Full Text Journal Articles by
Author Antonio Suglia

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

Cited: 0 times

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Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells.

Teresa Chioccarelli, Marina Migliaccio, Antonio Suglia, Francesco Manfrevola, Veronica Porreca, Nadia Diano, Sonia Errico, Silvia Fasano, Gilda Cobellis,

The objective of this work has been to characterize the estrogenic activity of bisphenol-A (BPA) and the adverse effects on the endocannabinoid system (ECS) in modulating germ cell progression. Male offspring exposed to BPA during the foetal-perinatal period at doses below the no-observed-adverse-effect-level were used to investigate the exposure effects ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.

Louis Legoff, Ouzna Dali, Shereen Cynthia D'Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner, Fatima Smagulova,

Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a carcinogenic compound with reproductive and developmental toxicity and is a recognized endocrine-disrupting chemical. In this ... Read more >>

Epigenetics Chromatin (Epigenetics & chromatin)
[2019, 12(1):29]

Cited: 2 times

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Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave.

Marina Migliaccio, Giulia Ricci, Antonio Suglia, Francesco Manfrevola, Ken Mackie, Silvia Fasano, Riccardo Pierantoni, Teresa Chioccarelli, Gilda Cobellis,

Endocannabinoids are lipid mediators, enzymatically synthesized and hydrolyzed, that bind cannabinoid receptors. Together with their receptors and metabolic enzymes, they form the "endocannabinoid system" (ECS). Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are the main endocannabinoids studied in testis. In this study, using the first wave of spermatogenesis as an in vivo ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2018, 9:269]

Cited: 8 times

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Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice.

Antonio Suglia, Rosanna Chianese, Marina Migliaccio, Concetta Ambrosino, Silvia Fasano, Riccardo Pierantoni, Gilda Cobellis, Teresa Chioccarelli,

Bisphenol A is an environment-polluting industrial chemical able to interfere with the endocrine system. An obesogenic effect in perinatally exposed rodents has been described as estrogenic activity. We exposed male mice to Bisphenol A during fetal-perinatal period (from 10 days post coitum to 31 days post partum) and investigated the ... Read more >>

Pharmacol Res (Pharmacological research)
[2016, 113(Pt A):376-383]

Cited: 10 times

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