Full Text Journal Articles by
Author Aparna Ramachandran

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Clinical Course, Imaging Characteristics, and Therapeutic Response in Myelin Oligodendrocyte Glycoprotein Antibody Disease: A Case Series.

Joe James, James Jose, V Abdul Gafoor, B Smita, Neetha Balaram, Aparna Ramachandran,

Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a novel central nervous system autoimmune disorder which forms part of aquaporin 4 (AQP-4) negative, neuromyelitis optica (NMO) spectrum disorder. It has a distinct clinical profile, neuroimaging features and courses from AQP-4 positive NMO and multiple sclerosis. This article is a case series ... Read more >>

J Neurosci Rural Pract (Journal of neurosciences in rural practice)
[2020, 11(1):205-210]

Cited: 0 times

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Targeted sequencing of the DMD locus: A comprehensive diagnostic tool for all mutations.

Sankaramoorthy Aravind, Berty Ashley, Ashraf Mannan, Aparna Ganapathy, Keerthi Ramesh, Aparna Ramachandran, Upendra Nongthomba, Arun Shastry,

Background & objectives:Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder and is caused mainly by deletion, duplication and point mutations in the DMD gene. Diagnosis of DMD has been a challenge as the mutations in the. DMD:gene are heterogeneous and require more than one diagnostic strategy for the validation ... Read more >>

Indian J. Med. Res. (The Indian journal of medical research)
[2019, 150(3):282-289]

Cited: 0 times

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Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase.

Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S Patel, Richard H Ebright, Bryce E Nickels,

Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD+ and NADH, and ... Read more >>

Elife (eLife)
[2018, 7:]

Cited: 2 times

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Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

Jeremy Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Megerditch Kiledjian, Dmitry Temiakov, Smita Patel, Richard Ebright, Bryce Nickels,

Abstract Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD + and NADH, using NAD + and NADH as non-canonical initiating nucleotides for transcription initiation. Here, we show that mitochondrial RNAPs (mtRNAPs) cap RNA with NAD ... Read more >>

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Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases.

Shemaila Sultana, Mihai Solotchi, Aparna Ramachandran, Smita S Patel,

Single-subunit RNA polymerases (RNAPs) are present in phage T7 and in mitochondria of all eukaryotes. This RNAP class plays important roles in biotechnology and cellular energy production, but we know little about its fidelity and error rates. Herein, we report the error rates of three single-subunit RNAPs measured from the ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2017, 292(44):18145-18160]

Cited: 7 times

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Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.

Aparna Ramachandran, Urmimala Basu, Shemaila Sultana, Divya Nandakumar, Smita S Patel,

Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT and TFB2M to melt the promoter. However, we show that TFAM has 'post-recruitment' roles in promoter melting and RNA synthesis, ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2017, 45(2):861-874]

Cited: 10 times

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The Yeast Mitochondrial RNA Polymerase and Transcription Factor Complex Catalyzes Efficient Priming of DNA Synthesis on Single-stranded DNA.

Aparna Ramachandran, Divya Nandakumar, Aishwarya P Deshpande, Thomas P Lucas, Ramanagouda R-Bhojappa, Guo-Qing Tang, Kevin Raney, Y Whitney Yin, Smita S Patel,

Primases use single-stranded (ss) DNAs as templates to synthesize short oligoribonucleotide primers that initiate lagging strand DNA synthesis or reprime DNA synthesis after replication fork collapse, but the origin of this activity in the mitochondria remains unclear. Herein, we show that the Saccharomyces cerevisiae mitochondrial RNA polymerase (Rpo41) and its ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(32):16828-16839]

Cited: 3 times

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Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference.

Aparna Ramachandran, Curt M Horvath,

The V protein of the paramyxovirus subfamily Paramyxovirinae is an important virulence factor that can interfere with host innate immunity by inactivating the cytosolic pathogen recognition receptor MDA5. This interference is a result of a protein-protein interaction between the highly conserved carboxyl-terminal domain of the V protein and the helicase ... Read more >>

J. Virol. (Journal of virology)
[2010, 84(21):11152-11163]

Cited: 37 times

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STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition.

Aparna Ramachandran, Jean-Patrick Parisien, Curt M Horvath,

Measles virus, a member of the Morbillivirus family, infects millions of people each year despite the availability of effective vaccines. The V protein of measles virus is an important virulence factor that can interfere with host innate immunity by inactivating alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling through protein interactions with ... Read more >>

J. Virol. (Journal of virology)
[2008, 82(17):8330-8338]

Cited: 62 times

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Sequence-specific deoxyribonucleic acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability.

Tanya H Little, Yongbo Zhang, Christina K Matulis, Jennifer Weck, Zhipeng Zhang, Aparna Ramachandran, Kelly E Mayo, Ishwar Radhakrishnan,

Steroidogenic factor 1 (SF1) is a member of the NR5A subfamily of nuclear hormone receptors and is considered a master regulator of reproduction because it regulates a number of genes encoding reproductive hormones and enzymes involved in steroid hormone biosynthesis. Like other NR5A members, SF1 harbors a highly conserved approximately ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2006, 20(4):831-843]

Cited: 35 times

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