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Author Atulya Iyengar

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Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila.

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of <i>Superoxide dismutase 1</i> (<i>Sod1</i>) and by paraquat (PQ) feeding in <i>Drosophila</i>. We demonstrated alterations in <i>Sod1</i> mutants; the larval neuromuscular junction displayed supernumerary discharges and the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Fly seizure EEG: field potential activity in the Drosophila brain.

Atulya Iyengar, Chun-Fang Wu,

Hypersynchronous neural activity is a characteristic feature of seizures. Although many <i>Drosophila</i> mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2021, 35(3):295-305]

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Fly seizure EEG: field potential activity in the Drosophila brain

Atulya Iyengar, Chun-Fang Wu,

Hypersynchronous neural activity is a characteristic feature of seizures. Although many Drosophila mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local ... Read more >>

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Diet modifies allele-specific phenotypes in Drosophila carrying epilepsy-associated PNPO variants

Wanhao Chi, Atulya SR Iyengar, Wenqin Fu, Wei Liu, Abigayle Berg, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox(am)ine 5’-phosphate oxidase (PNPO) catalyzes the rate-limiting step in the synthesis of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 required for the synthesis of neurotransmitters GABA and monoamines. Pathogenic variants in PNPO have been repeatedly identified in patients with neonatal epileptic encephalopathy and early-onset epilepsy. These patients often ... Read more >>

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Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of Superoxide dismutase ( Sod ) and by paraquat (PQ) feeding in Drosophila . We demonstrated alterations in Sod mutants; the larval neuromuscular junction displayed supernumerary discharges ... Read more >>

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Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster.

Wanhao Chi, Atulya S R Iyengar, Monique Albersen, Marjolein Bosma, Nanda M Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox (am) ine 5'-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5'-phosphate (PLP), the biologically active form of VB6 and involved in the synthesis of neurotransmitters including γ-aminobutyric acid (GABA), dopamine, and serotonin. In humans, PNPO mutations have been increasingly identified in neonatal ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2019, 28(18):3126-3136]

Cited: 2 times

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Milk-whey diet substantially suppresses seizure-like phenotypes of paraShu, a Drosophila voltage-gated sodium channel mutant.

Junko Kasuya, Atulya Iyengar, Hung-Lin Chen, Patrick Lansdon, Chun-Fang Wu, Toshihiro Kitamoto,

The <i>Drosophila</i> mutant <i>para<sup>Shu</sup></i> harbors a dominant, gain-of-function allele of the voltage-gated sodium channel gene, <i>paralytic</i> (<i>para</i>). The mutant flies display severe seizure-like phenotypes, including neuronal hyperexcitability, spontaneous spasms, ether-induced leg shaking, and heat-induced convulsions. We unexpectedly found that two distinct food recipes used routinely in the <i>Drosophila</i> research community ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2019, 33(3):164-178]

Cited: 4 times

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Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: Quantitative spike pattern analysis in Drosophila flight muscles

Jisue Lee, Atulya Iyengar, Chun-Fang Wu,

In Drosophila , high-frequency electrical stimulation across the brain triggers a highly stereotypic repertoire of spasms known as electroconvulsive seizures (ECS). The distinctive ECS spiking discharges manifest across the nervous system and can be stably assessed throughout the seizure repertoire in the large indirect flight muscles (DLMs). ECS discharges in ... Read more >>

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Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster

Wanhao Chi, Atulya Iyengar, Monique Albersen, Marjolein Bosma, Nanda Verhoeven-Duif, Chun-Fang Wu, Xiaoxi Zhuang,

Pyridox(am)ine 5’-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5’-phosphate (PLP), the biologically active form of VB6, and involved in the synthesis of neuro-transmitters including GABA, dopamine, and serotonin. In humans, PNPO mutations have been increasingly identified in neonatal epileptic encephalopathy and more ... Read more >>

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Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: quantitative spike pattern analysis in Drosophila flight muscles.

Jisue Lee, Atulya Iyengar, Chun-Fang Wu,

In <i>Drosophila</i>, high-frequency electrical stimulation across the brain triggers a highly stereotypic repertoire of spasms. These electroconvulsive seizures (ECS) manifest as distinctive spiking discharges across the nervous system and can be stably assessed throughout the seizure repertoire in the large indirect flight muscles dorsal longitudinal muscles (DLMs) to characterize modifications ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2019, 33(2):125-142]

Cited: 2 times

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Two Novel Forms of ERG Oscillation in Drosophila: Age and Activity Dependence

Atsushi Ueda, Scott Woods, Ian McElree, Tristan C.D.G. O’Harrow, Casey Inman, Savantha Thenuwara, Muhammad Aftab, Atulya Iyengar,

Over an animal’s lifespan, neuronal circuits and systems often decline in an inherently heterogeneous fashion. To compare the age-dependent progression of changes in visual behavior with alterations in retinal physiology, we examined phototaxis and electroretinograms (ERGs) in a wild-type D. melanogaster strain (Canton-S) across their lifespan. In aged flies (beyond ... Read more >>

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Two novel forms of ERG oscillation in Drosophila: age and activity dependence.

Atsushi Ueda, Scott Woods, Ian McElree, Tristan C D G O'Harrow, Casey Inman, Savantha Thenuwara, Muhammad Aftab, Atulya Iyengar,

Over an animal's lifespan, neuronal circuits and systems often decline in an inherently heterogeneous fashion. To compare the age-dependent progression of changes in visual behavior with alterations in retinal physiology, we examined phototaxis and electroretinograms (ERGs) in a wild-type D. melanogaster strain (Canton-S) across their lifespan. In aged flies (beyond ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2018, 32(2):118-126]

Cited: 1 time

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Mutation of orthologous prickle genes causes a similar epilepsy syndrome in flies and humans.

Salleh N Ehaideb, Elizabeth A Wignall, Junko Kasuya, William H Evans, Atulya Iyengar, Haley L Koerselman, Anthony J Lilienthal, Alexander G Bassuk, Toshihiro Kitamoto, J Robert Manak,

<h4>Objective</h4>Genetically tractable fruit flies have been used for decades to study seizure disorders. However, there is a paucity of data specifically correlating fly and human seizure phenotypes. We have previously shown that mutation of orthologous PRICKLE genes from flies to humans produce seizures. This study aimed to determine whether the ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2016, 3(9):695-707]

Cited: 5 times

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prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies.

Salleh N Ehaideb, Atulya Iyengar, Atsushi Ueda, Gary J Iacobucci, Cathryn Cranston, Alexander G Bassuk, David Gubb, Jeffrey D Axelrod, Shermali Gunawardena, Chun-Fang Wu, J Robert Manak,

Recent analyses in flies, mice, zebrafish, and humans showed that mutations in prickle orthologs result in epileptic phenotypes, although the mechanism responsible for generating the seizures was unknown. Here, we show that Prickle organizes microtubule polarity and affects their growth dynamics in axons of Drosophila neurons, which in turn influences ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(30):11187-11192]

Cited: 31 times

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Flight and seizure motor patterns in Drosophila mutants: simultaneous acoustic and electrophysiological recordings of wing beats and flight muscle activity.

Atulya Iyengar, Chun-Fang Wu,

Abstract Tethered flies allow studies of biomechanics and electrophysiology of flight control. We performed microelectrode recordings of spikes in an indirect flight muscle (the dorsal longitudinal muscle, DLMa) coupled with acoustic analysis of wing beat frequency (WBF) via microphone signals. Simultaneous electrophysiological recording of direct and indirect flight muscles has ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2014, 28(3-4):316-328]

Cited: 10 times

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Automated quantification of locomotion, social interaction, and mate preference in Drosophila mutants.

Atulya Iyengar, Jordan Imoehl, Atsushi Ueda, Jeffery Nirschl, Chun-Fang Wu,

Automated tracking methods facilitate screening for and characterization of abnormal locomotion or more complex behaviors in Drosophila. We developed the Iowa Fly Locomotion and Interaction Tracker (IowaFLI Tracker), a MATLAB-based video analysis system, to identify and track multiple flies in a small arena. We report altered motor activity in the ... Read more >>

J Neurogenet (Journal of neurogenetics)
[2012, 26(3-4):306-316]

Cited: 7 times

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Post-eclosion odor experience modifies olfactory receptor neuron coding in Drosophila.

Atulya Iyengar, Tuhin Subhra Chakraborty, Sarit Pati Goswami, Chun-Fang Wu, Obaid Siddiqi,

Olfactory responses of Drosophila undergo pronounced changes after eclosion. The flies develop attraction to odors to which they are exposed and aversion to other odors. Behavioral adaptation is correlated with changes in the firing pattern of olfactory receptor neurons (ORNs). In this article, we present an information-theoretic analysis of the ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2010, 107(21):9855-9860]

Cited: 15 times

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