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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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[From an enterovesical fistula to mammary carcinoma].

Evi Comploj, Esther Hanspeter, Matteo Bonatti, Salvatore Palermo, Giovanni Mazzucato, Armin Pycha, Emanuela Trenti,

We report a case of a 83-year-old woman with the initial diagnosis of an occult invasive lobular breast carcinoma due to gastrointestinal metastasis with an entervesical fistula. ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2021, :]

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Diagnostic value of Xpert® Bladder Cancer Monitor in the follow-up of patients affected by non-muscle invasive bladder cancer: an update.

Carolina D'Elia, Decio M Folchini, Christine Mian, Esther Hanspeter, Christine Schwienbacher, Giorgio Alfredo Spedicato, Stefan Pycha, Egils Vjaters, Stephan Degener, Mona Kafka, Armin Pycha, Emanuela Trenti,

<h4>Aims</h4>Xpert<sup>®</sup> Bladder Cancer Monitor is a urinary marker based on the evaluation of five target mRNAs overexpressed in patients with bladder cancer (BC). The aim of our study is to update our results regarding the diagnostic accuracy of the Xpert<sup>®</sup> Bladder Cancer Monitor test in the follow-up of patients with ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2021, 13:1756287221997183]

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Transarterial Embolization in the Management of Intractable Haemorrhage.

Evi Comploj, Alexander Pycha, Emanuela Trenti, Salvatore Palermo, Matteo Bonatti, Philipp Krause, Decio Maria Folchini, Armin Pycha,

<h4>Introduction</h4>The purpose of this study was to evaluate the effectiveness and long-term results of selective transarterial iliac embolization (STIE) in patients with intractable bladder haemorrhage (IBH).<h4>Methods</h4>Twenty-five patients with a median age of 84 (range 65-94) years underwent STIE because of IBH between 2002 and 2020. The median follow-up time was ... Read more >>

Urol Int (Urologia internationalis)
[2021, 105(1-2):95-99]

Cited: 1 time

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How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study.

Mauro Gacci, Walter Artibani, Pierfrancesco Bassi, Filippo Bertoni, Sergio Bracarda, Alberto Briganti, Giorgio Carmignani, Luca Carmignani, Giario Conti, Renzo Corvò, Cosimo De Nunzio, Ferdinando Fusco, Pierpaolo Graziotti, Isabella Greco, Stefania Maggi, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giuseppe Morgia, Giovanni Muto, Marianna Noale, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Elvio Russi, Giorgio Russo, Andrea Salonia, Alchiede Simonato, Sergio Serni, Davide Tomasini, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, ,

<h4>Purpose</h4>Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy.<h4>Methods</h4>The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1445-1452]

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[Bladder hernia: report of a case series and review of the literature].

Emanuela Trenti, Salvatore Palermo, Dorjan Huqi, Christian Ladurner, Philipp Krause, Armin Pycha, Evi Comploj,

Aktuelle Urol (Aktuelle Urologie)
[2021, 52(1):e3]

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The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group.

Philipp Gild, Malte W Vetterlein, Roland Seiler, Andrea Necchi, Kees Hendricksen, Laura S Mertens, Florian Roghmann, Nicolas V Landenberg, Paolo Gontero, Marcus Cumberbatch, Jakub Dobruch, Thomas Seisen, Pietro Grande, David D'Andrea, Julien Anract, Evi Comploj, Armin Pycha, Karim Saba, Cedric Poyet, Bas W van Rhijn, Aidan P Noon, Morgan Roupret, Shahrokh F Shariat, Margit Fisch, Evanguelos Xylinas, Michael Rink,

<h4>Objective</h4>To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials & methods</h4>We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 34:312-317]

Cited: 1 time

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[Bladder hernia: report of a case series and review of the literature].

Emanuela Trenti, Salvatore Palermo, Dorjan Huqi, Christian Ladurner, Philipp Krause, Armin Pycha, Evi Comploj,

Inguinal bladder hernia accounts for only 1 - 4 % of all inguinal hernias. It may be difficult to diagnose due to the atypical symptoms. In most cases, the diagnosis is only made intraoperatively. However, a preoperative diagnosis is important to avoid possible iatrogenic complications. We report a case series of five patients ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2021, 52(1):76-81]

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[Sigmoid colon conduit volvulus: an extremely rare complication of a sigmoid colon conduit].

Emanuela Trenti, Salvatore Palermo, Armin Pycha, Evi Comploj,

We report the case of an 84-year-old man with the rare diagnosis of a volvulus of an incontinent sigmoid colon urinary conduit after radical cystoprostatectomy due to urinary bladder cancer. To the best of our knowledge, this is the first case in literature of a volvulus of a sigmoid colon ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2020, :]

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Comparison of 2 new real-time polymerase chain reaction-based urinary markers in the follow-up of patients with non-muscle-invasive bladder cancer.

Emanuela Trenti, Stefan Pycha, Christine Mian, Christine Schwienbacher, Esther Hanspeter, Mona Kafka, Giorgio Alfredo Spedicato, Egils Vjaters, Stephan Degener, Armin Pycha, Carolina D'Elia,

BACKGROUND:The objective of the current study was to compare the diagnostic accuracy of 2 new real-time polymerase chain reaction-based urinary markers with each other and with urinary cytology, cystoscopy, and/or histology in patients being followed for non-muscle-invasive bladder cancer. METHODS:A total of 487 patients were enrolled in the study. Patients ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2020, 128(5):341-347]

Cited: 7 times

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Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study).

Alessandro Antonelli, Carlotta Palumbo, Marianna Noale, Walter Artibani, Pierfrancesco Bassi, Filippo Bertoni, Sergio Bracarda, Alessio Bruni, Renzo Corvò, Mauro Gacci, Stefano M Magrini, Rodolfo Montironi, Angelo Porreca, Andrea Tubaro, Vittorina Zagonel, Stefania Maggi, ,

<h4>Background</h4>We assessed patients and tumor characteristics, as well as health-related quality of life (HRQoL) items, associated with curative intent treatment decision-making in clinically localized prostate cancer (PCa) patients.<h4>Methods</h4>Clinically localized PCa treated with either radical prostatectomy (RP) or radiation therapy (RT) within 12 months from diagnosis were abstracted from The PROState ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, 72(5):595-604]

Cited: 3 times

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[Knowledge of German-speaking urologists regarding the association between penile cancer and human papilloma virus: results of a survey of the European PROspective Penile Cancer Study (E-PROPS)].

Steffen Lebentrau, Ingmar Wolff, Marie Christine Hempel, Marlene Haccius, Luis A Kluth, Armin Pycha, Sabine Brookman-May, Till Rasmus Schneider, Thomas Hermanns, Florian A Distler, Martin Boegemann, Hubert Kübler, Shahrokh F Shariat, Maximilian Burger, Matthias May,

<h4>Background</h4> A recent meta-analysis showed that penile cancer (PeC) is associated with the human papilloma virus (HPV) in 50 % of patients in Europe. It is unknown whether urologists are aware of the impact of viral carcinogenesis.<h4>Methods</h4> A (German-language) survey comprising 14 items was created and sent to urologists of 45 clinical centres ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, :]

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Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Vera Genitsch, Attila Kollár, Gillian Vandekerkhove, Jennifer Blarer, Marc Furrer, Matti Annala, Cameron Herberts, Armin Pycha, Joep J de Jong, Yang Liu, Friedemann Krentel, Elai Davicioni, Ewan A Gibb, Marianna Kruithof-de Julio, Alexander W Wyatt, Roland Seiler,

INTRODUCTION:The sarcomatoid morphology of muscle-invasive bladder cancer (MIBC) is associated with unfavorable prognosis. However, the genomic, transcriptomic, and proteomic relationship between conventional urothelial and synchronous sarcomatoid morphology is poorly defined. METHODS:We compiled a cohort of 21 MIBC patients with components of conventional urothelial and adjacent sarcomatoid morphology within the same ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(11):826-836]

Cited: 2 times

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Efficacy and Safety of Two Fosfomycin Regimens as Antimicrobial Prophylaxis for Transrectal Prostate Biopsy: A Randomised Study.

Carolina D'Elia, Christine Mian, Esther Hanspeter, Christian Ladurner, Salvatore Mario Palermo, Stefan Pycha, Omar Saleh, Tommaso Cai, Greta Spoladore, Mona Kafka, Armin Pycha, Emanuela Trenti,

PURPOSE:Prostate biopsy is the gold standard for prostate cancer diagnosis; unfortunately, this procedure is not free from complications. Recent studies have shown an increase in antibiotic resistance. The aim of our prospective randomized study was to evaluate the efficacy and safety of a prostate biopsy prophylaxis protocol using 2 vs. ... Read more >>

Urol Int (Urologia internationalis)
[2019, 103(4):433-438]

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Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Vera Genitsch, Attila Kollár, Gillian Vandekerkhove, Jennifer Blarer, Marc Furrer, Matti Annala, Cameron Herberts, Armin Pycha, Joep J de Jong, Yang Liu, Friedemann Krentel, Elai Davicioni, Ewan A Gibb, Marianna Kruithof-de Julio, Alexander W Wyatt, Roland Seiler,

<h4>Introduction</h4>The sarcomatoid morphology of muscle-invasive bladder cancer (MIBC) is associated with unfavorable prognosis. However, the genomic, transcriptomic, and proteomic relationship between conventional urothelial and synchronous sarcomatoid morphology is poorly defined.<h4>Methods</h4>We compiled a cohort of 21 MIBC patients with components of conventional urothelial and adjacent sarcomatoid morphology within the same tumor ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(9):573.e19-573.e29]

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Elderly patients undergoing cystectomy, comparing preoperative American Society of Anesthesiology and Eastern Cooperative Oncology Group scores and operative approaches.

Christopher Martin, Jeremy M West, Salvatore Palermo, Darshan P Patel, Angela P Presson, Evi Comploj, Armin Pycha, Joel B Hancock, Christopher B Dechet, Emanuela Trenti,

<h4>Objective</h4>To evaluate preoperative scoring systems and operative management and their relation to complications in patients older than 75 years undergoing cystectomy at two academic institutions.<h4>Methods</h4>In total, 212 patients aged 75-95 years with muscle invasive bladder cancer underwent cystectomy at the University of Utah and Central Hospital of Bolzano, Italy. The ... Read more >>

Urologia (Urologia)
[2019, 86(4):183-188]

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Diagnostic predictive value of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer.

Emanuela Trenti, Carolina D'Elia, Christine Mian, Christine Schwienbacher, Esther Hanspeter, Alexander Pycha, Mona Kafka, Stephan Degener, Hansjörg Danuser, Stephan Roth, Armin Pycha,

<h4>Background</h4>The objective of this study was to evaluate the diagnostic accuracy of the Bladder EpiCheck test in the follow-up of patients with non-muscle-invasive bladder cancer (NMIBC) and to compare it with the accuracy of urinary cytology, cystoscopy, and/or histology.<h4>Methods</h4>In total, 243 patients were enrolled in the current study. Patients were ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2019, 127(7):465-469]

Cited: 6 times

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[Urethral sarcoma 14 years after brachytherapy of the prostate gland].

Evi Comploj, Esther Hanspeter, Emanuela Trenti, Salvatore Palermo, Armin Pycha,

We report a case of an 83-year-old male patient with the rare diagnosis of a urethral sarcoma. ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, 50(3):298-300]

Cited: 0 times

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[Penile metastasis of a carcinoma of the salivary glands at the tongue base: a case report].

Tamara Tischler, Emanuela Trenti, Maria Basciu, Esther Hanspeter, Armin Pycha, Mona Kafka, Evi Comploj,

We report the case of a 64-year-old man, initially diagnosed with a polymorphous adenocarcinoma of the small salivary glands at the tongue base, with occurrence of a penile metastasis ten years after diagnosis. To our knowledge, only two such cases have been described in the literature to date. ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, :]

Cited: 0 times

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Use and duration of antibiotic prophylaxis and the rate of urinary tract infection after radical cystectomy for bladder cancer: Results of a multicentric series.

Maximilian Haider, Christian Ladurner, Roman Mayr, Zafer Tandogdu, Hans-Martin Fritsche, Vincent Fradet, Evi Comploj, Armin Pycha, Francis Lemire, Louis Lacombe, Yves Fradet, Paul Toren, Michele Lodde,

<h4>Objectives</h4>To assess the rate of urinary tract infection (UTI), the characteristics of the bacterial aetiological agents involved, the type and duration of antibiotics used, and the clinical risk factors of UTI in a multi-institutional cohort of patients who had undergone radical cystectomy (RC).<h4>Patients and methods</h4>The pre- and postoperative characteristics of ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(5):300.e9-300.e15]

Cited: 4 times

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Diagnostic predictive value of Xpert Bladder Cancer Monitor in the follow-up of patients affected by non-muscle invasive bladder cancer.

Carolina D Elia, Alexander Pycha, Decio M Folchini, Christine Mian, Esther Hanspeter, Christine Schwienbacher, Egils Vjaters, Armin Pycha, Emanuela Trenti,

<h4>Aims</h4>Cystoscopy and urine cytology represent the gold standard for monitoring superficial bladder cancer (BC). Xpert BC Monitor is a new urinary marker based on the evaluation of five target mRNAs overexpressed in patients with bladder cancer. The aim of our study was to evaluate the diagnostic accuracy of Xpert BC ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2019, 72(2):140-144]

Cited: 7 times

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Urachal carcinoma: from gross specimen to morphologic, immunohistochemical, and molecular analysis.

Giulio Riva, Christine Mian, Claudio Luchini, Ilaria Girolami, Claudio Ghimenton, Luca Cima, Luca Novelli, Esther Hanspeter, Guido Mazzoleni, Christine Schwienbacher, Stefan Pycha, Carolina D'Elia, Emanuela Trenti, Armin Pycha, Guido Martignoni, Ondrej Hes, Albino Eccher, Gabriella Nesi, Matteo Brunelli,

Urachal carcinoma (UrC) is an exceedingly rare neoplasm that develops from the urachus, an embryologic remnant of the urogenital sinus and allantois. The most commonly encountered histologic subtype is adenocarcinoma. The aim of this study is to characterize a series of UrC by morphology, immunohistochemistry, and molecular analysis. We retrospectively ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2019, 474(1):13-20]

Cited: 4 times

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Malignant mesothelioma of tunica vaginalis testis: Report of a very rare case with review of the literature.

Emanuela Trenti, Salvatore Mario Palermo, Carolina D'Elia, Evi Comploj, Alexander Pycha, Rodolfo Carella, Armin Pycha,

<h4>Introduction</h4>Mesothelioma of the tunica vaginalis testis is a extremely rare tumor and represents 0.3 to 0.5% of all malignant mesotheliomas. Exposure to asbestos often precedes illness. Because of its low incidence and nonspecific clinical presentation, it is mostly diagnosed accidentally during surgery for other reasons and the prognosis is usually ... Read more >>

Arch Ital Urol Androl (Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica)
[2018, 90(3):212-214]

Cited: 3 times

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Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study.

Angelo Porreca, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi, ,

<h4>Background</h4>The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2018, 16(1):122]

Cited: 10 times

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