Full Text Journal Articles by
Author Ashwin Prakash

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Challenges and lessons learned from the Pediatric Heart Network Normal Echocardiogram Database study.

Dongngan Truong, Leo Lopez, Peter C Frommelt, Jessica Stelter, Brenda Ni, Meryl S Cohen, Ashwin Prakash, Steven D Colan, Christopher Spurney, Jonathan Soslow, Gail D Pearson, Joseph Mahgerefteh, Ritu Sachdeva, Ricardo Pignatelli, Felicia Trachtenberg, Mario Stylianou, Karen Altmann, Kathleen A Rathge, Joseph Camarda, Shahryar Chowdhury, Andreea Dragulescu, Michele Frommelt, Olukayode Garuba, Brian Soriano, Shubhika Srivastava, Poonam Thankavel, Mary E van der Velde, L LuAnn Minich, ,

BACKGROUND:The Pediatric Heart Network Normal Echocardiogram Database Study had unanticipated challenges. We sought to describe these challenges and lessons learned to improve the design of future studies. METHODS:Challenges were divided into three categories: enrolment, echocardiographic imaging, and protocol violations. Memoranda, Core Lab reports, and adjudication logs were reviewed. A centre-level ... Read more >>

Cardiol Young (Cardiology in the young)
[2020, 30(4):456-461]

Cited: 0 times

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Challenges With Left Ventricular Functional Parameters: The Pediatric Heart Network Normal Echocardiogram Database.

Peter C Frommelt, L LuAnn Minich, Felicia L Trachtenberg, Karen Altmann, Joseph Camarda, Meryl S Cohen, Steven D Colan, Andreea Dragulescu, Michele A Frommelt, Tiffanie R Johnson, John P Kovalchin, Lina Lin, Joseph Mahgerefteh, Arni Nutting, David A Parra, Gail D Pearson, Ricardo Pignatelli, Ritu Sachdeva, Brian D Soriano, Christopher Spurney, Shubhika Srivastava, Christopher J Statile, Jessica Stelter, Mario Stylianou, Poonam P Thankavel, E Seda Tierney, Mary E van der Velde, Leo Lopez, ,

BACKGROUND:The reliability of left ventricular (LV) systolic functional indices calculated from blinded echocardiographic measurements of LV size has not been tested in a large cohort of healthy children. The objective of this study was to estimate interobserver variability in standard measurements of LV size and systolic function in children with ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2019, 32(10):1331-1338.e1]

Cited: 0 times

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Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE - COARCT Study.

José D Martins, Justin Zachariah, Elif Seda Selamet Tierney, Uyen Truong, Shaine A Morris, Shelby Kutty, Sarah D de Ferranti, Maria Guarino, Boban Thomas, Diana Oliveira, António Marinho, Marta António, Kimberlee Gauvreau, Nuno Jalles, Tal Geva, Miguel M Carmo, Ashwin Prakash, ,

Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment) study was done to compare vascular function in patients with ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(7):e011536]

Cited: 2 times

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Electrocardiographic Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome-Reply.

Ashwin Prakash, Leslie Smoot,

JAMA Cardiol (JAMA cardiology)
[2018, 3(10):1025]

Cited: 0 times

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Rationale and design of Long-term Outcomes and Vascular Evaluation after Successful Coarctation of the Aorta Treatment study.

Jose D Martins, Justin Zachariah, Elif Seda Selamet Tierney, Uyen Truong, Shaine A Morris, Shelby Kutty, Sarah D de Ferranti, Jonathan Rhodes, Marta Antonio, Maria Guarino, Boban Thomas, Diana Oliveira, Kimberlee Gauvreau, Nuno Jalles, Tal Geva, Miguel Carmo, Ashwin Prakash,

Background:Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2018, 11(3):282-296]

Cited: 1 time

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Coronary artery compression from epicardial leads: More common than we think.

Douglas Y Mah, Ashwin Prakash, Diego Porras, Francis Fynn-Thompson, Elizabeth S DeWitt, Puja Banka,

BACKGROUND:A child with an epicardial pacemaker presented with sudden death at our institution, secondary to coronary artery compression. This case prompted enhanced surveillance of all patients with epicardial pacing or defibrillation systems. OBJECTIVE:The purpose of this study was to determine the incidence of coronary artery compression and the diagnostic yield ... Read more >>

Heart Rhythm (Heart rhythm)
[2018, 15(10):1439-1447]

Cited: 0 times

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A National Population-based Study of Adults With Coronary Artery Disease and Coarctation of the Aorta.

Sarah S Pickard, Kimberlee Gauvreau, Michelle Gurvitz, Joshua J Gagne, Alexander R Opotowsky, Kathy J Jenkins, Ashwin Prakash,

Adults with repaired coarctation of the aorta (CoA) suffer reduced long-term survival compared with the general population, in part due to coronary artery disease (CAD). There is conflicting evidence as to whether or not CoA is an independent risk factor for CAD. The primary aim was to determine if CoA ... Read more >>

Am. J. Cardiol. (The American Journal of Cardiology)
[2018, 122(12):2120-2124]

Cited: 1 time

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Effects of Dose Reduction on Diagnostic Image Quality of Coronary Computed Tomography Angiography in Children Using a Third-Generation Dual-Source Computed Tomography Scanner.

Moustafa Rashed, Puja Banka, Ashita Barthur, Robert D MacDougal, Rahul H Rathod, Andrew J Powell, Ashwin Prakash,

Performing coronary computed tomography angiography (CCTA) using third-generation dual source computed tomography (3G-DSCT) scanners results in radiation dose reduction without sacrificing image quality in adults. The largest dose reductions have been reported with prospectively gated, high-pitch imaging. However, there are limited data to determine if these benefits extend to pediatric ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2018, 122(7):1260-1264]

Cited: 0 times

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Stroke in Adults With Coarctation of the Aorta: A National Population-Based Study.

Sarah S Pickard, Kimberlee Gauvreau, Michelle Gurvitz, Joshua J Gagne, Alexander R Opotowsky, Kathy J Jenkins, Ashwin Prakash,

BACKGROUND:Adults with repaired coarctation of the aorta (CoA) have reduced long-term survival compared with the general population. This study aimed to determine whether CoA is independently associated with premature ischemic and hemorrhagic stroke in the contemporary era. METHODS AND RESULTS:This was a cross-sectional study utilizing the National Inpatient Sample database ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2018, 7(11):]

Cited: 3 times

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Development of a congenital cardiovascular computed tomography imaging registry: Rationale and implementation.

B Kelly Han, Susan Casey, Dawn Witt, Jonathon Leipsic, Andrew Crean, Edward Nicol, Thomas Semple, James Shambrook, Ashwin Prakash, Puja Banka, Ross Garberich, Cynthia Rigsby, Anthony Hlavacek, John Lesser,

BACKGROUND:The cumulative exposure and risk of anesthesia, vascular access, contrast agents and radiation is emerging as a significant lifelong burden in patients with congenital heart disease (CHD). Latest generation computerized tomographic (CT) scanners are increasingly used for high resolution cardiovascular imaging and have both hardware and post processing radiation dose ... Read more >>

J Cardiovasc Comput Tomogr (Journal of cardiovascular computed tomography)
[2018, 12(3):263-266]

Cited: 0 times

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Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome.

Ashwin Prakash, Leslie B Gordon, Monica E Kleinman, Ellen B Gurary, Joseph Massaro, Ralph D'Agostino, Mark W Kieran, Marie Gerhard-Herman, Leslie Smoot,

Importance:Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare disorder associated with premature death due to cardiovascular events during the second decade of life. However, because of its rarity (107 identified living patients), the natural history of cardiac disease remains uncharacterized. Therefore, meaningful cardiac end points for clinical trials have been difficult ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2018, 3(4):326-334]

Cited: 7 times

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Inefficient Ventriculoarterial Coupling in Fontan Patients: A Cardiac Magnetic Resonance Study.

Max E Godfrey, Rahul H Rathod, Ellen Keenan, Kimberlee Gauvreau, Andrew J Powell, Tal Geva, Ashwin Prakash,

The ventriculoarterial coupling (VAC) ratio, the ratio of arterial elastance (Ea) to ventricular end-systolic elastance (Ees), reflects cardiovascular efficiency. Little is known about this ratio in patients who have undergone the Fontan procedure. Our aim was to assess the VAC ratio in a cohort of Fontan patients using a cardiac ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2018, 39(4):763-773]

Cited: 0 times

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Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database.

Leo Lopez, Steven Colan, Mario Stylianou, Suzanne Granger, Felicia Trachtenberg, Peter Frommelt, Gail Pearson, Joseph Camarda, James Cnota, Meryl Cohen, Andreea Dragulescu, Michele Frommelt, Olukayode Garuba, Tiffanie Johnson, Wyman Lai, Joseph Mahgerefteh, Ricardo Pignatelli, Ashwin Prakash, Ritu Sachdeva, Brian Soriano, Jonathan Soslow, Christopher Spurney, Shubhika Srivastava, Carolyn Taylor, Poonam Thankavel, Mary van der Velde, LuAnn Minich, ,

BACKGROUND:Published nomograms of pediatric echocardiographic measurements are limited by insufficient sample size to assess the effects of age, sex, race, and ethnicity. Variable methodologies have resulted in a wide range of Z scores for a single measurement. This multicenter study sought to determine Z scores for common measurements adjusted for ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2017, 10(11):]

Cited: 6 times

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Longitudinal Changes in Segmental Aortic Stiffness Determined by Cardiac Magnetic Resonance in Children and Young Adults With Connective Tissue Disorders (the Marfan, Loeys-Dietz, and Ehlers-Danlos Syndromes, and Nonspecific Connective Tissue Disorders).

Anthony Merlocco, Ronald V Lacro, Kimberlee Gauvreau, Nicole Rabideau, Michael N Singh, Ashwin Prakash,

Aortic stiffness measured by cardiac magnetic resonance (CMR) in connective tissue disorder (CTD) patients has been previously shown to be abnormal and to be associated with adverse aortic outcomes. The rate of increase in aortic stiffness with normal aging has been previously described. However, longitudinal changes in aortic stiffness have ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2017, 120(7):1214-1219]

Cited: 1 time

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Response to Letters Regarding Article "Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement".

Ashwin Prakash, Himanshu Adlakha, Nicole Rabideau, Cara J Hass, Shaine A Morris, Tal Geva, Kimberlee Gauvreau, Michael N Singh, Ronald V Lacro,

Circulation (Circulation)
[2016, 133(7):e405]

Cited: 0 times

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Persistent Aortic Arch Hypoplasia After Coarctation Treatment Is Associated With Late Systemic Hypertension.

Sophie Quennelle, Andrew J Powell, Tal Geva, Ashwin Prakash,

Mild transverse aortic arch (TAA) hypoplasia is common after coarctation treatment, but is considered benign in the absence of an arm-leg systolic blood pressure (SBP) difference. Hypertension (HTN) is a common long-term morbidity after successful coarctation treatment. We examined whether mild TAA hypoplasia after coarctation treatment is associated with late ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2015, 4(7):]

Cited: 5 times

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Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement.

Ashwin Prakash, Himanshu Adlakha, Nicole Rabideau, Cara J Hass, Shaine A Morris, Tal Geva, Kimberlee Gauvreau, Michael N Singh, Ronald V Lacro,

Aortic diameter is an imperfect predictor of aortic complications in connective tissue disorders (CTDs). Novel indicators of vascular phenotype severity such as aortic stiffness and vertebral tortuosity index have been proposed. We assessed the relation between aortic stiffness by cardiac MRI, surgical root replacement, and rates of aortic root dilation ... Read more >>

Circulation (Circulation)
[2015, 132(7):595-602]

Cited: 16 times

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Aortic Measurements in Patients with Aortopathy are Larger and More Reproducible by Cardiac Magnetic Resonance Compared with Echocardiography.

Atosa Nejatian, Johan Yu, Tal Geva, Matthew T White, Ashwin Prakash,

Accurate and reproducible aortic measurements are essential in aortopathy patients. Transthoracic echocardiography (TTE) is commonly used but has several limitations. Cardiac magnetic resonance (CMR) can offset these limitations but has not been directly compared with TTE. We compared the reproducibility of CMR and TTE measurements at multiple aortic levels. Patients ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2015, 36(8):1761-1773]

Cited: 7 times

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Persistent transverse arch hypoplasia is associated with systemic hypertension after coarctation of aorta repair.

Sophie Quennelle, Ashwin Prakash,

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2015, 17(Suppl 1):O59-O59]

Cited: 0 times

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Cardiovascular manifestations of tuberous sclerosis complex and summary of the revised diagnostic criteria and surveillance and management recommendations from the International Tuberous Sclerosis Consensus Group.

Robert B Hinton, Ashwin Prakash, Robb L Romp, Darcy A Krueger, Timothy K Knilans, ,

J Am Heart Assoc (Journal of the American Heart Association)
[2014, 3(6):e001493]

Cited: 21 times

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Bioinformatics analysis of plant orthologous introns: identification of an intronic tRNA-like sequence.

Evgeny E Akkuratov, Lorraine Walters, Arnab Saha-Mandal, Sushant Khandekar, Erin Crawford, Craig L Zirbel, Scott Leisner, Ashwin Prakash, Larisa Fedorova, Alexei Fedorov,

Orthologous introns have identical positions relative to the coding sequence in orthologous genes of different species. By analyzing the complete genomes of five plants we generated a database of 40,512 orthologous intron groups of dicotyledonous plants, 28,519 orthologous intron groups of angiosperms, and 15,726 of land plants (moss and angiosperms). ... Read more >>

Gene (Gene)
[2014, 548(1):81-90]

Cited: 3 times

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Patients with repaired tetralogy of Fallot suffer from intra- and inter-ventricular cardiac dyssynchrony: a cardiac magnetic resonance study.

Linyuan Jing, Christopher M Haggerty, Jonathan D Suever, Sudad Alhadad, Ashwin Prakash, Frank Cecchin, Oskar Skrinjar, Tal Geva, Andrew J Powell, Brandon K Fornwalt,

Patients with repaired tetralogy of Fallot (rTOF) frequently have right bundle branch block. To better understand the contribution of cardiac dyssynchrony to dysfunction, we developed a method to quantify left (LV), right (RV), and inter-ventricular dyssynchrony using standard cine cardiac magnetic resonance (CMR).Thirty patients with rTOF and 17 healthy controls ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2014, 15(12):1333-1343]

Cited: 18 times

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Factors associated with neurodevelopment for children with single ventricle lesions.

Caren S Goldberg, Minmin Lu, Lynn A Sleeper, William T Mahle, J William Gaynor, Ismee A Williams, Kathleen A Mussatto, Richard G Ohye, Eric M Graham, Deborah U Frank, Jeffrey P Jacobs, Catherine Krawczeski, Linda Lambert, Alan Lewis, Victoria L Pemberton, Renee Sananes, Erica Sood, Stephanie B Wechsler, David C Bellinger, Jane W Newburger, ,

To measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors.All subjects in the Single Ventricle Reconstruction Trial who were alive without cardiac transplant were eligible for ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2014, 165(3):490-496.e8]

Cited: 22 times

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Cardiac magnetic resonance parameters predict transplantation-free survival in patients with fontan circulation.

Rahul H Rathod, Ashwin Prakash, Yuli Y Kim, Ioannis E Germanakis, Andrew J Powell, Kimberlee Gauvreau, Tal Geva,

BACKGROUND:Several clinical risk factors for death and heart transplantation have been identified in patients with Fontan circulation. It is unknown whether cardiac magnetic resonance (CMR) measurements of ventricular size and function are independently associated with these outcomes and further improve risk stratification. METHODS AND RESULTS:Data on patients with Fontan circulation ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2014, 7(3):502-509]

Cited: 29 times

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Technical performance score is associated with outcomes after the Norwood procedure.

Meena Nathan, Lynn A Sleeper, Richard G Ohye, Peter C Frommelt, Christopher A Caldarone, James S Tweddell, Minmin Lu, Gail D Pearson, J William Gaynor, Christian Pizarro, Ismee A Williams, Steven D Colan, Carolyn Dunbar-Masterson, Peter J Gruber, Kevin Hill, Jennifer Hirsch-Romano, Jeffrey P Jacobs, Jonathan R Kaltman, S Ram Kumar, David Morales, Scott M Bradley, Kirk Kanter, Jane W Newburger, ,

The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood procedure in the Single Ventricle Reconstruction trial.We calculated the TPS (class 1, optimal; ... Read more >>

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2014, 148(5):2208-13, 2214.e1-6]

Cited: 14 times

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