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Author Armando Stabile

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Multiparametric MRI of the prostate underestimates tumor volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at mpMRI (MRIvol) and at radical prostatectomy (RPvol), stratifying it according to PI-RADS score.<h4>Materials and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS≥3) who underwent systematic plus targeted biopsy and subsequent RP at ... Read more >>

BJU Int (BJU international)
[2021, :]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Metastatic hormone-sensitive prostate cancer: local treatment strategies.

Francesco Montorsi, Alberto Martini, Giorgio Gandaglia, Nicola Fossati, Armando Stabile, Federico Dehò, Andrea Salonia, Alberto Briganti,

World J Urol (World journal of urology)
[2021, :]

Cited: 1 time

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Available evidence on HIFU for focal treatment of prostate cancer: a systematic review.

Arnas Bakavicius, Giancarlo Marra, Petr Macek, Cary Robertson, Andre L Abreu, Arvin K George, Bernard Malavaud, Patrick Coloby, Pascal Rischmann, Marco Moschini, Ardeshir R Rastinehad, Abhinav Sidana, Armando Stabile, Rafael Tourinho-Barbosa, Jean de la Rosette, Hashim Ahmed, Thomas Polascik, Xavier Cathelineau, Rafael Sanchez-Salas,

<h4>Purpose</h4>Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47:]

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Association Between Lesion Location and Oncological Outcomes after Focal Therapy for Localized Prostate Cancer Using Either High Intensity Focused Ultrasound or Cryotherapy.

Armando Stabile, Rafael Sanchez-Salas, Rafael Tourinho-Barbosa, Petr Macek, Francesco Pellegrino, Giorgio Gandaglia, Marco Moschini, Nathalie Cathala, Annick Mombet, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau,

<h4>Purpose</h4>To assess whether PCa location might affect oncological outcomes after focal therapy (FT) for prostate cancer (PCa).<h4>Materials and methods</h4>We identified 274 men receiving FT for prostate cancer (PCa) using either HIFU or cryotherapy at a high volume centre between 2009 to 2018. Survival analyses using Kaplan Meier method were used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001787]

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Reducing the Risk of Postoperative Complications After Robot-assisted Radical Prostatectomy in Prostate Cancer Patients: Results of an Audit and Feedback Intervention Following the Implementation of Prospective Data Collection.

Giuseppe Rosiello, Giorgio Gandaglia, Simone Scuderi, Francesco Barletta, Nicola Fossati, Armando Stabile, Andrea Gallina, Elio Mazzone, Luca Maria Vitale, Antony Pellegrino, Carlo Bravi, Alberto Martini, Vito Cucchiara, Pierre I Karakiewicz, Alexandre Mottrie, Alberto Briganti, Francesco Montorsi,

<h4>Background</h4>Prospective data collection for perioperative outcomes might increase awareness of surgical results obtained for patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). This would prompt the implementation of measures aimed at reducing the risk of adverse outcomes.<h4>Objective</h4>To assess the efficacy of an audit and feedback process aimed at ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Age and gleason score upgrading between prostate biopsy and radical prostatectomy: Is this still true in the multiparametric resonance imaging era?

Elio Mazzone, Armando Stabile, Gabriele Sorce, Francesco Pellegrino, Francesco Barletta, Giovanni Motterle, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Giorgio Brembilla, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Introduction</h4>Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still unknown. We hypothesized that the introduction of multiparametric magnetic resonance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Letter - Can micro-ultrasound be the new first-choice test for patients with a suspicion of prostate cancer? RE: Comparison of micro-ultrasound and multiparametric magnetic resonance imaging for prostate cancer, CUAJ, Jan 2021 (with author reply).

Francesco Montorsi, Armando Stabile, Giorgio Gandaglia, Federico Deho, Andrea Gallina, Alberto Briganti,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(2):E127-E128]

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Positive Predictive Value of Prostate Imaging Reporting and Data System Version 2 for the Detection of Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis.

Elio Mazzone, Armando Stabile, Francesco Pellegrino, Giuseppe Basile, Daniele Cignoli, Giuseppe Ottone Cirulli, Gabriele Sorce, Francesco Barletta, Simone Scuderi, Carlo Andrea Bravi, Vito Cucchiara, Nicola Fossati, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti,

<h4>Context</h4>The variability of the positive predictive value (PPV) represents a significant factor affecting the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI).<h4>Objective</h4>To analyze published studies reporting mpMRI PPV and the reasons behind the variability of clinically significant prostate cancer (csPCa) detection rates on targeted biopsies (TBx) according to Prostate Imaging ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

Cited: 1 time

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RE: Retzius Sparing Prostatectomy Effect on Symptomatic Lymphocele Rates.

Francesco Montorsi, Giorgio Gandaglia, Armando Stabile,

Urology (Urology)
[2021, 152:205]

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Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society.

Giancarlo Marra, Maria Pilar Laguna, Jochen Walz, Christian P Pavlovich, Fernando Bianco, Justin Gregg, Amir H Lebastchi, Herbert Lepor, Petr Macek, Soroush Rais-Bahrami, Cary Robertson, Daniel Rukstalis, Georg Salomon, Osamu Ukimura, Andre L Abreu, Yann Barbe, Xavier Cathelineau, Giorgio Gandaglia, Arvin K George, Juan Gomez Rivas, Rajan T Gupta, Nathan Lawrentschuk, Veeru Kasivisvanathan, Derek Lomas, Bernard Malavaud, Daniel Margolis, Yoh Matsuoka, Sherif Mehralivand, Marco Moschini, Marco Oderda, Hazem Orabi, Ardeshir R Rastinehad, Mesut Remzi, Ariel Schulman, Toshitaka Shin, Takumi Shiraishi, Abhinav Sidana, Sunao Shoji, Armando Stabile, Massimo Valerio, Varaha S Tammisetti, Wei Phin Tan, Willemien Van Den Bos, Arnaud Villers, Peter-Paul Willemse, Jean de la Rosette, Thomas Polascik, Rafael Sanchez-Salas, ,

<h4>Background</h4>Focal Therapy (FT) for Prostate Cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men undergoing FT, though there is limited evidence in this field to guide practice. We ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Association Between Multiparametric Magnetic Resonance Imaging of the Prostate and Oncological Outcomes after Primary Treatment for Prostate Cancer: A Systematic Review and Meta-analysis.

Armando Stabile, Elio Mazzone, Giuseppe O Cirulli, Francesco De Cobelli, Jeremy Grummet, Harriet C Thoeny, Mark Emberton, Morgan Pokorny, Peter A Pinto, Samir S Taneja,

<h4>Context</h4>The diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) for prostate cancer (PCa) diagnosis has been extensively explored. Little is known about the prognostic value of mpMRI suspicion scores and other quantitative mpMRI information.<h4>Objective</h4>To systematically review the current literature assessing the relationship between pretreatment mpMRI and oncological outcomes after primary ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

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Prediction of the Need for an Extended Lymphadenectomy at the Time of Radical Cystectomy in Patients with Bladder Cancer.

Marco Moschini, Luca Afferi, Giorgio Gandaglia, David D'Andrea, Stefania Zamboni, Carlo Di Bona, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Alberto Martini, Giusy Burgio, Shahrokh F Shariat, Rafael Sanchez-Salas, Xavier Cathelineau, Armando Stabile, Emanuele Zaffuto, Andrea Salonia, Renzo Colombo, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Andrea Gallina,

<h4>Background</h4>A prospective randomized trial (LEA AUO AB 25/02) found no survival benefit in extended compared with limited pelvic lymph node dissection (PLND) templates in bladder cancer (BCa) patients treated with radical cystectomy (RC). However, the rate of lymph node invasion (LNI) in the standard and extended templates was lower than ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Comparing Perioperative Complications Between Laparoscopic and Robotic Radical Cystectomy for Bladder Cancer.

Amandeep Arora, Felipe Pugliesi, Ahmed S Zugail, Marco Moschini, Cristiano Pazeto, Petr Macek, Armando Stabile, Camille Lanz, Annick Mombet, Mostefa Bennamoun, Rafael Sanchez-Salas, Xavier Cathelineau,

<b><i>Background:</i></b> Minimally invasive cystectomy is being increasingly performed, however, data comparing laparoscopic radical cystectomy (LRC) and robotic radical cystectomy (RRC) are scarce. We compared 30- and 90-day Clavien-Dindo Classification (CDC) complications between patients undergoing LRC and RRC at our center. <b><i>Materials and Methods:</i></b> We retrospectively evaluated 300 patients who underwent ... Read more >>

J Endourol (Journal of endourology)
[2020, 34(10):1033-1040]

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Natural history of prostate cancer on active surveillance: stratification by MRI using the PRECISE recommendations in a UK cohort.

Francesco Giganti, Armando Stabile, Vasilis Stavrinides, Elizabeth Osinibi, Adam Retter, Clément Orczyk, Valeria Panebianco, Bruce J Trock, Alex Freeman, Aiman Haider, Shonit Punwani, Clare Allen, Alex Kirkham, Mark Emberton, Caroline M Moore,

<h4>Objectives</h4>The PRECISE recommendations for magnetic resonance imaging (MRI) in patients on active surveillance (AS) for prostate cancer (PCa) include repeated measurement of each lesion, and attribution of a PRECISE radiological progression score for the likelihood of clinically significant change over time. We aimed to compare the PRECISE score with clinical ... Read more >>

Eur Radiol (European radiology)
[2021, 31(3):1644-1655]

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Does mpMRI guidance improve HIFU partial gland ablation compared to conventional ultrasound guidance? Early functional outcomes and complications from a single center.

Arjun Sivaraman, Giancarlo Marra, Armando Stabile, Annick Mombet, Petr Macek, Camille Lanz, Nathalie Cathala, Marco Moschini, Arie Carneiro, Rafael Sanchez-Salas, Xavier Cathelineau,

<h4>Background</h4>Focal therapy (FT) for localized prostate cancer (PCa) treatment is raising interest. New technological mpMRI-US guided FT devices have never been compared with the previous generation of ultrasound-only guided devices.<h4>Materials and methods</h4>We retrospectively analyzed prospectively recorded data of men undergoing FT for localized low- or intermediate-risk PCa with US- (Ablatherm®-2009 ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2020, 46(6):984-992]

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Higher nodal yield with robot-assisted pelvic lymph node dissection for bladder cancer compared to laparoscopic dissection: implications for more accurate staging.

Amandeep Arora, Felipe Pugliesi, Ahmed S Zugail, Marco Moschini, Cristiano Pazeto, Petr Macek, Armando Stabile, Camille Lanz, Nathalie Cathala, Mostefa Bennamoun, Rafael Sanchez-Salas, Xavier Cathelineau,

<h4>Objectives</h4>To compare the lymph node (LN) yield and adequacy of laparoscopic pelvic lymph node dissection (L-PLND) and robot-assisted PLND (R-PLND), as PLND is a fundamental component of radical cystectomy (RC) for bladder cancer (BCa), where a positive status is the most powerful predictor of disease recurrence and survival.<h4>Patents and methods</h4>We ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):92-97]

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Prognostic Implications of Multiparametric Magnetic Resonance Imaging and Concomitant Systematic Biopsy in Predicting Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer Patients Diagnosed with Magnetic Resonance Imaging-targeted Biopsy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Giancarlo Marra, Marco Moschini, Alberto Martini, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Luca Afferi, Arnas Rakauskas, Paolo Gontero, Agostino Mattei, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The prognostic role of multiparametric magnetic resonance imaging (mpMRI) and systematic biopsy in predicting biochemical recurrence (BCR) after radical prostatectomy (RP) in prostate cancer (PCa) patients has not been addressed yet.<h4>Objective</h4>To develop a risk tool predicting BCR after RP in patients diagnosed with magnetic resonance imaging (MRI)-targeted biopsy.<h4>Design, setting, and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):739-747]

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Combined Use of Prostate-specific Antigen Density and Magnetic Resonance Imaging for Prostate Biopsy Decision Planning: A Retrospective Multi-institutional Study Using the Prostate Magnetic Resonance Imaging Outcome Database (PROMOD).

Ugo Giovanni Falagario, Ivan Jambor, Anna Lantz, Otto Ettala, Armando Stabile, Pekka Taimen, Hannu J Aronen, Juha Knaapila, Ileana Montoya Perez, Giorgio Gandaglia, Nicola Fossati, Alberto Martini, Vito Cucchiara, Wolfgang Picker, Erik Haug, Parita Ratnani, Kenneth Haines, Sara Lewis, Nair Sujit, Oscar Selvaggio, Francesca Sanguedolce, Luca Macarini, Luigi Cormio, Tobias Nordström, Ash Tewari, Alberto Briganti, Peter J Boström, Giuseppe Carrieri,

<h4>Background</h4>Previous studies suggested that prostate-specific antigen (PSA) density (PSAd) combined with magnetic resonance imaging (MRI) may help avoid unnecessary prostate biopsy (PB) with a limited risk of missing clinically significant prostate cancer (csPCa; Gleason grade group [GGG] >1).<h4>Objective</h4>To define optimal diagnostic strategies based on the combined use of PSAd and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

Cited: 2 times

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Prostate cancer measurements on serial MRI during active surveillance: it's time to be PRECISE.

Francesco Giganti, Vasilis Stavrinides, Armando Stabile, Elizabeth Osinibi, Clement Orczyk, Jan Philipp Radtke, Alex Freeman, Aiman Haider, Shonit Punwani, Clare Allen, Mark Emberton, Alex Kirkham, Caroline M Moore,

<h4>Objective</h4>The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1116):20200819]

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Multiparametric magnetic resonance imaging and clinical variables: Which is the best combination to predict reclassification in active surveillance patients?

Marco Roscigno, Armando Stabile, Giovanni Lughezzani, Pietro Pepe, Lucio Dell'Atti, Angelo Naselli, Richard Naspro, Maria Nicolai, Giovanni La Croce, Aljoulani Muhannad, Giovanna Perugini, Giorgio Guazzoni, Francesco Montorsi, Luca Balzarini, Sandro Sironi, Luigi F Da Pozzo,

<h4>Introduction & objectives</h4>We tested the role of multiparametric magnetic resonance imaging (mpMRI) in disease reclassification and whether the combination of mpMRI and clinicopathological variables could represent the most accurate approach to predict the risk of reclassification during active surveillance.<h4>Materials & methods</h4>Three-hundred eighty-nine patients (pts) underwent mpMRI and subsequent confirmatory or ... Read more >>

Prostate Int (Prostate international)
[2020, 8(4):167-172]

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External Validation of the 2019 Briganti Nomogram for the Identification of Prostate Cancer Patients Who Should Be Considered for an Extended Pelvic Lymph Node Dissection.

Giorgio Gandaglia, Alberto Martini, Guillaume Ploussard, Nicola Fossati, Armando Stabile, Pieter De Visschere, Hendrik Borgmann, Isabel Heidegger, Fabian Steinkohl, Alexander Kretschmer, Giancarlo Marra, Romain Mathieu, Cristian Surcel, Derya Tilki, Igor Tsaur, Massimo Valerio, Roderick Van den Bergh, Piet Ost, Paolo Gontero, Francesco Montorsi, Alberto Briganti, ,

The 2019 Briganti nomogram was developed to calculate the risk of lymph node invasion (LNI) and identify prostate cancer (PCa) patients diagnosed with magnetic resonance imaging (MRI)-targeted biopsy who should be considered for an extended pelvic lymph node dissection (ePLND). Since its implementation is still limited by lack of a ... Read more >>

Eur Urol (European urology)
[2020, 78(2):138-142]

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The Role of Percentage of Prostate-specific Antigen Reduction After Focal Therapy Using High-intensity Focused Ultrasound for Primary Localised Prostate Cancer. Results from a Large Multi-institutional Series.

Armando Stabile, Clement Orczyk, Francesco Giganti, Marco Moschini, Clare Allen, Shonit Punwani, Nathalie Cathala, Hashim U Ahmed, Xavier Cathelineau, Francesco Montorsi, Mark Emberton, Alberto Briganti, Rafael Sanchez-Salas, Caroline M Moore,

Focal therapy (FT) for prostate cancer (PCa) is emerging as a novel therapeutic approach for patients with low- to intermediate-risk disease, in order to provide acceptable oncological control, whilst avoiding the side effects of radical treatment. Evidence regarding the ideal follow-up strategy and the significance of prostate-specific antigen (PSA) kinetics ... Read more >>

Eur Urol (European urology)
[2020, 78(2):155-160]

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Reply by Authors.

Oliver Rojas Claros, Rafael Rocha Tourinho-Barbosa, Aude Fregeville, Anna Colomer Gallardo, Fabio Muttin, Ariê Carneiro, Armando Stabile, Marco Moschini, Petr Macek, Nathalie Cathala, Annick Mombet, Rafael Sanchez-Salas, Xavier Cathelineau,

J Urol (The Journal of urology)
[2020, 203(5):924-925]

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