Full Text Journal Articles by
Author Asma Khalil

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The Prognostic Value of Angiogenic Markers in Twin Pregnancies to Predict Delivery Due to Maternal Complications of Preeclampsia.

Julia Binder, Pilar Palmrich, Petra Pateisky, Erkan Kalafat, Lorenz Kuessel, Harald Zeisler, March Munkhbaatar, Karin Windsperger, Basky Thilaganathan, Asma Khalil,

The sFlt-1 (soluble fms-like tyrosine kinase-1), PlGF (placental growth factor), and their ratio are useful for predicting delivery because of preeclampsia in singleton pregnancies. Evidence on the utility of sFlt-1/PlGF ratio in twin pregnancies is lacking. We aimed to evaluate the predictive value of sFlt-1/PlGF ratio for delivery because of ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, :HYPERTENSIONAHA12014957]

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COVID-19 screening of health-care workers in a London maternity hospital.

Asma Khalil, Robert Hill, Shamez Ladhani, Katherine Pattisson, Pat O'Brien,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, :]

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Maternal and Perinatal Outcomes of White Coat Hypertension During Pregnancy: A Systematic Review and Meta-Analysis.

Sonia Johnson, Becky Liu, Erkan Kalafat, Basky Thilaganathan, Asma Khalil,

The aim of this meta-analysis is to investigate whether white-coat hypertension (WCH) has an adverse effect on maternal, fetal, and neonatal outcomes. Medline, EMBASE, www.Clinicaltrials.gov, and Cochrane Library databases were searched electronically in December 2019. The outcomes were compared between pregnant women with WCH and normotensive controls, women with chronic ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, :HYPERTENSIONAHA11914627]

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Reproductive outcome after cesarean scar pregnancy: A systematic review and meta-analysis.

Maddalena Morlando, Danilo Buca, Ilan Timor-Tritsch, Giuseppe Cali, Jose Palacios-Jaraquemada, Ana Monteagudo, Asma Khalil, Carmen Cennamo, Viviana La Manna, Marco Liberati, Alice D'Amico, Luigi Nappi, Nicola Colacurci, Francesco D'Antonio,

INTRODUCTION:To evaluate subsequent reproductive among women with a prior cesarean scar pregnancy (CSP). MATERIAL AND METHODS:Medline, Embase and ClinicalTrials.gov databases were searched. Inclusion criteria were women with a prior CSP, defined as the gestational sac or trophoblast within the dehiscence/niche of the previous cesarean section scar or implanted on top ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, :]

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SARS-CoV-2 in pregnancy: symptomatic pregnant women are only the tip of the iceberg.

Asma Khalil, Robert Hill, Shamez Ladhani, Katherine Pattisson, Pat O'Brien,

Am. J. Obstet. Gynecol. (American Journal of Obstetrics and Gynecology)
[2020, :]

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Selective Fetal Growth Restriction in Dichorionic Twin Pregnancies: Diagnosis, Natural History, and Perinatal Outcome.

Nikolaos Antonakopoulos, Petra Pateisky, Becky Liu, Erkan Kalafat, Baskaran Thilaganathan, Asma Khalil,

This study aims to evaluate the natural history, disease progression, and outcomes in dichorionic twins with selective fetal growth restriction (sFGR) according to different diagnostic criteria and time of onset. Dichorionic twins seen from the first trimester were included. sFGR was classified according to the Delphi consensus, and was compared ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(5):]

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Outcome of twin-twin transfusion syndrome according to the Quintero stage of the disease: A systematic review and meta-analysis.

Daniele Di Mascio, Asma Khalil, Alice D'Amico, Danilo Buca, Pierluigi Benedetti Panici, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Luigi Nappi, Vincenzo Berghella, Francesco D'Antonio,

OBJECTIVES:To report the outcomes of twin-twin transfusion syndrome (TTTS) according to Quintero staging system. METHODS:Medline, Embase and Cinahl databases were searched for studies reporting outcomes of TTTS stratified by Quintero staging (I-V). The primary outcome was the survival rate according to TTTS stage. The secondary outcomes were gestational age at ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, :]

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Obstetrics risk Assessment: Evaluation of selection criteria for vaccine research studies in pregnant women.

Linda O Eckert, Christine E Jones, Alisa Kachikis, Azucena Bardají, Fernanda Tavares Da Silva, Judith Absalon, Caroline E Rouse, Asma Khalil, Clare L Cutland, Sonali Kochhar, Flor M Munoz,

Vaccines designed for use in pregnancy and vaccine trials specifically involving pregnant women are rapidly expanding. One of the key challenges in designing maternal immunization trials is that developing exclusion criteria requires understanding and quantifying the background risk for adverse pregnancy outcomes in the pregnancy being studied, which can occur ... Read more >>

Vaccine (Vaccine)
[2020, :]

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Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies.

Shemoon Marleen, Chamalika Dias, Rebecca MacGregor, John Allotey, Joseph Aquilina, Asma Khalil, Shakila Thangaratinam,

In women with twin pregnancies biomarkers are not used to predict preterm birth in clinical practice. This systematic review assessed the risk of both spontaneous and iatrogenic preterm birth in twin pregnancies based on biochemical predictors. We searched the electronic databases from January 1990 to June 2019 without language restrictions. ... Read more >>

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 250:130-142]

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Reduction in twin stillbirth following implementation of NICE guidance.

Asma Khalil, Elisa Giallongo, Amar Bhide, Aris Papageorghiou, Basky Thilaganathan,

BACKGROUND:There has been an unprecedented fall in stillbirth in twin pregnancies in the UK. It is contested whether implementation of the National Institute for Health and Care Excellence (NICE) guidance on the antenatal management of uncomplicated twin pregnancies may have contributed to this change. The aim of this study was ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, :]

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Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data.

Charlotte A Vollgraff Heidweiller-Schreurs, Ivy R van Osch, Martijn W Heymans, Wessel Ganzevoort, Linda J Schoonmade, Caroline J Bax, Ben Willem J Mol, Christianne Jm de Groot, Patrick Mm Bossuyt, Marjon A de Boer, ,

OBJECTIVE:To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone - standard of practice - for adverse perinatal outcome in singleton pregnancies. DESIGN AND SETTING:Meta-analysis based on individual participant data (IPD). POPULATION OR SAMPLE:Ten centres provided 17 datasets for 21 661 ... Read more >>

BJOG (BJOG : an international journal of obstetrics and gynaecology)
[2020, :]

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Hypertensive Disorders of Pregnancy and Future Cardiovascular Health.

Karen Melchiorre, Basky Thilaganathan, Veronica Giorgione, Anna Ridder, Alessia Memmo, Asma Khalil,

Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations. These women are known to have higher cardiovascular morbidity and mortality later in life in comparison with parous controls who had normotensive pregnancies. Several studies have demonstrated that women with preeclampsia present in a state of segmental impaired myocardial ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:59]

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Why not plan an elective Caesarean section for breech presentation at term - safety first?

Becky Liu, Mercede Sebghati, Asma Khalil,

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2020, :]

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Is Umbilicocerebral Ratio better than Cerebroplacental Ratio for Predicting Adverse Pregnancy and Neonatal Outcomes?

Erkan Kalafat, Zeynep Kalaylioglu, Basky Thilaganathan, Asma Khalil,

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis.

Daniele Di Mascio, Asma Khalil, Gabriele Saccone, Giuseppe Rizzo, Danilo Buca, Marco Liberati, Jacopo Vecchiet, Luigi Nappi, Giovanni Scambia, Vincenzo Berghella, Francesco D'Antonio,

Objective:The aim of this systematic review was to report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy. Data sources:Medline, Embase, Cinahl and Clinicaltrials.gov databases were searched electronically utilizing combinations of word variants for "coronavirus" or "severe acute respiratory syndrome" ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2020, :100107]

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Non-immune fetal hydrops: etiology and outcomes according to gestational age at diagnosis.

Filomena Giulia Sileo, Anay Kulkarni, Irina Branescu, Tessa Homfray, Esther Dempsey, Sahar Mansour, Basky Thilaganathan, Amar Bhide, Asma Khalil,

OBJECTIVES:Fetal hydrops is associated with increased perinatal mortality and morbidity. The etiology and outcomes of fetal hydrops may differ according to the gestational age (GA) at diagnosis. The aim of this study was to evaluate the causes, evolution and outcomes of non-immune fetal hydrops (NIFH) according to the GA at ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, :]

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Perinatal outcomes of twin pregnancies affected by early twin-twin transfusion syndrome: A systematic review and meta-analysis.

Francesco D'Antonio, Can Benlioglu, Filomena G Sileo, Basky Thilaganathan, Aris Papageorghiou, Amarnath Bhide, Asma Khalil,

INTRODUCTION:Twin-to-twin transfusion syndrome (TTTS) is associated with a high risk of perinatal mortality and morbidity if not treated. However, the optimal timing and management in case of early (occurring < 18 weeks) TTTS has not been established yet. MATERIAL AND METHODS:This is a systematic review and meta-analysis aiming at evaluating the outcomes of ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, :]

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The role of aspirin in prevention of preeclampsia in twin pregnancies: does the dose matter?

Erkan Kalafat, Amani Shirazi, Basky Thilaganathan, Asma Khalil,

Am. J. Obstet. Gynecol. (American Journal of Obstetrics and Gynecology)
[2020, :]

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Regulation of stanniocalcin-1 secretion by BeWo cells and first trimester human placental tissue from normal pregnancies and those at increased risk of developing preeclampsia.

Naila Abid, Joan Embola, Zoe Tryfonos, Julia Bercher, Sandra V Ashton, Asma Khalil, Baskaran Thilaganathan, Judith E Cartwright, Guy S Whitley,

Stanniocalcin-1 (STC-1) is a multi-functional glycosylated peptide present in the plasma of healthy women postpartum and increased further in pregnancies complicated by preeclampsia. Although the STC-1 gene is expressed by the placenta what regulates its secretion and from which cells at the feto-maternal interface is unknown. Here, we demonstrate for ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(5):6086-6098]

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Umbilicocerebral ratio: potential implications of inversing the cerebroplacental ratio.

Erkan Kalafat, Asma Khalil,

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, :]

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Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: A systematic review and meta-analysis.

Francesca Bascietto, Asma Khalil, Giuseppe Rizzo, Alexander Makatsariya, Danilo Buca, Claudia Silvi, Matteo Ucci, Marco Liberati, Alessandra Familiari, Francesco D'Antonio,

OBJECTIVES:To perform a systematic review of studies reporting the outcome of fetuses with a prenatal diagnosis of isolated duplex collecting system (DCS). METHODS:Inclusion criteria were studies reporting the outcome of fetuses with a prenatal diagnosis of isolated DCS, defined as DCS not associated with other major structural anomalies at the ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2020, 40(4):424-431]

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Angiogenic Marker Prognostic Models in Pregnant Women With Hypertension.

Helen Perry, Julia Binder, Erkan Kalafat, Stuart Jones, Basky Thilaganathan, Asma Khalil,

Angiogenic markers such as PlGF (placental growth factor) and sFlt-1 (soluble Fms-like tyrosine kinase-1) have been shown to be useful for predicting adverse outcome in women suspected of having preeclampsia. The aim of the current study was to evaluate the prognostic value of angiogenic markers and maternal risk factors in ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 75(3):755-761]

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Outcome of fetal echogenic bowel: a systematic review and meta-analysis.

Alice D'Amico, Danilo Buca, Giuseppe Rizzo, Asma Khalil, Claudia Silvi, Alexander Makatsariya, Luigi Nappi, Marco Liberati, Francesco D'Antonio,

The main aim of this systematic review was to explore the outcome of fetuses with isolated echogenic bowel (EB) on antenatal ultrasound. Inclusion criteria were singleton pregnancies with isolated EB no associated major structural anomalies at the time of diagnosis. The outcomes observed were: chromosomal anomalies, cystic fibrosis, associated structural ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2020, :]

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Evidence for uteroplacental malperfusion in fetuses with major congenital heart defects.

Julia Binder, Silvia Carta, Julene S Carvalho, Erkan Kalafat, Asma Khalil, Basky Thilaganathan,

AIMS:Fetuses affected by congenital heart defects (CHD) are considered to be at increased risk of fetal growth restriction and intrauterine demise. Whether these risks are a direct consequence of fetal CHD or a result of associated uteroplacental dysfunction is not evident from the data of recent studies. The aim of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(2):e0226741]

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Prenatal risk factors for urgent atrial septostomy at birth in fetuses with transposition of the great arteries: a systematic review and meta-analysis.

Danilo Buca, Per Winberg, Giuseppe Rizzo, Asma Khalil, Marco Liberati, Alexander Makatsariya, Francesca Greco, Luigi Nappi, Ganesh Acharya, Francesco D'Antonio,

Purpose of the article. To explore the role of fetal echocardiography in predicting the risk of urgent balloon atrial septostomy (BAS) at birth in fetuses diagnosed with transposition of the great arteries (TGA).Material and methods: Medline, Embase, and Cochrane databases were searched. The primary aim was to explore the differences ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-9]

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