Full Text Journal Articles by
Author Antonio Ruggiero

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The AIEOP 2nd series of children and adolescents intracranial Ependymoma. An integrated molecular and clinical characterization with a long-term follow-up.

Maura Massimino, Francesco Barretta, Piergiorgio Modena, Hendrik Witt, Simone Minasi, Stefan M Pfister, Kristian W Pajtler, Manila Antonelli, Lorenza Gandola, Maria Luisa Garrè, Daniele Bertin, Angela Mastronuzzi, Maurizio Mascarin, Lucia Quaglietta, Elisabetta Viscardi, Iacopo Sardi, Antonio Ruggiero, Bianca Pollo, Annamaria Buccoliero, Luna Boschetti, Elisabetta Schiavello, Luisa Chiapparini, Alessandra Erbetta, Isabella Morra, Marco Gessi, Vittoria Donofrio, Carlo Patriarca, Felice Giangaspero, Pascal Johann, Francesca Romana Buttarelli,

BACKGROUND:A prospective 2002-2014 study stratified 160 patients by resection extent and histological grade, reporting results in 2016. We reanalyzed the series after a median 119 months, adding retrospectively patients' molecular features. METHODS:Follow-up of all patients was updated. DNA copy-number analysis and gene-fusion detection could be completed for 94/160 patients, methylation ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, :]

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A New Personalised Telehealth Model in Chronic Pediatric Diseases and Disability During The COVID-19 ERA

Eugenio Mercuri, Giuseppe Zampino, Alisha Morsella, Marika Pane, Roberta Onesimo, Carmen Angioletti, Piero Valentini, Claudia Rendeli, Antonio Ruggiero, Lorenzo Nanni, Antonio Chiaretti, Giovanni Vento, David Korn, Emilio Meneschincheri, Paolo Sergi, Giovanni Scambia, Walter Ricciardi, Andrea Cambieri, Antonio Giulio De Belvis,

Abstract Background : Suspending ordinary care activities during the COVID-19 pandemic made it necessary to find alternative routes to comply with care recommendations not only for acute health needs but also for patients requiring follow-up and multidisciplinary visits. We present the ‘Contactless’ model, a comprehensive operational tool including a plurality ... Read more >>

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Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.

Alba Rubio-San-Simón, Nicolas André, Maria Giuseppina Cefalo, Isabelle Aerts, Alicia Castañeda, Sarah Benezech, Guy Makin, Natasha van Eijkelenburg, Karsten Nysom, Lynley Marshall, Marion Gambart, Raquel Hladun, Claudia Rossig, Luca Bergamaschi, Franca Fagioli, Ben Carpenter, Stephane Ducassou, Cormac Owens, Ingrid Øra, Antonio Juan Ribelles, Bram De Wilde, Pilar Guerra-García, Marion Strullu, Carmelo Rizzari, Torben Ek, Simone Hettmer, Nicolas U Gerber, Christine Rawlings, Manuel Diezi, Sauli Palmu, Antonio Ruggiero, Jaime Verdú, Teresa de Rojas, Gilles Vassal, Birgit Geoerger, Lucas Moreno, Francisco Bautista,

INTRODUCTION:Data regarding real-world impact on cancer clinical research during COVID-19 are scarce. We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I-II trials in Europe through the experience of the Innovative Therapies for Children with Cancer (ITCC). METHODS:A survey was sent to all ITCC-accredited ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 141:82-91]

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Cisplatin-induced nephrotoxicity in children: what is the best protective strategy?

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà,

INTRODUCTION:Platinum compounds, which are considerably effective for the treatment of childhood malignancies, have significantly contributed to the increase in long-term survival of children with cancer. Unfortunately, children receiving cisplatin-based chemotherapy have been known to be at risk for severe disabling adverse effects, such as nephrotoxicity. METHODS:A literature research of the ... Read more >>

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2020, :1078155220961550]

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Bone and Soft Tissue Sarcoma.

Antonio Ruggiero,

Bone and soft-tissue sarcomas are relatively rare tumors both in children and adults [...]. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective.

Maria Grazia Perrone, Antonio Ruggiero, Antonella Centonze, Antonio Carrieri, Savina Ferorelli, Antonio Scilimati,

Diffuse intrinsic pontine glioma (DIPG) mainly affects children with a median age of 6-7 years old. It accounts for 10% of all pediatric tumors. Unfortunately, DIPG has a poor prognosis, and the median survival is generally less than 16-24 months independently from the treatment received. Up to now, children with ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2020, :]

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CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models.

Roberta Antonelli, Carlos Jiménez, Misha Riley, Tiziana Servidei, Riccardo Riccardi, Aroa Soriano, Josep Roma, Elena Martínez-Saez, Maurizio Martini, Antonio Ruggiero, Lucas Moreno, Josep Sánchez de Toledo, Soledad Gallego, Jordi Bové, Jacob M Hooker, Miguel F Segura,

Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of cases develop in the posterior fossa and can be classified into two distinct molecular entities: EPN posterior fossa A (PF-EPN-A) and EPN posterior fossa B ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(7):]

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Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure.

Christian Siebel, Gudrun Würthwein, Claudia Lanvers-Kaminsky, Nicolas André, Frank Berthold, Ilaria Castelli, Pascal Chastagner, François Doz, Martin English, Gabriele Escherich, Michael C Frühwald, Norbert Graf, Andreas H Groll, Antonio Ruggiero, Georg Hempel, Joachim Boos,

BACKGROUND:Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for infants and younger children is required but is hampered by scarcely ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):37]

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Data acquired by wearable sensors for the evaluation of the flexion-relaxation phenomenon.

Michele Paoletti, Alberto Belli, Lorenzo Palma, Michele Paniccia, Francesca Tombolini, Antonio Ruggiero, Massimo Vallasciani, Paola Pierleoni,

The relationship between flexibility and the pattern formed by the surface electromyography activity of the back muscles while performing a dynamic trunk flexion-extension task is not yet thoroughly understood, although many previous studies have adopted it as their focus in the literature. Additionally, several studies have proposed technologies and algorithms ... Read more >>

Data Brief (Data in brief)
[2020, 31:105957]

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Diagnosis of COVID-19 infection in children: Less nasopharyngeal swabs, more saliva.

Antonio Ruggiero, Maurizio Sanguinetti, Antonio Gatto, Giorgio Attinà, Antonio Chiaretti,

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(9):1913-1914]

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Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer.

Alberto Romano, Michele Antonio Capozza, Stefano Mastrangelo, Palma Maurizi, Silvia Triarico, Rolando Rolesi, Giorgio Attinà, Anna Rita Fetoni, Antonio Ruggiero,

Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric patients, but they also cause some toxic effects: ototoxicity, myelosuppression, nephrotoxicity, and ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

Christian Siebel, Gudrun Würthwein, Claudia Lanvers-Kaminsky, Nicolas André, Frank Berthold, Ilaria Castelli, Pascal Chastagner, François Doz, Martin English, Gabriele Escherich, Michael Frühwald, Norbert Graf, Andreas Groll, Antonio Ruggiero, Georg Hempel, Joachim Boos,

Abstract Background: Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for infants and younger children is required but is hampered ... Read more >>

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Phase II results from a phase I/II study to assess the safety and efficacy of weekly nab-paclitaxel in paediatric patients with recurrent or refractory solid tumours: A collaboration with the European Innovative Therapies for Children with Cancer Network.

Loredana Amoroso, Victoria Castel, Gianni Bisogno, Michela Casanova, Catalina Marquez-Vega, Julia C Chisholm, François Doz, Lucas Moreno, Antonio Ruggiero, Nicolas U Gerber, Franca Fagioli, Pooja Hingorani, Soledad G Melcón, Ruta Slepetis, Nianhang Chen, Yvan le Bruchec, Mathew Simcock, Gilles Vassal,

BACKGROUND:The phase I component of a phase I/II study defined the recommended phase II dose and established the tolerability of nab-paclitaxel monotherapy in paediatric patients with recurrent or refractory solid tumours. The activity and safety of nab-paclitaxel monotherapy was further investigated in this phase II study. PATIENTS AND METHODS:Paediatric patients ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 135:89-97]

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Additional hypotheses about why COVID-19 is milder in children than adults.

Antonio Ruggiero, Giorgio Attinà, Antonio Chiaretti,

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(8):1690]

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Temozolomide and oral etoposide in children with recurrent malignant brain tumors.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà,

Despite advances in the treatment of brain tumors, the prognosis of children with recurrent malignant brain tumors remains poor. Etoposide (VP-16), an inhibitor of nuclear enzyme deoxyribonucleic acid (DNA)-topoisomerase II, has shown activity in brain tumors. Its efficacy appears schedule dependent but, to date, the most effective schedule of administration ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Facing the COVID-19 outbreak in children with cancer.

Antonio Ruggiero, Alberto Romano, Giorgio Attinà,

Europe is now the epicenter of the COVID-19 outbreak. Many concerns have arisen about the management and treatment of children with cancer while researchers are wondering how to deal with this devastating pandemic. In view of the epidemiological and clinical characteristics of the COVID-19 outbreak, it is fundamental to stress ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Covid-19 and children with cancer: are they at increased risk of infection?

Antonio Ruggiero, Alberto Romano, Giorgio Attinà,

Pediatr Res (Pediatric research)
[2020, :]

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Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management.

Antonio Ruggiero, Palma Maurizi, Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà,

Infantile haemangiomas (IHs) are the most common benign tumours of childhood; despite the benign histology, prognosis depends on severity of visceral involvement, with a mortality rate ranging from 50 to 90%. In this paper, we describe two infants with multifocal infantile haemangiomatosis and hepatic involvement. This condition should receive appropriate ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Gynecological cancer among adolescents and young adults (AYA).

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Adolescents and young adults (AYA) patients with cancer show specific biological, sociodemographic and behavioral features, with lower survival rates than younger group. Gynecologic malignancies that occur among AYA requires a multidisciplinary management and a tailored model of care, in order to enhance the early diagnosis, the adherence to the treatment, ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(6):397]

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Use of Eltrombopag in Children With Chronic Immune Thrombocytopenia (ITP): A Real Life Retrospective Multicenter Experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).

Paola Giordano, Giuseppe Lassandro, Angelica Barone, Simone Cesaro, Ilaria Fotzi, Fiorina Giona, Saverio Ladogana, Maurizio Miano, Antonio Marzollo, Margherita Nardi, Lucia Dora Notarangelo, Andrea Pession, Antonio Ruggiero, Giovanna Russo, Paola Saracco, Marco Spinelli, Alessandra Tolva, Assunta Tornesello, Valentina Palladino, Giovanni Carlo Del Vecchio,

Background: The thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of the present study was to characterize eltrombopag use in current clinical practice. Material and Methods: This is a retrospective multicenter study conducted in 17 centers affiliated ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:66]

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Neonatal pharmacology and clinical implications.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Pietro Ferrara, Giorgio Attinà,

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the ... Read more >>

(Drugs in context)
[2019, 8:212608]

Cited: 1 time

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Prognostic role of pleural effusion or ascites in localized rhabdomyosarcoma.

Daniela Di Carlo, Andrea Ferrari, Tiziana Toffolutti, Giuseppe Maria Milano, Carla Manzitti, Antonio Ruggiero, Patrizia Dall'Igna, Fraia Melchionda, Ilaria Zanetti, Giovanni Scarzello, Gianni Bisogno,

PURPOSE:The presence of pleural effusion or ascites at the time of diagnosis is generally considered a poor prognostic factor for children with rhabdomyosarcoma (RMS), and treatment is usually intensified despite the fact that there are no published studies to support this decision. We investigated the prognostic role of the presence ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(11):e27932]

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Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors.

Silvia Triarico, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Michele Antonio Capozza, Antonio Ruggiero,

The central nervous system (CNS) may be considered as a sanctuary site, protected from systemic chemotherapy by the meninges, the cerebrospinal fluid (CSF) and the blood-brain barrier (BBB). Consequently, parenchymal and CSF exposure of most antineoplastic agents following intravenous (IV) administration is lower than systemic exposure. In this review, we ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(6):]

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Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies.

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Opioids are essential for the treatment of pain, which is a serious symptom for children and adolescents affected by cancer. Intranasal opioids may be very useful for the treatment of breakthrough pain in children and adolescents with cancer, for their little invasiveness, ease of administration, rapid onset of action, and ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2019, 27(10):3639-3645]

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Relapsed papillary urothelial neoplasm of low malignant potential (PUNLMP) of the young age: a case report and a review of the literature.

Palma Maurizi, Michele Antonio Capozza, Silvia Triarico, Maria Luisa Perrotta, Vito Briganti, Antonio Ruggiero,

BACKGROUND:Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) are exceptionally rare in the first decade of life (mostly if multifocal) and there is a lack of standardized recommendations for the pediatric age. CASE PRESENTATION:We describe the case of a 9-year-old boy with a diagnosis of PUNLMP, who underwent to cystoscopic ... Read more >>

BMC Urol (BMC urology)
[2019, 19(1):36]

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