Full Text Journal Articles by
Author Aura Andreasen


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Technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries.

Suzanna C Francis, Arun Parajuli, Otilia Mardh, Jane Falconer, Aura Andreasen, Emma Harding-Esch, ,

OBJECTIVES:This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care for populations at risk for specific curable sexually transmitted infections (STIs) (chlamydia, gonorrhoea, syphilis, trichomoniasis, and Mycoplasma genitalium infections). ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):64]

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Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal.

Emma M Harding-Esch, Martin J Holland, Jean-François Schémann, Ansumana Sillah, Boubacar Sarr, Linus Christerson, Harry Pickering, Sandra Molina-Gonzalez, Isatou Sarr, Aura A Andreasen, David Jeffries, Chris Grundy, David C W Mabey, Bjorn Herrmann, Robin L Bailey,

BACKGROUND:Mass drug administration (MDA) with azithromycin is a cornerstone of the trachoma elimination strategy. Although the global prevalence of active trachoma has declined considerably, prevalence persists or even increases in some communities and districts. To increase understanding of MDA impact, we investigated the prevalence of active trachoma and ocular C. ... Read more >>

Parasit Vectors (Parasites & vectors)
[2019, 12(1):497]

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HPV prevalence around the time of sexual debut in adolescent girls in Tanzania.

Kathy J Baisley, Aura Andreasen, Julia Irani, Soori Nnko, John Changalucha, Tania Crucitti, Suzanna Francis, Christian Holm Hansen, Richard J Hayes, Anne Buvé, Deborah Watson-Jones,

OBJECTIVES:Cervical cancer is the leading cause of cancer-related mortality among women in sub-Saharan Africa (SSA). Data on human papillomavirus (HPV) epidemiology in adolescent girls in SSA are essential to inform HPV vaccine policy recommendations for cervical cancer prevention. We assessed the burden of HPV infection, and risk factors for infection, ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2020, 96(3):211-219]

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Immune Activation in the Female Genital Tract: Expression Profiles of Soluble Proteins in Women at High Risk for HIV Infection.

Suzanna C Francis, Yanwen Hou, Kathy Baisley, Janneke van de Wijgert, Deborah Watson-Jones, Trong T Ao, Carolina Herrera, Kaballa Maganja, Aura Andreasen, Saidi Kapiga, Gary R Coulton, Richard J Hayes, Robin J Shattock,

Soluble cervicovaginal biomarkers of inflammation, immune activation and risk of HIV acquisition are needed to reliably assess the safety of new biomedical prevention strategies including vaccines and microbicides. However, a fuller understanding of expression profiles in women at high risk for HIV infection is crucial to the effective use of ... Read more >>

PLoS ONE (PloS one)
[2016, 11(1):e0143109]

Cited: 19 times

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Longitudinal analysis of mature breastmilk and serum immune composition among mixed HIV-status mothers and their infants.

Sarah H Pedersen, Amanda L Wilkinson, Aura Andreasen, Safari M Kinung'hi, Mark Urassa, Denna Michael, Jim Todd, John Changalucha, Joann M McDermid,

Understanding mature breastmilk immunology may benefit infants chronically exposed to infectious pathogens in resource-limited regions.This prospective rural/semi-rural Tanzanian cohort of women (n = 102 at delivery; 38% HIV-positive) and their infants (n = 102) investigated breastmilk, maternal and infant serum immunoglobulins (IgA/IgG1-4/IgM) and cytokines (IL-1β/IL-2/IL-6/IL-10/IL-12p70/IL-13/IL-15/TNF-α/IFN-γ) at 1, 2, 3, 6-months postpartum.Milk immunoglobulins followed an ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2016, 35(4):871-879]

Cited: 5 times

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Correlates of the molecular vaginal microbiota composition of African women.

Raju Gautam, Hanneke Borgdorff, Vicky Jespers, Suzanna C Francis, Rita Verhelst, Mary Mwaura, Sinead Delany-Moretlwe, Gilles Ndayisaba, Jordan K Kyongo, Liselotte Hardy, Joris Menten, Tania Crucitti, Evgeni Tsivtsivadze, Frank Schuren, Janneke H H M van de Wijgert, ,

BACKGROUND:Sociodemographic, behavioral and clinical correlates of the vaginal microbiome (VMB) as characterized by molecular methods have not been adequately studied. VMB dominated by bacteria other than lactobacilli may cause inflammation, which may facilitate HIV acquisition and other adverse reproductive health outcomes. METHODS:We characterized the VMB of women in Kenya, Rwanda, ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2015, 15:86]

Cited: 17 times

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Cryptosporidium prevalence and risk factors among mothers and infants 0 to 6 months in rural and semi-rural Northwest Tanzania: a prospective cohort study.

Sarah H Pedersen, Amanda L Wilkinson, Aura Andreasen, David C Warhurst, Safari M Kinung'hi, Mark Urassa, Denna M Mkwashapi, Jim Todd, John Changalucha, Joann M McDermid,

Cryptosporidium epidemiology is poorly understood, but infection is suspected of contributing to childhood malnutrition and diarrhea-related mortality worldwide.A prospective cohort of 108 women and their infants in rural/semi-rural Tanzania were followed from delivery through six months. Cryptosporidium infection was determined in feces using modified Ziehl-Neelsen staining. Breastfeeding/infant feeding practices were ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2014, 8(10):e3072]

Cited: 7 times

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Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: a cross-sectional study.

Vicky Jespers, Tania Crucitti, Joris Menten, Rita Verhelst, Mary Mwaura, Kishor Mandaliya, Gilles F Ndayisaba, Sinead Delany-Moretlwe, Hans Verstraelen, Liselotte Hardy, Anne Buvé, Janneke van de Wijgert, ,

BACKGROUND:Clinical development of vaginally applied products aimed at reducing the transmission of HIV and other sexually transmitted infections, has highlighted the need for a better characterisation of the vaginal environment. We set out to characterise the vaginal environment in women in different settings in sub-Saharan Africa. METHODS:A longitudinal study was ... Read more >>

PLoS ONE (PloS one)
[2014, 9(10):e109670]

Cited: 37 times

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Deciphering the complex distribution of human immunodeficiency virus type 1 subtypes among different cohorts in Northern Tanzania.

Harr F Njai, Fiona M Ewings, Eric Lyimo, Vincent Foulongne, Dhamira Ngerageza, Aika Mongi, Deogratius Ssemwanga, Aura Andreasen, Balthazar Nyombi, Tony Ao, Denna Michael, Mark Urassa, Jim Todd, Basia Zaba, John Changalucha, Richard Hayes, Saidi H Kapiga,

Increased understanding of the genetic diversity of HIV-1 is challenging but important in the development of an effective vaccine. We aimed to describe the distribution of HIV-1 subtypes in northern Tanzania among women enrolled in studies preparing for HIV-1 prevention trials (hospitality facility-worker cohorts), and among men and women in ... Read more >>

PLoS ONE (PloS one)
[2013, 8(12):e81848]

Cited: 3 times

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Impact of malaria and helminth infections on immunogenicity of the human papillomavirus-16/18 AS04-adjuvanted vaccine in Tanzania.

Joelle Brown, Kathy Baisley, Bazil Kavishe, John Changalucha, Aura Andreasen, Philippe Mayaud, Balthazar Gumodoka, Saidi Kapiga, Richard Hayes, Deborah Watson-Jones,

Endemic malaria and helminth infections in sub-Saharan Africa can act as immunological modulators and impact responses to standard immunizations. We conducted a cohort study to measure the influence of malaria and helminth infections on the immunogenicity of the bivalent HPV-16/18 vaccine.We evaluated the association between malaria and helminth infections, and ... Read more >>

Vaccine (Vaccine)
[2014, 32(5):611-617]

Cited: 7 times

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HIV Infection among Young People in Northwest Tanzania: The Role of Biological, Behavioural and Socio-Demographic Risk Factors.

Francesca Lemme, Aoife M Doyle, John Changalucha, Aura Andreasen, Kathy Baisley, Kaballa Maganja, Deborah Watson-Jones, Saidi Kapiga, Richard J Hayes, David A Ross,

Young people are at high risk of HIV and developing appropriate prevention programmes requires an understanding of the risk factors for HIV in this age group. We investigated factors associated with HIV among participants aged 15-30 years in a 2007-8 cross-sectional survey nested within a community-randomised trial of the MEMA ... Read more >>

PLoS ONE (PloS one)
[2013, 8(6):e66287]

Cited: 4 times

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Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal.

Emma M Harding-Esch, Martin J Holland, Jean-François Schémann, Sandra Molina, Isatou Sarr, Aura A Andreasen, Chrissy h Roberts, Ansumana Sillah, Boubacar Sarr, Edward F Harding, Tansy Edwards, Robin L Bailey, David C W Mabey,

The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection in low prevalence and mass treated settings. Treatment decisions are currently based on the prevalence of clinical signs, and this may result in the unnecessary distribution of mass antibiotic treatment. We aimed to ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2011, 5(8):e1234]

Cited: 9 times

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Chlamydia trachomatis ompA variants in trachoma: what do they tell us?

Aura A Andreasen, Matthew J Burton, Martin J Holland, Spencer Polley, Nkoyo Faal, David C W Mabey, Robin L Bailey,

BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjunctival and nasal samples from a Gambian community were evaluated before and ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2008, 2(9):e306]

Cited: 20 times

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The impact of community level treatment and preventative interventions on trachoma prevalence in rural Ethiopia.

Phillippa Cumberland, Tansy Edwards, Girum Hailu, Emma Harding-Esch, Aura Andreasen, David Mabey, Jim Todd,

The International Trachoma Initiative (ITI) trachoma control programme based on the SAFE strategy (Surgery, Antibiotics, Facial cleanliness and Environmental improvement) was implemented in 2002 in two rural Ethiopian zones, with mass delivery of azithromycin starting in 2003. We evaluate the impact of combined antibiotic and health educational interventions on active ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2008, 37(3):549-558]

Cited: 16 times

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