Full Text Journal Articles by
Author Ashish K Khanna

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Association of perioperative hypotension with subsequent greater healthcare resource utilization.

Wolf H Stapelfeldt, Ashish K Khanna, Andrew D Shaw, Apeksha V Shenoy, Seungyoung Hwang, Mitali Stevens, Nathan J Smischney,

<h4>Study objective</h4>Determine if perioperative hypotension, a modifiable risk factor, is associated with increased postoperative healthcare resource utilization (HRU).<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Multicenter using the Optum® electronic health record database.<h4>Patients</h4>Patients discharged to the ward after non-cardiac, non-obstetric surgeries between January 1, 2008 and December 31, 2017 with six months of data, before and ... Read more >>

J Clin Anesth (Journal of clinical anesthesia)
[2021, 75:110516]

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Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry.

Utpal S Bhalala, Katja M Gist, Sandeep Tripathi, Karen Boman, Vishakha K Kumar, Lynn Retford, Kathleen Chiotos, Allison M Blatz, Heda Dapul, Sourabh Verma, Imran A Sayed, Varsha P Gharpure, Erica Bjornstad, Nancy Tofil, Katherine Irby, Ronald C Sanders, Julia A Heneghan, Melissa Thomas, Manoj K Gupta, Franscene E Oulds, Grace M Arteaga, Emily R Levy, Neha Gupta, Margit Kaufman, Amr Abdelaty, Mark Shlomovich, Shivanand S Medar, A M Iqbal O'Meara, Joshua Kuehne, Shina Menon, Paras B Khandhar, Aaron S Miller, Suzanne M Barry, Valerie C Danesh, Ashish K Khanna, Kimberly Zammit, Casey Stulce, Patrick W McGonagill, Asher Bercow, Ioana G Amzuta, Sandeep Gupta, Mohammed A Almazyad, Louisdon Pierre, Prithvi Sendi, Sidra Ishaque, Harry L Anderson, Pooja Nawathe, Murtaza Akhter, Patrick G Lyons, Catherine Chen, Allan J Walkey, Azra Bihorac, Imam Wada Bello, Judith Ben Ari, Tanja Kovacevic, Vikas Bansal, John T Brinton, Jerry J Zimmerman, Rahul Kashyap, ,

<h4>Objectives</h4>Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe the characteristics, ICU admissions, and outcomes among children hospitalized with coronavirus disease 2019 using Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry.

Sandeep Tripathi, Imran A Sayed, Heda Dapul, Jeremy S McGarvey, Jennifer A Bandy, Karen Boman, Vishakha K Kumar, Vikas Bansal, Lynn Retford, Sreekanth Cheruku, Margit Kaufman, Smith F Heavner, Valerie C Danesh, Catherine A St Hill, Ashish K Khanna, Utpal Bhalala, Rahul Kashyap, Ognjen Gajic, Allan J Walkey, Katja M Gist,

<h4>Importance</h4>Even with its proclivity for older age, coronavirus disease 2019 has been shown to affect all age groups. However, there remains a lack of research focused primarily on the young adult population.<h4>Objectives</h4>To describe the epidemiology and outcomes of coronavirus disease 2019 and identify the risk factors associated with critical illness ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(8):e0514]

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Emergency Airway Management Outside the Operating Room: Current Evidence and Management Strategies.

Kunal Karamchandani, Jonathan Wheelwright, Ae Lim Yang, Nathaniel D Westphal, Ashish K Khanna, Sheila N Myatra,

Emergency airway management outside the operating room (OR) is often associated with an increased risk of airway related, as well as cardiopulmonary, complications which can impact morbidity and mortality. These emergent airways may take place in the intensive care unit (ICU), where patients are critically ill with minimal physiological reserve, ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(3):648-662]

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A nomogram to predict postoperative pulmonary complications after cardiothoracic surgery.

Ashish K Khanna, Marta Kelava, Sanchit Ahuja, Natalya Makarova, Chen Liang, Donna Tanner, Steven R Insler,

<h4>Objective</h4>The objective was to develop a novel scoring system that would be predictive of postoperative pulmonary complications in critically ill patients after cardiac and major vascular surgery.<h4>Methods</h4>A total of 17,433 postoperative patients after coronary artery bypass graft, valve, or thoracic aorta repair surgery admitted to the cardiovascular intensive care units ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

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Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials.

Gregory B Hammer, Ashish K Khanna, Cathy Michalsky, Linda Wase, Mark A Demitrack, Roderick Little, Michael J Fossler, Sabry Ayad,

<h4>Introduction</h4>In the management of postoperative acute moderate-to-severe pain, opioids remain an important component. However, conventional opioids have a narrow therapeutic index and are associated with dose-limiting opioid-related adverse events (ORAEs) that can result in worse patient outcomes. Oliceridine, a new intravenous µ-opioid receptor agonist, is shown in nonclinical studies to ... Read more >>

Pain Ther (Pain and therapy)
[2021, 10(2):1343-1353]

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Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry.

Sandeep Tripathi, Katja M Gist, Erica C Bjornstad, Rahul Kashyap, Karen Boman, Kathleen Chiotos, Varsha P Gharpure, Heda Dapul, Imran A Sayed, Joshua Kuehne, Julia A Heneghan, Manoj Gupta, Paras B Khandhar, Shina Menon, Neha Gupta, Vishakha K Kumar, Lynn Retford, Jerry Zimmerman, Utpal S Bhalala, ,

<h4>Objectives</h4>To compare clinical characteristics and outcomes of children admitted to the PICU for severe acute respiratory syndrome coronavirus 2-related illness with or without multisystem inflammatory syndrome in children. The secondary objective was to identify explanatory factors associated with outcome of critical illness defined by a composite index of in-hospital mortality ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(7):603-615]

Cited: 4 times

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Intraoperative Hypotension Is Associated With Adverse Clinical Outcomes After Noncardiac Surgery.

Anne Gregory, Wolf H Stapelfeldt, Ashish K Khanna, Nathan J Smischney, Isabel J Boero, Qinyu Chen, Mitali Stevens, Andrew D Shaw,

<h4>Background</h4>Intraoperative hypotension (IOH) occurs frequently during surgery and may be associated with organ ischemia; however, few multicenter studies report data regarding its associations with adverse postoperative outcomes across varying hemodynamic thresholds. Additionally, no study has evaluated the association between IOH exposure and adverse outcomes among patients by various age groups.<h4>Methods</h4>A ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(6):1654-1665]

Cited: 2 times

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Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study.

Nida Qadir, Raquel R Bartz, Mary L Cooter, Catherine L Hough, Michael J Lanspa, Valerie M Banner-Goodspeed, Jen-Ting Chen, Shewit Giovanni, Dina Gomaa, Michael W Sjoding, Negin Hajizadeh, Jordan Komisarow, Abhijit Duggal, Ashish K Khanna, Rahul Kashyap, Akram Khan, Steven Y Chang, Joseph E Tonna, Harry L Anderson, Janice M Liebler, Jarrod M Mosier, Peter E Morris, Alissa Genthon, Irene K Louh, Mark Tidswell, R Scott Stephens, Annette M Esper, David J Dries, Anthony Martinez, Kraftin E Schreyer, William Bender, Anupama Tiwari, Pramod K Guru, Sinan Hanna, Michelle N Gong, Pauline K Park, , ,

<h4>Background</h4>Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown.<h4>Research question</h4>What is the impact of treatment variability on mortality in patients with moderate to severe ... Read more >>

Chest (Chest)
[2021, 160(4):1304-1315]

Cited: 3 times

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Modeling the Cost Savings of Continuous Pulse Oximetry and Capnography Monitoring of United States General Care Floor Patients Receiving Opioids Based on the PRODIGY Trial.

Ashish K Khanna, Carla R Jungquist, Wolfgang Buhre, Roy Soto, Fabio Di Piazza, Leif Saager, ,

<h4>Introduction</h4>Despite the high incidence of respiratory depression on the general care floor and evidence that continuous monitoring improves patient outcomes, the cost-benefit of continuous pulse oximetry and capnography monitoring of general care floor patients remains unknown. This study modeled the cost and length of stay savings, investment break-even point, and ... Read more >>

Adv Ther (Advances in therapy)
[2021, 38(7):3745-3759]

Cited: 0 times

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 83 times

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Postoperative Hypotension and Adverse Clinical Outcomes in Patients Without Intraoperative Hypotension, After Noncardiac Surgery.

Ashish K Khanna, Andrew D Shaw, Wolf H Stapelfeldt, Isabel J Boero, Qinyu Chen, Mitali Stevens, Anne Gregory, Nathan J Smischney,

<h4>Background</h4>Postoperative hypotension (POH) is associated with major adverse events. However, little is known about the association of blood pressure thresholds and outcomes in postoperative patients without intraoperative hypotension (IOH) on the general-care ward. We evaluated the association of POH with major adverse cardiac or cerebrovascular events (MACCE) in patients without ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(5):1410-1420]

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ABO blood types and sepsis mortality.

Theis S Itenov, Daniel I Sessler, Ashish K Khanna, Sisse R Ostrowski, Pär I Johansson, Christian Erikstrup, Ole B Pedersen, Sofie L Rygård, Lars B Holst, Morten H Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H Andersen, Thomas Mohr, Jens D Lundgren, Jens-Ulrik Jensen,

<h4>Background</h4>We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):61]

Cited: 0 times

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In Response.

Ashish K Khanna, Richard D Urman, Frank J Overdyk,

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):e61]

Cited: 0 times

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Renal Recovery in Critically Ill Adult Patients Treated with Veno-Venous Or Veno-Arterial Extra Corporeal Membrane Oxygenation: a Retrospective Cohort Analysis.

Braghadheeswar Thyagarajan, Mariana Murea, Deanna N Jones, Amit K Saha, Gregory B Russell, Ashish K Khanna,

<h4>Introduction</h4>Patients on extracorporeal membrane oxygenator (ECMO) therapy are critically ill and often develop acute kidney injury (AKI) during hospitalisation. Little is known about the association of exposure to and the effect of the type of ECMO and extent of renal recovery after AKI development.<h4>Aim of the study</h4>In patients who developed ... Read more >>

J Crit Care Med (Targu Mures) (Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures))
[2021, 7(2):104-112]

Cited: 0 times

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Opioid-induced respiratory depression increases hospital costs and length of stay in patients recovering on the general care floor.

Ashish K Khanna, Leif Saager, Sergio D Bergese, Carla R Jungquist, Hiroshi Morimatsu, Shoichi Uezono, Lian Kah Ti, Roy Soto, Wei Jiang, Wolfgang Buhre,

<h4>Background</h4>Opioid-induced respiratory depression is common on the general care floor. However, the clinical and economic burden of respiratory depression is not well-described. The PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) trial created a prediction tool to identify patients at risk of respiratory depression. The purpose of ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2021, 21(1):88]

Cited: 1 time

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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.

Sonia O Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J Brett, Silvia Calvino-Gunther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy François, Patrick M Honore, Radmilo Jankovic, Ashish K Khanna, Mireia Llaurado-Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn I Blot, , ,

Intensive Care Med (Intensive care medicine)
[2021, 47(4):503-520]

Cited: 0 times

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 9 times

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Myocardial Injury After Noncardiac Surgery-Slightly Heavier May Be Better.

Ashish K Khanna, Tong J Gan,

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):957-959]

Cited: 0 times

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Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients.

Jonathan H Chow, Erica D Wittwer, Patrick M Wieruszewski, Ashish K Khanna,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

Cited: 0 times

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Critical Care Medicine Practice: A Pilot Survey of US Anesthesia Critical Care Medicine-Trained Physicians.

Shahla Siddiqui, Karsten Bartels, Maximilian S Schaefer, Lena Novack, Roshni Sreedharan, Talia K Ben-Jacob, Ashish K Khanna, Mark E Nunnally, Michael Souter, Shawn T Simmons, George Williams,

<h4>Background</h4>This survey assessed satisfaction with the practice environment among physicians who have completed fellowship training in critical care medicine (CCM) as recognized by the American Board of Anesthesiology (and are members of the American Society of Anesthesiology) and evaluated the perceived effectiveness of training programs in preparing fellows for critical ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):761-769]

Cited: 0 times

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Response to: Comment on: Postoperative opioid administration characteristics associated with opioid-induced respiratory depression: Results from the PRODIGY trial.

Richard D Urman, Ashish K Khanna, Sergio D Bergese, Wolfgang Buhre, Maria Wittmann, Morgan Le Guen, Frank J Overdyk, Fabio Di Piazza, Leif Saager,

J Clin Anesth (Journal of clinical anesthesia)
[2021, 71:110228]

Cited: 0 times

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In Response.

Ashish K Khanna, Wolfgang Buhre, Frank J Overdyk,

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):e45-e46]

Cited: 0 times

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Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry.

Juan Pablo Domecq, Amos Lal, Christopher R Sheldrick, Vishakha K Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O Harhay, Michael A Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M Banner-Goodspeed, Harry L Anderson, Patrick S Milligan, Joshua L Denson, Catherine A St Hill, Kenneth W Dodd, Greg S Martin, Ognjen Gajic, Allan J Walkey, Rahul Kashyap, ,

<h4>Objectives</h4>To describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry.<h4>Design</h4>Cross-sectional observational study including coronavirus disease 2019 patients hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between February 15, 2020, and November 30, 2020, according to age and type of organ support therapies.<h4>Setting</h4>About 168 hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):437-448]

Cited: 5 times

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An Incidental Finding of Coronary-cameral Fistulas in a Critically Ill Patient with a Metastatic Cardiac Tumor.

Braghadheeswar Thyagarajan, Casey Bryant, Ashish K Khanna,

It is extremely rare for a cardiac tumor to present with coronary-cameral fistulas. A 66-year-old Caucasian male presented with worsening dyspnea and subsequently had a cardiac catheterization for an ST-elevation myocardial infarction, revealing no evidence of coronary artery disease but multiple coronary-cameral fistulas. Venoarterial (VA) extracorporeal membrane oxygenation was initiated ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2021, 25(3):340-342]

Cited: 0 times

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