Full Text Journal Articles by
Author Ashok Agarwal

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A scientometric analysis of research publications on male infertility and assisted reproductive technology.

Ashok Agarwal, Manesh Kumar Panner Selvam, Saradha Baskaran, Renata Finelli, Kristian Leisegang, Cătălina Barbăroșie, Peter Natesan Pushparaj, Kathy Amy Robert, Rafael Ambar, Concetta Iovine, Damayanthi Durairajanayagam, Ralf Henkel,

Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male infertility and ART over the past 20 years (2000-2019) by analysing scientometric data (the number of ... Read more >>

Andrologia (Andrologia)
[2020, :e13842]

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Prospective control trial: flexible CO2 laser vs. monopolar electrocautery for robotic microsurgical denervation of the spermatic cord.

Ahmet Gudeloglu, Ajoe John Kattoor, Jamin Brahmbhatt, Sijo Parekattil, Ashok Agarwal,

Microsurgical denervation of the spermatic cord (MDSC) is a treatment option in patients with chronic orchialgia. This procedure requires precise care to avoid any thermal damage to crucial adjacent tissues (arteries, veins, and lymphatics). Monopolar electrocautery is the standard ligation energy source, but may cause extensive collateral damage to the ... Read more >>

Int J Impot Res (International journal of impotence research)
[2020, 32(6):623-627]

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Epididymal contribution to male infertility: An overlooked problem.

Salah Elbashir, Yasmin Magdi, Ayman Rashed, Ralf Henkel, Ashok Agarwal,

The diagnosis and treatment of male infertility, excluding assisted conception, are limited because of, but not limited to, poor understanding of sperm post-testicular development and storage. Many may think that sperm dysfunction is only self-contained in the sperm cell itself as a result of defective spermatogenesis. However, it can also ... Read more >>

Andrologia (Andrologia)
[2020, :e13721]

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Author Correction: Alterations in seminal plasma proteomic profile in men with primary and secondary infertility.

Ana D Martins, Manesh Kumar Panner Selvam, Ashok Agarwal, Marco G Alves, Saradha Baskaran,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13402]

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An update on the techniques used to measure oxidative stress in seminal plasma.

Kathy A Robert, Rakesh Sharma, Ralf Henkel, Ashok Agarwal,

Reactive oxygen species (ROS) are produced in significant amounts by spermatozoa and leucocytes. They are necessary to carry out various physiological functions such as sperm capacitation, hyperactivation, acrosome reaction, sperm-zona binding and cellular signalling pathways. Oxidative stress (OS) results when the ROS levels overwhelm the available antioxidant reserve. A number ... Read more >>

Andrologia (Andrologia)
[2020, :e13726]

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TUNEL assay-Standardized method for testing sperm DNA fragmentation.

Rakesh Sharma, Concetta Iovine, Ashok Agarwal, Ralf Henkel,

Sperm DNA integrity is important for normal functions such as fertilization, implantation, pregnancy and fetal development. Sperm DNA fragmentation (SDF) is more common in infertile men and may be responsible for poor reproductive function. Although there are a number of tests available to measure SDF, the terminal deoxynucleotidyl transferase-mediated deoxyuridine ... Read more >>

Andrologia (Andrologia)
[2020, :e13738]

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PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: a prospective randomized trial.

Eman Hasanen, Khaled Elqusi, Salma ElTanbouly, Abd ElGhafar Hussin, Hanaa AlKhadr, Hosam Zaki, Ralf Henkel, Ashok Agarwal,

PURPOSE:To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation (SDF) in patients undergoing intracytoplasmic sperm injection (ICSI). METHODS:A prospective randomized trial included 413 ICSI cases with abnormal SDF (> 20.3%) by TUNEL ... Read more >>

J Assist Reprod Genet (Journal of assisted reproduction and genetics)
[2020, 37(10):2605-2613]

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Sperm DNA Fragmentation: A New Guideline for Clinicians.

Ashok Agarwal, Ahmad Majzoub, Saradha Baskaran, Manesh Kumar Panner Selvam, Chak Lam Cho, Ralf Henkel, Renata Finelli, Kristian Leisegang, Pallav Sengupta, Catalina Barbarosie, Neel Parekh, Marco G Alves, Edmund Ko, Mohamed Arafa, Nicholas Tadros, Ranjith Ramasamy, Parviz Kavoussi, Rafael Ambar, Manish Kuchakulla, Kathy Amy Robert, Concetta Iovine, Damayanthi Durairajanayagam, Sunil Jindal, Rupin Shah,

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology ... Read more >>

World J Mens Health (The world journal of men's health)
[2020, 38(4):412-471]

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An update on male infertility: Factors, mechanisms, and interventions.

Edmund Ko, Ranjith Ramasamy, Damayanthi Durairajanayagam, Saradha Baskaran, Ashok Agarwal,

Andrologia (Andrologia)
[2020, :e13741]

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Sperm selection strategies and their impact on assisted reproductive technology outcomes.

Soraia Pinto, David F Carrageta, Marco G Alves, António Rocha, Ashok Agarwal, Alberto Barros, Pedro F Oliveira,

The application of assisted reproductive technologies (ART) has revolutionised the treatment of human infertility, giving hope to the patients previously considered incapable of establishing pregnancy. While semen analysis is performed to access whether a sample has an adequate number of viable, motile and morphologically normal sperm cells able to achieve ... Read more >>

Andrologia (Andrologia)
[2020, :e13725]

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Causes and consequences of sperm mitochondrial dysfunction.

Damayanthi Durairajanayagam, Dipty Singh, Ashok Agarwal, Ralf Henkel,

Mitochondria have multiple functions, including synthesis of adenine triphosphate, production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis. Mitochondria have a significant contribution in regulating the various physiological aspects of reproductive function, from spermatogenesis up to fertilisation. Mitochondrial functionality and intact mitochondrial membrane potential are a pre-requisite for sperm ... Read more >>

Andrologia (Andrologia)
[2020, :e13666]

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Distinct Proteomic Profile of Spermatozoa from Men with Seminomatous and Non-Seminomatous Testicular Germ Cell Tumors.

Manesh Kumar Panner Selvam, Marco G Alves, Tânia R Dias, Peter N Pushparaj, Ashok Agarwal,

Testicular germ cell tumors (TGCTs) are predominant in young males (15-44 years). Seminomatous and non-seminomatous TGCTs account for about 98% of all TGCTs cases. In this study, we aimed to compare the sperm proteome of patients with seminomatous and non-seminomatous TGCTs to identify possible protein biomarkers that could help distinguish ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(14):]

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Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation.

Sulagna Dutta, Ralf Henkel, Ashok Agarwal,

Male infertility has a complex etiology, and many times, the cause is unknown. While routine semen analysis provides an overview of basic semen parameters, such as sperm concentration, motility, viability and morphology, a significant overlap of these parameters has been reported in fertile and infertile men. Moreover, conventional semen parameters ... Read more >>

Andrologia (Andrologia)
[2020, :e13718]

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Comparing four laboratory three-parent techniques to construct human aged non-surrounded nucleolus germinal vesicle oocytes: A case-control study.

Sara Darbandi, Mahsa Darbandi, Ashok Agarwal, Hamid Reza Khorram Khorshid, Mohammad Reza Sadeghi, Sandro C Esteves, Pallav Sengupta, Sulagna Dutta, Zohreh Fathi, Hojjat Zeraati, Mohammad Mehdi Akhondi,

Background:The three-parent assisted reproductive technique may increase oocyte competence. Objective:In this case-control study, the suitability of germinal vesicle transfer (GVT), synchronous ooplasmic transfer (sOT), asynchronous ooplasmic transfer using cryopreserved MII oocyte (caOT), and asynchronous ooplasmic transfer using waste MII oocyte (waOT) for maturation of the human-aged non-surrounded nucleolus germinal vesicle-stage ... Read more >>

Int J Reprod Biomed (International journal of reproductive biomedicine)
[2020, 18(6):425-438]

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The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review.

Rafael F Ambar, Ashok Agarwal, Ahmad Majzoub, Sarah Vij, Nicholas N Tadros, Chak Lam Cho, Neel Parekh, Edson Borges, Sidney Glina,

The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced ... Read more >>

World J Mens Health (The world journal of men's health)
[2020, :]

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Proteomics and metabolomics - Current and future perspectives in clinical andrology.

Manesh Kumar Panner Selvam, Renata Finelli, Ashok Agarwal, Ralf Henkel,

Proteomics and metabolomics are emerging as promising tools to investigate the molecular mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in regulating the molecular pathways associated with physiological functions of spermatozoa. Semen analysis, physical examination and laboratory work up cannot identify the etiology of infertility in ... Read more >>

Andrologia (Andrologia)
[2020, :e13711]

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Etiologies of sperm DNA damage and its impact on male infertility.

Manesh Kumar Panner Selvam, Rafael F Ambar, Ashok Agarwal, Ralf Henkel,

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the male fertility potential with high sensitivity and specificity. Different etiologies have been linked ... Read more >>

Andrologia (Andrologia)
[2020, :e13706]

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Scientific landscape of oxidative stress in male reproductive research: A scientometric study.

Ashok Agarwal, Saradha Baskaran, Manesh Kumar Panner Selvam, Renata Finelli, Catalina Barbarosie, Kathy Amy Robert, Concetta Iovine, Kruyanshi Master, Ralf Henkel,

Unraveling the role of reactive oxygen species and associated oxidative stress (OS) in male reproduction is one of the key areas of male reproductive research. This article illustrates the scientific landscape of OS in male reproductive research over the past several decades (1941-2018) using a scientometric approach. Scientometric data (articles ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, 156:36-44]

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The Impact of Single- and Double-Strand DNA Breaks in Human Spermatozoa on Assisted Reproduction.

Ashok Agarwal, Cătălina Barbăroșie, Rafael Ambar, Renata Finelli,

Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis are the main mechanisms that cause DNA breaks in sperm. The two-tailed Comet assay is the only technique that ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

Cited: 1 time

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Diagnostic value of advanced semen analysis in evaluation of male infertility.

Cătălina Barbăroșie, Ashok Agarwal, Ralf Henkel,

Conventional semen analysis is the standard of care to initially evaluate the fertility status of a male patient. However, it has some limitations and among these are failure to correctly identify the aetiology underlying fertility problems, intra- and inter-observer variability and incomplete information about sperm function. Considering these drawbacks, advanced ... Read more >>

Andrologia (Andrologia)
[2020, :e13625]

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Environmental contaminants and male infertility: Effects and mechanisms.

Vaithinathan Selvaraju, Saradha Baskaran, Ashok Agarwal, Ralf Henkel,

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth ... Read more >>

Andrologia (Andrologia)
[2020, :e13646]

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Diagnostic value of routine semen analysis in clinical andrology.

Saradha Baskaran, Renata Finelli, Ashok Agarwal, Ralf Henkel,

Infertility is a major health issue affecting over 48.5 million couples around the world, with the male factor accounting for about 50% of the cases. The conventional semen analysis recommended by the World Health Organization (WHO) is the cornerstone in the evaluation of male fertility status. It includes macroscopic and microscopic ... Read more >>

Andrologia (Andrologia)
[2020, :e13614]

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Protein profiling in unlocking the basis of varicocele-associated infertility.

Manesh Kumar Panner Selvam, Saradha Baskaran, Ashok Agarwal, Ralf Henkel,

Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality ... Read more >>

Andrologia (Andrologia)
[2020, :e13645]

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Seminal oxidation-reduction potential levels are not influenced by the presence of leucocytospermia.

Mohamed Arafa, Ralf Henkel, Ashok Agarwal, Kathy Robert, Renata Finelli, Ahmad Majzoub, Haitham ElBardisi,

Oxidative stress (OS) is characterised by an excessive amount of reactive oxygen species (ROS) which negatively affect sperm functions. In this study, the influence of leucocytes on seminal oxidation-reduction potential (ORP) and sperm DNA fragmentation (SDF) was investigated in 1,068 men. Seminal leucocyte concentration did not correlate with SDF, unadjusted ... Read more >>

Andrologia (Andrologia)
[2020, 52(7):e13609]

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High levels of oxidation-reduction potential in frozen-thawed human semen are significantly correlated with poor post-thaw sperm quality.

Ramadan Saleh, Mohamed Elsuity, Ralf Henkel, Ashok Agarwal,

This study examined the relationship between oxidation-reduction potential (ORP) in frozen-thawed semen and the post-thaw sperm parameters. Levels of ORP were measured in 25 samples from men presenting for routine infertility work-up and were expressed as millivolt (mV)/106 sperm/ml. Frozen-thawed samples were examined for post-thaw total motility (TM%), progressive motility ... Read more >>

Andrologia (Andrologia)
[2020, 52(6):e13608]

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