Full Text Journal Articles by
Author Arpan Mehta

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Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.

Emma M Perkins, Karen Burr, Poulomi Banerjee, Arpan R Mehta, Owen Dando, Bhuvaneish T Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M Henstridge, Thomas H Gillingwater, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran, Matthew R Livesey,

<h4>Background</h4>Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72<sup>RE</sup>) mutation - the most common genetic impairment causal to ALS and FTD. Noting that perturbations in cortical function are evidenced pre-symptomatically, ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2021, 16(1):13]

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Cajal's illustrations inspire reparative acts.

Arpan Mehta,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):174]

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Neuromuscular junctions: mind meeting matter.

Richard R Ribchester, Arpan R Mehta,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(2):93]

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Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Arpan R Mehta, Jenna M Gregory, Owen Dando, Roderick N Carter, Karen Burr, Jyoti Nanda, David Story, Karina McDade, Colin Smith, Nicholas M Morton, Don J Mahad, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj,

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, raising the question of whether MN cellular ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2021, 141(2):257-279]

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A museum for Cajal's Legacy.

Javier DeFelipe, Juan A De Carlos, Arpan R Mehta,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(1):25]

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The medicolegal landscape through the lens of COVID-19: time for reform.

Arpan R Mehta, Tamás Szakmany, Annie Sorbie,

J R Soc Med (Journal of the Royal Society of Medicine)
[2021, 114(2):55-59]

Cited: 1 time

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The Cajal Embroidery Project: celebrating neuroscience

Arpan R Mehta, Catherine M Abbott, Siddharthan Chandran, Jane E Haley, The Cajal Embroidery Project,

Lancet Neurol (The Lancet. Neurology)
[2020, 19(12):797-797]

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Correction to: The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland.

Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,

The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal and ... Read more >>

J Neurol (Journal of neurology)
[2020, :]

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The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland.

Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,

J Neurol (Journal of neurology)
[2020, :]

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A systematic review of neuropsychiatric and cognitive assessments used in clinical trials for amyotrophic lateral sclerosis.

Emily Beswick, Emily Park, Charis Wong, Arpan R Mehta, Rachel Dakin, Siddharthan Chandran, Judith Newton, Alan Carson, Sharon Abrahams, Suvankar Pal,

<h4>Background</h4>Up to 50% of people with amyotrophic lateral sclerosis (ALS) experience cognitive dysfunction, whilst depression and anxiety are reported in up to 44% and 33%, respectively. These symptoms impact on quality of life, and are associated with a poorer prognosis. Historically, outcomes in clinical trials have focused on the effect of ... Read more >>

J Neurol (Journal of neurology)
[2020, :]

Cited: 0 times

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Defining novel functions for cerebrospinal fluid in ALS pathophysiology.

Koy Chong Ng Kee Kwong, Arpan R Mehta, Maiken Nedergaard, Siddharthan Chandran,

Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which has recently been recognised as a major clearance pathway for the brain, has received considerable attention in several neurological conditions, particularly Alzheimer's disease. ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):140]

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Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies.

Koy Chong Ng Kee Kwong, Jenna M Gregory, Suvankar Pal, Siddharthan Chandran, Arpan R Mehta,

Various studies have suggested that a neurotoxic cerebrospinal fluid profile could be implicated in amyotrophic lateral sclerosis. Here, we systematically review the evidence for cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis and explore its clinical correlates. We searched the following databases with no restrictions on publication date: PubMed, Embase and ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa121]

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Riluzole prescribing, uptake and treatment discontinuation in people with amyotrophic lateral sclerosis in Scotland.

Kiran Jayaprakash, Stella A Glasmacher, Bernard Pang, Emily Beswick, Arpan R Mehta, Rachel Dakin, Judith Newton, Siddharthan Chandran, Suvankar Pal, ,

J Neurol (Journal of neurology)
[2020, 267(8):2459-2461]

Cited: 1 time

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COVID-19, SARS and MERS: A neurological perspective.

Koy Chong Ng Kee Kwong, Puja R Mehta, Garima Shukla, Arpan R Mehta,

Central to COVID-19 pathophysiology is an acute respiratory infection primarily manifesting as pneumonia. Two months into the COVID-19 outbreak, however, a retrospective study in China involving more than 200 participants revealed a neurological component to COVID-19 in a subset of patients. The observed symptoms, the cause of which remains unclear, ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 77:13-16]

Cited: 13 times

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Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction.

Arpan R Mehta, Bhuvaneish T Selvaraj, Samantha K Barton, Karina McDade, Sharon Abrahams, Siddharthan Chandran, Colin Smith, Jenna M Gregory,

The <i>C9orf72</i> hexanucleotide repeat expansion is the commonest known genetic mutation in amyotrophic lateral sclerosis. A neuropathological hallmark is the intracellular accumulation of RNA foci. The role that RNA foci play in the pathogenesis of amyotrophic lateral sclerosis is widely debated. Historically, <i>C9orf72</i> RNA foci have been identified using <i>in ... Read more >>

Brain Commun (Brain communications)
[2020, 2(1):fcaa009]

Cited: 2 times

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Grey Matter Etymology and the neuron(e).

Arpan R Mehta, Puja R Mehta, Stephen P Anderson, Barbara L H MacKinnon, Alastair Compston,

Brain (Brain : a journal of neurology)
[2020, 143(1):374-379]

Cited: 0 times

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Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.

Chen Zhao, Anna-Claire Devlin, Amit K Chouhan, Bhuvaneish T Selvaraj, Maria Stavrou, Karen Burr, Veronica Brivio, Xin He, Arpan R Mehta, David Story, Christopher E Shaw, Owen Dando, Giles E Hardingham, Gareth B Miles, Siddharthan Chandran,

Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS). Accumulating evidence implicates astrocytes as important non-cell autonomous contributors to ALS pathogenesis, although the potential deleterious effects of astrocytes on the function of motor neurons remains to be determined in a completely humanized model of C9orf72-mediated ... Read more >>

Glia (Glia)
[2020, 68(5):1046-1064]

Cited: 8 times

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Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Arpan R Mehta, Rachel Walters, Fergal M Waldron, Suvankar Pal, Bhuvaneish T Selvaraj, Malcolm R Macleod, Giles E Hardingham, Siddharthan Chandran, Jenna M Gregory,

Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral sclerosis. The aim of this systematic review was to assess the efficacy of targeting mitochondria as a potential therapeutic target in amyotrophic lateral sclerosis. Preclinical studies written in the English language were identified with ... Read more >>

Brain Commun (Brain communications)
[2019, 1(1):fcz009]

Cited: 3 times

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The effect of virtual reality bronchoscopy simulator training on performance of bronchoscopic-guided intubation in patients: A randomised controlled trial.

David T Wong, Arpan Mehta, Kawal P Singh, Siaw M Leong, Alister Ooi, Ahtsham Niazi, Eric You-Ten, Allan Okrainec, Rajesh Patel, Mandeep Singh, Jean Wong,

<h4>Background</h4>The use of a flexible optical bronchoscopic (FOB) for intubation is an essential airway management skill.<h4>Objective(s)</h4>Our primary objective was to compare the effects of simulator training (ORSIM high-fidelity simulator) with no simulation training on the performance of FOB intubation in anaesthetised patients.<h4>Design</h4>Randomised controlled trial.<h4>Setting</h4>Single-centre tertiary hospital; trial conducted between April ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2019, 36(3):227-233]

Cited: 1 time

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NK/T Cell Lymphoma: A Tertiary Centre Experience.

Neeraj Arora, Arpan Mehta, Sriram Ravichandran, Indu Arun, Rimpa Basu Achari, Anupam Chakrapani, Saurabh Jayant Bhave, Mammen Chandy, Reena Nair,

Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is a rare type of non-Hodgkin lymphoma that is commonly seen in East Asian countries and is associated with Epstein-Barr virus infection. This is a retrospective study where we describe nine cases of ENKTL; nasal type diagnosed and treated at our center over a ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2017, 33(1):69-73]

Cited: 2 times

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Montage matters: the influence of transcranial alternating current stimulation on human physiological tremor.

Arpan R Mehta, Alek Pogosyan, Peter Brown, John-Stuart Brittain,

<h4>Background</h4>Classically, studies adopting non-invasive transcranial electrical stimulation have placed greater importance on the position of the primary "stimulating" electrode than the secondary "reference" electrode. However, recent current density modeling suggests that ascribing a neutral role to the reference electrode may prove an inappropriate oversimplification.<h4>Hypothesis</h4>We set out to test the hypothesis ... Read more >>

Brain Stimul (Brain stimulation)
[2015, 8(2):260-268]

Cited: 22 times

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Hydroxyurea in Sickle Cell Disease: Our Experience in Western India.

S V Deshpande, S S Bhatwadekar, Parth Desai, Tarang Bhavsar, Ankit Patel, Amey Koranne, Arpan Mehta, Shweta Khadse,

Sickle cell disease (SCD) is common in tribal belt of Gujarat, but not addressed effectively as it should be with effective use of Hydroxyurea, supportive care and counseling. In our single centre study of 70 patients of SCD who were only on Folic acid and Blood transfusion support, were analyzed ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2016, 32(2):215-220]

Cited: 4 times

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Distinguishing the central drive to tremor in Parkinson's disease and essential tremor.

John-Stuart Brittain, Hayriye Cagnan, Arpan R Mehta, Tabish A Saifee, Mark J Edwards, Peter Brown,

Parkinson's disease (PD) and essential tremor (ET) are the two most common movement disorders. Both have been associated with similar patterns of network activation leading to the suggestion that they may result from similar network dysfunction, specifically involving the cerebellum. Here, we demonstrate that parkinsonian tremors and ETs result from ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(2):795-806]

Cited: 32 times

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The selective influence of rhythmic cortical versus cerebellar transcranial stimulation on human physiological tremor.

Arpan R Mehta, John-Stuart Brittain, Peter Brown,

The influence of central neuronal oscillators on human physiological tremor is controversial. To address this, transcranial alternating current stimulation (TACS) was delivered at peak tremor frequency to 12 healthy volunteers in a 2 × 2 crossover study. Two sites were stimulated [contralateral primary motor cortex (M1), vs ipsilateral cerebellum] while ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(22):7501-7508]

Cited: 18 times

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A survey of Canadian anesthesiologists' preferences in difficult intubation and "cannot intubate, cannot ventilate" situations.

David T Wong, Arpan Mehta, Amanda D Tam, Brian Yau, Jean Wong,

<h4>Introduction</h4>The purpose of this survey was to determine the equipment that anesthesiologists prefer in difficult tracheal intubation and "cannot intubate, cannot ventilate" (CICV) situations.<h4>Methods</h4>A questionnaire was e-mailed to members of the Canadian Anesthesiologists' Society to ascertain their preferences, experience, and comfort level with regard to their use of airway equipment ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2014, 61(8):717-726]

Cited: 23 times

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