Full Text Journal Articles by
Author Arun Upadhyay

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Asymptomatic malaria infection prevailing risks for human health and malaria elimination.

Dhaneswar Prusty, Nidhi Gupta, Arun Upadhyay, Ashraf Dar, Biswajit Naik, Navin Kumar, Vijay Kumar Prajapati,

There has been a consistent rise in malaria cases in the last few years. The existing malaria control measures are challenged by insecticide resistance in the mosquito vector, drug résistance in parasite populations, and asymptomatic malaria (ASM) in healthy individuals. The absence of apparent malaria symptoms and the presence of ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2021, 93:104987]

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Herpesviruses and the hidden links to Multiple Sclerosis neuropathology.

Shweta Jakhmola, Arun Upadhyay, Khushboo Jain, Amit Mishra, Hem Chandra Jha,

Herpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2021, 358:577636]

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Flavonoid-Based Nanomedicines in Alzheimer's Disease Therapeutics: Promises Made, a Long Way To Go.

Pragya Prasanna, Arun Upadhyay,

Alzheimer's disease (AD) is characterized by the continuous decline of the cognitive abilities manifested due to the accumulation of large aggregates of amyloid-beta 42 (Aβ42), the formation of neurofibrillary tangles of hyper-phosphorylated forms of microtubule-associated tau protein, which may lead to many alterations at the cellular and systemic level. The ... Read more >>

ACS Pharmacol Transl Sci (ACS pharmacology & translational science)
[2021, 4(1):74-95]

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Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.

Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, Rohan Dhiman, Vijay Kumar Prajapati, Krishna Mohan Poluri, Amit Mishra,

Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule ... Read more >>

Drug Metab Rev (Drug metabolism reviews)
[2021, 53(1):100-121]

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Cloning, purification, and homology modeling of Histone deacetylase in Leishmania donovani.

Pragya Prasanna, Rakesh Kumar, Vijay Kumar Singh, Arun Upadhyay,

Neglected diseases, such as leishmaniasis, are still a major health problem in poor countries. To date, there is a severe lack of effective, safe, and affordable treatment for leishmaniasis. Currently, there are very limited chemotherapeutic options, and the development of vaccines is still underway. Hence, novel therapeutic strategies need to ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2021, 89:104738]

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Complex Inclusion Bodies and Defective Proteome Hubs in Neurodegenerative Disease: New Clues, New Challenges.

Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra,

A healthy physiological environment of cells represents the dynamic homeostasis of crowded molecules. A subset of cellular proteome forms protein quality control (PQC) machinery to maintain an uninterrupted synthesis of new polypeptides and targeted elimination of old or defective proteins. The process of PQC may get overwhelmed under specific genetic ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421989582]

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Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils.

Pragya Prasanna, Arun Upadhyay,

<i>Leishmania</i>, the causative agent of leishmaniasis, is an intracellular pathogen that thrives in the insect gut and mammalian macrophages to complete its life cycle. Apart from temperature difference (26 to 37°C), it encounters several harsh conditions, including oxidative stress, inflammatory reactions, and low pH. Heat shock proteins (HSPs) play essential ... Read more >>

Infect Immun (Infection and immunity)
[2021, 89(2):]

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LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.

Ribhav Mishra, Vibhuti Joshi, Arun Upadhyay, Ayeman Amanullah, Ankur Rakesh Dubey, Sarika Singh, Vikash Kumar Dubey, Krishna Mohan Poluri, Nihar Ranjan Jana, Amit Mishra,

Numerous proteins participate and actively contribute to the various cellular mechanisms, where several of them are crucial for regular metabolism, including survival. Thus, to maintain optimal cellular physiology, cells govern protein quality control functions with the assistance of comprehensive actions of molecular chaperones, the ubiquitin-proteasome system, and autophagy. In the ... Read more >>

Cell Signal (Cellular signalling)
[2021, 77:109836]

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Cancer: An unknown territory; rethinking before going ahead.

Arun Upadhyay,

Cancer is a disease of altered signaling and metabolism, causing uncontrolled division and survival of transformed cells. A host of molecules, factors, and conditions have been designated as underlying causes for the inception and progression of the disease. An enormous amount of data is available, system-wide interaction networks of the ... Read more >>

Genes Dis (Genes & diseases)
[2021, 8(5):655-661]

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Nr2e3 is a genetic modifier that rescues retinal degeneration and promotes homeostasis in multiple models of retinitis pigmentosa.

Sujun Li, Shyamtanu Datta, Emily Brabbit, Zoe Love, Victoria Woytowicz, Kyle Flattery, Jessica Capri, Katie Yao, Siqi Wu, Michael Imboden, Arun Upadhyay, Rasappa Arumugham, Wallace B Thoreson, Margaret M DeAngelis, Neena B Haider,

Recent advances in viral vector engineering, as well as an increased understanding of the cellular and molecular mechanism of retinal diseases, have led to the development of novel gene therapy approaches. Furthermore, ease of accessibility and ocular immune privilege makes the retina an ideal target for gene therapies. In this ... Read more >>

Gene Ther (Gene therapy)
[2021, 28(5):223-241]

Cited: 6 times

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Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death.

Ribhav Mishra, Ayeman Amanullah, Arun Upadhyay, Rohan Dhiman, Ankur Rakesh Dubey, Sarika Singh, Amit Prasad, Amit Mishra,

Accumulation of aberrant misfolded proteins is a major hallmark of several neurodegenerative diseases. Intracellular accumulations of such abnormal proteins are selectively cleared by the ubiquitin-proteasome system (UPS). But how the failure of misfolded protein degradation cause proteinopathies is still an unanswered question?. Previous studies have suggested that few selective quality ... Read more >>

Int J Biochem Cell Biol (The international journal of biochemistry & cell biology)
[2020, 120:105697]

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How autophagy can restore proteostasis defects in multiple diseases?

Vibhuti Joshi, Arun Upadhyay, Vijay K Prajapati, Amit Mishra,

Cellular evolution develops several conserved mechanisms by which cells can tolerate various difficult conditions and overall maintain homeostasis. Autophagy is a well-developed and evolutionarily conserved mechanism of catabolism, which endorses the degradation of foreign and endogenous materials via autolysosome. To decrease the burden of the ubiquitin-proteasome system (UPS), autophagy also ... Read more >>

Med Res Rev (Medicinal research reviews)
[2020, 40(4):1385-1439]

Cited: 1 time

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Structure of proteins: Evolution with unsolved mysteries.

Arun Upadhyay,

Evolution of macromolecules could be considered as a milestone in the history of life. Nucleic acids are the long stretches of nucleotides that contain all the possible codes and information of life. On the other hand, proteins are their actual translated outcomes, or reflections of modifications in their structure that ... Read more >>

Prog Biophys Mol Biol (Progress in biophysics and molecular biology)
[2019, 149:160-172]

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Dynamics of carbohydrate strands in water and interactions with clay minerals: influence of pH, surface chemistry, and electrolytes.

Tariq Jamil, Jacob R Gissinger, Amanda Garley, Nabanita Saikia, Arun K Upadhyay, Hendrik Heinz,

Carbohydrate hydrogels are extensively used in pharmaceuticals and engineered biomaterials. Molecular conformations, assembly, and interactions of the carbohydrate strands with stabilizers such as clay minerals in aqueous solution are difficult to quantify in experiments and the hydrogel properties remain largely a result of trial-and-error studies. We analyzed the assembly of ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(23):11183-11194]

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Ag(I) and Au(III) Mercaptobenzothiazole complexes induced apoptotic cell death.

Jositta Sherine, Arun Upadhyay, Amit Mishra, Deepak Kumar, Samanwita Pal, S Harinipriya,

2-Mercaptobenzothiazole (MBT) complexes of Ag(I) and Au(III) were synthesized by wet chemical method. The structural, optical, 1HNMR, ICP - MS and electrochemical studies of the complexes were carried out. The TUNEL assay studies of Ag(I)MBT and Au(III)MBT complexes on A549 cell line indicated induced apoptosis in the cells. TUNEL assay ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):621]

Cited: 2 times

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Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation.

Vibhuti Joshi, Ribhav Mishra, Arun Upadhyay, Ayeman Amanullah, Krishna Mohan Poluri, Sarika Singh, Amit Kumar, Amit Mishra,

Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant proteins aggregates play a critical role in protein homeostasis imbalance and failure of protein quality control (PQC) mechanism, leading to disease conditions. However, we still do not ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(11):20900-20914]

Cited: 8 times

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LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases.

Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Rohan Dhiman, Krishna Mohan Poluri, Nihar Ranjan Jana, Amit Mishra,

Cellular protein quality control (PQC) plays a significant role in the maintenance of cellular homeostasis. Failure of PQC mechanism may lead to various neurodegenerative diseases due to accumulation of aberrant proteins. To avoid such fatal neuronal conditions PQC employs autophagy and ubiquitin proteasome system (UPS) to degrade misfolded proteins. Few ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2019, 76(11):2093-2110]

Cited: 2 times

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Proteasome-mediated proteostasis: Novel medicinal and pharmacological strategies for diseases.

Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Amit Mishra,

Proteins actively participate in a wide range of cellular physiological functions. But aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded proteins often causes many diseases. During abnormal protein aggregation events, cells try to cope against such deleterious consequences because of the remarkable functional attempts of two distinct ... Read more >>

Med Res Rev (Medicinal research reviews)
[2018, 38(6):1916-1973]

Cited: 4 times

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Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins?

Vibhuti Joshi, Arun Upadhyay, Deepak Chhangani, Ayeman Amanullah, Rajesh N Sharan, Amit Mishra,

In cells, protein synthesis and degradation are normal processes, which are tightly regulated by various cellular metabolic pathways. Cellular protein quality control (PQC) mechanisms always present a continuous and rigorous check over all intracellular proteins before they can participate in various cellular physiological processes with the help of PQC pathways ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2018, 233(10):6352-6368]

Cited: 0 times

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Amyloids of multiple species: are they helpful in survival?

Arun Upadhyay, Amit Mishra,

Amyloids are primarily known for their roles in neurodegenerative disorders, as well as in systemic diseases like diabetes. Evolutionary forces tend to maintain a healthy set of heritable characteristics, while eliminating toxic or unfavourable elements; but amyloids seem to represent an exception to this fundamental concept. In addition to their ... Read more >>

Biol Rev Camb Philos Soc (Biological reviews of the Cambridge Philosophical Society)
[2018, 93(3):1363-1386]

Cited: 2 times

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Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs).

Eshan Khan, Arpita Tawani, Subodh Kumar Mishra, Arun Kumar Verma, Arun Upadhyay, Mohit Kumar, Rajat Sandhir, Amit Mishra, Amit Kumar,

Huntington's disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2018, 13(1):180-188]

Cited: 7 times

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Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration.

Ayeman Amanullah, Arun Upadhyay, Vibhuti Joshi, Ribhav Mishra, Nihar Ranjan Jana, Amit Mishra,

Proteins are ordered useful cellular entities, required for normal health and organism's survival. The proteome is the absolute set of cellular expressed proteins, which regulates a wide range of physiological functions linked with all domains of life. In aging cells or under unfavorable cellular conditions, misfolding of proteins generates common ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2017, 159:1-38]

Cited: 6 times

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Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.

Vibhuti Joshi, Arun Upadhyay, Amit Kumar, Amit Mishra,

As per the requirement of metabolism and fitness, normal cellular functions are controlled by several proteins, and their interactive molecular and signaling events at multiple levels. Protein quality control (PQC) mechanisms ensure the correct folding and proper utilization of these proteins to avoid their misfolding and aggregation. To maintain the ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2017, 11:259]

Cited: 12 times

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Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities.

Ayeman Amanullah, Ribhav Mishra, Arun Upadhyay, Pothula P Reddy, Ranabir Das, Amit Mishra,

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that are mainly used to treat pain, inflammation, and fever via cyclooxygenase-2 (COX-2) inhibition. There are abundant findings that uncover the hidden critical chemotherapeutics potential of NSAIDs in cancer treatment. However, still the precise mechanism by which NSAIDs could be used ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2018, 233(2):1685-1699]

Cited: 3 times

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E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration.

Arun Upadhyay, Vibhuti Joshi, Ayeman Amanullah, Ribhav Mishra, Naina Arora, Amit Prasad, Amit Mishra,

Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging. The cellular protein quality control system develop various defense mechanisms against the accumulation of misfolded and aggregated proteins. The mechanisms underlying the selective recognition of ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2017, 10:151]

Cited: 20 times

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