Emma M Perkins, Karen Burr, Poulomi Banerjee, Arpan R Mehta, Owen Dando, Bhuvaneish T Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M Henstridge, Thomas H Gillingwater, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran, Matthew R Livesey,
<h4>Background</h4>Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72<sup>RE</sup>) mutation - the most common genetic impairment causal to ALS and FTD. Noting that perturbations in cortical function are evidenced pre-symptomatically, ... Read more >>
Mol Neurodegener (Molecular neurodegeneration)
[2021, 16(1):13]
Cited: 0 times
Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):174]
Cited: 0 times
Richard R Ribchester, Arpan R Mehta,
Lancet Neurol (The Lancet. Neurology)
[2021, 20(2):93]
Cited: 0 times
Arpan R Mehta, Jenna M Gregory, Owen Dando, Roderick N Carter, Karen Burr, Jyoti Nanda, David Story, Karina McDade, Colin Smith, Nicholas M Morton, Don J Mahad, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj,
Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, raising the question of whether MN cellular ... Read more >>
Acta Neuropathol (Acta neuropathologica)
[2021, 141(2):257-279]
Cited: 0 times
Javier DeFelipe, Juan A De Carlos, Arpan R Mehta,
Lancet Neurol (The Lancet. Neurology)
[2021, 20(1):25]
Cited: 0 times
Arpan R Mehta, Tamás Szakmany, Annie Sorbie,
J R Soc Med (Journal of the Royal Society of Medicine)
[2021, 114(2):55-59]
Cited: 1 time
Arpan R Mehta, Catherine M Abbott, Siddharthan Chandran, Jane E Haley, The Cajal Embroidery Project,
Lancet Neurol (The Lancet. Neurology)
[2020, 19(12):797-797]
Cited: 0 times
Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,
The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal and ... Read more >>
J Neurol (Journal of neurology)
[2020, :]
Cited: 0 times
Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,
J Neurol (Journal of neurology)
[2020, :]
Cited: 0 times
Emily Beswick, Emily Park, Charis Wong, Arpan R Mehta, Rachel Dakin, Siddharthan Chandran, Judith Newton, Alan Carson, Sharon Abrahams, Suvankar Pal,
<h4>Background</h4>Up to 50% of people with amyotrophic lateral sclerosis (ALS) experience cognitive dysfunction, whilst depression and anxiety are reported in up to 44% and 33%, respectively. These symptoms impact on quality of life, and are associated with a poorer prognosis. Historically, outcomes in clinical trials have focused on the effect of ... Read more >>
J Neurol (Journal of neurology)
[2020, :]
Cited: 0 times
Koy Chong Ng Kee Kwong, Arpan R Mehta, Maiken Nedergaard, Siddharthan Chandran,
Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer's disease. ... Read more >>
Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):140]
Cited: 0 times
Koy Chong Ng Kee Kwong, Jenna M Gregory, Suvankar Pal, Siddharthan Chandran, Arpan R Mehta,
Various studies have suggested that a neurotoxic cerebrospinal fluid profile could be implicated in amyotrophic lateral sclerosis. Here, we systematically review the evidence for cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis and explore its clinical correlates. We searched the following databases with no restrictions on publication date: PubMed, Embase and ... Read more >>
Brain Commun (Brain communications)
[2020, 2(2):fcaa121]
Cited: 0 times
Kiran Jayaprakash, Stella A Glasmacher, Bernard Pang, Emily Beswick, Arpan R Mehta, Rachel Dakin, Judith Newton, Siddharthan Chandran, Suvankar Pal, ,
J Neurol (Journal of neurology)
[2020, 267(8):2459-2461]
Cited: 1 time
Koy Chong Ng Kee Kwong, Puja R Mehta, Garima Shukla, Arpan R Mehta,
Central to COVID-19 pathophysiology is an acute respiratory infection primarily manifesting as pneumonia. Two months into the COVID-19 outbreak, however, a retrospective study in China involving more than 200 participants revealed a neurological component to COVID-19 in a subset of patients. The observed symptoms, the cause of which remains unclear, ... Read more >>
J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 77:13-16]
Cited: 13 times
Arpan R Mehta, Bhuvaneish T Selvaraj, Samantha K Barton, Karina McDade, Sharon Abrahams, Siddharthan Chandran, Colin Smith, Jenna M Gregory,
The <i>C9orf72</i> hexanucleotide repeat expansion is the commonest known genetic mutation in amyotrophic lateral sclerosis. A neuropathological hallmark is the intracellular accumulation of RNA foci. The role that RNA foci play in the pathogenesis of amyotrophic lateral sclerosis is widely debated. Historically, <i>C9orf72</i> RNA foci have been identified using <i>in ... Read more >>
Brain Commun (Brain communications)
[2020, 2(1):fcaa009]
Cited: 2 times
Arpan R Mehta, Puja R Mehta, Stephen P Anderson, Barbara L H MacKinnon, Alastair Compston,
Brain (Brain : a journal of neurology)
[2020, 143(1):374-379]
Cited: 0 times
Chen Zhao, Anna-Claire Devlin, Amit K Chouhan, Bhuvaneish T Selvaraj, Maria Stavrou, Karen Burr, Veronica Brivio, Xin He, Arpan R Mehta, David Story, Christopher E Shaw, Owen Dando, Giles E Hardingham, Gareth B Miles, Siddharthan Chandran,
Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS). Accumulating evidence implicates astrocytes as important non-cell autonomous contributors to ALS pathogenesis, although the potential deleterious effects of astrocytes on the function of motor neurons remains to be determined in a completely humanized model of C9orf72-mediated ... Read more >>
Glia (Glia)
[2020, 68(5):1046-1064]
Cited: 8 times
Arpan R Mehta, Rachel Walters, Fergal M Waldron, Suvankar Pal, Bhuvaneish T Selvaraj, Malcolm R Macleod, Giles E Hardingham, Siddharthan Chandran, Jenna M Gregory,
Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral sclerosis. The aim of this systematic review was to assess the efficacy of targeting mitochondria as a potential therapeutic target in amyotrophic lateral sclerosis. Preclinical studies written in the English language were identified with ... Read more >>
Brain Commun (Brain communications)
[2019, 1(1):fcz009]
Cited: 3 times
David T Wong, Arpan Mehta, Kawal P Singh, Siaw M Leong, Alister Ooi, Ahtsham Niazi, Eric You-Ten, Allan Okrainec, Rajesh Patel, Mandeep Singh, Jean Wong,
<h4>Background</h4>The use of a flexible optical bronchoscopic (FOB) for intubation is an essential airway management skill.<h4>Objective(s)</h4>Our primary objective was to compare the effects of simulator training (ORSIM high-fidelity simulator) with no simulation training on the performance of FOB intubation in anaesthetised patients.<h4>Design</h4>Randomised controlled trial.<h4>Setting</h4>Single-centre tertiary hospital; trial conducted between April ... Read more >>
Eur J Anaesthesiol (European journal of anaesthesiology)
[2019, 36(3):227-233]
Cited: 1 time
Neeraj Arora, Arpan Mehta, Sriram Ravichandran, Indu Arun, Rimpa Basu Achari, Anupam Chakrapani, Saurabh Jayant Bhave, Mammen Chandy, Reena Nair,
Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is a rare type of non-Hodgkin lymphoma that is commonly seen in East Asian countries and is associated with Epstein-Barr virus infection. This is a retrospective study where we describe nine cases of ENKTL; nasal type diagnosed and treated at our center over a ... Read more >>
Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2017, 33(1):69-73]
Cited: 2 times
Arpan R Mehta, Alek Pogosyan, Peter Brown, John-Stuart Brittain,
<h4>Background</h4>Classically, studies adopting non-invasive transcranial electrical stimulation have placed greater importance on the position of the primary "stimulating" electrode than the secondary "reference" electrode. However, recent current density modeling suggests that ascribing a neutral role to the reference electrode may prove an inappropriate oversimplification.<h4>Hypothesis</h4>We set out to test the hypothesis ... Read more >>
Brain Stimul (Brain stimulation)
[2015, 8(2):260-268]
Cited: 22 times
S V Deshpande, S S Bhatwadekar, Parth Desai, Tarang Bhavsar, Ankit Patel, Amey Koranne, Arpan Mehta, Shweta Khadse,
Sickle cell disease (SCD) is common in tribal belt of Gujarat, but not addressed effectively as it should be with effective use of Hydroxyurea, supportive care and counseling. In our single centre study of 70 patients of SCD who were only on Folic acid and Blood transfusion support, were analyzed ... Read more >>
Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2016, 32(2):215-220]
Cited: 4 times
John-Stuart Brittain, Hayriye Cagnan, Arpan R Mehta, Tabish A Saifee, Mark J Edwards, Peter Brown,
Parkinson's disease (PD) and essential tremor (ET) are the two most common movement disorders. Both have been associated with similar patterns of network activation leading to the suggestion that they may result from similar network dysfunction, specifically involving the cerebellum. Here, we demonstrate that parkinsonian tremors and ETs result from ... Read more >>
J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(2):795-806]
Cited: 32 times
Arpan R Mehta, John-Stuart Brittain, Peter Brown,
The influence of central neuronal oscillators on human physiological tremor is controversial. To address this, transcranial alternating current stimulation (TACS) was delivered at peak tremor frequency to 12 healthy volunteers in a 2 × 2 crossover study. Two sites were stimulated [contralateral primary motor cortex (M1), vs ipsilateral cerebellum] while ... Read more >>
J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(22):7501-7508]
Cited: 18 times
David T Wong, Arpan Mehta, Amanda D Tam, Brian Yau, Jean Wong,
<h4>Introduction</h4>The purpose of this survey was to determine the equipment that anesthesiologists prefer in difficult tracheal intubation and "cannot intubate, cannot ventilate" (CICV) situations.<h4>Methods</h4>A questionnaire was e-mailed to members of the Canadian Anesthesiologists' Society to ascertain their preferences, experience, and comfort level with regard to their use of airway equipment ... Read more >>
Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2014, 61(8):717-726]
Cited: 23 times