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Author Ao Wang

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The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.

Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li,

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis; however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was used to predict the potential upstream targets of HDAC2, and the role of miR-455-3p was explored. The dual luciferase reporter assay showed that miR-455-3p binds to the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21700]

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miR-206-G6PD axis regulates lipogenesis and cell growth in hepatocellular carcinoma cell.

Ao Wang, Bocen Chen, Shaoqin Jian, Wangwei Cai, Man Xiao, Guankui Du,

miR-206 plays an essential role in repressing the growth of multiple cancer cells. Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. However, it is mostly unknown whether G6PD is associated with miR-206-mediated growth repression of hepatocellular carcinoma (HCC) cells. In this study, we found that the ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2021, 32(5):508-516]

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mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.

Ke Li, Hongguang Wu, Ao Wang, Jean Charron, Yuji Mishina, Samy L Habib, Huijuan Liu, Baojie Li,

mTOR, the sensor of nutrients and growth factors, has important roles in tissue homeostasis and tumorigenesis. However, how mTOR controls gastric epithelial cell turnover and gastric cancer development, a leading malignancy, remains poorly understood. Here, we provide genetic evidence that mTOR activation promotes proliferation and inhibits differentiation of Lgr5<sup>+</sup> gastric ... Read more >>

Cell Rep (Cell reports)
[2021, 35(5):109069]

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How do varying socio-economic driving forces affect China's carbon emissions? New evidence from a multiscale geographically weighted regression model.

Shukui Tan, Maomao Zhang, Ao Wang, Xuesong Zhang, Tianchi Chen,

The increase in carbon emissions has had great negative impacts on the healthy developments of the human environment and economic society. However, it is unclear how specific socio-economic factors are driving carbon emissions. Based on the multiscale geographically weighted regression (MGWR) model, this paper analyzes the impact mechanism of China's ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Drought alters the carbon footprint of trees in soils-tracking the spatio-temporal fate of 13 C-labelled assimilates in the soil of an old-growth pine forest.

Decai Gao, Jobin Joseph, Roland A Werner, Ivano Brunner, Alois Zürcher, Christian Hug, Ao Wang, Chunhong Zhao, Edith Bai, Katrin Meusburger, Arthur Gessler, Frank Hagedorn,

Above and belowground compartments in ecosystems are closely coupled on daily to annual timescales. In mature forests, this interlinkage and how it is impacted by drought is still poorly understood. Here, we pulse-labelled 100-year-old trees with <sup>13</sup> CO<sub>2</sub> within a 15-year-long irrigation experiment in a naturally dry pine forest to ... Read more >>

Glob Chang Biol (Global change biology)
[2021, 27(11):2491-2506]

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The autocrine regulation of insulin-like growth factor-1 in human brain of Alzheimer's disease.

Dali Kang, Henry J Waldvogel, Ao Wang, Dawei Fan, Richard L M Faull, Maurice A Curtis, Paul R Shorten, Jian Guan,

<h4>Background</h4>Insulin-like growth factor (IGF) binding protein (IGFBP)-3 and cyclic Glycine-Proline (cGP) regulate circulating IGF-1 function that is associated with cognition. The association between IGF-1 function and Alzheimer's disease (AD) remains inconclusive. This study evaluated the changes of IGFBPs and cGP, and their effects on the bioavailability and function of IGF-1 ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2021, 127:105191]

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Metabolic profiling reveals alterations in the erythrocyte response to fava bean ingestion in G6PD‐deficient mice

Guankui Du, Man Xiao, Bochen Chen, Ao Wang, Qiwei Zhu, Wangwei Cai,

BACKGROUND: Favism is an acute hemolytic syndrome caused by fava bean (FB) ingestion. The purpose of this study was to investigate the possible influences of FB on the metabonomic profile of erythrocytes in glucose‐6‐phosphate dehydrogenase (G6PD)‐deficient (G6PDx) and wild‐type (WT) mice. RESULTS: Ninety‐two metabolites were identified in the comparison of ... Read more >>

J Sci Food Agric (Journal of the science of food and agriculture)
[2021, 101(4):1562-1571]

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Distinct genomic profile in h. pylori-associated gastric cancer.

Xiaochen Zhang, Fang Liu, Hua Bao, Ao Wang, Ming Han, Xue Wu, Yanhong Gu, Leizhen Zheng,

Gastric cancer is one of the most common and deadly cancer types. Currently, four subtypes have been identified with unique molecular alterations: Epstein-Barr virus (EBV)-positive, microsatellite instability (MSI), chromosomal instability (CIN), and genomic stable (GS) tumors. Notably, many gastric tumors are associated with the bacterium Helicobacter pylori but the genomic ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Spatio-Temporal Evolution and Driving Factors of Rural Settlements in Low Hilly Region-A Case Study of 17 Cities in Hubei Province, China.

Shukui Tan, Maomao Zhang, Ao Wang, Qianlin Ni,

With the rapid development of the social economy, factors of social and economic development in China's rural areas have been continuously reorganized, and the pattern and distribution of rural residential areas have undergone significant changes. In rural areas, there have been many peculiar phenomena of "reducing people but not reducing ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(5):]

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Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy.

Gang Wu, Bao Jiang, Lin Zhou, Ao Wang, Shaohua Wei,

Exploiting new non-metal-based peroxidase-mimic nanoenzymes for chemodynamic therapy (CDT) in cancer treatment is an active and challenging field. Here, we found that activated carbon nanoparticles (denoted as ANs) fabricated from coconut shell have satisfactory peroxidase-mimic nanoenzyme activity. Based on this positive result, gadodiamide, a clinically used nuclear magnetic imaging contrast ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2021, 9(10):2447-2456]

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Characterization of a carboxylesterase with hyper-thermostability and alkali-stability from Streptomyces lividans TK24.

Xin Chang, Shuang Wu, Jie Chen, Shengqi Xiong, Peng Wang, Xueqin Shi, Ao Wang, Baojuan Wang,

A gene (estA', 804 bp) from Streptomyces lividans TK24 was artificially synthesized and successfully overexpressed as a 6His-tagged fusion protein in Escherichia coli. It encoded a carboxylesterase (EstA) that composed of 267 amino acids with a predicted molecular weight of 28.56 kDa. Multiple sequence alignment indicated that EstA has typical characteristics of ... Read more >>

Extremophiles (Extremophiles : life under extreme conditions)
[2021, 25(2):115-128]

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Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy.

Daniel V Araujo, Ao Wang, Dax Torti, Alberto Leon, Kayla Marsh, Aoife McCarthy, Hal Berman, Anna Spreafico, Aaron R Hansen, Albiruni-Abdul Razak, Philippe L Bedard, Lisa Wang, Eric Plackmann, Helen Chow, Hua Bao, Xue Wu, Trevor J Pugh, Lillian L Siu,

<h4>Background</h4>The correlation between blood-based tumor mutation burden (bTMB) and tissue-based tumor mutation burden(tTMB) has not been broadly tested in a multicancer cohort. Here, we assess the correlation between bTMB with tTMB in phase I trial patients treated with immunotherapy. As an exploratory analysis, we evaluated circulating tumor DNA (ctDNA) dynamics ... Read more >>

JNCI Cancer Spectr (JNCI cancer spectrum)
[2021, 5(3):pkaa122]

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Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

Jie Zhang, Shijun You, Dongsheng Niu, Karla Giovana Gavilanez Guaman, Ao Wang, Hafiz Sohaib Ahmed Saqib, Weiyi He, Yuan Yu, Guang Yang, Gabor Pozsgai, Minsheng You,

<h4>ABSTRACT</h4> <h4>Background</h4> Conservation biological control provides an environment-friendly approach to improve the efficacy of natural enemies. Although numerous studies have demonstrated the potential of semi-natural habitats in promoting biological control in organic or unsprayed agroecosystems, few studies were conducted in conventional agricultural fields. In this study, we investigated the effects ... Read more >>

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ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.

Ye Yuan, Gege Yan, Mingyu He, Hong Lei, Linqiang Li, Yang Wang, Xiaoqi He, Guanghui Li, Quan Wang, Yuelin Gao, Zhezhe Qu, Zhongting Mei, Zhihua Shen, Jiaying Pu, Ao Wang, Wei Zhao, Huiwei Jiang, Weijie Du, Lei Yang,

ALKBH5 is the main enzyme for m<sup>6</sup>A-based demethylation of RNAs and it has been implicated in many biological and pathophysiological processes. Here, we aimed to explore the potential involvement of ALKBH5 in osteosarcoma and decipher the underlying cellular/molecular mechanisms. We discovered downregulated levels of demethylase ALKBH5 were correlated with increased ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(1):60]

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Mercury accumulation in vegetable Houttuynia cordata Thunb. from two different geological areas in southwest China and implications for human consumption.

Qingfeng Wang, Zhonggen Li, Xinbin Feng, Ao Wang, Xinyu Li, Dan Wang, Leilei Fan,

Houttuynia cordata Thunb. (HCT) is a common vegetable native to southwest China, and grown for consumption. The results suggested that THg contents in all parts and MeHg in underground parts of HCT in Hg mining areas were much higher than those in non-Hg mining areas. The highest THg and MeHg content of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):52]

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Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis.

Fang-Tian Bu, Yan Zhu, Xin Chen, Ao Wang, Ya-Fei Zhang, Hong-Mei You, Yang Yang, Ya-Ru Yang, Cheng Huang, Jun Li,

Recently, circular RNAs (circRNAs) have been frequently reported to be involved in hepatocellular carcinoma (HCC) development and progression. However, the role of circRNAs in hepatic fibrosis (HF) is still unclear. Our previous high-throughput screen revealed changes in many circRNAs in mice with carbon tetrachloride (CCl<sub>4</sub>)-induced HF. For instance, the expression ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2021, 23:847-862]

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Effects of soil moisture, needle age and leaf morphology on carbon and oxygen uptake, incorporation and allocation: a dual labeling approach with 13CO2 and H218O in foliage of a coniferous forest.

Ao Wang, Rolf T W Siegwolf, Jobin Joseph, Frank M Thomas, Willy Werner, Arthur Gessler, Andreas Rigling, Marcus Schaub, Matthias Saurer, Mai-He Li, Marco M Lehmann,

The carbon and oxygen isotopic composition of water and assimilates in plants reveals valuable information on plant responses to climatic conditions. Yet, the carbon and oxygen uptake, incorporation and allocation processes determining isotopic compositions are not fully understood. We carried out a dual-isotope labeling experiment at high humidity with 18O-enriched ... Read more >>

Tree Physiol (Tree physiology)
[2021, 41(1):50-62]

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Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.

Adam Kositzke, Dacheng Fan, Ao Wang, Hao Li, Matthew Worth, Jiaoyang Jiang,

The essential human O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme responsible for modifying thousands of intracellular proteins with the monosaccharide O-GlcNAc. This unique modification plays crucial roles in human health and disease, but the substrate recognition of OGT remains poorly understood. Intriguingly, the only human enzyme reported to ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 169:51-59]

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Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer.

Ao Wang, Yawan Wang, Xin Meng, Yushe Yang,

Prostate cancer (PC) is the most common malignancy in men worldwide. Here, two series of novel thiohydantoin derivatives of enzalutamide as potent androgen receptor (AR) antagonists were designed and synthesized. Among them, compound 31c was identified as an AR antagonist which is 2.3-fold more potent than enzalutamide. Molecular docking studies ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2021, 31:115953]

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Increased Expression of LYNX1 in Ovarian Serous Cystadenocarcinoma Predicts Poor Prognosis.

Hui Liu, Ao Wang, Yushan Ma,

Few studies have reported the function of LYNX1 in ovarian cancer. We retrieved LYNX1 gene expression data and clinical information of 376 patients with ovarian cancer from The Cancer Genome Atlas (TCGA) project website. Wilcoxon signed-rank test and logistic regression were used to analyze the relationship between clinical pathologic features ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:1392674]

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Prediction of COVID-19 Patients at High Risk of Progression to Severe Disease.

Zhenyu Dai, Dong Zeng, Dawei Cui, Dawei Wang, Yanling Feng, Yuhan Shi, Liangping Zhao, Jingjing Xu, Wenjuan Guo, Yuexiang Yang, Xinguo Zhao, Duoduo Li, Ye Zheng, Ao Wang, Minmin Wu, Shu Song, Hongzhou Lu,

In order to develop a novel scoring model for the prediction of coronavirus disease-19 (COVID-19) patients at high risk of severe disease, we retrospectively studied 419 patients from five hospitals in Shanghai, Hubei, and Jiangsu Provinces from January 22 to March 30, 2020. Multivariate Cox regression and orthogonal projections to ... Read more >>

Front Public Health (Frontiers in public health)
[2020, 8:574915]

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Alterations of circulating bacterial DNA in colorectal cancer and adenoma: A proof-of-concept study.

Qian Xiao, Wei Lu, Xiangxing Kong, Yang W Shao, Yeting Hu, Ao Wang, Hua Bao, Ran Cao, Kaihua Liu, Xiaonan Wang, Xue Wu, Shu Zheng, Ying Yuan, Kefeng Ding,

The gut microbiota is closely associated with colorectal neoplasia. While most metagenomics studies utilized fecal samples, circulating bacterial DNA in colorectal neoplasia patients remained unexplored. This proof-of-concept study aims to characterize alterations of circulating bacterial DNA in colorectal neoplasia patients. We performed WGS of plasma samples from 25 colorectal cancer ... Read more >>

Cancer Lett (Cancer letters)
[2021, 499:201-208]

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Increased peripheral helper T cells type 17 subset correlates with the severity of psoriasis vulgaris.

Wenjing Liu, Xuefeng Zhou, Ao Wang, Jie Ma, Yanping Bai,

Recently, a new subgroup of T cells, named peripheral helper T (Tph) cells, has been implicated in autoimmune pathogenesis. An imbalance of Tph cell subsets influences the severity of immune-related diseases. However, the characteristics and roles of Tph cell subsets in psoriasis remain unknown. Programmed cell death 1-positive, chemokine C-X-C ... Read more >>

Immunol Lett (Immunology letters)
[2021, 229:48-54]

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LncRNA NEAT1: Shedding light on mechanisms and opportunities in liver diseases.

Fang-Tian Bu, Ao Wang, Yan Zhu, Hong-Mei You, Ya-Fei Zhang, Xiao-Ming Meng, Cheng Huang, Jun Li,

With advances in genome and transcriptome research technology, the function and mechanism of lncRNAs in physiological and pathological states have been gradually revealed. Nuclear Enriched Abundant Transcript 1 (NEAT1, a long non-coding RNA), a vital component of paraspeckles, plays an indispensable role in the formation and integrity of paraspeckles. Throughout ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(11):2612-2626]

Cited: 2 times

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Role of microRNAs in Hepatic Stellate Cells and Hepatic Fibrosis: an Update.

Sai Zhu, Xin Chen, Yu Chen, Xiao-Feng Li, Si-Yu Chen, Juan-Juan Li, Ao Wang, Cheng Huang, Jun Li,

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targets genes by binding to the 3'-untranslated regions. They play vital roles in diverse biological processes, including the development of hepatic fibrosis (HF). HF is characterized by the accumulation of extracellular matrix (ECM) and hepatic stellate cells (HSCs) ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2020, :]

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