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Author Arash Khojasteh

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Comparison of osteogenic differentiation potential of induced pluripotent stem cells and buccal fat pad stem cells on 3D-printed HA/β-TCP collagen-coated scaffolds.

Sheida Hashemi, Leila Mohammadi Amirabad, Saeed Farzad-Mohajeri, Maryam Rezai Rad, Farahnaz Fahimipour, Abdolreza Ardeshirylajimi, Erfan Dashtimoghadam, Mohammad Salehi, Masoud Soleimani, Mohammad Mehdi Dehghan, Lobat Tayebi, Arash Khojasteh,

Production of a 3D bone construct with high-yield differentiated cells using an appropriate cell source provides a reliable strategy for different purposes such as therapeutic screening of the drugs. Although adult stem cells can be a good source, their application is limited due to invasive procedure of their isolation and ... Read more >>

Cell Tissue Res (Cell and tissue research)
[2021, :]

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Various Cell Therapy Approaches for Bone Diseases in the Controlled Clinical Trials: A Systematic Review and Meta-analysis study.

Mahboubeh Bouhlouli, Neda Izadi, Arash Khojasteh,

The objective of this review was to answer two critical questions in the cell-based bone defect therapies that were as follows: 1) does cell therapy associate with the increase in the occurrence of adverse events in the patients compared to control groups, 2) does the use of various cell therapy ... Read more >>

Curr Stem Cell Res Ther (Current stem cell research & therapy)
[2020, :]

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Effects of Platelet-Rich Fibrin/Collagen Membrane on Sciatic Nerve Regeneration.

Peyman Vares, Mohammad Mehdi Dehghan, Farshid Bastami, Esmaeil Biazar, Nafiseh Shamloo, Saeed Heidari Keshel, Arash Khojasteh,

Alternative treatment approaches to improve the regeneration ability of damaged peripheral nerves are currently under investigation. The aim of the current study was to evaluate the effects of leucocyte/platelet-rich fibrin (L-PRF) with or without a collagen membrane as a supporter on crushed sciatic nerve healing in a rat model. Recovery ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, :]

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MicroRNA-218 competes with differentiation media in the induction of osteogenic differentiation of mesenchymal stem cell by regulating β-catenin inhibitors.

Zohreh Karimi, Ehsan Seyedjafari, Arash Khojasteh, Seyed Mahmoud Hashemi, Bahram Kazemi, Samira Mohammadi-Yeganeh,

Osteoporosis, a systemic skeletal disorder specified by low bone mass, is associated with bone fragility and the raised risk of fractures. Activation of the Wnt/β-catenin signaling pathway has been directly demonstrated as a prominent biological event in the prevention of osteoporosis. Recently, critical roles of microRNAs (miRNAs) were further revealed ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2020, 47(11):8451-8463]

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Bone tissue engineering gelatin-hydroxyapatite/graphene oxide scaffolds with the ability to release vitamin D: fabrication, characterization, and in vitro study.

Reza Mahdavi, Ghazal Belgheisi, Masoumeh Haghbin-Nazarpak, Meisam Omidi, Arash Khojasteh, Mehran Solati-Hashjin,

Developing smart scaffolds with drug release capability is one of the main approaches to bone tissue engineering. The current study involves the fabrication of novel gelatin (G)-hydroxyapatite (HA)-/vitamin D (VD)-loaded graphene oxide (GO) scaffolds with different concentrations through solvent-casting method. Characterizations confirmed the successful synthesis of HA and GO, and ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2020, 31(11):97]

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Country Quarantine During COVID-19: Critical or Not?

Noosha Samieefar, Reza Yari Boroujeni, Mahnaz Jamee, Melika Lotfi, Mohammad Rasul Golabchi, Alireza Afshar, Hamidreza Miri, Mohammad Amin Khazeei Tabari, Pouya Darzi, Morteza Abdullatif Khafaie, Bagher Amirheidari, Amin Tamadon, Niloofar Rambod Rad, Nastaran Samimi, Mojtaba Farjam, Fatemeh Shiravi, Narges Farshidi, Mojtaba Hedayati Ch, Donya Doostkamel, Radin Alikhani, Mahboobeh Razmkhah, Saeed Abdollahifard, Rasoul Nasiri Kalmarzi, Roya Kelishadi, Hosseinali Khazaei, Asghar Aghamohammadi, Farzaneh S Jafari Mousavi, Morteza Shamsizadeh, Arash Khojasteh, Nima Rezaei,

Disaster Med Public Health Prep (Disaster medicine and public health preparedness)
[2020, :1-2]

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Cartilage regeneration with dual-drug-releasing injectable hydrogel/microparticle system: In vitro and in vivo study.

Ziba Naghizadeh, Akbar Karkhaneh, Hanieh Nokhbatolfoghahaei, Saeed Farzad-Mohajeri, Maryam Rezai-Rad, Mohammad M Dehghan, Pouyan Aminishakib, Arash Khojasteh,

In this study, we developed an injectable in situ forming hydrogel/microparticle system consisting of two drugs, melatonin and methylprednisolone, to investigate the capability of the system for chondrogenesis in vitro and in vivo. The chemical, mechanical, and rheological properties of the hydrogel/microparticle were investigated. For in vitro evaluation, the adipose-derived stem ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, 236(3):2194-2204]

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Stem Cell-Derived Exosomes as Treatment for Stroke: a Systematic Review.

Leila Dehghani, Seyed Mahmoud Hashemi, Mohammad Saadatnia, Alireza Zali, Saeed Oraee-Yazdani, Saeed Heidari Keshel, Arash Khojasteh, Masoud Soleimani,

<h4>Background</h4>The therapeutic potential of stem cells may largely be mediated by paracrine factors contained in exosomes released from intracellular endosomes. A systematic review was performed to identify the effects of stem cell-derived exosomes for their ability to induce restorative effects in animal models of stroke.<h4>Methods</h4>PubMed, Scopus, and ISI Web of ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2020, :]

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Computational modeling of media flow through perfusion-based bioreactors for bone tissue engineering.

Hanieh Nokhbatolfoghahaei, Mahboubeh Bohlouli, Kazem Adavi, Zahrasadat Paknejad, Maryam Rezai Rad, Mohammad Mehdi Khani, Nasim Salehi-Nik, Arash Khojasteh,

Bioreactor system has been used in bone tissue engineering in order to simulate dynamic nature of bone tissue environments. Perfusion bioreactors have been reported as the most efficient types of shear-loading bioreactor. Also, combination of forces, such as rotation plus perfusion, has been reported to enhance cell growth and osteogenic ... Read more >>

Proc Inst Mech Eng H (Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine)
[2020, 234(12):1397-1408]

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The promise of regenerative medicine in the treatment of urogenital disorders.

Saeed Heidari Keshel, Azam Rahimi, Zoe Hancox, Maryam Ebrahimi, Arash Khojasteh, Farshid Sefat,

Polymers and scaffolds are the most significant tools in regenerative medicine. Urogenital disorders are an important group of diseases that greatly affect the patient's life expectancy and quality. Reconstruction of urogenital defects is one of the current challenges in regenerative medicine. Regenerative medicine, as well as tissue engineering, may offer ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2020, 108(8):1747-1759]

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Bioreactor cultivation condition for engineered bone tissue: Effect of various bioreactor designs on extra cellular matrix synthesis.

Hanieh Nokhbatolfoghahaei, Mahboubeh Bohlouli, Zahrasadat Paknejad, Maryam R Rad, Leila M Amirabad, Nasim Salehi-Nik, Mohammad M Khani, Shayan Shahriari, Nasser Nadjmi, Adel Ebrahimpour, Arash Khojasteh,

Dynamic-based systems are bio-designed in order to mimic the micro-environments of the bone tissue. There is limited direct comparison between perfusion and perfusion-rotation forces in designing a bioreactor. Hence, in current study, we aimed to compare given bioreactors for bone regeneration. Two types of bioreactors including rotating & perfusion and ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2020, 108(8):1662-1672]

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Polyvinyl alcohol modified polyvinylidene fluoride-graphene oxide scaffold promotes osteogenic differentiation potential of human induced pluripotent stem cells.

Esmaeel Azadian, Bahar Arjmand, Abdolreza Ardeshirylajimi, Simzar Hosseinzadeh, Meisam Omidi, Arash Khojasteh,

Tissue engineering is fast becoming a key approach in bone medicine studies. Designing the ideally desirable combination of stem cells and scaffolds are at the hurt of efforts for producing implantable bone substitutes. Clinical application of stem cells could be associated with serious limitations, and engineering scaffolds that are able ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2020, 121(5-6):3185-3196]

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In vitro osteogenic differentiation of stem cells with different sources on composite scaffold containing natural bioceramic and polycaprolactone.

Fatemeh Sadat Hosseini, Fatemeh Soleimanifar, Abdolreza Ardeshirylajimi, Saeid Vakilian, Majid Mossahebi-Mohammadi, Seyed Ehsan Enderami, Arash Khojasteh, Shohreh Zare Karizi,

Stem cells can be obtained from a variety of sources. To compare the effect of cell source on the osteogenic differentiation potential, buccal fat pad-derived mesenchymal stem cells (BFP-MSCs), bone marrow-derived MSCs (BM-MSCs) and unrestricted somatic stem cells (USSCs) with different accessibility in time and region, were cultured on bioceramic ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2019, 47(1):300-307]

Cited: 1 time

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Role of mesenchymal stem cells derived exosomes therapy in neuronal remodeling after ischemic stroke.

Leila Dehghani, Arash Khojasteh, Saeed Oraee Yazdani, Marjan Oustad, Masoud Soleimani,

Minerva Med (Minerva medica)
[2019, :]

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Biological behavior of the curcumin incorporated chitosan/poly(vinyl alcohol) nanofibers for biomedical applications.

Ali Golchin, Simzar Hosseinzadeh, Masumeh Staji, Masoud Soleimani, Abdolreza Ardeshirylajimi, Arash Khojasteh,

Electrospun composite scaffolds show high ability to be used in regenerative medicine and drug delivery, due to the nanofibrous structure and high surface area to volume ratio. In this study, we used nanofibrous scaffolds fabricated by chitosan (CS), poly(vinyl alcohol) (PVA), carbopol, and polycaprolactone using a dual electrospinning technique while ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2019, 120(9):15410-15421]

Cited: 2 times

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Reconstruction of a Mandibular Defect with Toronto Bridge Following Tumor Resection and Bone Graft: A Case Report.

Hakimeh Siadat, Arash Khojasteh, Elaheh Beyabanaki,

Dental implants are highly recommended to improve the retention, stability, and support of prostheses in edentulous patients with large surgical defects. Depending on the size of the defect, a bone graft procedure might be necessary. However, due to limitations of bone grafts, some complications might negatively affect the prosthetic rehabilitation ... Read more >>

Front Dent (Frontiers in dentistry)
[2019, 16(2):153-157]

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Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory prospective clinical study.

Arash Khojasteh, Sepanta Hosseinpour, Maryam Rezai Rad, Marzieh Alikhasi, Homayoun H Zadeh,

BACKGROUND:Application of adipose-derived stem cells originated from buccal fat pad (BFP) can simplify surgical procedures and diminish clinical risks compared to large autograft harvesting. PURPOSE:This study sought to evaluate and compare the efficacy of buccal fat pad-derived stem cells (BFPSCs) in combination with anorganic bovine bone mineral (ABBM) for vertical ... Read more >>

Clin Implant Dent Relat Res (Clinical implant dentistry and related research)
[2019, 21(2):292-300]

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Egg shell-derived calcium phosphate/carbon dot nanofibrous scaffolds for bone tissue engineering: Fabrication and characterization.

Shervin Shafiei, Meisam Omidi, Fatemeh Nasehi, Hossein Golzar, Dorsa Mohammadrezaei, Maryam Rezai Rad, Arash Khojasteh,

Recent exciting findings of the particular properties of Carbon dot (CDs) have shed light on potential biomedical applications of CDs-containing composites. While CDs so far have been widely used as biosensors and bioimaging agents, in the present study for the first time, we evaluate the osteoconductivity of CDs in poly ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2019, 100:564-575]

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Improved bone regeneration through amniotic membrane loaded with buccal fat pad-derived MSCs as an adjuvant in maxillomandibular reconstruction.

Fahimeh Akhlaghi, Nima Hesami, Maryam Rezai Rad, Pantea Nazeman, Farahnaz Fahimipour, Arash Khojasteh,

<h4>Background</h4>Human amniotic membranes (HAMs), as a biological membrane with healing, osteogenic, and cell therapy potential, has been in the spotlight to enhance the outcomes of treating bone defects. Present study aims to clinically assess the potential of HAM loaded with buccal fat pad-derived stem cells (BFSCs) as an osteogenic coverage ... Read more >>

J Craniomaxillofac Surg (Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery)
[2019, 47(8):1266-1273]

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Baghdadite nanoparticle-coated poly l-lactic acid (PLLA) ceramics scaffold improved osteogenic differentiation of adipose tissue-derived mesenchymal stem cells.

Zohreh Karimi, Ehsan Seyedjafari, Fatemeh Sadat Mahdavi, Seyed Mahmoud Hashemi, Arash Khojasteh, Bahram Kazemi, Samira Mohammadi-Yeganeh,

Bone repair has been a new approach in regenerative medicine especially by application of stem cells. Discovering a suitable combination of scaffolds to stimulate osteogenesis is one of the major concerns in this issue. Porous polymeric scaffolds such as poly l-lactic acid (PLLA) have been attracted a lot of attention ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2019, 107(6):1284-1293]

Cited: 1 time

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The Effect of Mandibular Flexure on Stress Distribution in the All-on-4 Treated Edentulous Mandible: A Comparative Finite-Element Study Based on Mechanostat Theory.

Shayan Shahriari, Azim Parandakh, Mohammad-Mehdi Khani, Nima Azadikhah, Paniz Naraghi, Mahsa Aeinevand, Mohammad Nikkhoo, Arash Khojasteh,

The All-on-4 treatment concept is a felicitous approach for treatment of edentulous mandible. Mandibular flexure plays a decisive role in several restorative failures-for instance, screw loosening, particularly in widely separated implant supports such as those utilized in All-on-4 treatment methods. We investigated the effect of mandibular flexure on stress distribution ... Read more >>

J Long Term Eff Med Implants (Journal of long-term effects of medical implants)
[2019, 29(1):79-86]

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Increased osteogenic differentiation potential of MSCs cultured on nanofibrous structure through activation of Wnt/β-catenin signalling by inorganic polyphosphate.

Abdolreza Ardeshirylajimi, Ali Golchin, Arash Khojasteh, Mojgan Bandehpour,

There are several signal pathways involved in bone regeneration that can be triggered by several factors including mechanical, physical and chemical factors. Chemical growth factors are commonly used in differentiation induction to stem cells, while have side effects. In this study, inorganic poly-phosphate (poly-P) as a natural-based molecule was used ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2018, 46(sup3):S943-S949]

Cited: 2 times

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Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) improved osteogenic differentiation of the human induced pluripotent stem cells while considered as an artificial extracellular matrix.

Fatemeh Sadat Hosseini, Fatemeh Soleimanifar, Amir Aidun, Seyedeh Elnaz Enderami, Ehsan Saburi, Hadi Zare Marzouni, Mohammad-Mehdi Khani, Arash Khojasteh, Abdolreza Ardeshirylajimi,

Cocell polymers can be the best implants for replacing bone defects in patients. The pluripotent stem cells produced from the patient and the nanofibrous polymeric scaffold that can be completely degraded in the body and its produced monomers could be also usable are the best options for this implant. In ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(7):11537-11544]

Cited: 2 times

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The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review.

Ali Golchin, Tahereh Z Farahany, Arash Khojasteh, Fatemeh Soleimanifar, Abdolreza Ardeshirylajimi,

The skin is one of the crucial body organs with anatomy and physiology linked to various disorders including congenital and acquired diseases. Nowadays, mesenchymal stem cell (MSCs)- based therapy has appeared as a promising therapeutic field, in which many see opportunities to cure the costliest and incurable diseases. However, one ... Read more >>

Curr Stem Cell Res Ther (Current stem cell research & therapy)
[2019, 14(1):22-33]

Cited: 14 times

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Buccal Fat Pad-Derived Stem Cells in Three-Dimensional Rehabilitation of Large Alveolar Defects: A Report of Two Cases.

Arash Khojasteh, Sepanta Hosseinpour, Maryam Rezai Rad, Marzieh Alikhasi,

This case report seeks to describe efficient clinical application of adipose-derived stem cells (AdSCs) originated from buccal fat pad (BFP) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after extraction of multiple impacted teeth. The first case was a 19-year-old woman ... Read more >>

J Oral Implantol (The Journal of oral implantology)
[2019, 45(1):45-54]

Cited: 0 times

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