleder-Schweiger, Wieland Kiess, Christof Schöfl, Reinhard W Holl, ,

Seasonal variation in blood pressure (BP) has been observed in different populations. However, only few studies have focused on BP seasonality in diabetic patients. This study examined the seasonal patterns in BP in 62,589 patients with type 1 diabetes mellitus (T1DM) and in 99,546 patients with type 2 diabetes mellitus ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2016, 18(4):270-278]

Cited: 5 times

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Non-High-Density Lipoprotein Cholesterol in Children with Diabetes: Proposed Treatment Recommendations Based on Glycemic Control, Body Mass Index, Age, Sex, and Generally Accepted Cut Points.

K Otfried Schwab, Jürgen Doerfer, Andreas Hungele, Nicole Scheuing, Andreas Krebs, Axel Dost, Tilman R Rohrer, Sabine Hofer, Reinhard W Holl,

Percentile-based non-high-density lipoprotein cholesterol levels were analyzed by glycemic control, weight, age, and sex of children with type 1 diabetes (n = 26,358). Ten percent of all children and 25% of overweight adolescent girls require both immediate lipid-lowering medication and lifestyle changes to achieve non-high-density lipoprotein cholesterol levels <120 mg/dL ... Read more >>

J Pediatr (The Journal of pediatrics)
[2015, 167(6):1436-1439]

Cited: 6 times

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Hyperthyroidism in 276 Children and Adolescents with Type 1 Diabetes from Germany and Austria.

Axel Dost, Tilman R Rohrer, Elke Fröhlich-Reiterer, Esther Bollow, Beate Karges, Andreas Böckmann, Johannes Hamann, Reinhard W Holl, ,

<h4>Background/aims</h4>Little is known about the incidence and clinical consequences of hyperthyroidism in pediatric patients with type 1 diabetes mellitus (T1DM).<h4>Methods</h4>We analyzed the DPV database (Diabetes Prospective Follow-Up Registry) to investigate the rate of hyperthyroidism in pediatric T1DM patients, its impact on metabolic control, and potential associations with organ-specific autoantibodies.<h4>Results</h4>Hyperthyroidism was ... Read more >>

Horm Res Paediatr (Hormone research in paediatrics)
[2015, 84(3):190-198]

Cited: 9 times

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Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States.

Stephanie N DuBose, Julia M Hermann, William V Tamborlane, Roy W Beck, Axel Dost, Linda A DiMeglio, Karl Otfried Schwab, Reinhard W Holl, Sabine E Hofer, David M Maahs, ,

<h4>Objective</h4>To examine the current extent of the obesity problem in 2 large pediatric clinical registries in the US and Europe and to examine the hypotheses that increased body mass index (BMI) z-scores (BMIz) are associated with greater hemoglobin A1c (HbA1c) and increased frequency of severe hypoglycemia in youth with type ... Read more >>

J Pediatr (The Journal of pediatrics)
[2015, 167(3):627-32.e1-4]

Cited: 46 times

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Accuracy of blood glucose meters for self-monitoring affects glucose control and hypoglycemia rate in children and adolescents with type 1 diabetes.

Claudia Boettcher, Axel Dost, Stefan A Wudy, Marion Flechtner-Mors, Martin Borkenstein, Ralf Schiel, Dieter Weitzel, Susanne Bechtold-Dalla Pozza, Johannes Wolf, Reinhard W Holl, ,

<h4>Aims/hypothesis</h4>This study investigated the accuracy of blood glucose meters for self-monitoring and its influence on glycated hemoglobin (HbA1c) levels and the frequency of hypoglycemic coma.<h4>Materials and methods</h4>Self-measured and simultaneously obtained laboratory blood glucose values from 9,163 patients with type 1 diabetes <18 years of age in the German/Austrian Diabetes Prospective ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2015, 17(4):275-282]

Cited: 17 times

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Tracking of metabolic control from childhood to young adulthood in type 1 diabetes.

Sabine E Hofer, Klemens Raile, Elke Fröhlich-Reiterer, Thomas Kapellen, Axel Dost, Joachim Rosenbauer, Jürgen Grulich-Henn, Reinhard W Holl, , ,

<h4>Objective</h4>This prospective longitudinal survey was designed to follow patients with diabetes from disease onset in childhood over an extended period of time including puberty until young adulthood with respect to metabolic control.<h4>Study design</h4>An electronic diabetes patient documentation system used in diabetes centers in Austria and Germany was utilized for standardized ... Read more >>

J Pediatr (The Journal of pediatrics)
[2014, 165(5):956-61.e1-2]

Cited: 21 times

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Pulse pressure in children and adolescents with type 1 diabetes mellitus in Germany and Austria.

Axel Dost, Esther Molz, Andreas Krebs, Susanne Bechtold, Thomas Kapellen, Tilman Rohrer, Klemens Raile, Maria Fritsch, Karl Otfried Schwab, Reinhard Holl,

BACKGROUND:Impaired blood pressure regulation contributes to the development of diabetic complications. The influence of systolic (SBP) vs.diastolic blood pressure (DBP) is still controversial. Peripheral pulse pressure(PP), the difference between SBP and DBP, is an indicator for arterial stiffness. Only little data are available for PP in children. Therefore, we studied ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2014, 15(3):236-243]

Cited: 7 times

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Algorithm-based cholesterol monitoring in children with type 1 diabetes.

K Otfried Schwab, Jürgen Doerfer, Christa Scheidt-Nave, Bärbel-Maria Kurth, Andreas Hungele, Nicole Scheuing, Andreas Krebs, Axel Dost, Tilman R Rohrer, Edith Schober, Reinhard W Holl, ,

<h4>Objective</h4>To facilitate child-specific and diabetes-related cholesterol control, we developed a monitoring algorithm derived from population-based reference values.<h4>Study design</h4>Low-density lipoprotein (LDL)-, non-high-density lipoprotein (HDL)-, and HDL cholesterol percentile values were calculated for children with type 1 diabetes (T1D) and their peers without T1D within algorithm-based categories of sex, age: 1-10 vs ... Read more >>

J Pediatr (The Journal of pediatrics)
[2014, 164(5):1079-1084.e2]

Cited: 3 times

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Children and adolescents with type 1 diabetes in Germany are more overweight than healthy controls: results comparing DPV database and CrescNet database.

Thomas M Kapellen, Ruth Gausche, Axel Dost, Susanna Wiegand, Marion Flechtner-Mors, Eberhard Keller, Wieland Kiess, Reinhard W Holl, ,

<h4>Aims</h4>To describe the development of weight in children and adolescents with type 1 diabetes in Germany.<h4>Methods</h4>We analyzed the body mass index (BMI) of the most recent treatment year of each patient with diabetes in the Pediatric Quality Initiative (DPV) database. BMI SD score (SDS) was calculated based on pooled historical ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2014, 27(3-4):209-214]

Cited: 17 times

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Higher relative risk for multiple sclerosis in a pediatric and adolescent diabetic population: analysis from DPV database.

Susanne Bechtold, Astrid Blaschek, Klemens Raile, Axel Dost, Clemens Freiberg, Meik Askenas, Elke Fröhlich-Reiterer, Esther Molz, Reinhard W Holl,

OBJECTIVE Type 1 diabetes and multiple sclerosis (MS) are typical autoimmune diseases in children and young adults. We assessed the co-occurrence of type 1 diabetes and MS by estimating the relative risk (RR) for MS in a pediatric and adolescent diabetic population and looked for possible influencing factors. RESEARCH DESIGN ... Read more >>

Diabetes Care (Diabetes care)
[2014, 37(1):96-101]

Cited: 5 times

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Growth in children and adolescents with type 1 diabetes.

Walter Bonfig, Thomas Kapellen, Axel Dost, Maria Fritsch, Tilman Rohrer, Johannes Wolf, Reinhard W Holl, ,

OBJECTIVE: To investigate the effect of type 1 diabetes on growth and adult height. STUDY DESIGN: Data from 22 651 children (10 494 females) with type 1 diabetes documented at onset of the disease from specialized centers in Germany and Austria were analyzed. Patients of non-German and non-Austrian origin and ... Read more >>

J Pediatr (The Journal of pediatrics)
[2012, 160(6):900-3.e2]

Cited: 24 times

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Improved metabolic control in children and adolescents with type 1 diabetes: a trend analysis using prospective multicenter data from Germany and Austria.

Joachim Rosenbauer, Axel Dost, Beate Karges, Andreas Hungele, Anna Stahl, Christina Bächle, Eva Maria Gerstl, Christian Kastendieck, Sabine E Hofer, Reinhard W Holl, ,

<h4>Objective</h4>To investigate the temporal trend of metabolic control and potential predictors in German and Austrian children and adolescents with type 1 diabetes.<h4>Research design and methods</h4>This study is based on a large, multicenter database for prospective longitudinal documentation of diabetes care in Germany and Austria. Data from 30,708 patients documented in ... Read more >>

Diabetes Care (Diabetes care)
[2012, 35(1):80-86]

Cited: 109 times

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Association of epilepsy and type 1 diabetes mellitus in children and adolescents: is there an increased risk for diabetic ketoacidosis?

Edith Schober, Klaus Peter Otto, Axel Dost, Norbert Jorch, Reinhard Holl, ,

<h4>Objective</h4>To estimate the prevalence of epilepsy and possible risk factors in children and adolescents with diabetes mellitus.<h4>Study design</h4>We conducted an observational cohort study based on the Diabetes Patienten Verlaufsdokumentation database including data from 45 851 patients (52% male) with type 1 diabetes mellitus, age 13.9 ± 4.3 years (mean ± ... Read more >>

J Pediatr (The Journal of pediatrics)
[2012, 160(4):662-666.e1]

Cited: 13 times

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Bone maturation in 1788 children and adolescents with diabetes mellitus type 1.

Axel Dost, Tilman Rohrer, Jörg Fussenegger, Christian Vogel, Bernd Schenk, Martin Wabitsch, Beate Karges, Claudia Vilser, Reinhard W Holl, , ,

Diabetes mellitus type 1 might interfere with pubertal development. Particularly, long-term metabolic control and intensity of insulin treatment have been reported to contribute to a delay in pubertal onset. Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2010, 23(9):891-898]

Cited: 2 times

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Initial insulin therapy in children and adolescents with type 1 diabetes mellitus.

Dieter Weitzel, Ulla Pfeffer, Axel Dost, Antje Herbst, Ina Knerr, Reinhard Holl,

<h4>Objective</h4>The aim of the study was to define parameters that influence the initial insulin dosage in young subjects with type 1 diabetes regarding the amount of daily insulin, the ratios of basal and prandial insulin, and the insulin/carbohydrate ratios.<h4>Study design</h4>We used a computer-based registry (with prospectively collected data) in Germany ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2010, 11(3):159-165]

Cited: 1 time

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Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: a multicenter longitudinal survey in Germany and Austria.

Ina Knerr, Axel Dost, Rudolf Lepler, Klemens Raile, Edith Schober, Wolfgang Rascher, Reinhard W Holl, ,

<h4>Objective</h4>Arterial blood pressure was followed in 868 patients with type 1 diabetes aged 6.0-19.9 years in 95 centers in Germany and Austria.<h4>Research design and methods</h4>European blood pressure reference data for 28,043 children and adolescents were used with respect to age and sex. Data were stratified into three groups: prepubertal, pubertal, ... Read more >>

Diabetes Care (Diabetes care)
[2008, 31(4):726-727]

Cited: 14 times

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Arterial hypertension determined by ambulatory blood pressure profiles: contribution to microalbuminuria risk in a multicenter investigation in 2,105 children and adolescents with type 1 diabetes.

Axel Dost, Christoph Klinkert, Thomas Kapellen, Andreas Lemmer, Andrea Naeke, Matthias Grabert, Joachim Kreuder, Reinhard W Holl, ,

<h4>Objective</h4>Arterial hypertension is a key player in the development of diabetes complications. We used a nationwide database to study risk factors for abnormal 24-h blood pressure regulation and microalbuminuria in children and adolescents with type 1 diabetes.<h4>Research design and methods</h4>Ambulatory blood pressure monitoring was performed in 2,105 children and adolescents ... Read more >>

Diabetes Care (Diabetes care)
[2008, 31(4):720-725]

Cited: 36 times

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Effect of dexamethasone on the IGFBP-1 regulation in premature infants during the first weeks of life.

Axel Dost, Eberhard Kauf, Dorothea Schlenvoigt, Dirk Schramm, Felix Zintl, Axel Hübler,

<h4>Background</h4>Early glucosteroid treatment in preterm infants has a negative impact on physical growth and development. So far, data on dexamethasone effect on the GH/IGF axis and the clinical outcome are conflicting.<h4>Objective</h4>Therefore, we studied the effect of dexamethasone treatment on parameters of somatic growth and on the secretion of insulin like ... Read more >>

Biologics (Biologics : targets & therapy)
[2007, 1(4):449-453]

Cited: 1 time

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