Full Text Journal Articles by
Author Asta Valanciute

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Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19.

Clark D Russell, Asta Valanciute, Naomi N Gachanja, Jillian Stephen, Rebekah Penrice-Randal, Stuart D Armstrong, Sara Clohisey, Bo Wang, Wael Al Qsous, William A Wallace, Gabriel C Oniscu, Jo Stevens, David J Harrison, Kevin Dhaliwal, Julian A Hiscox, J Kenneth Baillie, Ahsan R Akram, David A Dorward, Christopher D Lucas,

Immunopathology occurs in the lung and spleen in fatal COVID-19, involving monocytes/macrophages and plasma cells. Anti-inflammatory therapy reduces mortality but additional therapeutic targets are required. We aimed to gain mechanistic insight into COVID-19 immunopathology by targeted proteomic analysis of pulmonary and splenic tissues. Lung parenchymal and splenic tissue was obtained ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, :]

Cited: 0 times

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Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes

Clark Donald Russell, Asta Valanciute, Naomi Gachanja, Jillian Stephen, Rebekah Penrice-Randal, Stuart Armstrong, Sara Clohisey, Bo Wang, Wael Al Qsous, William Wallace, Gabriel Oniscu, Jo Stevens, David Harrison, Kevin Dhaliwal, Julian Hiscox, Kenneth Baillie, Ahsan Akram, David Dorward, Christopher Lucas,

Background: Tissue inflammation in fatal COVID-19 is concentrated in the lung and spleen. Anti-inflammatory therapy reduces mortality but knowledge on the host response at the level of inflamed tissues is incomplete. <br><br>Methods: We performed targeted proteomic analysis of pulmonary and splenic tissues from 13 fatal cases of COVID-19 ... Read more >>

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Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1.

Karen Dunbar, Asta Valanciute, Ana Cristina Silva Lima, Paz Freile Vinuela, Thomas Jamieson, Vidya Rajasekaran, James Blackmur, Anna-Maria Ochocka-Fox, Alice Guazzelli, Patrizia Cammareri, Mark J Arends, Owen J Sansom, Kevin B Myant, Susan M Farrington, Malcolm G Dunlop, Farhat V N Din,

<h4>Background & aims</h4>Aspirin reduces colorectal cancer (CRC) incidence and mortality. Understanding the biology responsible for this protective effect is key to developing biomarker-led approaches for rational clinical use. Wnt signaling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations. Here, we ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2021, 11(2):465-489]

Cited: 2 times

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Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoids

Karen Dunbar, Asta Valanciute, Vidya Rajasekaran, Thomas Jamieson, Paz Freile Vinuela, Ana Lima, James Blackmur, Anna-Maria Ochocka-Fox, Mark Arends, Owen Sansom, Kevin Myant, Susan Farrington, Malcolm Dunlop, Farhat V.N. Din,

<h4>ABSTRACT</h4> Aspirin reduces the incidence and mortality of colorectal cancer (CRC). Wnt signalling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations (CSC). Here, we investigated whether aspirin can rescue these pro-invasive phenotypes associated with CRC progression in Wnt-driven human and ... Read more >>

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Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.

Farhat V N Din, Asta Valanciute, Vanessa P Houde, Daria Zibrova, Kevin A Green, Kei Sakamoto, Dario R Alessi, Malcolm G Dunlop,

<h4>Background & aims</h4>Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates proliferation. We investigated whether aspirin affects adenosine monophosphate-activated protein kinase (AMPK) and mTOR signaling in CRC cells.<h4>Methods</h4>The effects of ... Read more >>

Gastroenterology (Gastroenterology)
[2012, 142(7):1504-15.e3]

Cited: 197 times

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Potential role of soluble ST2 protein in idiopathic nephrotic syndrome recurrence following kidney transplantation.

Sarah Bruneau, Ludmilla Le Berre, Caroline Hervé, Asta Valanciuté, Maud Kamal, Jeanne Naulet, Laurent Tesson, Yohann Foucher, Jean-Paul Soulillou, Djillali Sahali, Jacques Dantal,

<h4>Background</h4>Corticosteroid-resistant idiopathic nephrotic syndrome (INS) recurs rapidly after transplantation in 30% to 50% of transplant recipients, suggesting the presence of 1 or more circulating factors that alter the glomerular filtration barrier. We investigated the possible role in INS recurrence of soluble ST2 (sST2) protein, a marker of T helper type ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2009, 54(3):522-532]

Cited: 17 times

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C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity.

Maud Kamal, Asta Valanciute, Karine Dahan, Virginie Ory, Andre Pawlak, P Lang, Georges Guellaen, Djillali Sahali,

The fine regulation of NF-kappaB activity is crucial for both resting and stimulated cells and relies on complex balance between multiple activators and inhibitors. We report here that c-mip, a recently identified pleckstrin homology (PH) and leucine-rich repeat (LRR)-domain-containing protein, inactivates GSKbeta and interacts with RelA, a key member of ... Read more >>

Mol Immunol (Molecular immunology)
[2009, 46(5):991-998]

Cited: 21 times

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C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.

Maud Kamal, Andre Pawlak, Fatima BenMohamed, Asta Valanciuté, Karine Dahan, Marina Candelier, Philippe Lang, Georges Guellaën, Djillali Sahali,

In naive T cells, Lck exerts a negative control on the ERK/MAPK pathway. We show that c-mip (c-maf inducing protein) interacts with the p85 subunit of PI3 kinase and inactivates Lck, which results in Erk1/2 and p38 MAPK activation. This effect is not enough to activate AP1 given the inability ... Read more >>

FEBS Lett (FEBS letters)
[2010, 584(3):500-506]

Cited: 17 times

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The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway.

Philippe Grimbert, Asta Valanciute, Vincent Audard, Philippe Lang, Georges Guellaën, Djillali Sahali,

Using a yeast two-hybrid screen, we identified Filamin-A as a binding partner of the new adapter protein c-mip (c-maf inducing protein) and it's splice variant Tc-mip (truncated c-maf inducing protein). We have previously shown that Tc-mip is involved in Th2 signaling pathway and cytoskeletal reorganization in patients with minimal change ... Read more >>

Mol Immunol (Molecular immunology)
[2004, 40(17):1257-1261]

Cited: 14 times

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NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome.

Asta Valanciuté, Sabine le Gouvello, Brigitte Solhonne, André Pawlak, Philippe Grimbert, Luc Lyonnet, Sophie Hue, Philippe Lang, Philippe Remy, Rémy Salomon, Albert Bensman, Georges Guellaën, Djillali Sahali,

Mechanisms underlying the pathophysiology of minimal change nephrotic syndrome (MCNS), the most frequent of glomerular diseases in children, remain elusive, although recent arguments suggest that T cell dysfunction may be involved in the pathogenesis of this disease. Recently, we reported that activated T cells of these patients display a down-regulation ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2004, 172(1):688-698]

Cited: 25 times

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Transcriptional and post-transcriptional alterations of IkappaBalpha in active minimal-change nephrotic syndrome.

Djillali Sahali, André Pawlak, Sabine LE Gouvello, Philippe Lang, Asta Valanciuté, Philippe Remy, Chantal Loirat, Patrick Niaudet, Albert Bensman, Georges Guellaen,

Minimal-change nephrotic syndrome (MCNS) is a renal disease characterized by heavy glomerular proteinuria and increased production of cytokines by immune cells. Because of the central role of nuclear factor-kappaB (NF-kappaB) in the regulation of cytokine expression, its activity during the relapse and remission phases of steroid-sensitive MCNS was analyzed. During ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2001, 12(8):1648-1658]

Cited: 45 times

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Abnormal RNA processing and altered expression of serin-rich proteins in minimal-change nephrotic syndrome.

Philippe Grimbert, Vincent Audard, Asta Valanciute, André Pawlak, Philippe Lang, Georges Guellaën, Djillali Sahali,

Mechanisms underlying the pathophysiology of minimal-change nephrotic syndrome (MCNS), the most frequent glomerular disease in children, remain elusive, but recent findings argue for a T cell dysfunction. Starting from a differential cDNA library from T cells of a patient under relapse and remission, we identified 16 transcripts specific for MCNS. ... Read more >>

Pediatr Res (Pediatric research)
[2005, 57(1):133-137]

Cited: 4 times

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A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening.

Djillali Sahali, André Pawlak, Asta Valanciuté, Philippe Grimbert, Philippe Lang, Philippe Remy, Albert Bensman, Georges Guellën,

Clinical and experimental observations suggest that minimal-change nephrotic syndrome (MCNS) results from T cell dysfunction, via unknown mechanisms. For the identification of genes that are potentially involved in MCNS, a subtractive cDNA library was constructed from cDNA from T cell-enriched peripheral blood mononuclear cells obtained from the same patient during ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2002, 13(5):1238-1247]

Cited: 61 times

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Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization.

Philippe Grimbert, Asta Valanciute, Vincent Audard, André Pawlak, Sabine Le gouvelo, Philippe Lang, Patrick Niaudet, Albert Bensman, Georges Guellaën, Djillali Sahali,

Several arguments suggest that minimal change nephrotic syndrome (MCNS) results from yet unknown systemic disorder of T cell function. By screening a cDNA library from T cell relapse, we identified a new pleckstrin homology (PH) domain-containing protein encoded by a gene located on chromosome 16q24. Two alternative transcripts were identified. ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2003, 198(5):797-807]

Cited: 44 times

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