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PSMA-Specific CAR-Engineered T Cells for Prostate Cancer: CD28 Outperforms Combined CD28-4-1BB "Super-Stimulation".

Gaia Zuccolotto, Alessandro Penna, Giulio Fracasso, Debora Carpanese, Isabella Monia Montagner, Silvia Dalla Santa, Antonio Rosato,

Prostate cancer (PCa) is the second leading cause of malignancy-related mortality in males in the Western world. Although treatment like prostatectomy and radiotherapy for localized cancer have good results, similar positive outcomes are not achieved in metastatic PCa. Consequently, these aggressive and metastatic forms of PCa urgently need new methods ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:708073]

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Hematopoietic and non-hematopoietic p66Shc differentially regulates stem cell traffic and vascular response to ischemia in diabetes.

Mattia Albiero, Marianna D'Anna, Benedetta Maria Bonora, Gaia Zuccolotto, Antonio Rosato, Marco Giorgio, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini,

<h4>Aims</h4>Peripheral artery disease (PAD) is a severe complication of diabetes, characterized by defective traffic of hematopoietic stem/progenitor cells (HSPCs). We examined the hematopoietic versus non-hematopoietic role of p66Shc in regulating HSPC traffic and blood flow recovery after ischemia in diabetic mice.<h4>Results</h4>Using streptozotocin-induced diabetes, chimeric mice with GFP+ bone marrow (BM), ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

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Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials.

Giovanni Petrillo, Cinzia Tavani, Lara Bianchi, Alice Benzi, Maria Maddalena Cavalluzzi, Lara Salvagno, Laura Quintieri, Annalisa De Palma, Leonardo Caputo, Antonio Rosato, Giovanni Lentini,

Twenty-two novel, variously substituted nitroazetidines were designed as both sulfonamide and urethane vinylogs possibly endowed with antimicrobial activity. The compounds under study were obtained following a general procedure recently developed, starting from 4-nitropentadienoates deriving from a common β-nitrothiophenic precursor. While being devoid of any activity against fungi and Gram-negative bacteria, ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(13):]

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Synergistic Activity of New Diclofenac and Essential Oils Combinations against Different Candida spp.

Antonio Rosato, Elisabetta Altini, Sabina Sblano, Lara Salvagno, Filippo Maggi, Giuliana de Michele, Alessia Carocci, Maria Lisa Clodoveo, Filomena Corbo, Giuseppe Fracchiolla,

According to recent studies, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have shown a good antimicrobial and antifungal activity. Their association with essential oils (EOs) could be useful for the treatment of infections caused by <i>Candida spp</i>. The aim of this studyis to evaluate the synergistic antifungal activity of new combinations between Diclofenac ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(6):]

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Preclinical dosimetric studies of 177 Lu-scFvD2B and comparison with 177 Lu-PSMA-617 and 177 Lu-iPSMA endoradiotherapeutic agents.

Laura Meléndez-Alafort, Guillermina Ferro-Flores, Clara Santos-Cuevas, Blanca Ocampo-García, Sofia Turato, Giulio Fracasso, Cristina Bolzati, Antonio Rosato, Laura De Nardo,

<h4>Purpose</h4>Internal dosimetry has become a very important tool to evaluate the risks and benefits of new endoradiotherapeutic agents. Nowadays, some of the most successful targeted radionuclide therapy (TRT) agents are <sup>177</sup> Lu-DOTA conjugates based on low molecular weight (LMW) Glu-ureido PSMA inhibitors. It has, however, been demonstrated that the DOTA ... Read more >>

Med Phys (Medical physics)
[2021, 48(7):4064-4074]

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Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem.

Rodrigo V Honorato, Panagiotis I Koukos, Brian Jiménez-García, Andrei Tsaregorodtsev, Marco Verlato, Andrea Giachetti, Antonio Rosato, Alexandre M J J Bonvin,

Structural biology aims at characterizing the structural and dynamic properties of biological macromolecules at atomic details. Gaining insight into three dimensional structures of biomolecules and their interactions is critical for understanding the vast majority of cellular processes, with direct applications in health and food sciences. Since 2010, the WeNMR project ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2021, 8:729513]

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Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity.

Alessia Catalano, Antonio Rosato, Lara Salvagno, Domenico Iacopetta, Jessica Ceramella, Giuseppe Fracchiolla, Maria Stefania Sinicropi, Carlo Franchini,

Triclocarban (TCC) is a polychlorinated, aromatic, antimicrobial agent commercially used since the 1950s in personal care products for the prevention of spoilage and infections. Humans are frequently exposed to TCC due to its widespread use, leading to its substantial release into the aquatic environment. With the recent ban of TCC ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(7):]

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Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cells.

Anna Dalla Pietà, Elisa Cappuzzello, Pierangela Palmerini, Annavera Ventura, Andrea Visentin, Giuseppe Astori, Katia Chieregato, Valentina Mozzo, Omar Perbellini, Maria Chiara Tisi, Livio Trentin, Carlo Visco, Marco Ruggeri, Roberta Sommaggio, Antonio Rosato,

<h4>Background</h4>Patients affected by aggressive B-cell malignancies who are resistant to primary or salvage chemoimmunotherapy have an extremely poor prognosis and limited therapeutic options. Promising therapeutic success has been achieved with the infusion of CD19 chimeric antigen receptor-T cells, but several limits still restrain the administration to a limited proportion of ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(7):]

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Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models.

Gualtiero Milani, Maria Maddalena Cavalluzzi, Roberta Solidoro, Lara Salvagno, Laura Quintieri, Angela Di Somma, Antonio Rosato, Filomena Corbo, Carlo Franchini, Angela Duilio, Leonardo Caputo, Solomon Habtemariam, Giovanni Lentini,

Berberine, the main bioactive component of many medicinal plants belonging to various genera such as <i>Berberis</i>, <i>Coptis</i>, and <i>Hydrastis</i> is a multifunctional compound. Among the numerous interesting biological properties of berberine is broad antimicrobial activity including a range of Gram-positive and Gram-negative bacteria. With the aim of identifying berberine analogues ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(5):]

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The immune cell landscape of metastatic uveal melanoma correlates with overall survival.

Anna Tosi, Rocco Cappellesso, Angelo Paolo Dei Tos, Valentina Rossi, Camillo Aliberti, Jacopo Pigozzo, Alessio Fabozzi, Marta Sbaraglia, Stella Blandamura, Paola Del Bianco, Vanna Chiarion-Sileni, Antonio Rosato,

<h4>Background</h4>Uveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years from diagnosis, with the liver as the most common site. Upon metastatization, life expectancy strongly reduces and immune checkpoint inhibitors that prove effective in cutaneous melanoma do ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2021, 40(1):154]

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Inhibition of SGLT2 Rescues Bone Marrow Cell Traffic for Vascular Repair: Role of Glucose Control and Ketogenesis.

Mattia Albiero, Serena Tedesco, Francesco Ivan Amendolagine, Marianna D'Anna, Ludovica Migliozzi, Gaia Zuccolotto, Antonio Rosato, Roberta Cappellari, Angelo Avogaro, Gian Paolo Fadini,

The mechanisms by which sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in people with diabetes are incompletely understood. Recent studies show that SGLT2i may increase the levels of circulating cells with vascular regenerative capacity, at least in part by lowering glycemia. In this study, we used mice with streptozotocin-induced ... Read more >>

Diabetes (Diabetes)
[2021, 70(8):1767-1779]

Cited: 1 time

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Clinical Efficacy and Safety of Angiogenesis Inhibitors: Sex Differences and Current Challenges.

Andrea Cignarella, Gian Paolo Fadini, Chiara Bolego, Lucia Trevisi, Carlotta Boscaro, Viola Sanga, Teresa Maria Seccia, Antonio Rosato, Gian Paolo Rossi, Matthias Barton,

Vasoactive molecules, such as vascular endothelial growth factor (VEGF) and endothelins, share cytokine-like activities and regulate endothelial cell (EC) growth, migration and inflammation. Some endothelial mediators and their receptors are targets for currently approved angiogenesis inhibitors, drugs that are either monoclonal antibodies raised towards VEGF, or inhibitors of vascular receptor ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, :]

Cited: 1 time

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Searching for Small Molecules as Antibacterials: Non-Cytotoxic Diarylureas Analogues of Triclocarban.

Alessia Catalano, Domenico Iacopetta, Antonio Rosato, Lara Salvagno, Jessica Ceramella, Francesca Longo, Maria Stefania Sinicropi, Carlo Franchini,

Triclocarban (TCC), a broad-spectrum lipophilic antimicrobial agent, is a diarylurea derivative that has been used for more than 60 years as a major ingredient of toys, clothing, food packaging materials, food industry floors, medical supplies and especially of personal care products, such as soaps, toothpaste and shampoo. In September 2016, ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(2):]

Cited: 3 times

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Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies.

Maria Maddalena Cavalluzzi, Roberta Budriesi, Maria Antonietta De Salvia, Laura Quintieri, Monica Piarulli, Gualtiero Milani, Roberta Gualdani, Matteo Micucci, Ivan Corazza, Antonio Rosato, Maurizio Viale, Leonardo Caputo, Carlo Franchini, Giovanni Lentini,

<h4>Background</h4>Lubeluzole, a neuroprotective anti-ischemic drug, was tested for its ability to act as both antibiotic chemosensitizing and antipropulsive agent for the treatment of infectious diarrhea.<h4>Methods</h4>In the present report, the effect of lubeluzole against antidiarrheal target was tested. The antimicrobial activity towards Gram-positive and Gram-negative bacteria was investigated together with its ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2021, 73(1):172-184]

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Labelled micelles for the delivery of cytotoxic Cu(II) and Ru(III) compounds in the treatment of aggressive orphan cancers: Design and biological in vitro data.

Leonardo Brustolin, Nicolò Pettenuzzo, Chiara Nardon, Santina Quarta, Isabella Montagner, Patrizia Pontisso, Antonio Rosato, Pierfranco Conte, Stefano Merigliano, Dolores Fregona,

A recent study on our metal-dithiocarbamato complexes pointed out the antiproliferative properties and the druglikeness of some new patented derivatives. In this work, the best compounds have been encapsulated in micellar nanocarriers, being also carbohydrate-functionalized on their hydrophilic surface to investigate the possibility of a cancer-selective delivery. In particular, the ... Read more >>

J Inorg Biochem (Journal of inorganic biochemistry)
[2020, 213:111259]

Cited: 2 times

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Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled with47Sc produced throughnatV(p,x)47Sc cyclotron irradiation.

Laura De Nardo, Gaia Pupillo, Liliana Mou, Davide Furlanetto, Antonio Rosato, Juan Esposito, Laura Meléndez-Alafort,

<sup>47</sup>Sc is one of the most promising theranostic radionuclides, thanks to its low energy γ-ray emission (159 keV), suitable for SPECT imaging and its intense β<sup>-</sup>emission, useful for tumor treatment. Despite promising preclinical results, the translation of<sup>47</sup>Sc-therapeutic agents to the clinic is hampered by its limited availability. Among different<sup>47</sup>Sc-production routes ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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Reduction of T Lymphoma Cells and Immunological Invigoration in a Patient Concurrently Affected by Melanoma and Sezary Syndrome Treated With Nivolumab.

Maria Grazia Narducci, Anna Tosi, Alessandra Frezzolini, Enrico Scala, Francesca Passarelli, Laura Bonmassar, Alessandro Monopoli, Maria Pina Accetturi, Maria Cantonetti, Gian Carlo Antonini Cappellini, Federica De Galitiis, Antonio Rosato, Mario Picozza, Giandomenico Russo, Stefania D'Atri,

Despite the recent availability of several new drugs in hemato-oncology, T-cell lymphomas are still incurable and PD-1 blockade could represent a therapeutic chance for selected patients affected by these malignancies, although further studies are required to understand the biological effects of anti-PD-1 mAbs on neoplastic T-cells and to identify biomarkers ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:579894]

Cited: 1 time

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Anti-Biofilm Inhibitory Synergistic Effects of Combinations of Essential Oils and Antibiotics.

Antonio Rosato, Sabina Sblano, Lara Salvagno, Alessia Carocci, Maria Lisa Clodoveo, Filomena Corbo, Giuseppe Fracchiolla,

In recent years, the increase of bacteria antibiotic- resistance has been a severe problem for public health. A useful solution could be to join some phytochemicals naturally present in essential oils (EOs) to the existing antibiotics, with the aim to increase their efficacy in therapies. According to in vitro studies, ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2020, 9(10):]

Cited: 2 times

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A serum-free protocol for the ex vivo expansion of Cytokine-Induced Killer cells using gas-permeable static culture flasks.

Pierangela Palmerini, Anna Dalla Pietà, Roberta Sommaggio, Annavera Ventura, Giuseppe Astori, Katia Chieregato, Maria Chiara Tisi, Carlo Visco, Omar Perbellini, Marco Ruggeri, Elisa Cappuzzello, Antonio Rosato,

Cytokine-Induced (CIK) cells represent an attractive approach for cell-based immunotherapy, as they show several advantages compared with other strategies. Here we describe an original serum-free protocol for CIK cell expansion that employs G-Rex devices and compare the resulting growth, viability, phenotypic profile and cytotoxic activity with conventional culture in tissue ... Read more >>

Cytotherapy (Cytotherapy)
[2020, 22(9):511-518]

Cited: 3 times

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Anomalous aortic origin of coronary artery biomechanical modeling: Toward clinical application.

Mauro Lo Rito, Rodrigo Maximiliano Romarowski, Antonio Rosato, Silvia Pica, Francesco Secchi, Alessandro Giamberti, Ferdinando Auricchio, Alessandro Frigiola, Michele Conti,

<h4>Objectives</h4>Anomalous aortic origin of the coronary artery can be associated with sudden cardiac death and ischemic events. Anatomic static characteristics mainly dictated surgical indications, although adverse events are usually related to dynamic physical effort. We developed a computational model able to simulate anomalous coronary behavior, and we aimed to assess ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2020, :]

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Development of 177Lu-scFvD2B as a Potential Immunotheranostic Agent for Tumors Overexpressing the Prostate Specific Membrane Antigen.

Debora Carpanese, Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Clara Santos-Cuevas, Nicola Salvarese, Mariangela Figini, Giulio Fracasso, Laura De Nardo, Cristina Bolzati, Antonio Rosato, Laura Meléndez-Alafort,

The clinical translation of theranostic <sup>177</sup>Lu-radiopharmaceuticals based on inhibitors of the prostate-specific membrane antigen (PSMA) has demonstrated positive clinical responses in patients with advanced prostate cancer (PCa). However, challenges still remain, particularly regarding their pharmacokinetic and dosimetric properties. We developed a potential PSMA-immunotheranostic agent by conjugation of a single-chain variable ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9313]

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PSMA-Specific Car-Engineered T Cells for Prostate Cancer: CD28 outperforms combined CD28-41BB “Super- stimulation”

Gaia Zuccolotto, Alessandro Penna, Giulio Fracasso, Isabella Monia Montagner, Debora Carpanese, Anna Tosi, Antonio Rosato,

Despite advances in the understanding of its molecular pathophysiology, prostate cancer remains largely incurable, highlighting the need for novel therapies. We developed a chimeric antigen receptor (CAR) specific for prostate specific membrane antigen (PSMA), a glycoprotein that is overexpressed in prostate cancer, which expression involves neovasculature of several tumor entities, ... Read more >>

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Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.

Roberta Sommaggio, Elisa Cappuzzello, Anna Dalla Pietà, Anna Tosi, Pierangela Palmerini, Debora Carpanese, Lorenzo Nicolè, Antonio Rosato,

Cytokine-Induced Killer (CIK) cells share several functional and phenotypical properties of both T and natural killer (NK) cells. They represent an attractive approach for cell-based immunotherapy, as they do not require antigen-specific priming for tumor cell recognition, and can be rapidly expanded <i>in vitro</i>. Their relevant expression of FcγRIIIa (CD16a) ... Read more >>

Oncoimmunology (Oncoimmunology)
[2020, 9(1):1777046]

Cited: 2 times

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Anti-PSMA CAR-Engineered NK-92 Cells: An Off-the-Shelf Cell Therapy for Prostate Cancer

Isabella Monia Montagner, Alessandro Penna, Giulio Fracasso, Debora Carpanese, Anna Dalla Pietà, Vito Barbieri, Gaia Zuccolotto, Antonio Rosato,

Prostate cancer (PCa) has become the most common tumor among males in Europe and the USA. Adoptive immunotherapy appears as a promising strategy to control the advanced stages of the disease by specific targeting the tumor, in particular through chimeric antigen receptor T (CAR-T) cell therapy. Despite the advancements of ... Read more >>

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Publisher Correction: Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.

Tito Panciera, Anna Citron, Daniele Di Biagio, Giusy Battilana, Alessandro Gandin, Stefano Giulitti, Mattia Forcato, Silvio Bicciato, Valeria Panzetta, Sabato Fusco, Luca Azzolin, Antonio Totaro, Angelo Paolo Dei Tos, Matteo Fassan, Vincenzo Vindigni, Franco Bassetto, Antonio Rosato, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Mater (Nature materials)
[2020, 19(4):475]

Cited: 1 time

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