Full Text Journal Articles by
Author Asma Tulbah

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Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations.

Maria Arafah, Sameera Rashid, Asma Tulbah, Mohammed Akhtar,

Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):150-170]

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Single-Institute Review of HER-2/Neu-Positive Invasive Lobular Breast Carcinoma in an Arab Population.

Asif Husain Osmani, Asma M Tulbah, Adher AlSayed, Ali AlShanqeeti, Taher Al-Twegieri, Dahish S Ajarim, Kausar Suleman,

BACKGROUND Invasive lobular carcinoma is special subtype of breast cancer that has clinical behavior and morphology distinct from other breast cancer subtypes. It accounts for 5-15% of breast cancer. Overall, HER-2 gene amplification occurs at a significantly lower rate in ILC, but also has been linked to adverse outcomes. Most ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e928012]

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Impact of Pathologic Complete Response following Neoadjuvant Chemotherapy ± Trastuzumab in Locally Advanced Breast Cancer.

Taher Al-Tweigeri, Mahmoud Elshenawy, Ahmed Badran, Ayman Omar, Kausar Suleman, Osama Al Malik, Ihab Anwar, Noha Jastaniya, Asma Tulbah, Mohammad Al Shabanah, Dahish Ajarim, Adher Al Sayed,

<h4>Purpose</h4>This study was designed to examine the relationship between breast cancer molecular subtypes and pathological response to neoadjuvant chemotherapy (NAC) ± trastuzumab, in locally advanced breast cancer (LABC).<h4>Methods</h4>Female patients with LABC (T2-T4, N0-N2, and M0) who received neoadjuvant chemotherapy + trastuzumab if HER2+ subtype, followed by surgery and radiotherapy ± hormonal therapy, were identified. The primary ... Read more >>

J Oncol (Journal of oncology)
[2021, 2021:6639763]

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Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation.

Sandeep Kumar Parvathareddy, Abdul K Siraj, Ismail A Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Khawla S Al-Kuraya,

Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical challenge, highlighting the need for new therapeutic strategies. This study was ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):3750]

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High Expression of Cyclin D1 Is An Independent Marker for Favorable Prognosis in Middle Eastern Breast Cancer

Abdul Siraj, Sandeep Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda Ahmed, Nabil Siraj, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla Al-Kuraya,

<h4>Background: </h4> The cyclin D1 protein regulates cell cycle progression which is mediated by its interactions with cyclin-dependent kinases. Over-expression of cyclin D1 has been observed in several human cancers. This study was conducted to evaluate cyclin D1 expression in a large cohort of Middle Eastern breast cancers and determine ... Read more >>

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PD-L1 Protein Expression in Middle Eastern Breast Cancer Predicts Favorable Outcome in Triple-Negative Breast Cancer.

Sandeep Kumar Parvathareddy, Abdul K Siraj, Saeeda O Ahmed, Laila Omar Ghazwani, Saud M Aldughaither, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S Al-Kuraya,

Programmed cell-death ligand 1 (PD-L1) has been shown to induce potent T-cell mediated anti-tumoral immunity. The significance of PD-L1 expression in the prognosis of breast cancer (BC) remains controversial and its prevalence and prognostic value in breast cancer from Middle Eastern ethnicity is lacking. A total of 1003 unselected Middle ... Read more >>

Cells (Cells)
[2021, 10(2):]

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Clinical and functional significance of tumor/stromal ATR expression in breast cancer patients.

Mysoon M Al-Ansari, Maher Al-Saif, Maria Arafah, Abdelmonneim M Eldali, Asma Tulbah, Taher Al-Tweigeri, Abdelhabib Semlali, Khalid S Khabar, Abdelilah Aboussekhra,

BACKGROUND:Most breast cancer-associated fibroblasts (CAFs) are active and important cancer-promoting cells, with significant impact on patient prognosis. Therefore, we investigated here the role of the protein kinase ATR in breast stromal fibroblasts in the prognosis of locally advanced breast cancer patients. METHODS:We have used immunohistochemistry to assess the level of ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2020, 22(1):49]

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Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases.

Tariq Masoodi, Sarah Siraj, Abdul K Siraj, Saud Azam, Zeeshan Qadri, Sandeep K Parvathareddy, Asma Tulbah, Fouad Al-Dayel, Hamed AlHusaini, Osama AlOmar, Ismail A Al-Badawi, Fowzan S Alkuraya, Khawla S Al-Kuraya,

<h4>Background</h4>High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although metastatic processes are becoming more understandable, the genomic landscape and metastatic progression in HGSOC has not been elucidated.<h4>Methods</h4>Multi-region whole-exome sequencing was performed on HGSOC primary tumours and their ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 122(8):1219-1230]

Cited: 4 times

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Complete Response of Chemo-Refractory Metastatic Metaplastic Breast Cancer to Paclitaxel-Immunotherapy Combination.

Adher D Al Sayed, Mahmoud A Elshenawy, Asma Tulbah, Taher Al-Tweigeri, Hazem Ghebeh,

BACKGROUND Metaplastic breast cancer (MPBC) is a rare subtype of breast cancer that is difficult to manage and is resistant to therapy. Immunotherapy is becoming a promising option for care of several types of cancers including triple negative breast cancer. CASE REPORT We present a case of a patient with ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1630-1635]

Cited: 3 times

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Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population.

Abdul K Siraj, Rong Bu, Kaleem Iqbal, Sandeep Kumar Parvathareddy, Nabil Siraj, Sarah Siraj, Mark Ranier F Diaz, Dionne Rae Rala, Allianah D Benito, Maria Angelita Sabido, Maha Al-Rasheed, Khadija A S Al-Obaisi, Wael Al-Haqawi, Ingrid G Victoria, Wafaa Al Balawy, Malak Abedalthagafi, Salma Majid Wakil, Dahish Ajarim, Shamayel Mohammed, Turki Alhussain, Asma Tulbah, Ismail A Al-Badawi, Fouad Al-Dayel, Khawla S Al-Kuraya,

Sanger Sequencing and immunohistochemistry was employed to investigate the TERT promoter mutations and TERT protein expression with their association to clinicopathological characteristics in over 2200 samples of Middle Eastern origin from 13 different types of cancers. The TERT promoter mutations were most frequently present in bladder cancer (68.6%), followed by ... Read more >>

Genomics (Genomics)
[2020, 112(2):1746-1753]

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Prevalence of Human Papillomavirus (HPV) Infection and the Association with Survival in Saudi Patients with Head and Neck Squamous Cell Carcinoma.

Ghazi Alsbeih, Najla Al-Harbi, Sara Bin Judia, Wejdan Al-Qahtani, Hatim Khoja, Medhat El-Sebaie, Asma Tulbah,

Head and neck squamous cell carcinoma (HNSCC) shows wide disparities, association with human papillomavirus (HPV) infection, and prognosis. We aimed at determining HPV prevalence, and its prognostic association with overall survival (OS) in Saudi HNSCC patients. The study included 285 oropharyngeal and oral-cavity HNSCC patients. HPV was detected using HPV ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(6):]

Cited: 4 times

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Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East.

Abdul K Siraj, Rong Bu, Kaleem Iqbal, Nabil Siraj, Wael Al-Haqawi, Ismail A Al-Badawi, Sandeep Kumar Parvathareddy, Tariq Masoodi, Asma Tulbah, Fouad Al-Dayel, Khawla S Al-Kuraya,

Germline mutations in breast cancer susceptibility gene 1 and 2 have previously been estimated to contribute to 13-18% of all epithelial ovarian cancer (EOC). To characterize the prevalence and effect of BRCA1 and BRCA2 mutations in Middle Eastern EOC patients, BRCA mutation screening was performed in 407 unselected ovarian cancer ... Read more >>

Hum Mutat (Human mutation)
[2019, 40(6):729-733]

Cited: 2 times

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Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects.

Huda H Al-Khalaf, Bothaina Al-Harbi, Adher Al-Sayed, Maria Arafah, Asma Tulbah, Abdulaziz Jarman, Falah Al-Mohanna, Abdelilah Aboussekhra,

Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive. We show here that cancer-associated adipocytes (CAAs) isolated from 10 invasive breast carcinomas are proinflammatory and exhibit active phenotypes, including higher proliferative, invasive, ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2019, 39(2):]

Cited: 7 times

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Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment.

Abdul Khalid Siraj, Poyil Pratheeshkumar, Sandeep Kumar Parvathareddy, Sasidharan Padmaja Divya, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S Al-Kuraya,

Patients with aggressive breast cancer (BC) subtypes usually don't have favorable prognosis despite the improvement in treatment modalities. These cancers still remain a major cause of morbidity and mortality in females. This has fostered a major effort to discover actionable molecular targets to treat these patients. Poly ADP ribose polymerase ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(99):37319-37332]

Cited: 3 times

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FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer.

Abdul Khalid Siraj, Poyil Pratheeshkumar, Sandeep Kumar Parvathareddy, Zeeshan Qadri, Saravanan Thangavel, Saeeda Ahmed, Fouad Al-Dayel, Asma Tulbah, Dahish Ajarim, Khawla S Al-Kuraya,

Breast cancer (BC) is the most common cause of cancer-related death in females in Saudi Arabia. BC in Saudi women tend to behave more aggressively than breast cancer in the West. Therefore, identification of new molecular targets and treatment strategies are highly warranted to improve patient outcome. FoxM1 has been ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(25):17466-17482]

Cited: 6 times

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FoxM1 and β-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells.

Poyil Pratheeshkumar, Sasidharan Padmaja Divya, Sandeep Kumar Parvathareddy, Norah M Alhoshani, Ismail A Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Abdul K Siraj, Khawla S Al-Kuraya,

Epithelial ovarian cancer (EOC) is a highly lethal disease with poor prognosis especially in advanced stage tumor. Emerging evidence has reported that aberrant upregulation of FoxM1 and β-catenin are closely associated with aggressiveness of human cancer. However, interplay between these factors in the aggressiveness of EOC is not fully illustrated. ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(3):3590-3604]

Cited: 6 times

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The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts.

Layla A Al-Kharashi, Falah H Al-Mohanna, Asma Tulbah, Abdelilah Aboussekhra,

The activation of breast stromal fibroblasts is a crucial step toward tumor growth and spread. Therefore, it is extremely important to understand the molecular basis of this activation and determine the molecules and the mechanisms responsible for its sustainability. In the present report we have shown that the DNA methyl-transferase ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(2):2329-2343]

Cited: 3 times

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Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.

Huda H Al-Khalaf, Mrad Amir, Falah Al-Mohanna, Asma Tulbah, Adher Al-Sayed, Abdelilah Aboussekhra,

Obesity is increasingly recognized as a risk factor for breast cancer development. However, the molecular basis of obesity-related breast carcinogenesis remains elusive. In this study, we have shown that obesity reduces the level of the tumor suppressor p16<sup>INK4A</sup> protein in breast adipocytes, which showed active features and strong procarcinogenic potential ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2017, 37(17):]

Cited: 6 times

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Expanding the spectrum of germline variants in cancer.

Abdul K Siraj, Tariq Masoodi, Rong Bu, Sandeep Kumar Parvathareddy, Ismail A Al-Badawi, Nasser Al-Sanea, Luai H Ashari, Alaa Abduljabbar, Samar Alhomoud, Saif S Al-Sobhi, Asma Tulbah, Dahish Ajarim, Khalid Alzoman, Muna Aljuboury, Hussam Bin Yousef, Mohammed Al-Dawish, Fouad Al-Dayel, Fowzan S Alkuraya, Khawla S Al-Kuraya,

Our ability to identify germline variants in hereditary cancer cases remains challenged by the incomplete cataloging of relevant genes and lack of consensus on who should be tested. We designed a panel [hereditary oncogenesis predisposition evaluation (HOPE)] that encompasses most of the genes known to be associated with cancer development ... Read more >>

Hum Genet (Human genetics)
[2017, 136(11-12):1431-1444]

Cited: 9 times

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Synovial sarcoma of the hard palate: The third case in the medical literature.

Aseel Doubi, Motaz Doubi, Nabil Alzaher, Asma Tulbah,

Synovial sarcoma is a high-grade soft tissue sarcoma that rarely arises in the head and neck region. It affects the parapharyngeal space and the hypopharynx most commonly and it has different presentations based on the affected site. In extremely rare occasions, it involves the hard palate such as in our ... Read more >>

Hematol Oncol Stem Cell Ther (Hematology/oncology and stem cell therapy)
[2019, 12(1):60-63]

Cited: 0 times

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Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence.

Ghazi A Alsbeih, Najla M Al-Harbi, Sara S Bin Judia, Hatim A Khoja, Mohamed M Shoukri, Asma M Tulbah,

<h4>Background</h4>Cervical cancer is a predominantly human papillomavirus (HPV)-driven disease worldwide. However, its incidence is unexplainably low in western Asia, including Saudi Arabia. Using this paradigm, we investigated the role of HPV infection rate and host genetic predisposition in TP53 G72C single nucleotide polymorphism (SNP) presumed to affect cancer incidence.<h4>Methods</h4>Patients treated ... Read more >>

Cancer (Cancer)
[2017, 123(13):2459-2466]

Cited: 5 times

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Reply to "letter to the editor concerning the article-Impact of surgery on survival in stage IV breast cancer".

Badria Al Johani, Osama Al Malik, Ehab Anwar, Asma Tulbah, Mohamed Alshabanah, Adher AlSyaed, Dahish Ajarim, Taher Al-Tweigeri,

Breast J (The breast journal)
[2017, 23(6):775]

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Reply to "Letter to the Editor Concerning the Article-Impact of Surgery on Survival in Stage IV Breast Cancer".

Badria Al Johani, Osama Al Malik, Ehab Anwar, Asma Tulbah, Mohamed Alshabanah, Adher AlSayed, Dahish Ajarim, Taher Al-Tweigeri,

Breast J (The breast journal)
[2017, 23(1):119]

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Impact of Surgery on Survival in Stage IV Breast Cancer.

Badria AlJohani, Osama AlMalik, Ehab Anwar, Asma Tulbah, Mohamed Alshabanah, Adher AlSyaed, Dahish Ajarim, Taher ALTweigeri,

We aimed to assess retrospectively the survival outcome in patients with stage IV breast cancer who underwent surgery. In a retrospective, nonrandomized study of stage IV breast cancer patients diagnosed in a single institution between 2000 and 2012, we assessed patient's survival in the context of baseline characteristics. A total ... Read more >>

Breast J (The breast journal)
[2016, 22(6):678-682]

Cited: 10 times

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Sentinel lymph node biopsy in clinically detected ductal carcinoma in situ.

Ahmed Yahia Al-Ameer, Sahar Al Nefaie, Badria Al Johani, Ihab Anwar, Taher Al Tweigeri, Asma Tulbah, Mohmmed Alshabanah, Osama Al Malik,

<h4>Aim</h4>To study the indications for sentinel lymph node biopsy (SLNB) in clinically-detected ductal carcinoma in situ (CD-DCIS).<h4>Methods</h4>A retrospective analysis of 20 patients with an initial diagnosis of pure DCIS by an image-guided core needle biopsy (CNB) between June 2006 and June 2012 was conducted at King Faisal Specialist Hospital. The ... Read more >>

World J Clin Oncol (World journal of clinical oncology)
[2016, 7(2):258-264]

Cited: 6 times

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