Full Text Journal Articles by
Author Anu Soininen


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Persistence of Hepatitis B Immune Memory Until 6 Years of Age Following Hexavalent DTaP-IPV-HB-PRP~T Vaccination in a 3-, 5- and 11- to 12-month Schedule and Response to a Subsequent Hepatitis B Challenge Vaccination.

Miia Virta, Anu Soininen, Dhaval M Patel, Céline Petit, Cynthia Tabar, Olga Lyabis,

Anti-hepatitis B (HBs) antibody persistence and hepatitis B challenge were evaluated at 6 years of age following vaccination of fully liquid DTaP-IPV-HB-PRP~T or reconstituted DTaP-IPV-HB//PRP~T at 3, 5, 11-12 months of age. At 6 years, 53.8% and 73.5% had seroprotective anti-HBs antibodies (≥10 mIU/mL), increasing to 96.7% and 95.9% postchallenge, ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e28-e30]

Cited: 0 times

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Effectiveness of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media-A Double-Blind Randomized Clinical Trial in Finland.

Timo Vesikari, Aino Forsten, Ilkka Seppä, Tarja Kaijalainen, Taneli Puumalainen, Anu Soininen, Magali Traskine, Patricia Lommel, Sonia Schoonbroodt, Marjan Hezareh, Marta Moreira, Dorota Borys, Lode Schuerman,

<h4>Unlabelled</h4>After administering the 10-valent pneumococcal polysaccharide nontypeable Haemophilus influenzae protein D-conjugated vaccine (PHiD-CV) to children aged 2-18 months, we observed a reduction in vaccine-type nasopharyngeal carriage, resulting in a reduction of overall pneumococcal nasopharyngeal carriage, which may be important for indirect vaccine effects. We noted a trend toward reduction of ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2016, 5(3):237-248]

Cited: 33 times

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Disease mapping for informing targeted health interventions: childhood pneumonia in Bohol, Philippines.

Deborah S K Thomas, Peter Anthamatten, Elisabeth Dowling Root, Marilla Lucero, Hanna Nohynek, Veronica Tallo, Gail M Williams, Eric A F Simões, ,

<h4>Background</h4>Acute lower respiratory tract infections (ALRI) are the leading cause of childhood mortality worldwide. Currently, most developing countries assign resources at a district level, and yet District Medical Officers have few tools for directing targeted interventions to high mortality or morbidity areas. Mapping of ALRI at the local level can ... Read more >>

Trop Med Int Health (Tropical medicine & international health : TM & IH)
[2015, 20(11):1525-1533]

Cited: 3 times

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Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination.

Merja Väkeväinen, Anu Soininen, Marilla Lucero, Hanna Nohynek, Kari Auranen, P Helena Mäkelä, Gail Williams, Helena Käyhty, ,

<h4>Objective</h4>To determine whether pneumococcal carriage at the time of 11-valent pneumococcal conjugate vaccine (PCV-11) administration interferes with immune response in infants.<h4>Study design</h4>A total of 1111 Filipino infants recruited into an immunogenicity and carriage study, nested in an efficacy trial, received PCV-11 or saline solution placebo at 6, 10, and 14 ... Read more >>

J Pediatr (The Journal of pediatrics)
[2010, 157(5):778-83.e1]

Cited: 36 times

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Efficacy of an 11-valent pneumococcal conjugate vaccine against radiologically confirmed pneumonia among children less than 2 years of age in the Philippines: a randomized, double-blind, placebo-controlled trial.

Marilla G Lucero, Hanna Nohynek, Gail Williams, Veronica Tallo, Eric A F Simões, Socorro Lupisan, Diozele Sanvictores, Simon Forsyth, Taneli Puumalainen, Juanita Ugpo, Marites Lechago, Margaret de Campo, Erma Abucejo-Ladesma, Lydia Sombrero, Antti Nissinen, Anu Soininen, Petri Ruutu, Ian Riley, Helen P Mäkelä,

<h4>Background</h4>Pneumococcus is a leading cause of childhood pneumonia worldwide. Pneumococcal conjugate vaccines (PCV) have demonstrated efficacy against childhood invasive pneumococcal disease (IPD) and pneumonia in the United States and Africa. No information is available from Asia on the impact of PCV on childhood pneumonia.<h4>Methods</h4>We conducted a randomized, placebo-controlled, double-blind trial ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2009, 28(6):455-462]

Cited: 75 times

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IgG antibody concentrations after immunization with 11-valent mixed-carrier pneumococcal conjugate vaccine in efficacy trial against pneumonia among Filipino infants.

Anu Soininen, Hanna Nohynek, Marilla Lucero, Kaisa Jousimies, Juanita Ugpo, Gail Williams, Helena Käyhty, ,

<h4>Background</h4>Pneumococcal pneumonia is a major cause of morbidity and mortality worldwide. Efficacy of pneumococcal conjugate vaccines (PCV) in reducing childhood pneumonia has been estimated in four double-blind, randomized, controlled trials. An investigational 11-valent pneumococcal conjugate vaccine (11PCV) had an efficacy of 22.9% against radiologically defined pneumonia during first 2 years ... Read more >>

Vaccine (Vaccine)
[2009, 27(20):2680-2688]

Cited: 2 times

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Long-term immunogenicity and efficacy of a 9-valent conjugate pneumococcal vaccine in human immunodeficient virus infected and non-infected children in the absence of a booster dose of vaccine.

Shabir A Madhi, Peter Adrian, Locadiah Kuwanda, Wasilla Jassat, Stephanie Jones, Tessa Little, Anu Soininen, Clare Cutland, Keith P Klugman,

The long-term immunogenicity and vaccine efficacy (VE) of a 9-valent conjugate pneumococcal vaccine was studied in HIV infected and HIV non-infected children. VE against vaccine-serotype invasive pneumococcal disease following 6.16 years of follow-up persisted in HIV non-infected children (77.8%; 95% CI 34.4-92.5 compared to 83% after 2.3 years of follow-up), ... Read more >>

Vaccine (Vaccine)
[2007, 25(13):2451-2457]

Cited: 69 times

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Response and persistence of antibodies to PRP-T and DTwP vaccines with concomitant administration of conjugate vaccines.

Arnaldo F Ocampo, Christel Biltoft, Marilla Lucero, Rose-Marie Olander, Juanita Ugpo, Kari Auranen, Anu Soininen, Hanna Nohynek, Helena Käyhty,

We first studied the immunogenicity of PRP-T and DTwP vaccines in Filipino infants given at 6, 10 and 14 weeks concomitantly with either an aluminum adjuvanted eleven-valent pneumococcal conjugate vaccine (11PncTD) or a meningococcal diphtheria-conjugated vaccine as compared to a control group that received only DTwP/PRP-T. The GMCs and proportions ... Read more >>

Vaccine (Vaccine)
[2007, 25(4):605-611]

Cited: 1 time

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Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study.

David Goldblatt, Mahein Hussain, Nick Andrews, Lindsey Ashton, Camilla Virta, Alessia Melegaro, Richard Pebody, Robert George, Anu Soininen, John Edmunds, Nigel Gay, Helena Kayhty, Elizabeth Miller,

<h4>Background</h4>Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques.<h4>Methods</h4>We enrolled 121 families with young children into this study. Nasopharyngeal (NP) swabs ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2005, 192(3):387-393]

Cited: 132 times

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Antibody response to pneumococcal capsular polysaccharides in children with acute otitis media.

Anu Soininen, Mika Lahdenkari, Terhi Kilpi, Pirjo Helena Mäkelä, Helena Käyhty,

<h4>Background</h4>To describe the antibody response to pneumococcal capsular polysaccharides in children <2 years of age with pneumococcal acute otitis media (AOM) caused by serotypes 6A, 6B, 11A, 14, 19F or 23F. These serotypes were commonly found in both nasopharyngeal carriage and AOM in children of the study population in Finland.<h4>Methods</h4>Serum ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2002, 21(3):186-192]

Cited: 7 times

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Specificities and opsonophagocytic activities of antibodies to pneumococcal capsular polysaccharides in sera of unimmunized young children.

Anu Soininen, Maijastiina Karpala, Sirkka-Liisa Wahlman, Hannele Lehtonen, Helena Käyhty,

An enzyme immunoassay (EIA) for antibodies to pneumococcal capsular polysaccharides (Pnc PSs) detects in some cases antibodies that are cross-reactive within different Pnc PSs. Recently, it has been suggested that for detection of only serotype-specific antibodies, EIA can be modified by removing cross-reactive antibodies by absorption with an irrelevant PS, ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[2002, 9(5):1032-1038]

Cited: 17 times

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Are the enzyme immunoassays for antibodies to pneumococcal capsular polysaccharides serotype specific?

A Soininen, G van den Dobbelsteen, L Oomen, H Käyhty,

The specificity of antibody binding to pneumococcal capsular polysaccharides (Pnc PSs) measured by enzyme immunoassay (EIA) was studied by inhibition of antibody binding by homologous and heterologous PSs. We found extensive cross-reactivity of antibody binding to type 6B, 19F, and 23F PSs but not to type 14 PS, even after ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[2000, 7(3):468-476]

Cited: 28 times

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Assignment of immunoglobulin G1 and G2 concentrations to pneumococcal capsular polysaccharides 3, 6B, 14, 19F, and 23F in pneumococcal reference serum 89-SF.

A Soininen, I Seppälä, T Wuorimaa, H Käyhty,

We describe standardization of an enzyme-linked immunosorbent assay (ELISA) for measuring immunoglobulin G1 (IgG1) and IgG2 concentrations of antibodies to pneumococcal capsular polysaccharide (Pnc PS). The ELISA uses a human pneumococcal reference serum pool, lot 89-SF, as a reference. IgG1 and IgG2 concentrations were assigned to antibodies to Pnc PS ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[1998, 5(4):561-566]

Cited: 11 times

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