Full Text Journal Articles by
Author Ari Bitnun

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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"It's Not Easy": Infant Feeding in the Context of HIV in a Resource-Rich Setting: Strengths, Challenges and Choices, a Qualitative Study.

Sarah Khan, Victoria Logan Kennedy, Mona Loutfy, Jay MacGillivray, Mark Yudin, Stanley Read, Ari Bitnun,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, :]

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Predictive value of repeated cerebrospinal fluid parameters in the outcomes of bacterial meningitis in infants <90 days of age.

Joseph Y Ting, Ashley Roberts, Sarah Khan, Ari Bitnun, Michael Hawkes, Michelle Barton, Jennifer Bowes, Jason Brophy, Lynda Ouchenir, Christian Renaud, Andrée-Anne Boisvert, Jane McDonald, Joan L Robinson,

BACKGROUND:There are variations in recommendations from different guidelines regarding the indications for repeat lumbar puncture (LP) in young infants with the diagnosis of bacterial meningitis. OBJECTIVE:To evaluate the frequency of repeat LPs and the characteristics of cerebrospinal fluid (CSF) parameters in repeated sampling and their predictive values for adverse outcomes ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0238056]

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Enteroviral and Herpes Simplex Virus  Central Nervous System Infections in Infants <90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

Abstract Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. Methods: In this cross-sectional retrospective study, seven centers from the Pediatric ... Read more >>

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Atovaquone-proguanil treatment failure in a case of pediatric Plasmodium falciparum infection: Malabsorption and resistance.

Arnaud G L'Huillier, Rachel Lau, Ari Bitnun, Andrea K Boggild,

Travel Med Infect Dis (Travel medicine and infectious disease)
[2020, 37:101829]

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Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.

Abhinav Ajaykumar, Mayanne Zhu, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Hugo Soudeyns, Sara Saberi, Arianne Y K Albert, Deborah M Money, Hélène C F CÔtÉ, ,

BACKGROUND:Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure to maternal HIV and/or cART could have long-term effects on children HIV-exposed uninfected (CHEU). Our objective was to compare blood mitochondrial DNA (mtDNA) content in CHEU and children HIV-unexposed ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Urinary symptoms and quality of life in women living with HIV: a cross-sectional study.

Maryse Larouche, Arianne Y K Albert, Nancy Lipsky, Sharon Walmsley, Mona Loutfy, Fiona Smaill, Sylvie Trottier, Ari Bitnun, Mark H Yudin, Geoffrey W Cundiff, Deborah M Money,

INTRODUCTION AND HYPOTHESIS:To determine prevalence and quality of life impact of lower urinary tract symptoms (LUTS) in women living with HIV (WLWH). METHODS:Cross-sectional urinary questionnaires were included in a multicenter national prospective study of the HPV vaccine in WLWH. Demographic and clinical information was abstracted from the parent study. The ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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Challenges to achieving and maintaining viral suppression among children living with HIV.

Fatima Kakkar, Terry Lee, Michael T Hawkes, Jason Brophy, Samson Lindy, Joel Singer, Hinatea Dieumegard, Laura Sauve, Ariane Alimenti, Wendy Vaudry, Sandra Seigel, Ben Tan, Christos Karatzios, Valerie Lamarre, Stanley Read, Hugo Soudeyns, Ari Bitnun, ,

OBJECTIVES:The objective of this study was to determine the time to, and durability of, viral suppression, among Canadian children living with HIV after initiation of combination antiretroviral therapy (cART). DESIGN:Prospective, multicenter Canadian cohort study (Early Pediatric Initiation Canada Child Cure Cohort), using both prospective and retrospectively collected data. METHODS:Kaplan-Meir survival ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(5):687-697]

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Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV.

Elisabeth McClymont, Gina Ogilvie, Arianne Albert, Angela Johnston, Janet Raboud, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Mark H Yudin, Marina B Klein, Marianne Harris, Wendy Wobeser, Ari Bitnun, Fatima Kakkar, Lindy Samson, Jason Brophy, Christos Karatzios, Deborah Money, ,

HPV vaccination schedules have changed as evidence has supported reduced dosing and extended intervals. Women living with HIV (WLWH) represent an important population with no data on alternative dosing. Girls and WLWH received quadrivalent HPV (qHPV) vaccine in a pan-Canadian study of immunogenicity and efficacy. Serology was performed at months ... Read more >>

Vaccine (Vaccine)
[2020, 38(15):3073-3078]

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Brief Report: Persistence of Non-Vaccine Oncogenic HPV Genotypes in Quadrivalent HPV-Vaccinated Women Living With HIV.

Elisabeth McClymont, François Coutlée, Marette Lee, Arianne Albert, Janet Raboud, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Marina B Klein, Mark H Yudin, Marianne Harris, Wendy Wobeser, Ari Bitnun, Lindy Samson, Deborah Money, ,

BACKGROUND:Human papillomavirus (HPV) vaccines have promising safety and immunogenicity data in women living with HIV (WLWH). However, it is critical to understand the residual burden of oncogenic HPV within WLWH to inform postvaccination cervical screening needs. We assessed rates of persistent infection with nonquadrivalent HPV (qHPV) oncogenic types in a ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(3):230-234]

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Non-immune Hydrops Fetalis and Hepatic Dysfunction in a Preterm Infant With Congenital Syphilis.

Jessica Duby, Ari Bitnun, Vibhuti Shah, Patrick Shannon, Shiri Shinar, Hilary Whyte,

We report a case of a preterm infant with congenital syphilis who presented with non-immune hydrops fetalis. Hepatic dysfunction was present at birth and acutely worsened following antibiotic administration. Placental pathology demonstrated infiltration with numerous spirochetes. Although critically ill, the infant recovered with intravenous penicillin G and supportive care. This ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:508]

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Transition from Pediatric to Adult HIV Care for Young Women Living with HIV.

Victoria Logan Kennedy, Kaitlyn Luisa Mellor, Jason Brophy, Ari Bitnun, Ariane Alimenti, Fatima Kakkar, Carmen Helen Logie, Kath Webster, Karène Proulx-Boucher, Erin Ding, Shahab Jabbari, Angela Kaida, Alexandra de Pokomandy, Mona Loutfy, ,

Transitioning from pediatric to adult care is a complicated process for youth with chronic illnesses. This study elucidates the unique factors affecting transition preparedness and perception of adult HIV care among a cohort of young women with HIV. Between 2013 and 2015, 48 women with HIV, who had experience with ... Read more >>

J Int Assoc Provid AIDS Care (Journal of the International Association of Providers of AIDS Care)
[2020, 19:2325958220903574]

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2587. Etiology and Outcome of Acute Neonatal Infectious Encephalitis.

Craig Frankel, Hilary Whyte, Vann Chau, Daune MacGregor, Sanjay Mahant, Helen Branson, Aaron Campigotto, Ari Bitnun,

AbstractBackgroundThere are very few studies on acute encephalitis with onset during the neonatal period. The objectives of this study were to investigate the etiology and salient clinical features of neonatal encephalitis.MethodsNeonates with possible infectious encephalitis (IE) were prospectively enrolled. Inclusion criteria included encephalopathy (altered/fluctuating level of consciousness ≥24 hours) plus ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S899-S899]

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44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundHerpes simplex virus (HSV) and enterovirus (EV) are important causes of central nervous system (CNS) infections in young infants. Though long-term morbidity has been linked to HSV, there is still limited data on outcomes of other viral CNS infections in young infants.Objectives1) Conduct a descriptive analysis of viral CNS infections ... Read more >>

(Paediatrics & child health)
[2019, 24(Suppl 2):e18-e18]

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Treatment of rituximab-associated chronic CNS enterovirus using IVIg and fluoxetine.

Lauren Sham, Ari Bitnun, Helen Branson, Lili-Naz Hazrati, Sharon D Dell, Rae S M Yeung, Joley Johnstone, E Ann Yeh,

Neurology (Neurology)
[2019, 92(19):916-918]

Cited: 1 time

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Sporadic Creutzfeldt-Jakob Disease in a Young Girl With Unusually Long Survival.

Colleen E D'Arcy, Ari Bitnun, Michael B Coulthart, Rolande D'Amour, Jeremy Friedman, J David Knox, Adam Rapoport, Snead Carter, Elysa Widjaja, Lili-Naz Hazrati, Gerard H Jansen,

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal degenerative encephalopathy caused by a pathologically altered form of the prion protein (PrP). CJD is rare, with 1 and 2 cases per million per year reported in the general population, mostly in individuals over 50 years of age. It is almost unknown ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2019, 78(4):373-378]

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Brief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV.

Vishrut Gulhati, Jeremy Soo, Doris G Ransy, Jason Brophy, Fatima Kakkar, Ari Bitnun, Lindy Samson, Stanley Read, Hugo Soudeyns, Michael T Hawkes, ,

BACKGROUND:Systemic inflammation, platelet dysfunction, and endothelial activation persist in people living with HIV despite sustained virologic suppression (SVS) with combined antiretroviral therapy (cART) and may lead to complications such as atherosclerosis and cardiovascular disease. Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 80(5):590-595]

Cited: 1 time

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PANDAS/PANS in childhood: Controversies and evidence.

Colin Wilbur, Ari Bitnun, Sefi Kronenberg, Ronald M Laxer, Deborah M Levy, William J Logan, Michelle Shouldice, E Ann Yeh,

Since first defined in 1998, paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS), have garnered significant attention and controversy. The role of streptococcal infection in children with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of ... Read more >>

(Paediatrics & child health)
[2019, 24(2):85-91]

Cited: 4 times

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Acute flaccid myelitis.

Peter J Gill, Ari Bitnun, E Ann Yeh,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2018, 190(48):E1418]

Cited: 1 time

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2342. Treatment Implications of Herpes Simplex Virus Central Nervous System Infection in Canadian Infants <90 Days Old: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason C Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane Mcdonald, André-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundIn the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy and long-term prophylaxis improve outcomes, clinicians need to be able to clinically detect young infants most likely to have HSV to facilitate early initiation of therapy. Limited data exist ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S696-S696]

Cited: 0 times

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Acute Flaccid Myelitis in a 10-Year-Old Girl.

Birgit Ertl-Wagner, Helen Branson, Manohar Shroff, Ari Bitnun, E Ann Yeh,

Radiology (Radiology)
[2019, 290(1):31]

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Adenovirus-Associated Central Nervous System Disease in Children.

Kevin L Schwartz, Susan E Richardson, Daune MacGregor, Sanjay Mahant, Kamini Raghuram, Ari Bitnun,

OBJECTIVE:To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children. STUDY DESIGN:Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 205:130-137]

Cited: 1 time

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Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV.

Jason Brophy, Ari Bitnun, Ariane Alimenti, Normand Lapointe, Lindy Samson, Stanley Read, Christos Karatzios, Simon Dobson, Erin Moses, Sandra Blitz, Nancy-Grace Lipsky, Gina Ogilvie, Sharon Walmsley, Janet Raboud, Deborah Money, ,

We evaluated quadrivalent human papillomavirus vaccine seroresponses among 35 girls living with HIV (9-13 years of ages) and compared with data on girls without HIV, as part of a subgroup analysis. The quadrivalent human papillomavirus vaccine was safe and well tolerated. However, antibody response was significantly lower in girls living ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(6):595-597]

Cited: 1 time

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Acute Flaccid Paralysis and Enteroviral Infections.

Ari Bitnun, E Ann Yeh,

PURPOSE OF REVIEW:The focus of this review is on enterovirus (EV)-associated acute flaccid paralysis (AFP) due to spinal cord anterior horn cell disease. Emphasis is placed on the epidemiology, pathogenesis, diagnosis, treatment, and outcome of AFP caused by polioviruses, vaccine-derived polioviruses, EV-D68, and EV-A71. RECENT FINDINGS:Since the launch of The ... Read more >>

(Current infectious disease reports)
[2018, 20(9):34]

Cited: 12 times

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