Full Text Journal Articles by
Author Aseem K Tiwari

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Utility of grey zone testing strategy in transfusion transmissible infection testing in blood bank is of limited value!

Gunjan Bhardwaj, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Divya Setya,

Several blood banks use grey zone (GZ) phenomenon (defined as samples with optical density within 10% below the cut off in enzyme immuno-assay [EIA]/chemiluminescence immunoassay [CLIA]) to further augment blood safety. There is paucity of data regarding usefulness of GZ sample and its application in Transfusion Transmissible Infection (TTI) screening ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2020, 63(2):255-257]

Cited: 0 times

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Matched unrelated donor hematopoietic progenitor cell transplantation: A report based on a single registry in India.

Aseem K Tiwari, Vikash Chandra Mishra, Apeksha Tiwari, Pranav Dorwal, Kapil Gupta, Dinesh Chandra, Vimarsh Raina,

Introduction:Currently, more than 10,000 matched unrelated donor transplants (MUDT) are performed annually worldwide. India has recorded a significant increase in the number of hematopoietic progenitor cell transplantation (HPCT) centers reporting transplants. The number of HPCTs increases by approximately 10% every year, with 1878 transplants reported by Indian stem cell transplant ... Read more >>

Leuk Res Rep (Leukemia research reports)
[2019, 11:17-20]

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Successful treatment of Sezary syndrome with extracorporeal photopheresis - The first attempt in India.

Aseem K Tiwari, Dinesh Arora, Pratibha Dhiman, Sheilly Kapoor, Geet Aggarwal, Ravi C Dara, Ashok Vaid,

Sezary syndrome (SS) is more aggressive leukemic variant of cutaneous T-cell lymphoma in which a significant number of circulating malignant (Sezary) cells are observed in peripheral blood. Although single-agent or combination chemotherapy regimens have produced moderately high response rates in patients with advanced-stage SS, these responses are invariably not durable. ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2019, 13(1):66-69]

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A guide to organize voluntary stem cell donors recruitment drive for hematopoietic progenitor stem cell transplant.

Vikash Chandra Mishra, Aseem K Tiwari, Pranav Dorwal, Vimarsh Raina, Girish Sharma,

BACKGROUND:Hematopoietic progenitor cell transplantation (HPCT) is used as a definitive treatment in hematological malignancies. For a successful HPCT, the donor and recipient should have matching human leukocyte antigens (HLAs). About 25% of patients have a chance of finding matching HLA within family, while rests 75% are dependent on voluntary stem ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2019, 13(1):39-42]

Cited: 0 times

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Applying newer parameter Ret-He (reticulocyte haemoglobin equivalent) to assess latent iron deficiency (LID) in blood donors-study at a tertiary care hospital in India.

Aseem K Tiwari, Gunjan Bhardwaj, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Ravi C Dara, Ritesh Sachdev, Arun Raizada, Monisha Sethi,

BACKGROUND:It is important to detect Latent Iron Deficiency (LID) to prevent development of an overt iron deficiency anemia. Early detection is difficult by using conventional hematological and biochemical parameters. Soluble transferrin receptor (sTfR) is presently the gold standard for diagnosing LID. We evaluated the utility of Reticulocyte Hemoglobin Equivalent (Ret-He), ... Read more >>

Vox Sang. (Vox sanguinis)
[2018, 113(7):639-646]

Cited: 1 time

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Clinically significant naturally occurring anti-N and anti-S in a blood donor: a rare finding.

Sheetal Malhotra, Gita Negi, Aseem K Tiwari,

CONCLUSIONS:To the Editors: Alloimmunization is triggered when an individual whose red blood cells (RBCs) are lacking particular antigens is exposed to these antigens through transfusion or pregnancy, causing the formation of immune antibodies. In addition to these exogenous exposures, underlying inflammatory or autoimmune conditions may lead to formation of unexpected ... Read more >>

Immunohematology (Immunohematology)
[2018, 34(2):66-68]

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Notification and counselling of hepatitis positive blood donors, their immediate emotional response, contact-testing and their follow-up: Study from a tertiary care hospital!

Aseem K Tiwari, Gunjan Bhardwaj, Ravi C Dara, Dinesh Arora, Geet Aggarwal, Richa Bhargava, Kaushal Madan,

INTRODUCTION:Post-donation counselling informs donors of unusual test results. Timely notification and counselling regarding their Transfusion Transmitted Infection (TTI) status is necessary for early clinical intervention in the donor and reducing risk of transmission. We share our experience with respect to Hepatitis B (HBV) and Hepatitis C (HCV) positive donors who ... Read more >>

Transfus. Apher. Sci. (Transfusion and Apheresis Science)
[2018, 57(3):391-397]

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Advantages of type and screen policy: Perspective from a developing country!

Geet Aggarwal, Aseem K Tiwari, Dinesh Arora, Ravi C Dara, Devi P Acharya, Gunjan Bhardwaj, Jyoti Sharma,

The authors' center recently changed their pretransfusion testing protocol from "conventional" type and screen (TS) with anti-human globulin (AHG) crossmatch (Policy A) to TS with immediate-spin (IS) crossmatch (Policy B). Red blood cell (RBC) units were issued after compatible IS crossmatch as and when required instead of AHG crossmatch. This ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2018, 12(1):42-45]

Cited: 1 time

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Changing Trends in Therapeutic Plasmapheresis: An Indian Perspective.

Aseem K Tiwari, Gunjan Bhardwaj, Geet Aggarwal, Dinesh Arora, Ravi C Dara, Devi P Acharya, Sangeetha Gayam, Jui Choudhuri,

Indications for therapeutic apheresis (TA) are dynamic; they keep changing and expanding because of introduction of newer treatment modalities and accumulating evidence in the form of case-reports, case-series and original articles. We evaluated our therapeutic plasmapheresis (TP) data and compared this data with an earlier published Indian report for indications, ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2017, 21(5):500-506]

Cited: 2 times

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False negative single antigen bead assay: Is it always an effect of prozone?

Dharmendra Jain, Jui Choudhuri, Rajni Chauhan, Pranav Dorwal, Deepak Sharma, Aseem K Tiwari, Vimarsh Raina,

BACKGROUND:Bead based flow cytometry and Luminex play a major role in identification of alloantibodies in renal transplant work-up. Strong sensitization events may lead to prozone phenomenon that can affect single antigen bead (SAB) assay and result in false negativity. However, this can also be due to high titer of other ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2018, 32(2):]

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Co-infection of blood borne viruses in blood donors: A cross-sectional study from North India.

Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Ganesh Singh Rawat, Jyoti Sharma, Devi Prasad Acharya, Gunjan Bhardwaj,

There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors.The cross-sectional analysis was conducted in blood donors. All donors were ... Read more >>

Transfus. Apher. Sci. (Transfusion and Apheresis Science)
[2017, 56(3):367-370]

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Applications of selected cells in immunohematology in a developing country: case studies.

Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Subhasis Mitra, Geet Aggarwal, Devi P Acharya, Gunjan Bhardwaj,

When an antibody is detected, its specificity should be determined and its likely clinical significance should be assessed. When one antibody has been identified, it becomes necessary to confirm the presence of additional significant antibodies to ensure that compatible blood is provided to the patient. To perform this confirmation, specific ... Read more >>

Immunohematology (Immunohematology)
[2017, 33(1):27-35]

Cited: 0 times

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Post-donation telephonic interview of blood donors providing an insight into delayed adverse reactions: First attempt in India.

Aseem K Tiwari, Geet Aggarwal, Ravi C Dara, Dinesh Arora, Khushboo Srivastava, Vimarsh Raina,

Blood donor experiences both immediate adverse reactions (IAR) and delayed adverse reactions (DAR). With limited published data available on the incidence of DAR, a study was conducted to estimate incidence and profile of DAR through telephonic interview.Study was conducted over a 45-day period for consecutive volunteer whole blood donations at ... Read more >>

Transfus. Apher. Sci. (Transfusion and Apheresis Science)
[2017, 56(2):141-146]

Cited: 0 times

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Cascade plasmapheresis as preconditioning regimen for ABO-incompatible renal transplantation: a single-center experience.

Pranaw K Jha, Aseem K Tiwari, Shyam B Bansal, Sidharth K Sethi, Rajesh Ahlawat, Vijay Kher,

Removal of anti-ABO is an important component of the preconditioning regimen for ABO-incompatible (ABOi) renal transplant. Cascade plasmapheresis (CP) is one of the extracorporeal methods of antibody removal, others being conventional plasma exchange (PE) and immunoadsorption. There is no previous published experience with CP in this context. The purpose of ... Read more >>

Transfusion (Transfusion)
[2016, 56(4):956-961]

Cited: 5 times

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Autologous peripheral blood stem cell harvest: Collection efficiency and factors affecting it.

Aseem K Tiwari, Prashant Pandey, Harini Subbaraman, Rahul Bhargava, Ganesh Rawat, Shivani Madiraju, Vimarsh Raina, Richa Bhargava,

Harvest of hematopoietic progenitor cells via leukapheresis is being used increasingly for transplants in India. Adequate yield of cells per kilogram body weight of recipient is required for successful engraftment. Collection efficiency (CE) is an objective quality parameter used to assess the quality of leukapheresis program. In this study, we ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2016, 10(1):93-97]

Cited: 1 time

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Incidence of clinically significant antibodies in patients and healthy blood donors: a prospective cross-sectional study from a tertiary healthcare center in India.

Aseem K Tiwari, Prashant Pandey, Jyoti Sharma, Kumari Shailja, Surbhi Dixit, Vimarsh Raina,

INTRODUCTION: Since there is scarce data available on incidence and type of irregular antibodies in patients and donors in India, a study was undertaken to find the incidence of irregular antibodies in patients and irregular antibodies and a positive Direct Antiglobulin Test (DAT) in blood donors. MATERIALS AND METHODS: Antibody ... Read more >>

Transfus. Apher. Sci. (Transfusion and Apheresis Science)
[2014, 50(2):230-234]

Cited: 5 times

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A cost effective model for appropriate administration of red cell units and salvaging un-transfused red cell units by using temperature sensitive indicators for blood component transportation in a hospital setting.

Aseem K Tiwari, Pooja Sharma, Prashant K Pandey, Ganesh S Rawat, Surbhi Dixit, Vimarsh Raina, Richa Bhargava,

BACKGROUND: A rule called "30-min rule" defines that red cell unit cannot be used if it has been out of blood bank refrigerator for over 30 min. This rule is useful to guide initiation of transfusion, but is inadequate for deciding whether to reuse or discard units received-back at blood ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2015, 9(1):36-40]

Cited: 1 time

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Approach to a case of multiple irregular red cell antibodies in a liver transplant recipient: Need for developing competence.

Ravi C Dara, Aseem K Tiwari, Prashant Pandey, Dinesh Arora,

Liver transplant procedure acts as a challenge for transfusion services in terms of specialized blood components, serologic problems, and immunologic effects of transfusion. Red cell alloimmunization in patients awaiting a liver transplant complicate the process by undue delay or unavailability of compatible red blood cell units. Compatible blood units can ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2015, 9(1):94-97]

Cited: 0 times

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Probability of Finding Marrow Unrelated Donor (MUD) for an Indian patient in a Multi-national Human Leukocyte Antigen (HLA) Registry.

Aseem K Tiwari, Himakshi Bhati-Kushwaha, Pooja Kukreja, Vikash C Mishra, Neetu Tyagi, Ashish Sharma, Vimarsh Raina,

With an increase in the number of transplants happening globally, hematopoietic stem cells (HSC) transplantation from matched unrelated donor (MUD) has begun. The increasing trend of MUD transplants across countries has been largely facilitated with the conspicuous growth of volunteer HSC donor noted in the last decade i.e. 8 million ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2015, 31(2):186-195]

Cited: 2 times

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Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other.

Ritesh Sachdev, Aseem K Tiwari, Shalini Goel, Vimarsh Raina, Monisha Sethi,

AIMS: This study aims to establish biological reference interval for novel platelet parameters. SETTINGS AND DESIGN: A total of 945 healthy individuals, age ranges from 18 to 64 years (881 males and 64 females) coming for voluntary blood donation from June to August 2012 (3 months) were enrolled after exclusion ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2014, 57(2):231-235]

Cited: 10 times

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Perioperative use of allogenic blood components in live-related donor orthotopic liver transplantation: A cross sectional study.

Prashant Pandey, Aseem K Tiwari, Jyoti Sharma, Divyajyoti Srivastava, Surbhi Dixit, Vimarsh Raina,

BACKGROUND: In spite of many improvements that have reduced the blood component requirements, substantial numbers of transfusions are still needed in liver transplantation. AIMS: The objective of the present study was to analyze the perioperative usage of allogenic blood components and predict the preoperative factors as predictors of red cell ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2013, 7(1):68-72]

Cited: 1 time

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Knowledge, attitude and practices of people towards voluntary blood donation in Uttarakhand.

Amit Agrawal, Aseem K Tiwari, Alok Ahuja, Rakesh Kalra,

INTRODUCTION: Blood transfusions form a crucial and irreplaceable part in the medical management of many diseases. The collection of blood from voluntary, non-remunerated blood donors from low risk populations is an important measure for ensuring the availability and safety of blood transfusion. In a state like Uttarakhand which is visited ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2013, 7(1):59-62]

Cited: 5 times

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Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening.

Aseem K Tiwari, Iva Chandola,

BACKGROUND: The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. MATERIALS AND METHODS: Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2009, 3(2):99-102]

Cited: 3 times

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