Full Text Journal Articles by
Author April C Pettit

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Optimal testing choice and diagnostic strategies for latent tuberculosis infection among U.S.-born people living with HIV.

April C Pettit, Jason E Stout, Robert Belknap, Constance A Benson, Marie Nancy Séraphin, Michael Lauzardo, David J Horne, Richard S Garfein, Fernanda Maruri, Christine S Ho, ,

BACKGROUND:Increased risk of progression from latent tuberculosis infection (LTBI) to tuberculosis (TB) disease among people living with HIV (PLWH) prioritizes them for LTBI testing and treatment. Studies comparing the performance of interferon gamma release assays (IGRAs) and the tuberculin skin test (TST) among PLWH are lacking. METHODS:We used Bayesian latent ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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High-dose rifapentine with or without moxifloxacin for shortening treatment of pulmonary tuberculosis: Study protocol for TBTC study 31/ACTG A5349 phase 3 clinical trial.

Susan E Dorman, Payam Nahid, Ekaterina V Kurbatova, Stefan V Goldberg, Lorna Bozeman, William J Burman, Kwok-Chiu Chang, Michael Chen, Mark Cotton, Kelly E Dooley, Melissa Engle, Pei-Jean Feng, Courtney V Fletcher, Phan Ha, Charles M Heilig, John L Johnson, Erica Lessem, Beverly Metchock, Jose M Miro, Nguyen Viet Nhung, April C Pettit, Patrick P J Phillips, Anthony T Podany, Anne E Purfield, Kathleen Robergeau, Wadzanai Samaneka, Nigel A Scott, Erin Sizemore, Andrew Vernon, Marc Weiner, Susan Swindells, Richard E Chaisson, ,

INTRODUCTION:Phase 2 clinical trials of tuberculosis treatment have shown that once-daily regimens in which rifampin is replaced by high dose rifapentine have potent antimicrobial activity that may be sufficient to shorten overall treatment duration. Herein we describe the design of an ongoing phase 3 clinical trial testing the hypothesis that ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 90:105938]

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Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium.

John M Humphrey, Philani Mpofu, April C Pettit, Beverly Musick, E Jane Carter, Eugène Messou, Olivier Marcy, Brenda Crabtree-Ramirez, Marcel Yotebieng, Kathryn Anastos, Timothy R Sterling, Constantin Yiannoutsos, Lameck Diero, Kara Wools-Kaloustian,

Background:In resource-constrained settings, many people with HIV (PWH) are treated for tuberculosis (TB) without bacteriologic testing. Their mortality compared with those with bacteriologic testing is uncertain. Methods:We conducted an observational cohort study among PWH ≥15 years of age initiating TB treatment at sites affiliated with 4 International epidemiology Databases to Evaluate ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(1):ofaa006]

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Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature.

Charles Muiruri, Chris T Longenecker, Eric G Meissner, Nwora Lance Okeke, April C Pettit, Kevin Thomas, Eric Velazquez, Gerald S Bloomfield,

Despite developments to improve health in the United States, racial and ethnic disparities persist. These disparities have profound impact on the wellbeing of historically marginalized racial and ethnic groups. This narrative review explores disparities by race in people living with cardiovascular disease (CVD) and the Human Immunodeficiency Virus (HIV). We ... Read more >>

Prog Cardiovasc Dis (Progress in cardiovascular diseases)
[2020, 63(2):142-148]

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Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries.

April C Pettit, Cathy A Jenkins, Meridith Blevins Peratikos, Marcel Yotebieng, Lameck Diero, Cuong D Do, Jeremy Ross, Valdilea G Veloso, Denise Hawerlander, Olivier Marcy, Bryan E Shepherd, Lukas Fenner, Timothy R Sterling, ,

INTRODUCTION:Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to identify factors associated with a decreased risk of unfavourable TB treatment outcomes among people living with HIV-infection (PLHIV) in low- and middle-income ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(12):e25423]

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Clinic-Level Factors Associated with Retention in Care among People Living with HIV in a Multi-Site United States Cohort, 2010-2016.

Cassandra D Oliver, Peter F Rebeiro, Bryan E Shepherd, Jeanne Keruly, Kenneth H Mayer, W Christopher Mathews, Bulent Turan, Richard D Moore, Heidi M Crane, Elvin Geng, Sonia Napravnik, Mari M Kitahata, Michael J Mugavero, April C Pettit, ,

BACKGROUND:Retention in care (RIC) leads to reduced HIV transmission and mortality. Few studies have investigated the availability of clinic services and RIC among people living with HIV (PLWH) in the United States (US). We conducted a multi-site retrospective cohort study to identify clinic services associated with RIC from 2010-2016 in ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, :]

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Temporal Trends and Sociodemographic Correlates of PrEP Uptake in Tennessee, 2017.

Meredith L Brantley, Peter F Rebeiro, April C Pettit, Allison Sanders, Lyle Cooper, Shanell McGoy, Melissa Morrison,

Client-level data from two Tennessee-based PrEP navigation demonstration projects reported to the Tennessee Department of Health from January to December 2017 were evaluated to determine the proportion of clients who accepted, were linked to, and were prescribed PrEP. Disparities by age, race, transmission risk, and geographic region as well as ... Read more >>

AIDS Behav (AIDS and behavior)
[2019, 23(Suppl 3):304-312]

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Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study.

Kathrin Zürcher, Marie Ballif, Sasisopin Kiertiburanakul, Henri Chenal, Marcel Yotebieng, Beatriz Grinsztejn, Denna Michael, Timothy R Sterling, Kapella M Ngonyani, Anna M Mandalakas, Matthias Egger, April C Pettit, Lukas Fenner, ,

INTRODUCTION:Extrapulmonary tuberculosis (EPTB) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under-resourced settings. We studied diagnostic modalities and clinical outcomes of EPTB compared to pulmonary tuberculosis (PTB) among HIV-positive adults in antiretroviral therapy (ART) programmes in low- and middle-income countries (LMIC). METHODS:We ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(9):e25392]

Cited: 3 times

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Trends and Disparities in Mortality and Progression to AIDS in the Highly Active Antiretroviral Therapy Era: Tennessee, 1996-2016.

Peter F Rebeiro, April C Pettit, Lindsey Sizemore, Samantha A Mathieson, Carolyn Wester, Aaron Kipp, Bryan E Shepherd, Timothy R Sterling,

Objectives. To use statewide surveillance data to examine trends and disparities in mortality and progression from HIV to AIDS comprehensively in Tennessee over the past 20 years.Methods. Individuals diagnosed with HIV in Tennessee from 1996 to 2016 were identified through the Tennessee Department of Health Enhanced HIV/AIDS Reporting System. Clinical ... Read more >>

Am J Public Health (American journal of public health)
[2019, 109(9):1266-1272]

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On the assessment of trend in CD4+ cell count and viral suppression after transition to adult care.

Cassandra Oliver, Peter F Rebeiro, April C Pettit,

AIDS (AIDS (London, England))
[2019, 33(9):1536-1537]

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Substance Use, Demographic and Socioeconomic Factors Are Independently Associated With Postpartum HIV Care Engagement in the Southern United States, 1999-2016.

Cassandra Oliver, Peter F Rebeiro, Mary J Hopkins, Beverly Byram, Lavenia Carpenter, Kate Clouse, Jessica L Castilho, William Rogers, Megan Turner, Sally S Bebawy, April C Pettit,

Background:Retention in care (RIC) and viral suppression (VS) are associated with reduced HIV transmission and mortality. Studies addressing postpartum engagement in HIV care have been limited by small sample size, short follow-up, and a lack of data from the Southeast United States. Methods:HIV-positive adult women with ≥1 prenatal visit at ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(2):ofz023]

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Use of Social Network Strategy Among Young Black Men Who Have Sex With Men for HIV Testing, Linkage to Care, and Reengagement in Care, Tennessee, 2013-2016.

Shanell L McGoy, April C Pettit, Melissa Morrison, Leah R Alexander, Phadre Johnson, Brandon Williams, Darion Banister, Mary K Young, Carolyn Wester, Peter F Rebeiro,

OBJECTIVES:Tennessee was 1 of 8 states that received funding from the Care and Prevention in the United States Demonstration Project, which aimed to reduce HIV-related morbidity and mortality among racial/ethnic and sexual minority populations. The objective of this study was to describe implementation of a social network strategy (SNS) program, ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2018, 133(2_suppl):43S-51S]

Cited: 2 times

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Treatment of drug-susceptible tuberculosis among people living with human immunodeficiency virus infection: an update.

April C Pettit, Bryan E Shepherd, Timothy R Sterling,

PURPOSE OF REVIEW:The present review describes recent advances in the treatment of drug-susceptible tuberculosis (DS-TB) among people living with human immunodeficiency virus (PLWH). RECENT FINDINGS:Higher than standard rifampicin doses (>10 mg/kg/day) are well tolerated and have improved sterilizing activity. Standard pyrazinamide doses may result in low drug exposures; modeling reveals that ... Read more >>

Curr Opin HIV AIDS (Current opinion in HIV and AIDS)
[2018, 13(6):469-477]

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Evaluating latent tuberculosis infection diagnostics using latent class analysis.

Jason E Stout, Yanjue Wu, Christine S Ho, April C Pettit, Pei-Jean Feng, Dolly J Katz, Smita Ghosh, Thara Venkatappa, Ruiyan Luo, ,

BACKGROUND:Lack of a gold standard for latent TB infection has precluded direct measurement of test characteristics of the tuberculin skin test and interferon-γ release assays (QuantiFERON Gold In-Tube and T-SPOT.TB). OBJECTIVE:We estimated test sensitivity/specificity and latent TB infection prevalence in a prospective, US-based cohort of 10 740 participants at high risk ... Read more >>

Thorax (Thorax)
[2018, 73(11):1062-1070]

Cited: 3 times

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Health Literacy and Demographic Disparities in HIV Care Continuum Outcomes.

Peter F Rebeiro, Tristan D McPherson, Kathryn M Goggins, Megan Turner, Sally S Bebawy, William B Rogers, Lauren Brinkley-Rubinstein, Anna K Person, Timothy R Sterling, Sunil Kripalani, April C Pettit,

Studies evaluating the association between human immunodeficiency virus (HIV) infection continuum of care outcomes [antiretroviral (ART) adherence, retention in care, viral suppression] and health literacy have yielded conflicting results. Moreover, studies from the southern United States, a region of the country disproportionately affected by the HIV epidemic and low health ... Read more >>

AIDS Behav (AIDS and behavior)
[2018, 22(8):2604-2614]

Cited: 2 times

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Increased non-AIDS mortality among persons with AIDS-defining events after antiretroviral therapy initiation.

April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling, ,

INTRODUCTION:HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS:We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2018, 21(1):]

Cited: 2 times

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Health Care Provider Knowledge and Attitudes Regarding Reporting Diseases and Events to Public Health Authorities in Tennessee.

Mary-Margaret A Fill, Rendi Murphree, April C Pettit,

CONTEXT:In the United States, state laws require health care providers to report specific diseases and events to public health authorities, a fundamental facet of disease surveillance. However, reporting by providers is often inconsistent, infrequent, and delayed. OBJECTIVE:To examine knowledge, attitudes, and practices regarding provider disease reporting and to understand current ... Read more >>

J Public Health Manag Pract (Journal of public health management and practice : JPHMP)
[2017, 23(6):581-588]

Cited: 2 times

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Tuberculosis Treatment Outcomes Among HIV/TB-Coinfected Children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Network.

James G Carlucci, Meridith Blevins Peratikos, Aaron M Kipp, Mary L Lindegren, Quy T Du, Lorna Renner, Gary Reubenson, John Ssali, Marcel Yotebieng, Anna M Mandalakas, Mary-Ann Davies, Marie Ballif, Lukas Fenner, April C Pettit, ,

INTRODUCTION:Management of tuberculosis (TB) is challenging in HIV/TB-coinfected children. The World Health Organization recommends nucleic acid amplification tests for TB diagnosis, a 4-drug regimen including ethambutol during intensive phase (IP) of treatment, and initiation of antiretroviral therapy (ART) within 8 weeks of TB diagnosis. We investigated TB treatment outcomes by ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2017, 75(2):156-163]

Cited: 9 times

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Trends in HIV Continuum of Care Outcomes over Ten Years of Follow-Up at a Large HIV Primary Medical Home in the Southeastern United States.

Michael K Ghiam, Peter F Rebeiro, Megan Turner, William B Rogers, Sally S Bebawy, Stephen P Raffanti, Anna K Person, April C Pettit,

Longitudinal studies of retention in care (RIC) and viral suppression (VS) in the southeastern United States (US), a region disproportionately affected by HIV infection, are lacking. HIV-infected adults with ≥1 medical visit at the Vanderbilt Comprehensive Care Clinic (Nashville, Tennessee) from 2004 to 2013 were included. RIC was ≥2 (a) ... Read more >>

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2017, 33(10):1027-1034]

Cited: 1 time

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Design and use of mouse control DNA for DNA biomarker extraction and PCR detection from urine: Application for transrenal Mycobacterium tuberculosis DNA detection.

Hali Bordelon, Keersten M Ricks, Megan E Pask, Patricia K Russ, Francesca Solinas, Mark L Baglia, Philip A Short, Andrew Nel, Jonathan Blackburn, Keertan Dheda, Carlos Zamudio, Tatiana Cáceres, David W Wright, Frederick R Haselton, April C Pettit,

Urine samples are increasingly used for diagnosing infections including Escherichia coli, Ebola virus, and Zika virus. However, extraction and concentration of nucleic acid biomarkers from urine is necessary for many molecular detection strategies such as polymerase chain reaction (PCR). Since urine samples typically have large volumes with dilute biomarker concentrations ... Read more >>

J. Microbiol. Methods (Journal of microbiological methods)
[2017, 136:65-70]

Cited: 1 time

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The 2013 HIV Continuum of Care in Tennessee: Progress Made, but Disparities Persist.

Carolyn Wester, Peter F Rebeiro, Thomas J Shavor, Bryan E Shepherd, Shanell L McGoy, Benn Daley, Melissa Morrison, Sten H Vermund, April C Pettit,

We measured patient engagement in the human immunodeficiency virus (HIV) continuum of care in Tennessee after implementation of enhanced surveillance activities to assess progress toward 2015 statewide goals. We also examined subgroup disparities to identify groups at risk for poor outcomes.We estimated linkage to care, retention in care, and viral ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2016, 131(5):695-703]

Cited: 5 times

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Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment.

April C Pettit, Adell Mendes, Cathy Jenkins, Sonia Napravnik, Aimee Freeman, Bryan E Shepherd, David Dowdy, John Gill, Anita Rachlis, Richard Moore, Timothy R Sterling, ,

BACKGROUND:Tuberculosis (TB) risk and mortality increase in the 6 months after highly active antiretroviral therapy (HAART) initiation. This short-term risk may be a consequence of HAART initiation and immune reconstitution. Alternatively, it may be due to confounding by low CD4 counts and high HIV viral loads (VLs). We assessed the ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2016, 72(5):572-578]

Cited: 3 times

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(1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections.

Anurag N Malani, Bonita Singal, L Joseph Wheat, Ola Al Sous, Theresa A Summons, Michelle M Durkin, April C Pettit,

Prompt diagnosis and treatment of fungal meningitis are critical, but culture is insensitive. (1,3)-β-d-Glucan (BDG) testing is FDA approved for serological diagnosis of invasive fungal disease; however, BDG testing is not approved for cerebrospinal fluid (CSF), and the appropriate cutoff value is unknown. We aimed to validate the diagnostic accuracy ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2015, 53(3):799-803]

Cited: 13 times

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Outbreak of fungal infections associated with contaminated methylprednisolone acetate: an update.

April C Pettit, Anurag N Malani,

In September 2012, an unprecedented outbreak of fungal infections due to preservative-free, injectable methylprednisolone acetate (MPA) was identified. Exserohilum rostratum was quickly identified as the predominant organism involved in disease cases. Prior to this outbreak, little was known about the pathogenesis, treatment, and prognosis of infections due to this unusual ... Read more >>

Curr Infect Dis Rep (Current Infectious Disease Reports)
[2015, 17(1):441]

Cited: 3 times

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Histoplasmosis Masquerading as a Rheumatoid Nodule in an Immunocompromised Host: A Case Report.

April C Pettit, Martin B Raynor, Herbert S Schwartz, Patty W Wright,

JBJS Case Connect (JBJS case connector)
[2014, 4(3):e75-e5]

Cited: 0 times

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