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Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer.

Alberto Romano, Michele Antonio Capozza, Stefano Mastrangelo, Palma Maurizi, Silvia Triarico, Rolando Rolesi, Giorgio Attinà, Anna Rita Fetoni, Antonio Ruggiero,

Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric patients, but they also cause some toxic effects: ototoxicity, myelosuppression, nephrotoxicity, and ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

Christian Siebel, Gudrun Würthwein, Claudia Lanvers-Kaminsky, Nicolas André, Frank Berthold, Ilaria Castelli, Pascal Chastagner, François Doz, Martin English, Gabriele Escherich, Michael Frühwald, Norbert Graf, Andreas Groll, Antonio Ruggiero, Georg Hempel, Joachim Boos,

Abstract Background: Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for infants and younger children is required but is hampered ... Read more >>

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Facing the COVID-19 outbreak in children with cancer.

Antonio Ruggiero, Alberto Romano, Giorgio Attinà,

Europe is now the epicenter of the COVID-19 outbreak. Many concerns have arisen about the management and treatment of children with cancer while researchers are wondering how to deal with this devastating pandemic. In view of the epidemiological and clinical characteristics of the COVID-19 outbreak, it is fundamental to stress ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Additional hypotheses about why COVID-19 is milder in children than adults.

Antonio Ruggiero, Giorgio Attinà, Antonio Chiaretti,

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Covid-19 and children with cancer: are they at increased risk of infection?

Antonio Ruggiero, Alberto Romano, Giorgio Attinà,

Pediatr. Res. (Pediatric research)
[2020, :]

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Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management.

Antonio Ruggiero, Palma Maurizi, Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà,

Infantile haemangiomas (IHs) are the most common benign tumours of childhood; despite the benign histology, prognosis depends on severity of visceral involvement, with a mortality rate ranging from 50 to 90%. In this paper, we describe two infants with multifocal infantile haemangiomatosis and hepatic involvement. This condition should receive appropriate ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Gynecological cancer among adolescents and young adults (AYA).

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Adolescents and young adults (AYA) patients with cancer show specific biological, sociodemographic and behavioral features, with lower survival rates than younger group. Gynecologic malignancies that occur among AYA requires a multidisciplinary management and a tailored model of care, in order to enhance the early diagnosis, the adherence to the treatment, ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(6):397]

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Use of Eltrombopag in Children With Chronic Immune Thrombocytopenia (ITP): A Real Life Retrospective Multicenter Experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).

Paola Giordano, Giuseppe Lassandro, Angelica Barone, Simone Cesaro, Ilaria Fotzi, Fiorina Giona, Saverio Ladogana, Maurizio Miano, Antonio Marzollo, Margherita Nardi, Lucia Dora Notarangelo, Andrea Pession, Antonio Ruggiero, Giovanna Russo, Paola Saracco, Marco Spinelli, Alessandra Tolva, Assunta Tornesello, Valentina Palladino, Giovanni Carlo Del Vecchio,

Background: The thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of the present study was to characterize eltrombopag use in current clinical practice. Material and Methods: This is a retrospective multicenter study conducted in 17 centers affiliated ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:66]

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Neonatal pharmacology and clinical implications.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Pietro Ferrara, Giorgio Attinà,

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212608]

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Prognostic role of pleural effusion or ascites in localized rhabdomyosarcoma.

Daniela Di Carlo, Andrea Ferrari, Tiziana Toffolutti, Giuseppe Maria Milano, Carla Manzitti, Antonio Ruggiero, Patrizia Dall'Igna, Fraia Melchionda, Ilaria Zanetti, Giovanni Scarzello, Gianni Bisogno,

PURPOSE:The presence of pleural effusion or ascites at the time of diagnosis is generally considered a poor prognostic factor for children with rhabdomyosarcoma (RMS), and treatment is usually intensified despite the fact that there are no published studies to support this decision. We investigated the prognostic role of the presence ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(11):e27932]

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Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors.

Silvia Triarico, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Michele Antonio Capozza, Antonio Ruggiero,

The central nervous system (CNS) may be considered as a sanctuary site, protected from systemic chemotherapy by the meninges, the cerebrospinal fluid (CSF) and the blood-brain barrier (BBB). Consequently, parenchymal and CSF exposure of most antineoplastic agents following intravenous (IV) administration is lower than systemic exposure. In this review, we ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(6):]

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Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies.

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Opioids are essential for the treatment of pain, which is a serious symptom for children and adolescents affected by cancer. Intranasal opioids may be very useful for the treatment of breakthrough pain in children and adolescents with cancer, for their little invasiveness, ease of administration, rapid onset of action, and ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2019, 27(10):3639-3645]

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Relapsed papillary urothelial neoplasm of low malignant potential (PUNLMP) of the young age: a case report and a review of the literature.

Palma Maurizi, Michele Antonio Capozza, Silvia Triarico, Maria Luisa Perrotta, Vito Briganti, Antonio Ruggiero,

BACKGROUND:Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) are exceptionally rare in the first decade of life (mostly if multifocal) and there is a lack of standardized recommendations for the pediatric age. CASE PRESENTATION:We describe the case of a 9-year-old boy with a diagnosis of PUNLMP, who underwent to cystoscopic ... Read more >>

BMC Urol (BMC urology)
[2019, 19(1):36]

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The impact of lacto-ovo-/lacto-vegetarian and vegan diets during pregnancy on the birth anthropometric parameters of the newborn.

Pietro Ferrara, Federica Sandullo, Federica Di Ruscio, Giulia Franceschini, Benedetta Peronti, Valeria Blasi, Sabina Bietolini, Antonio Ruggiero,

INTRODUCTION:The data in the literature on the appropriateness of vegetarian diets during pregnancy and the impact on the birth anthropometric parameters of the newborn are divergent and conflicting. The aim of the present study is to compare the birth anthropometric parameters of three groups of children distinguished according to the ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-7]

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Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis.

Michele A Capozza, Antonio Ruggiero, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Silvia Triarico, Maria Vellone, Felice Giuliante,

Definitive diagnosis of pediatric liver masses can be challenging, because clinical manifestations are nonspecific, and ultimate diagnosis may be delayed. We describe 2 patients with liver masses that initially were misdiagnosed and treated as infectious hepatic lesions. Only after histologic examination the correct diagnosis of undifferentiated embryonal sarcoma of the ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2019, 41(2):e132-e134]

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Innocent heart murmurs and enuresis: Examining a possible link.

Pietro Ferrara, Federica Di Ruscio, Margherita Zona, Antonio Ruggiero,

OBJECTIVE:The aim of this study was to evaluate the prevalence of innocent heart murmurs in children affected by nocturnal enuresis (NE). RESULTS:The prevalence of innocent heart murmurs in G2 was 6.34%. This condition was significantly more frequent in children who suffered from NE. Indeed, in G1, the prevalence of innocent ... Read more >>

Turk J Urol (Turkish journal of urology)
[2019, 45(4):312-315]

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Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction.

Daniela Meco, Angela Maria Di Francesco, Linda Melotti, Antonio Ruggiero, Riccardo Riccardi,

OBJECTIVE:The neurotrophin nerve growth factor (NGF) affects survival, regulation and differentiation of both central and peripheral nervous system neurons. NGF exerts its effects primarily through tropomyosin receptor kinase A (TrkA), inducing a cascade of tyrosine kinase-initiated responses. In spite of its importance, the general behavior of NGF looks contradictory: its ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(5):6820-6830]

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Pediatric intracranial ependymoma: correlating signs and symptoms at recurrence with outcome in the second prospective AIEOP protocol follow-up.

Maura Massimino, Francesco Barretta, Piergiorgio Modena, Felice Giangaspero, Luisa Chiapparini, Alessandra Erbetta, Luna Boschetti, Manila Antonelli, Paolo Ferroli, Daniele Bertin, Emilia Pecori, Veronica Biassoni, Maria Luisa Garrè, Elisabetta Schiavello, Iacopo Sardi, Elisabetta Viscardi, Giovanni Scarzello, Maurizio Mascarin, Lucia Quaglietta, Giuseppe Cinalli, Lorenzo Genitori, Paola Peretta, Anna Mussano, Salvina Barra, Angela Mastronuzzi, Carlo Giussani, Carlo Efisio Marras, Rita Balter, Patrizia Bertolini, Assunta Tornesello, Milena La Spina, Francesca Romana Buttarelli, Antonio Ruggiero, Massimo Caldarelli, Geraldina Poggi, Lorenza Gandola,

PURPOSE:The aims of patients' radiological surveillance are to: ascertain relapse; apply second-line therapy; accrue patients in phase 1/2 protocols if second-line therapy is not standardized/curative; and assess/treat iatrogenic effects. To lessen the emotional and socioeconomic burdens for patients and families, we ideally need to establish whether scheduled radiological surveillance gives ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2018, 140(2):457-465]

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Correction to: Multimodal treatment of pediatric patients with Askin's tumors: our experience.

Silvia Triarico, Giorgio Attinà, Palma Maurizi, Stefano Mastrangelo, Lorenzo Nanni, Vito Briganti, Elisa Meacci, Stefano Margaritora, Mario Balducci, Antonio Ruggiero,

[This corrects the article DOI: 10.1186/S12957-018-1434-2.]. ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2018, 16:193]

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Topotecan/carboplatin regimen for refractory/recurrent rhabdomyosarcoma in children: Report from the AIEOP Soft Tissue Sarcoma Committee.

Alessia Compostella, Maria Carmen Affinita, Michela Casanova, Giuseppe Maria Milano, Angela Scagnellato, Patrizia Dall'Igna, Stefano Chiaravalli, Marta Pierobon, Carla Manzitti, Ilaria Zanetti, Amalia Schiavetti, Silvia Sorbara, Rosella Maria Mura, Antonio Ruggiero, Andrea Ferrari, Gianni Bisogno,

INTRODUCTION:From 2002 to 2011, the Italian Soft Tissue Sarcoma Committee explored a combination of topotecan and carboplatin as a second-line strategy for children with resistant or relapsing rhabdomyosarcoma. METHODS:Patients received two blocks of topotecan 2 mg/m2 on days 1, 2, and 3, and carboplatin 250 mg/m2 on days 4 and ... Read more >>

Tumori (Tumori)
[2019, 105(2):138-143]

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The impact of motivational therapy in the management of enuretic children.

Pietro Ferrara, Maria Elisa Amodeo, Annamaria Sbordone, Francesca Ianniello, Alberto Verrotti, Tommaso Petitti, Antonio Ruggiero,

The aim of this study is to determine the impact of a motivational therapy (MT) on the outcomes for individuals diagnosed with nocturnal enuresis (NE).We enrolled 158 patients with NE referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to September 2017. Of these, ... Read more >>

Turk J Urol (Turkish journal of urology)
[2018, 44(4):346-350]

Cited: 1 time

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EPEN-03. PEDIATRIC INTRACRANIAL EPENDYMOMA: CORRELATION OF SYMPTOMS AND SIGNS AT RECURRENCE WITH OUTCOME IN THE SECOND PROSPECTIVE AIEOP PROTOCOL FOLLOW-UP.

Maura Massimino, Francesco Barretta, Felice Giangaspero, Luisa Chiapparini, Alessandra Erbetta, Luna Boschetti, Piergiorgio Modena, Manila Antonelli, Paolo Ferroli, Daniele Bertin, Emilia Pecori, Veronica Biassoni, Maria Luisa Garrè, Elisabetta Schiavello, Iacopo Sardi, Elisabetta Viscardi, Giovanni Scarzello, Maurizio Mascarin, Lucia Quaglietta, Giuseppe Cinalli, Lorenzo Genitori, Paola Peretta, Anna Mussano, Salvina Barra, Angela Mastronuzzi, Carlo Giussani, Carlo Efisio Marras, Rita Balter, Patrizia Bertolini, Assunta Tornesello, Milena La Spina, Francesca Romana Buttarelli, Antonio Ruggiero, Massimo Caldarelli, Geraldina Poggi, Lorenza Gandola,

AbstractAims of patient follow-up are: discovering relapse to apply second-line therapy for possible cure, accruing patients in phase 1/2 protocols if second-line therapy is not standardized/curative, evaluating/treating iatrogenic effects. To lessen the patient/family emotional and social economic burdens, we should ideally understand if scheduled radiological follow-up has a better rationale/outcome ... Read more >>

Neuro-oncology (Neuro-oncology)
[2018, 20(Suppl 2):i73-i74]

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Multimodal treatment of pediatric patients with Askin's tumors: our experience.

Silvia Triarico, Giorgio Attinà, Palma Maurizi, Stefano Mastrangelo, Lorenzo Nanni, Vito Briganti, Elisa Meacci, Stefano Margaritora, Mario Balducci, Antonio Ruggiero,

BACKGROUND:We report our experience and outcomes about the management of Askin's tumors [AT], which are rare primitive neuroectodermal tumors (PNETs) that develop within the soft tissue of the thoracopulmonary region, typically in children and adolescents. METHODS:We retrospectively analyzed the charts of 9 patients affected by AT (aged 6-15 years), treated at ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2018, 16(1):140]

Cited: 1 time

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"Lambda-wave" ST-elevation is associated with severe prognosis in stress (takotsubo) cardiomyopathy.

Nicola Tarantino, Francesco Santoro, Francesca Guastafierro, Luigi F M Di Martino, Maria Scarcia, Riccardo Ieva, Antonio Ruggiero, Andrea Cuculo, Enrica Mariano, Matteo Di Biase, Natale Daniele Brunetti,

BACKGROUND:Persistent ST-segment elevation in acute coronary syndrome is associated with both short and long-term complications. By contrast, there is limited information about ST-elevation and its evolution during takotsubo (stress) cardiomyopathy (TTC). AIM:To evaluate whether persistent downsloping ST-elevation in the early stages of TTC might correlate with short and long-term clinical ... Read more >>

Ann Noninvasive Electrocardiol (Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc)
[2018, 23(6):e12581]

Cited: 2 times

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One-Year Clinical Outcomes of Forty-Eight Millimeter Everolimus-Eluting Stent Implanted in Very Long Lesions: A Propensity-Matched Comparison (The FREIUS Study).

Gioel Gabrio Secco, Matteo Tebaldi, Rosario Parisi, Andrea Cuculo, Carlo Di Mario, Pietro Sangiorgio, Alfonso Ielasi, Antonio Centola, Rossella Fattori, Matteo Vercellino, Giovanni Longo, Gianfranco Pistis, Simone Biscaglia, Antonio Ruggiero, Paolo Nicola Marino, Gianluca Campo,

BACKGROUND:Long coronary lesions still remain a challenge, with poor immediate results and suboptimal outcomes when compared to class A/B1 lesions. The presence of overlapped segments of metal struts and polymer might trigger an abnormal inflammatory reaction, resulting in a higher restenosis rate. The aim of our study was to evaluate ... Read more >>

J Invasive Cardiol (The Journal of invasive cardiology)
[2018, 30(4):133-137]

Cited: 1 time

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