Full Text Journal Articles by
Author Asmita Pant

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A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.

Adam Miszta, Anna K Kopec, Asmita Pant, Lori A Holle, James R Byrnes, Daniel A Lawrence, Kirk C Hansen, Matthew J Flick, James P Luyendyk, Bas de Laat, Alisa S Wolberg,

Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolytic mechanisms affected by obesity poorly defined. Using a plasmin-specific fluorogenic substrate, we developed a plasmin generation ... Read more >>

Blood (Blood)
[2020, 135(19):1704-1717]

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Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation.

Kevin S Baker, Anna K Kopec, Asmita Pant, Lauren G Poole, Holly Cline-Fedewa, Dora Ivkovich, Mojtaba Olyaee, Benjamin L Woolbright, Adam Miszta, Hartmut Jaeschke, Alisa S Wolberg, James P Luyendyk,

OBJECTIVE:Regulation of TF (tissue factor):FVIIa (coagulation factor VIIa) complex procoagulant activity is especially critical in tissues where plasma can contact TF-expressing cells. One example is the liver, where hepatocytes are routinely exposed to plasma because of the fenestrated sinusoidal endothelium. Although liver-associated TF contributes to coagulation, the mechanisms controlling the ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2019, 39(10):2038-2048]

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Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells.

Asmita Pant, Elizabeth A Rondini, Thomas A Kocarek,

Non-alcoholic fatty liver disease is manifested by hepatic accumulation of triglycerides (TG) and is commonly associated with metabolic syndrome. The isoprenoid farnesol (FOH) modulates lipid metabolism and reduces hepatic TG content in rodents. This effect involves activation of at least two nuclear receptors, peroxisome proliferator-activated receptor ╬▒ (PPAR╬▒) and farnesoid ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2019, 365:61-70]

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Role of the blood coagulation cascade in hepatic fibrosis.

Asmita Pant, Anna K Kopec, James P Luyendyk,

Liver is the primary source of numerous proteins that are critical for normal function of the blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated with severe complications like cirrhosis, are associated with abnormalities of blood clotting. Although conventional interpretation has inferred cirrhosis as a disorder ... Read more >>

Am. J. Physiol. Gastrointest. Liver Physiol. (American journal of physiology. Gastrointestinal and liver physiology)
[2018, 315(2):G171-G176]

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Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.

Asmita Pant, Anna K Kopec, Kevin S Baker, Holly Cline-Fedewa, Daniel A Lawrence, James P Luyendyk,

Acetaminophen (APAP)-induced liver injury in mice is associated with activation of the coagulation cascade and deposition of fibrin in liver. Plasminogen activator inhibitor-1 (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and plays a critical role in fibrinolysis. PAI-1 expression is increased in both experimental APAP-induced liver ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2018, 188(5):1204-1212]

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Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes.

Asmita Pant, Thomas A Kocarek,

Farnesyl pyrophosphate (FPP) is a branch-point intermediate in the mevalonate pathway that is normally converted mainly to squalene by squalene synthase in the first committed step of sterol biosynthesis. Treatment with the squalene synthase inhibitor squalestatin 1 (SQ1) causes accumulation of FPP, its dephosphorylated metabolite farnesol, and several oxidized farnesol-derived ... Read more >>

Drug Metab. Dispos. (Drug metabolism and disposition: the biological fate of chemicals)
[2016, 44(3):352-355]

Cited: 1 time

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Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes.

Elizabeth A Rondini, Asmita Pant, Thomas A Kocarek,

Cytosolic sulfotransferase 1C2 (SULT1C2) is expressed in the kidney, stomach, and liver of rats; however, the mechanisms regulating expression of this enzyme are not known. We evaluated transcriptional regulation of SULT1C2 by mevalonate (MVA)-derived intermediates in primary cultured rat hepatocytes using several cholesterol synthesis inhibitors. Blocking production of mevalonate with ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2015, 355(3):429-441]

Cited: 1 time

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