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Author Arijit Biswas

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Hypoxic Wharton's Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells.

Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas, Ariff Bongso,

Mesenchymal stem cells from Wharton's jelly of the human umbilical cord (hWJSCs), and the conditioned medium (hWJSC-CM) prepared from them, were shown to be tumoricidal on many cancers. However, these tumoricidal effects were observed in hWJSCs grown under normoxic conditions of 21% oxygen in the laboratory. Since oxygen concentrations in ... Read more >>

Stem Cells Int (Stem cells international)
[2020, 2020:4670948]

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Coronavirus disease 2019 (COVID-19) pandemic and pregnancy.

Pradip Dashraath, Jing Lin Jeslyn Wong, Mei Xian Karen Lim, Li Min Lim, Sarah Li, Arijit Biswas, Mahesh Choolani, Citra Mattar, Lin Lin Su,

The current coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally at an accelerated rate, with a basic reproduction number (R0) of 2-2.5, indicating that 2-3 persons will be infected from an index patient. A serious public health emergency, it ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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Identification and characterization of a novel variant in C-terminal region of Antithrombin (Ala427Thr) associated with type II AT deficiency leading to polymer formation.

Teena Bhakuni, Amit Sharma, Arijit Biswas, Shadabi Bano, Manoranjan Mahapatra, Renu Saxena, Mohamad Aman Jairajpuri,

Antithrombin (AT) deficiency is a rare but strong risk factor for the thrombosis development. Mutations in gene encoding AT (SERPINC1) have provided a detailed understanding of AT deficiency and subsequent development of thrombotic complications. In the present study, we describe a case of thrombotic patient with reduced AT activity and ... Read more >>

J. Thromb. Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, :]

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Inhibition of growth of Asian keloid cells with human umbilical cord Wharton's jelly stem cell-conditioned medium.

Subramanian Arjunan, Shu Uin Gan, Mahesh Choolani, Vaishnevi Raj, Jane Lim, Arijit Biswas, Ariff Bongso, Chui Yee Fong,

BACKGROUND:Keloid formation occurs in Caucasian, African, and Asian populations and is a severe psychosocial burden on patients. There is no permanent treatment for this problem as its pathogenesis is not properly understood. Furthermore, differences in keloid behavior between ethnic groups are not known. It has been hypothesized that keloids behave ... Read more >>

Stem Cell Res Ther (Stem Cell Research & Therapy)
[2020, 11(1):78]

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The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex.

Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean-Luc Pellequer, Alisa S Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas,

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A2B2). FXIII-A2 and -B2 subunits are synthesized separately and then assembled in plasma. Following proteolytic activation by thrombin ... Read more >>

Biomolecules (Biomolecules)
[2019, 9(12):]

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MEchanical DIlatation of the Cervix-- in a Scarred uterus (MEDICS): the study protocol of a randomised controlled trial comparing a single cervical catheter balloon and prostaglandin PGE2 for cervical ripening and labour induction following caesarean delivery.

Soe-Na Choo, Abhiram Kanneganti, Muhammad Nur Dinie Bin Abdul Aziz, Leta Loh, Carol Hargreaves, Vikneswaran Gopal, Arijit Biswas, Yiong Huak Chan, Ida Suzani Ismail, Claudia Chi, Citra Mattar,

INTRODUCTION:Labour induction in women with a previous caesarean delivery currently uses vaginal prostaglandin E2 (PGE2), which carries the risks of uterine hyperstimulation and scar rupture. We aim to compare the efficacy of mechanical labour induction using a transcervically applied Foley catheter balloon (FCB) with PGE2 in affected women attempting trial ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e028896]

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Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma.

Amit Sharma, Arijit Biswas, Hongde Liu, Sagnik Sen, Anoosha Paruchuri, Panagiotis Katsonis, Olivier Lichtarge, Tikam Chand Dakal, Ujjwal Maulik, M Michael Gromiha, Sanghamitra Bandyopadhyay, Michael Ludwig, Frank G Holz, Karin U Loeffler, Martina C Herwig-Carl,

The BAP1 (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its gene product being a nuclear ubiquitin carboxy-terminal hydrolase with deubiquitinase activity, BAP1 acts as a tumor suppressor gene with potential pleiotropic effects in multiple tumor types. Herein, we focused specifically on uveal melanoma (UM) ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(10):]

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Characterization of the mutation spectrum in a Pakistani cohort of type 3 von Willebrand disease.

Shariq Ahmed, Hamideh Yadegari, Arshi Naz, Arijit Biswas, Ulrich Budde, Nazish Saqlain, Samina Amanat, Shehla Tariq, Fazle Raziq, Shahtaj Masood, Anna Pavlova, Tahir Sultan Shamsi, Johannes Oldenburg,

INTRODUCTION:Type 3 von Willebrand disease (VWD), a severe autosomal recessive hereditary bleeding disorder, is described by the virtual absence of von Willebrand factor (VWF). In consanguineous populations, for example Pakistan, the disease is reported with a higher incidence rate than the worldwide prevalence. AIMS:This study aims to characterize molecular pathology ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2019, 25(6):1035-1044]

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Structure functional insights into calcium binding during the activation of coagulation factor XIII A.

Sneha Singh, Johannes Dodt, Peter Volkers, Emma Hethershaw, Helen Philippou, Vytautus Ivaskevicius, Diana Imhof, Johannes Oldenburg, Arijit Biswas,

The dimeric FXIII-A2, a pro-transglutaminase is the catalytic part of the heterotetrameric coagulation FXIII-A2B2 complex that upon activation by calcium binding/thrombin cleavage covalently cross-links preformed fibrin clots protecting them from premature fibrinolysis. Our study characterizes the recently disclosed three calcium binding sites of FXIII-A concerning evolution, mutual crosstalk, thermodynamic activation ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):11324]

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Exploring the structural similarity yet functional distinction between coagulation factor XIII-B and complement factor H sushi domains.

Mohammad Suhail Akhter, Sneha Singh, Hamideh Yadegari, Vytautas Ivaskevicius, Johannes Oldenburg, Arijit Biswas,

Coagulation factor XIII (FXIII) covalently crosslinks pre-formed fibrin clots preventing their premature fibrinolysis. In plasma, FXIII circulates as a zymogenic heterotetramer composed of catalytic FXIII-A subunits, and carrier/regulatory FXIII-B subunits. FXIII-A is a well characterized component of this complex, and has been associated with several pleiotropic roles outside coagulation as ... Read more >>

J. Thromb. Thrombolysis (Journal of thrombosis and thrombolysis)
[2019, 48(1):95-102]

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Short-Term Prediction of Adverse Outcomes Using the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio in Asian Women With Suspected Preeclampsia.

Xuming Bian, Arijit Biswas, Xianghuang Huang, Kyoung Jin Lee, Thomas Kwok-To Li, Hisashi Masuyama, Akihide Ohkuchi, Joong Shin Park, Shigeru Saito, Kok Hian Tan, Tatsuo Yamamoto, Angela Dietl, Sonja Grill, Wilma D J Verhagen-Kamerbeek, Jae-Yoon Shim, Martin Hund,

Current diagnostic criteria have limited clinical value for prediction of preeclampsia and fetal adverse outcomes. The prediction of short-term outcome in pregnant women with suspected preeclampsia study in Asia (PROGNOSIS Asia) was a prospective, multicenter study designed to investigate the value of the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 74(1):164-172]

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The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex

Sneha Singh, Alexis Nazabal, Senthilvelrajan Kaniyappan, Jean-Luc Pellequer, Alisa Wolberg, Diana Imhof, Johannes Oldenburg, Arijit Biswas,

Abstract Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with 2 catalytic A subunits and 2 carrier-protective B subunits in a heterotetramer (FXIII-A 2 B 2 ). FXIII-A 2 and -B 2 subunits are synthesized separately and then assembled ... Read more >>

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Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton's Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus.

Chiou-Mee Kong, Arjunan Subramanian, Arijit Biswas, Walter Stunkel, Yap-Seng Chong, Ariff Bongso, Chui-Yee Fong,

Gestational diabetes mellitus (GDM) has been associated with an increased risk of maternal and neonatal morbidity. The Wharton's jelly (WJ) of the umbilical cord (UC) is a useful indicator of the deleterious effects of hyperglycemia on fetal tissues as it represents the fetus embryologically, physiologically and genetically. We studied WJ ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2019, 15(3):415-426]

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Identification of Potential Novel Interacting Partners for Coagulation Factor XIII B (FXIII-B) Subunit, a Protein Associated with a Rare Bleeding Disorder.

Sneha Singh, Mohammad Suhail Akhter, Johannes Dodt, Peter Volkers, Andreas Reuter, Christoph Reinhart, Christoph Krettler, Johannes Oldenburg, Arijit Biswas,

Coagulation factor XIII (FXIII) is a plasma-circulating heterotetrameric pro-transglutaminase complex that is composed of two catalytic FXIII-A and two protective/regulatory FXIII-B subunits. FXIII acts by forming covalent cross-links within a preformed fibrin clots to prevent its premature fibrinolysis. The FXIII-A subunit is known to have pleiotropic roles outside coagulation, but ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(11):]

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Trisomy 21 in both fetuses in a DCDA twin pregnancy.

Jiawen Ong, Arundhati Gosavi, Arijit Biswas, Mahesh Choolani,

A woman's chances of having a child with Down syndrome increases with age. By age 40, the risk of conceiving a child with Down syndrome is about 1 in 100. We report a rare case of dizygotic dichorionic diamniotic twin pregnancy conceived via in vitro fertilisation, with both twins having ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(4):]

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Correction to: Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population.

Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi, Johannes Oldenburg,

[This corrects the article DOI: 10.1186/s12959-017-0143-3.]. ... Read more >>

Thromb J (Thrombosis journal)
[2019, 17:5]

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Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder.

Sneha Singh, Mohammad Suhail Akhter, Johannes Dodt, Amit Sharma, Senthilvelrajan Kaniyappan, Hamideh Yadegari, Vytautas Ivaskevicius, Johannes Oldenburg, Arijit Biswas,

Congenital FXIII deficiency is a rare bleeding disorder in which mutations are detected in F13A1 and F13B genes that express the two subunits of coagulation FXIII, the catalytic FXIII-A, and protective FXIII-B. Mutations in FXIII-B subunit are considerably rarer compared to FXIII-A. Three mutations in the F13B gene have been ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(8):]

Cited: 1 time

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Manufacturing of human Wharton's jelly stem cells for clinical use: selection of serum is important.

Chiou Mee Kong, Hao Daniel Lin, Arijit Biswas, Ariff Bongso, Chui-Yee Fong,

BACKGROUND:Human Wharton's jelly-derived mesenchymal stromal cells (hWJSCs) have gained considerable attention for their use in cell therapy. Many of these applications would require manufacturing of millions of hWJSCs. It is, therefore, necessary to develop a Good Manufacturing Practice (GMP)-compliant hWJSC expansion protocol, allowing the generation of a large quantity of ... Read more >>

Cytotherapy (Cytotherapy)
[2019, 21(4):483-495]

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Histological, immunohistochemical, and genomic evaluation of excisional and diabetic wounds treated with human Wharton's jelly stem cells with and without a nanocarrier.

Vaishnevi Raj, Stephanie Claudine, Arjunan Subramanian, Kimberley Tam, Arijit Biswas, Ariff Bongso, Chui-Yee Fong,

We showed in previous studies that human umbilical cord Wharton's jelly stem cells (hWJSCs) improved the healing rates of excisional and diabetic wounds in the mouse model. As an extension of those studies, we report here the more detailed quantitative histological, immunohistochemical, and genomic evaluation of biopsies from those excisional ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2019, :]

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Fetoscopic versus Ultrasound-Guided Intravascular Delivery of Maternal Bone Marrow Cells in Fetal Macaques: A Technical Model for Intrauterine Haemopoietic Cell Transplantation.

Citra N Z Mattar, Yi-Wan Tan, Nuryanti Johana, Arijit Biswas, Lay-Geok Tan, Mahesh Choolani, Sonia Bakkour, Mark Johnson, Jerry K Y Chan, Alan W Flake,

INTRODUCTION:Significant limitations with existing treatments for major haemoglobinopathies motivate the development of effective intrauterine therapy. We assessed the feasibility of fetoscopic and ultrasound-guided intrauterine haemopoietic cell transplantation (IUHCT) in macaque fetuses in early gestation when haemopoietic and immunological ontogeny is anticipated to enable long-term donor cell engraftment. MATERIAL AND METHODS:Fluorescent-labelled ... Read more >>

Fetal. Diagn. Ther. (Fetal diagnosis and therapy)
[2019, 46(3):175-186]

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Basal cell carcinomas developing independently from BAP1-tumor predisposition syndrome in a patient with bilateral uveal melanoma: Diagnostic challenges to identify patients with BAP1-TPDS.

Charlotte Melzer, Amit Sharma, Sophia Peters, Stefan Aretz, Arijit Biswas, Frank G Holz, Karin U Loeffler, Martina C Herwig-Carl,

Basal cell carcinomas (BCC) have been recently included into the spectrum of BAP1-tumor predisposition syndrome (TPDS). Uveal melanoma (UM) is also a tumor often observed in patients with this hereditary tumor syndrome, in particular bilateral UM is highly suspicious for BAP1-TPDS although no patient has been reported yet. Based on ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2019, 58(6):357-364]

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Human Wharton's Jelly Mesenchymal Stem Cells Show Unique Gene Expression Compared with Bone Marrow Mesenchymal Stem Cells Using Single-Cell RNA-Sequencing.

Angela N Barrett, Chui-Yee Fong, Arjunan Subramanian, Wenting Liu, Yirui Feng, Mahesh Choolani, Arijit Biswas, Jagath C Rajapakse, Ariff Bongso,

Human Wharton's jelly stem cells (hWJSCs) isolated from the human umbilical cord are a unique population of mesenchymal stem cells (MSCs) with significant clinical utility. Their broad differentiation potential, high rate of proliferation, ready availability from discarded cords, and prolonged maintenance of stemness properties in culture make them an attractive ... Read more >>

Stem Cells Dev. (Stem cells and development)
[2019, 28(3):196-211]

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Influence of Interleukin-6 (IL-6) Promoter Gene Polymorphisms (-174G>C, -572G>C, and -597G>A) on IL-6 Plasma Levels and Their Impact in the Development of Acute Ischemic Stroke in Young Indians.

Mohammad Suhail Akhter, Arijit Biswas, Saleh Mohammed Abdullah, Yahya Hobani, Ravi Ranjan, Madhuri Behari, Renu Saxena,

This study aimed to determine whether there is an influence of interleukin 6 (IL-6) gene promoter polymorphisms on IL-6 plasma levels and its role in the development of ischemic stroke in young Indians. One hundred young patients with ischemic stroke (age ≥ 45 years) and equal number of age- and ... Read more >>

Clin. Appl. Thromb. Hemost. (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2019, 25:1076029619854136]

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Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Hwee Ying Lim, Sheau Yng Lim, Chek Kun Tan, Chung Hwee Thiam, Chi Ching Goh, Daniel Carbajo, Samantha Hui Shang Chew, Peter See, Svetoslav Chakarov, Xiao Nong Wang, Li Hui Lim, Louise A Johnson, Josephine Lum, Chui Yee Fong, Ariff Bongso, Arijit Biswas, Chern Goh, Maximilien Evrard, Kim Pin Yeo, Ranu Basu, Jun Kit Wang, Yingrou Tan, Rohit Jain, Shweta Tikoo, Cleo Choong, Wolfgang Weninger, Michael Poidinger, E Richard Stanley, Matthew Collin, Nguan Soon Tan, Lai Guan Ng, David G Jackson, Florent Ginhoux, Véronique Angeli,

Immunity (Immunity)
[2018, 49(6):1191]

Cited: 3 times

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Altered Placental Chorionic Arterial Biomechanical Properties During Intrauterine Growth Restriction.

Shier Nee Saw, Jess Jia Hwee Tay, Yu Wei Poh, Liying Yang, Wei Ching Tan, Lay Kok Tan, Alys Clark, Arijit Biswas, Citra Nurfarah Zaini Mattar, Choon Hwai Yap,

Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to serious mortality and morbidity risks. There is no treatment for IUGR despite having a prevalence of 3% in developed countries, giving rise to an urgency to ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):16526]

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