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Author Artem Fadeev

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Highly Pathogenic Avian Influenza A(H5N8) Virus Clade 2.3.4.4b, Western Siberia, Russia, 2020.

Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov,

Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2224-2227]

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Mucosal Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens Provides Protection against Mycobacterium tuberculosis in Mice and Guinea Pigs.

Mariia Sergeeva, Ekaterina Romanovskaya-Romanko, Natalia Zabolotnyh, Anastasia Pulkina, Kirill Vasilyev, Anna Polina Shurigina, Janna Buzitskaya, Yana Zabrodskaya, Artem Fadeev, Andrey Vasin, Tatiana I Vinogradova, Marina A Stukova,

New strategies providing protection against tuberculosis (TB) are still pending. The airborne nature of Mycobacterium tuberculosis (<i>M.tb)</i> infection assumes that the mucosal delivery of the TB vaccine could be a more promising strategy than the systemic route of immunization. We developed a mucosal TB vaccine candidate based on recombinant attenuated ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(4):]

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Genomic epidemiology of the early stages of the SARS-CoV-2 outbreak in Russia.

Andrey B Komissarov, Ksenia R Safina, Sofya K Garushyants, Artem V Fadeev, Mariia V Sergeeva, Anna A Ivanova, Daria M Danilenko, Dmitry Lioznov, Olga V Shneider, Nikita Shvyrev, Vadim Spirin, Dmitry Glyzin, Vladimir Shchur, Georgii A Bazykin,

The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):649]

Cited: 5 times

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Antigenic and Genetic Characterization of Swine Influenza Viruses Identified in the European Region of Russia, 2014-2020.

Daria M Danilenko, Andrey B Komissarov, Artem V Fadeev, Mikhail I Bakaev, Anna A Ivanova, Polina A Petrova, Anastasia D Vassilieva, Kseniya S Komissarova, Alyona I Zheltukhina, Nadezhda I Konovalova, Andrey V Vasin,

Pigs have long been recognized as "mixing vessels" in which new viruses are formed by reassortment involving various influenza virus lineages (avian, animal, human). However, surveillance of swine influenza viruses only gained real significance after the 2009 pandemic. A fundamentally important point is the fact that there is still no ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:662028]

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Respiratory Syncytial Virus G Protein Sequence Variability among Isolates from St. Petersburg, Russia, during the 2013-2014 Epidemic Season.

Vera Krivitskaya, Kseniya Komissarova, Maria Pisareva, Maria Sverlova, Artem Fadeev, Ekaterina Petrova, Veronika Timonina, Anna Sominina, Daria Danilenko,

Human respiratory syncytial virus (RSV) is the most common cause of upper and lower respiratory tract infections in infants and young children. It is actively evolving under environmental and herd immunity influences. This work presents, for the first time, sequence variability analysis of RSV G gene and G protein using ... Read more >>

Viruses (Viruses)
[2021, 13(1):]

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Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.

Erik Alm, Eeva K Broberg, Thomas Connor, Emma B Hodcroft, Andrey B Komissarov, Sebastian Maurer-Stroh, Angeliki Melidou, Richard A Neher, Áine O'Toole, Dmitriy Pereyaslov, , ,

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(32):]

Cited: 45 times

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Genomic epidemiology of the early stages of SARS-CoV-2 outbreak in Russia

Andrey Komissarov, Ksenia Safina, Sofya Garushyants, Artem Fadeev, Mariia Sergeeva, Anna Ivanova, Daria Danilenko, Dmitry Lioznov, Olga Shneider, Nikita Shvyrev, Vadim Spirin, Dmitry Glyzin, Vladimir Shchur, Georgii Bazykin,

The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has ... Read more >>

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Experimental Infection of Adapted Influenza B Virus in Mice Model

Elena Prokopyeva, Olga Kurskaya, Ivan Sobolev, Mariia Solomatina, Tatyana Murashkina, Anastasia Suvorova, Alexander Alekseev, Daria Danilenko, Andrey Kommissarov, Artem Fadeev, Alexander Shestopalov, Alexander Dygai, Kirill Sharshov,

Over the years influenza B virus (IBV) contribute annual disease and can lead to serious respiratory disease among humans. More attention should be paid to the mammalian adaptive processes of B viruses and development of vaccines against current influenza. Because of preclinical trials of anti-influenza drugs are conducted mainly on ... Read more >>

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Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection.

Irina Baranovskaya, Mariia Sergeeva, Artem Fadeev, Renata Kadirova, Anna Ivanova, Edward Ramsay, Andrey Vasin,

RNA secondary structures play a key role in splicing, gene expression, microRNA biogenesis, RNA editing, and other biological processes. The importance of RNA structures has been demonstrated in the life cycle of RNA-containing viruses, including the influenza virus. At least two regions of conserved secondary structure in NS segment (+) ... Read more >>

Virol J (Virology journal)
[2019, 16(1):162]

Cited: 2 times

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Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats.

Olga V Fedorova, Artem V Fadeev, Yulia N Grigorova, Courtney A Marshall, Valentina Zernetkina, Nikolai I Kolodkin, Natalia I Agalakova, Alexandra O Konradi, Edward G Lakatta, Alexei Y Bagrov,

Endogenous cardiotonic steroid, marinobufagenin (MBG), induces Fli1-dependent tissue fibrosis. We hypothesized that an increase in MBG initiates the development of aortic fibrosis in salt-loaded rats with type 2 diabetes mellitus (DM2) via pressure-independent mechanism. DM2 was induced by a single intraperitoneal administration of 65 mg/kg streptozotocin to neonatal (4-5 days) ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2019, 74(5):436-442]

Cited: 3 times

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Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.

Elena A Prokopyeva, Vsevolod A Zinserling, You-Chan Bae, Yongkuk Kwon, Olga G Kurskaya, Ivan A Sobolev, Peter M Kozhin, Andrey Komissarov, Artem Fadeev, Vladimir Petrov, Alexander M Shestopalov, Kirill A Sharshov,

The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration. We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the ... Read more >>

Interdiscip Perspect Infect Dis (Interdisciplinary perspectives on infectious diseases)
[2019, 2019:4124865]

Cited: 5 times

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Development of a realtime RT-PCR assay for the rapid detection of influenza A(H2) viruses.

Andrey Komissarov, Andrey Komissarov, Artem Fadeev, Anna Kosheleva, Kseniya Sintsova, Mikhail Grudinin,

Influenza and other acute respiratory infections are of great concern for public health, causing excessive morbidity and mortality throughout the world. Influenza virus A(H2N2), which caused a pandemic of so called "Asian flu" in 1957 was expelled from the human population by the new pandemic virus subtype H3N2 in 1968, ... Read more >>

Mol Cell Probes (Molecular and cellular probes)
[2017, 35:57-63]

Cited: 1 time

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Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.

F Xavier López-Labrador, Angels Natividad-Sancho, Maria Pisareva, Andrey Komissarov, Karina Salvatierra, Artem Fadeev, Andrés Moya, Mikhail Grudinin, Javier Díez-Domingo, Olga Afanasieva, Nadezhda Konovalova, Anna Sominina, Joan Puig-Barberà,

<h4>Background</h4>Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control.<h4>Objectives</h4>To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season.<h4>Study design</h4>Comparative phylogenetic analysis of full-length hemagglutinin genes from ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2016, 84:32-38]

Cited: 1 time

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Influenza epidemiology and influenza vaccine effectiveness during the 2014-2015 season: annual report from the Global Influenza Hospital Surveillance Network.

Joan Puig-Barberà, Elena Burtseva, Hongjie Yu, Benjamin J Cowling, Selim Badur, Jan Kyncl, Anna Sominina, ,

The Global Influenza Hospital Surveillance Network (GIHSN) has established a prospective, active surveillance, hospital-based epidemiological study to collect epidemiological and virological data for the Northern and Southern Hemispheres over several consecutive seasons. It focuses exclusively on severe cases of influenza requiring hospitalization. A standard protocol is shared between sites allowing ... Read more >>

BMC Public Health (BMC public health)
[2016, 16 Suppl 1:757]

Cited: 14 times

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Reintroduction of highly pathogenic avian influenza A/H5N8 virus of clade 2.3.4.4. in Russia.

Vasiliy Y Marchenko, Ivan M Susloparov, Andrey B Komissarov, Artem Fadeev, Nataliya I Goncharova, Andrey V Shipovalov, Svetlana V Svyatchenko, Alexander G Durymanov, Tatyana N Ilyicheva, Lyudmila K Salchak, Elena P Svintitskaya, Valeriy N Mikheev, Alexander B Ryzhikov,

In the spring of 2016, a loss of wild birds was observed during the monitoring of avian influenza virus activity in the Republic of Tyva. That outbreak was caused by influenza H5N8 virus of clade 2.3.4.4. In the fall, viruses of H5N8 clade 2.3.4.4 were propagated in European countries. This ... Read more >>

Arch Virol (Archives of virology)
[2017, 162(5):1381-1385]

Cited: 9 times

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Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation).

Andrey Komissarov, Andrey Komissarov, Artem Fadeev, Maria Sergeeva, Sergey Petrov, Kseniya Sintsova, Anna Egorova, Maria Pisareva, Zhanna Buzitskaya, Tamila Musaeva, Daria Danilenko, Nadezhda Konovalova, Polina Petrova, Kirill Stolyarov, Elizaveta Smorodintseva, Elena Burtseva, Kirill Krasnoslobodtsev, Elena Kirillova, Lyudmila Karpova, Mikhail Eropkin, Anna Sominina, Mikhail Grudinin,

A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm09 viruses ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2016, 10(4):247-253]

Cited: 9 times

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Predominance of influenza A(H1N1)pdm09 virus genetic subclade 6B.1 and influenza B/Victoria lineage viruses at the start of the 2015/16 influenza season in Europe.

Eeva Broberg, Angeliki Melidou, Katarina Prosenc, Karoline Bragstad, Olav Hungnes, ,

Influenza A(H1N1)pdm09 viruses predominated in the European influenza 2015/16 season. Most analysed viruses clustered in a new genetic subclade 6B.1, antigenically similar to the northern hemisphere vaccine component A/California/7/2009. The predominant influenza B lineage was Victoria compared with Yamagata in the previous season. It remains to be evaluated at the ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2016, 21(13):]

Cited: 19 times

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In preeclampsia endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteries.

Elena R Nikitina, Anton V Mikhailov, Ekaterina S Nikandrova, Elena V Frolova, Artem V Fadeev, Vera V Shman, Victoria Y Shilova, Natalia I Tapilskaya, Joseph I Shapiro, Olga V Fedorova, Alexei Y Bagrov,

<h4>Background</h4>Marinobufagenin (MBG), a bufadienolide cardiotonic steroid, induces cardiovascular fibrosis. Because levels of MBG in preeclampsia are increased, and anti-MBG monoclonal antibody reduces blood pressure (BP) in a rat model of preeclampsia, we hypothesized that in preeclampsia, elevated MBG levels would be associated with the development of fibrosis in feto-placental circulation ... Read more >>

J Hypertens (Journal of hypertension)
[2011, 29(4):769-776]

Cited: 23 times

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