Full Text Journal Articles by
Author Aubrey J Cunnington

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

Cited: 0 times

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A More Granular View of Neutrophils in Malaria.

Borko Amulic, Christopher A Moxon, Aubrey J Cunnington,

Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions. ... Read more >>

Trends Parasitol. (Trends in parasitology)
[2020, 36(6):501-503]

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Correspondence regarding recently published editorial: 'Will children reveal their secret? The coronavirus dilemma'.

Stefan Ebmeier, Aubrey J Cunnington,

Eur. Respir. J. (The European respiratory journal)
[2020, :]

Cited: 0 times

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Clinical and laboratory features associated with serum phosphate concentrations in malaria and other febrile illnesses.

Ho-Ming E Suen, Geoffrey Pasvol, Aubrey J Cunnington,

BACKGROUND:Hypophosphatemia is common in severe infections including malaria. Previous studies suggested that serum phosphate concentrations correlate with temperature, but it is unclear whether the type of infection and other factors occurring during infection influence this association. Here relationships were investigated between serum phosphate levels, cause of fever, demographic, clinical and ... Read more >>

Malar. J. (Malaria journal)
[2020, 19(1):85]

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Secondary re-analysis of the FEAST trial - Authors' reply.

Michael Levin, Aubrey J Cunnington, Clive J Hoggart,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(10):e31]

Cited: 0 times

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Shedding of the Vascular Endothelial Glycocalyx: A Common Pathway to Severe Malaria?

Athina Georgiadou, Aubrey J Cunnington,

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(10):1721-1723]

Cited: 0 times

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In transition: current health challenges and priorities in Sudan.

Esmita Charani, Aubrey J Cunnington, AlaEldin H A Yousif, Mohammed Seed Ahmed, Ammar E M Ahmed, Souad Babiker, Shahinaz Badri, Wouter Buytaert, Michael A Crawford, Mustafa I Elbashir, Kamal Elhag, Kamal E Elsiddig, Nadey Hakim, Mark R Johnson, Alexander D Miras, Mohamed O Swar, Michael R Templeton, Simon David Taylor-Robinson,

A recent symposium and workshop in Khartoum, the capital of the Republic of Sudan, brought together broad expertise from three universities to address the current burden of communicable and non-communicable diseases facing the Sudanese healthcare system. These meetings identified common challenges that impact the burden of diseases in the country, ... Read more >>

BMJ Glob Health (BMJ global health)
[2019, 4(4):e001723]

Cited: 0 times

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Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.

Sebastian Lorenz Knackstedt, Athina Georgiadou, Falko Apel, Ulrike Abu-Abed, Christopher A Moxon, Aubrey J Cunnington, Bärbel Raupach, Deirdre Cunningham, Jean Langhorne, Renate Krüger, Valentina Barrera, Simon P Harding, Aase Berg, Sam Patel, Kari Otterdal, Benjamin Mordmüller, Evelin Schwarzer, Volker Brinkmann, Arturo Zychlinsky, Borko Amulic,

Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs) when they die. This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we define two mechanisms ... Read more >>

Sci Immunol (Science immunology)
[2019, 4(40):]

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Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions.

Athina Georgiadou, Hyun Jae Lee, Michael Walther, Anna E van Beek, Fadlila Fitriani, Diana Wouters, Taco W Kuijpers, Davis Nwakanma, Umberto D'Alessandro, Eleanor M Riley, Thomas D Otto, Azra Ghani, Michael Levin, Lachlan J Coin, David J Conway, Michael T Bretscher, Aubrey J Cunnington,

During infection, increasing pathogen load stimulates both protective and harmful aspects of the host response. The dynamics of this interaction are hard to quantify in humans, but doing so could improve understanding of the mechanisms of disease and protection. We sought to model the contributions of the parasite multiplication rate ... Read more >>

Nat Microbiol (Nature microbiology)
[2019, 4(9):1592-1602]

Cited: 0 times

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Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial.

Michael Levin, Aubrey J Cunnington, Clare Wilson, Simon Nadel, Hans Joerg Lang, Nelly Ninis, Mignon McCulloch, Andrew Argent, Heloise Buys, Christopher A Moxon, Abigail Best, Ruud G Nijman, Clive J Hoggart,

BACKGROUND:Fluid resuscitation is the recommended management of shock, but increased mortality in febrile African children in the FEAST trial. We hypothesised that fluid bolus-induced deaths in FEAST would be associated with detectable changes in cardiovascular, neurological, or respiratory function, oxygen carrying capacity, and blood biochemistry. METHODS:We developed composite scores for ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(7):581-593]

Cited: 0 times

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Complement Factor H Levels Associate With Plasmodium falciparum Malaria Susceptibility and Severity.

Anna E van Beek, Isatou Sarr, Simon Correa, Davis Nwakanma, Mieke C Brouwer, Diana Wouters, Fatou Secka, Suzanne T B Anderson, David J Conway, Michael Walther, Michael Levin, Taco W Kuijpers, Aubrey J Cunnington,

Background:Plasmodium falciparum may evade complement-mediated host defense by hijacking complement Factor H (FH), a negative regulator of the alternative complement pathway. Plasma levels of FH vary between individuals and may therefore influence malaria susceptibility and severity. Methods:We measured convalescent FH plasma levels in 149 Gambian children who had recovered from ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(7):ofy166]

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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.

Hyun Jae Lee, Athina Georgiadou, Michael Walther, Davis Nwakanma, Lindsay B Stewart, Michael Levin, Thomas D Otto, David J Conway, Lachlan J Coin, Aubrey J Cunnington,

The pathogenesis of infectious diseases depends on the interaction of host and pathogen. In Plasmodium falciparum malaria, host and parasite processes can be assessed by dual RNA sequencing of blood from infected patients. We performed dual transcriptome analyses on samples from 46 malaria-infected Gambian children to reveal mechanisms driving the ... Read more >>

Sci Transl Med (Science translational medicine)
[2018, 10(447):]

Cited: 8 times

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Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.

Hyun Jae Lee, Athina Georgiadou, Thomas D Otto, Michael Levin, Lachlan J Coin, David J Conway, Aubrey J Cunnington,

Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to investigate host and pathogen processes in infectious diseases. Technical and bioinformatic advances have permitted increasingly thorough analyses of the association of RNA expression with fundamental biology, immunity, pathogenesis, diagnosis, and prognosis. Transcriptomic approaches can now be used to ... Read more >>

Microbiol. Mol. Biol. Rev. (Microbiology and molecular biology reviews : MMBR)
[2018, 82(2):]

Cited: 2 times

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Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates.

Andrew J McArdle, James Webbe, Kathleen Sim, Graham Parrish, Clive Hoggart, Yifei Wang, J Simon Kroll, Sunit Godambe, Aubrey J Cunnington,

Carboxyhemoglobin levels in blood reflect endogenous carbon monoxide production and are often measured during routine blood gas analysis. Endogenous carbon monoxide production has been reported to be increased during sepsis, but carboxyhemoglobin levels have not been thoroughly evaluated as a biomarker of sepsis. We sought to determine whether carboxyhemoglobin levels ... Read more >>

PLoS ONE (PloS one)
[2016, 11(8):e0161784]

Cited: 2 times

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"Vaginal seeding" of infants born by caesarean section.

Aubrey J Cunnington, Kathleen Sim, Aniko Deierl, J Simon Kroll, Eimear Brannigan, Jonathan Darby,

BMJ (BMJ (Clinical research ed.))
[2016, 352:i227]

Cited: 18 times

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Author's reply to Banda and Lokugamage.

Aubrey J Cunnington,

BMJ (BMJ (Clinical research ed.))
[2016, 352:i1738]

Cited: 0 times

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Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Jessica H Chertow, Matthew S Alkaitis, Glenn Nardone, Allison K Ikeda, Aubrey J Cunnington, Joseph Okebe, Augustine O Ebonyi, Madi Njie, Simon Correa, Shamanthi Jayasooriya, Climent Casals-Pascual, Oliver Billker, David J Conway, Michael Walther, Hans Ackerman,

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an endogenous NO synthase (NOS) inhibitor, and arginine, the NOS substrate. We carried out a community-based case-control ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2015, 11(9):e1005119]

Cited: 10 times

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Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection.

Katharine Orf, Aubrey J Cunnington,

Increased susceptibility to co-infection with enteric Gram-negative bacteria, particularly non-typhoidal Salmonella, is reported in malaria and Oroya fever (Bartonella bacilliformis infection), and can lead to increased mortality. Accumulating epidemiological evidence indicates a causal association with risk of bacterial co-infection, rather than just co-incidence of common risk factors. Both malaria and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2015, 6:666]

Cited: 10 times

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The importance of pathogen load.

Aubrey J Cunnington,

PLoS Pathog. (PLoS pathogens)
[2015, 11(1):e1004563]

Cited: 6 times

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Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes.

Aubrey J Cunnington, Eleanor M Riley, Michael Walther,

Severe malaria defines individuals at increased risk of death from their infection. Proposed pathogenic mechanisms include parasite sequestration, inflammation, and endothelial dysfunction. Severe malaria is not a single entity, manifesting with distinct syndromes such as severe anemia, severe respiratory distress or coma, each characterized by differences in epidemiology, underlying biology, ... Read more >>

Trends Parasitol. (Trends in parasitology)
[2013, 29(12):585-592]

Cited: 33 times

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Piecing together the puzzle of severe malaria.

Aubrey J Cunnington, Michael Walther, Eleanor M Riley,

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identified as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these findings into new therapies. ... Read more >>

Sci Transl Med (Science translational medicine)
[2013, 5(211):211ps18]

Cited: 16 times

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Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria.

Aubrey J Cunnington, Michael T Bretscher, Sarah I Nogaro, Eleanor M Riley, Michael Walther,

To determine whether sequestration of parasitized red blood cells differs between children with uncomplicated and severe Plasmodium falciparum malaria.We quantified circulating-, total- and sequestered-parasite biomass, using a mathematical model based on plasma concentration of P. falciparum histidine rich protein 2, in Gambian children with severe (n = 127) and uncomplicated ... Read more >>

J. Infect. (The Journal of infection)
[2013, 67(3):220-230]

Cited: 23 times

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Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction.

Aubrey J Cunnington, Madi Njie, Simon Correa, Ebako N Takem, Eleanor M Riley, Michael Walther,

It is not known why people are more susceptible to bacterial infections such as nontyphoid Salmonella during and after a malaria infection, but in mice, malarial hemolysis impairs resistance to nontyphoid Salmonella by impairing the neutrophil oxidative burst. This acquired neutrophil dysfunction is a consequence of induction of the cytoprotective, ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2012, 189(11):5336-5346]

Cited: 61 times

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Microvascular dysfunction in severe Plasmodium falciparum Malaria.

Aubrey J Cunnington, Eleanor M Riley, Michael Walther,

J. Infect. Dis. (The Journal of infectious diseases)
[2013, 207(2):369-370]

Cited: 7 times

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Suppression of vaccine responses by malaria: insignificant or overlooked?

Aubrey J Cunnington, Eleanor M Riley,

Malaria is widely reported to suppress immune responses to heterologous antigens, including vaccines, but the evidence base for this assumption is patchy and confusing. Here we review the evidence for malaria-mediated suppression of responses to vaccination and conclude that: there is evidence of impairment of responses to heterologous polysaccharide antigens ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2010, 9(4):409-429]

Cited: 25 times

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