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Author Asuncion Mejias

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Age-dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

<h4>Background</h4>Age-dependent differences in clinical presentation and viral loads in infants and young children with respiratory syncytial virus (RSV) infection, and their correlation with disease severity are poorly defined.<h4>Methods</h4>Previously healthy children <2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and viral loads measured by polymerase chain ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):116-122]

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A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque.

Tiffany Jenkins, Rongzhang Wang, Olivia Harder, Miaoge Xue, Phylip Chen, Jacqueline Corry, Christopher Walker, Michael Teng, Asuncion Mejias, Octavio Ramilo, Stefan Niewiesk, Jianrong Li, Mark E Peeples,

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in children of <5 years of age worldwide, infecting the majority of infants in their first year of life. Despite the widespread impact of this virus, no vaccine is currently available. For more than 50 years, ... Read more >>

J Virol (Journal of virology)
[2021, 95(3):]

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Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood.

Johanna Lempainen, Laura S Korhonen, Katri Kantojärvi, Santtu Heinonen, Laura Toivonen, Panu Räty, Octavio Ramilo, Asuncion Mejias, Antti-Pekka Laine, Tytti Vuorinen, Matti Waris, Linnea Karlsson, Hasse Karlsson, Tiina Paunio, Ville Peltola,

<h4>Background</h4>Genetic heterogeneity in type I interferon (IFN)-related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children.<h4>Methods</h4>In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 223(1):157-165]

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Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection.

Darawan Rinchai, Matthew C Altman, Oceane Konza, Signe Hässler, Federica Martina, Mohammed Toufiq, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Karolina Palucka, Asuncion Mejias, Octavio Ramilo, Davide Bedognetti, Encarnita Mariotti-Ferrandiz, David Klatzmann, Damien Chaussabel,

Biomarkers to assess the risk of developing severe respiratory syncytial virus (RSV) infection are needed. We conducted a meta-analysis of 490 unique profiles from six public RSV blood transcriptome datasets. A repertoire of 382 well-characterized transcriptional modules was used to define dominant host responses to RSV infection. The consolidated RSV ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2020, 10(8):e244]

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Skin Manifestations During the COVID-19 Pandemic in the Pediatric Emergency Department.

Silvia Oliva Rodríguez-Pastor, Laura Martín Pedraz, Begoña Carazo Gallego, Rocío Galindo Zavala, Gema Lozano Sánchez, Inmaculada de Toro Peinado, Margarita Rodriguez Benjumea, Asuncion Mejias, Esmeralda Núñez Cuadros,

<h4>Background</h4>The role of SARS-CoV-2 as the cause of chilblains in children remains a matter of debate, but important to elucidate for patient isolation and contact tracing. We sought to define the etiology, clinical presentation, time course and outcomes of children presenting to the Emergency Department (ED) with cutaneous manifestations shortly ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Clinical Disease Severity Scores and Viral Loads in Children with RSV Infection.

Asuncion Mejias, Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Octavio Ramilo,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans.

Russell C Ault, Colwyn A Headley, Alexander E Hare, Bridget J Carruthers, Asuncion Mejias, Joanne Turner,

Tuberculosis (TB) is the leading cause of death due to a single infectious disease. Knowing when a person was infected with Mycobacterium tuberculosis (M.tb) is critical as recent infection is the strongest clinical risk factor for progression to TB disease in immunocompetent individuals. However, time since M.tb infection is challenging ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):16873]

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1410. Neonatal Herpes Simplex Virus (HSV) Infection: Is It the Only Pathogen?

Alvaro Dendi, Ingrith Viviana Hoyos Garcia, Asuncion Mejias, Cory T Hanlon, Pablo J Sanchez,

Abstract <h4>Background</h4> Neonatal HSV infection is associated with substantial morbidity and mortality. Therefore, prompt identification and treatment of infected neonates is paramount. At Nationwide Children’s Hospital (NCH), Columbus, OH all neonates admitted in the first 2 weeks (up to 2010) and 4 weeks (since 2010) of age are evaluated for ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S712-S713]

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1465. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children with Respiratory Syncytial Virus Infection (RSV) Infection

Helena Brenes-Chacon, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Differences in clinical presentation and viral loads according to age in young children with RSV, and their correlation with disease severity are poorly defined. The aim of this study was to define age-dependent the differences in demographic, clinical factors and viral loads between children < 2 years of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S734-S735]

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Recurrent wheezing during the first 3 years of life in a birth cohort of moderate-to-late preterm infants.

Antonio Moreno-Galdó, Eduardo G Pérez-Yarza, Octavio Ramilo, Teresa Rubí, Amparo Escribano, Antonio Torres, Olaia Sardón, Concepción Oliva, Guadalupe Pérez, Isidoro Cortell, Sandra Rovira-Amigo, Maria D Pastor-Vivero, Javier Pérez-Frías, Valle Velasco, Javier Torres, Joan Figuerola, María Isabel Barrio, Gloria García-Hernández, Asunción Mejías, ,

<h4>Background</h4>Data addressing short- and long-term respiratory morbidity in moderate-late preterm infants are limited. We aim to determine the incidence of recurrent wheezing and associated risk and protective factors in these infants during the first 3 years of life.<h4>Methods</h4>Prospective, multicenter birth cohort study of infants born at 32<sup>+0</sup> to 35<sup>+0</sup>  weeks' gestation ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(2):124-132]

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Year-Round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants.

Cristina Tomatis Souverbielle, Huanyu Wang, John Feister, Jason Campbell, Alexandra Medoro, Asuncion Mejias, Octavio Ramilo, Domenico Pietropaolo, Douglas Salamon, Amy Leber, Guliz Erdem,

<h4>Objectives</h4>To test our hypothesis that routine year-round testing of specimens from multiple body sites and genotyping of detected virus would describe seasonal changes, increase diagnostic yield, and provide a better definition of clinical manifestations of human parechovirus (PeV-A) infections in young febrile infants.<h4>Study design</h4>PeV-A reverse-transcriptase polymerase chain reaction (RT-PCR) analysis ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, :]

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131. The Protective Role of Mucosal Interferons in Infants with Respiratory Syncytial Virus (RSV) Infection

Jeanette Taveras, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Mark E Peeples, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Despite the high burden associated with RSV infection in young children the factors that determine disease severity are not well understood. The objective of this study was to assess the association of mucosal cytokine profiles, RSV loads (VL) and RSV disease severity. <h4>Methods</h4> Single-center, prospective study in previously ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S195-S196]

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Development of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

Matthew Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Kabeer, Mohamed Alfaki, Scott Presnell, Prasong Khaenam, Aaron Ayllon-Benitez, Fleur Mougin, Patricia Thébault, Laurent chiche, Noemie Jourde-Chiche, Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert Wilkinson, Christine Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiébaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel,

As the capacity for generating large scale data continues to grow the ability to extract meaningful biological knowledge from it remains a limitation. Here we describe the development of a new fixed repertoire of transcriptional modules. It is meant to serve as a stable reusable framework for the analysis and ... Read more >>

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Preventive Strategies for Respiratory Syncytial Virus Infection in Young Infants.

Jeanette Taveras, Octavio Ramilo, Asuncion Mejias,

Respiratory syncytial virus (RSV) is the leading cause of acute viral lower respiratory tract infections in young children, with the peak of severe disease occurring in infants younger than 6 months of age. Most infants who develop severe RSV infection are born full-term and previously healthy; however, premature infants represent ... Read more >>

Neoreviews (NeoReviews)
[2020, 21(8):e535-e545]

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Author Correction: Baseline and Disease-Induced Transcriptional Profiles in Children with Sickle Cell Disease.

Susan Creary, Chandra L Shrestha, Kavitha Kotha, Abena Minta, James Fitch, Lisa Jaramillo, Shuzhong Zhang, Swaroop Pinto, Rohan Thompson, Octavio Ramilo, Peter White, Asuncion Mejias, Benjamin T Kopp,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13530]

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Blood genome expression profiles in infants with congenital cytomegalovirus infection.

Christopher P Ouellette, Pablo J Sánchez, Zhaohui Xu, Derek Blankenship, Fiker Zeray, Andrea Ronchi, Masako Shimamura, Damien Chaussabel, Lizette Lee, Kris E Owen, Angela G Shoup, Octavio Ramilo, Asuncion Mejias,

Congenital CMV infection (cCMVi) affects 0.5-1% of all live births worldwide, making it the leading cause of sensorineural hearing loss (SNHL) in childhood. The majority of infants with cCMVi have normal hearing at birth, but are at risk of developing late-onset SNHL. Currently, we lack reliable biomarkers to predict the ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3548]

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Mapping systemic lupus erythematosus heterogeneity at the single-cell level.

Djamel Nehar-Belaid, Seunghee Hong, Radu Marches, Guo Chen, Mohan Bolisetty, Jeanine Baisch, Lynnette Walters, Marilynn Punaro, Robert J Rossi, Cheng-Han Chung, Richie P Huynh, Prashant Singh, William F Flynn, Joy-Ann Tabanor-Gayle, Navya Kuchipudi, Asuncion Mejias, Magalie A Collet, Anna Lisa Lucido, Karolina Palucka, Paul Robson, Santhanam Lakshminarayanan, Octavio Ramilo, Tracey Wright, Virginia Pascual, Jacques F Banchereau,

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 matched controls. Increased expression of interferon-stimulated genes (ISGs) distinguished ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(9):1094-1106]

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Upper airway microbiome changes in children with sickle cell disease during vaso-occlusive and acute chest syndrome episodes.

Brett R Loman, Chandra L Shrestha, Kavitha Kotha, Abena Minta, Shuzhong Zhang, Asuncion Mejias, Michael T Bailey, Susan Creary, Benjamin T Kopp,

Am J Hematol (American journal of hematology)
[2020, :]

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Meeting Report: Harmonization of RSV therapeutics – from design to performance

Harish Nair, Octavio Ramilo, Irmgard Eichler, Eric Pelfrene, Asuncion Mejias, Fernando P Polack, Koen B. Pouwels, Joanne M. Langley, Marta Nunes, Nicoline van der Maas, Leyla Kragten–Tabatabaie, Eugenio Baraldi, Terho Heikkinen, Brigitte Fauroux, Mike Sharland, Cyrus Park, Paolo Manzoni, Nikolaos G. Papadopoulos, Federico Martinón–Torres, Renato Stein, Louis Bont, in collaboration with Respiratory Syncytial Virus Network (ReSViNET),

(Journal of Global Health)
[0, 6(1):]

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Metabolomics profiling of tobacco exposure in children with cystic fibrosis.

Benjamin L Wisniewski, Chandra L Shrestha, Shuzhong Zhang, Rohan Thompson, Myron Gross, Judith A Groner, Karan Uppal, Octavio Ramilo, Asuncion Mejias, Benjamin T Kopp,

BACKGROUND:Inflammation is integral to early disease progression in children with CF. The effect of modifiable environmental factors on infection and inflammation in persons with CF is poorly understood. Our prior studies determined that secondhand smoke exposure (SHSe) is highly prevalent in young children with CF. SHSe is associated with increased ... Read more >>

J Cyst Fibros (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2020, 19(5):791-800]

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Measuring the Burden of RSV in Children to Precisely Assess the Impact of Preventive Strategies.

Octavio Ramilo, Asuncion Mejias,

Pediatrics (Pediatrics)
[2020, 146(1):]

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Hepatitis in children with tuberculosis: a case report and review of the literature.

Maria Sanchez-Codez, W Garret Hunt, Joshua Watson, Asuncion Mejias,

<h4>Background</h4>Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment.<h4>Case presentation</h4>We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):173]

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Baseline and Disease-Induced Transcriptional Profiles in Children with Sickle Cell Disease.

Susan Creary, Chandra L Shrestha, Kavitha Kotha, Abena Minta, James Fitch, Lisa Jaramillo, Shuzhong Zhang, Swaroop Pinto, Rohan Thompson, Octavio Ramilo, Peter White, Asuncion Mejias, Benjamin T Kopp,

Acute chest syndrome (ACS) is a significant cause of morbidity and mortality in sickle cell disease (SCD), but preventive, diagnostic, and therapeutic options are limited. Further, ACS and acute vasoccclusive pain crises (VOC) have overlapping features, which causes diagnostic dilemmas. We explored changes in gene expression profiles among patients with ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9013]

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Advanced Live Attenuated Vaccines for the Prevention of Respiratory Syncytial Virus Infections in Young Children.

Octavio Ramilo, Rosa Rodriguez-Fernandez, Mark E Peeples, Asuncion Mejias,

J Infect Dis (The Journal of infectious diseases)
[2020, 222(1):4-6]

Cited: 1 time

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Age and environmental exposures influence the fecal bacteriome of young children with cystic fibrosis.

Brett R Loman, Chandra L Shrestha, Rohan Thompson, Judith A Groner, Asuncion Mejias, Kathryn L Ruoff, George A O'Toole, Michael T Bailey, Benjamin T Kopp,

BACKGROUND:Mechanisms that facilitate early infection and inflammation in cystic fibrosis (CF) are unclear. We previously showed that young CF children with secondhand smoke exposure (SHSe) have increased susceptibility to respiratory infections. We aimed to define the impact of SHSe and other external factors upon the fecal bacteriome in early CF. ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(7):1661-1670]

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