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Author Asmat Ullah Khan

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A glance on the role of actin in osteogenic and adipogenic differentiation of mesenchymal stem cells.

Asmat Ullah Khan, Rongmei Qu, Tingyu Fan, Jun Ouyang, Jingxing Dai,

Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages including osteogenic and adipogenic lineages. An increasing number of studies have indicated that lineage commitment by MSCs is influenced by actin remodeling. Moreover, actin has roles in determining cell shape, nuclear shape, cell spreading, and cell stiffness, which ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):283]

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Actin Polymerization State Regulates Osteogenic Differentiation in Human Adipose-derived Stem Cells

Bing Sun, Xin Jiang, Rongmei Qu, Tingyu Fan, Yuchao Yang, Asmat Ullah Khan, Zhitao Zhou, Jun Ouyang, jingxing dai,

Abstract Background: Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport. In this study, we explored the effect of actin polymerization state on the osteogenic differentiation of human adipose-derived stem cells (hASCs). Methods: The ... Read more >>

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Epidemiology of CoViD-19 Pandemic: Recovery and mortality ratio around the globe.

Aziz Ullah Noor, Farhana Maqbool, Zulfiqar A Bhatti, Asmat Ullah Khan,

Coronavirus Disease 2019 (CoViD-19) is the third type of coronavirus disease after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) that appears in human population from the past two decades. It is highly contagious and rapidly spread in the human population and compelled global public health institutions ... Read more >>

(Pakistan journal of medical sciences)
[2020, 36(COVID19-S4):S79-S84]

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Role of Nucleoporins and Transport Receptors in Cell Differentiation.

Asmat Ullah Khan, Rongmei Qu, Jun Ouyang, Jingxing Dai,

Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane. These macromolecular structures are composed of several nucleoporins, which form seven different subcomplexes based on their biochemical affinity. These nucleoporins are integral components of the complex, not only allowing passive ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:239]

Cited: 1 time

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Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB1 receptor in the ventromedial hypothalamus.

Asmat Ullah Khan, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Maria de Fátima Dos Santos Sampaio, José Alexandre de Souza Crippa, Leda Menescal-de-Oliveira, Norberto Cysne Coimbra,

RATIONALE:The behavioural effects elicited by chemical constituents of Cannabis sativa, such as cannabidiol (CBD), on the ventromedial hypothalamus (VMH) are not well understood. There is evidence that VMH neurons play a relevant role in the modulation of unconditioned fear-related defensive behavioural reactions displayed by laboratory animals. OBJECTIVES:This study was designed ... Read more >>

Psychopharmacology (Berl.) (Psychopharmacology)
[2020, 237(4):1063-1079]

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Awareness and current knowledge of epilepsy.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Naheed Akhter, Muhammad Riaz, Naheed Akhtar, Mohammad Ali Shariati, Fozia Anjum, Samreen Gul Khan, Abida Parveen, Saeed Ahmad,

Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30-40% of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(1):45-63]

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Awareness and current knowledge of Parkinson's disease: a neurodegenerative disorder.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Rida Zainab,

CONTEXT:Parkinson's disease (PD) is the second common progressive neurodegenerative disease, distressing older men and is prevalent Worldwide. OBJECTIVES:This article is aimed to review the epidemiology, etiology, pathogenesis, clinical manifestation, diagnosis and management of PD. METHODS:A google search was performed to recognise studies that review the characteristics of PD. Search terms ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2019, 129(1):55-93]

Cited: 1 time

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Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception.

Rithiele Cristina de Oliveira, Ricardo de Oliveira, Luiz Luciano Falconi-Sobrinho, Audrey Franceschi Biagioni, Rafael Carvalho Almada, Tayllon Dos Anjos-Garcia, Guilherme Bazaglia-de-Sousa, Asmat Ullah Khan, Norberto Cysne Coimbra,

Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold. The pedunculopontine tegmental nucleus (PPTN) plays a crucial role in the regulation of seizures as well as the modulation of pain, but its role in postictal antinociceptive processes remains unclear. In the ... Read more >>

Physiol. Behav. (Physiology & behavior)
[2018, 194:162-169]

Cited: 1 time

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Awareness and current knowledge of breast cancer.

Muhammad Akram, Mehwish Iqbal, Muhammad Daniyal, Asmat Ullah Khan,

Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the ... Read more >>

Biol. Res. (Biological research)
[2017, 50(1):33]

Cited: 63 times

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µ1 -Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post-ictal antinociception.

Renato Leonardo de Freitas, Priscila Medeiros, Asmat Ullah Khan, Norberto Cysne Coimbra,

Generalised tonic and tonic-clonic seizures are followed by significant increase in nociceptive thresholds in both laboratory animals and humans. The endogenous opioid peptides play a role in antinociceptive signalling, and the periaqueductal grey matter (PAG) is recruited to induce analgesia. Thus, the aim of this investigation was to evaluate the ... Read more >>

Synapse (Synapse (New York, N.Y.))
[2016, 70(12):519-530]

Cited: 1 time

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Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour.

Farhad Ullah, Tayllon Dos Anjos-Garcia, Joyce Mendes-Gomes, Daoud Hibrahim Elias-Filho, Luiz Luciano Falconi-Sobrinho, Renato Leonardo de Freitas, Asmat Ullah Khan, Ricardo de Oliveira, Norberto Cysne Coimbra,

The electrical and chemical stimulation of the dorsal periaqueductal grey matter (dPAG) elicits panic-like explosive escape behaviour. Although neurons of the ventromedial hypothalamus (VMH) seem to organise oriented escape behaviour, when stimulated with excitatory amino acids at higher doses, non-oriented/explosive escape reactions can also be displayed. The aim of this ... Read more >>

Behav. Brain Res. (Behavioural brain research)
[2017, 319:135-147]

Cited: 9 times

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The μ1-opioid receptor and 5-HT2A- and 5HT2C-serotonergic receptors of the locus coeruleus are critical in elaborating hypoalgesia induced by tonic and tonic-clonic seizures.

Renato Leonardo de Freitas, Priscila Medeiros, Juliana Almeida da Silva, Rithiele Cristina de Oliveira, Ricardo de Oliveira, Farhad Ullah, Asmat Ullah Khan, Norberto Cysne Coimbra,

It has been proposed that the post-ictal state is associated with the expression of hypoalgesia. It is clear that the projections among the periaqueductal gray matter (PAG), dorsal raphe nucleus (DRN) and locus coeruleus (LC) play a role in pain management. These mesencephalic structures have direct reciprocal opioid and monoaminergic ... Read more >>

Neuroscience (Neuroscience)
[2016, 336:133-145]

Cited: 2 times

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A report on the high prevalence of Anaplasma sp. in buffaloes from two provinces in Pakistan.

Qurat U A Ashraf, Asmat Ullah Khan, Rehman Mehmood Khattak, Muhammad Ali, Rehan Sadiq Shaikh, Muhammad Ali, Furhan Iqbal,

The present study was designed to use a PCR-RFLP protocol for the molecular detection of Anaplasma sp. and to compare its prevalence in blood samples from buffaloes (Bubalus bubalis) from 2 provinces of Pakistan and to determine the risk factors associated with the spread of Anaplasma infection. A total of ... Read more >>

Ticks Tick Borne Dis (Ticks and tick-borne diseases)
[2013, 4(5):395-398]

Cited: 8 times

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