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Author Antonio Marchini

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A Roadmap for the Success of Oncolytic Parvovirus-Based Anticancer Therapies.

Anna Hartley, Gayatri Kavishwar, Ilaria Salvato, Antonio Marchini,

Autonomous rodent protoparvoviruses (PVs) are promising anticancer agents due to their excellent safety profile, natural oncotropism, and oncosuppressive activities. Viral infection can trigger immunogenic cell death, activating the immune system against the tumor. However, the efficacy of this treatment in recent clinical trials is moderate compared with results seen in ... Read more >>

Annu Rev Virol (Annual review of virology)
[2020, :]

Cited: 0 times

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Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects.

Jubayer A Hossain, Antonio Marchini, Boris Fehse, Rolf Bjerkvig, Hrvoje Miletic,

Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been the most prominent both in preclinical and clinical settings. Failure of a number of promising suicide gene therapy strategies in the clinic ... Read more >>

Neurooncol Adv (Neuro-oncology advances)
[2020, 2(1):vdaa013]

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ATIM-40. HIGH RATE OF OBJECTIVE ANTI-TUMOR RESPONSE IN 9 PATIENTS WITH GLIOBLASTOMA AFTER VIRO-IMMUNOTHERAPY WITH ONCOLYTIC PARVOVIRUS H-1 IN COMBINATION WITH BEVACICUMAB AND PD-1 CHECKPOINT BLOCKADE.

Karsten Geletneky, Andreas Bartsch, Christian Weiss, Helga Bernhard, Antonio Marchini, Jean Rommelaere,

AbstractBACKGROUNDCombination therapy is an emerging concept to improve the clinical effects of oncolytic virus based anti-cancer strategies. In a phase I/IIa trial (ParvOryx01) the oncolytic H-1 parvovirus (H-1PV) induced markers of immune activation in patients with recurrent glioblastoma. The goal of this investigation was to enhanced H-1PV efficiency by combination ... Read more >>

Neuro-oncology (Neuro-oncology)
[2018, 20(Suppl 6):vi10-vi10]

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Virotherapy Research in Germany: From Engineering to Translation.

Guy Ungerechts, Christine E Engeland, Christian J Buchholz, Jürgen Eberle, Henry Fechner, Karsten Geletneky, Per Sonne Holm, Florian Kreppel, Florian Kühnel, Karl Sebastian Lang, Mathias F Leber, Antonio Marchini, Markus Moehler, Michael D Mühlebach, Jean Rommelaere, Christoph Springfeld, Ulrich M Lauer, Dirk M Nettelbeck,

Virotherapy is a unique modality for the treatment of cancer with oncolytic viruses (OVs) that selectively infect and lyse tumor cells, spread within tumors, and activate anti-tumor immunity. Various viruses are being developed as OVs preclinically and clinically, several of them engineered to encode therapeutic proteins for tumor-targeted gene therapy. ... Read more >>

Hum. Gene Ther. (Human gene therapy)
[2017, 28(10):800-819]

Cited: 7 times

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A Track Record on SHOX: From Basic Research to Complex Models and Therapy.

Antonio Marchini, Tsutomu Ogata, Gudrun A Rappold,

SHOX deficiency is the most frequent genetic growth disorder associated with isolated and syndromic forms of short stature. Caused by mutations in the homeobox gene SHOX, its varied clinical manifestations include isolated short stature, Léri-Weill dyschondrosteosis, and Langer mesomelic dysplasia. In addition, SHOX deficiency contributes to the skeletal features in ... Read more >>

Endocr. Rev. (Endocrine reviews)
[2016, 37(4):417-448]

Cited: 13 times

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Identification of novel SHOX target genes in the developing limb using a transgenic mouse model.

Katja U Beiser, Anne Glaser, Kerstin Kleinschmidt, Isabell Scholl, Ralph Röth, Li Li, Norbert Gretz, Gunhild Mechtersheimer, Marcel Karperien, Antonio Marchini, Wiltrud Richter, Gudrun A Rappold,

Deficiency of the human short stature homeobox-containing gene (SHOX) has been identified in several disorders characterized by reduced height and skeletal anomalies such as Turner syndrome, Léri-Weill dyschondrosteosis and Langer mesomelic dysplasia as well as isolated short stature. SHOX acts as a transcription factor during limb development and is expressed ... Read more >>

PLoS ONE (PloS one)
[2014, 9(6):e98543]

Cited: 8 times

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SHOX triggers the lysosomal pathway of apoptosis via oxidative stress.

Georgi Hristov, Tiina Marttila, Claudia Durand, Beate Niesler, Gudrun A Rappold, Antonio Marchini,

The SHOX gene encodes for a transcription factor important for normal bone development. Mutations in the gene are associated with idiopathic short stature and are responsible for the growth failure and skeletal defects found in the majority of patients with Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia. SHOX is expressed ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2014, 23(6):1619-1630]

Cited: 12 times

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Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species.

Georgi Hristov, Melanie Krämer, Junwei Li, Nazim El-Andaloussi, Rodrigo Mora, Laurent Daeffler, Hanswalter Zentgraf, Jean Rommelaere, Antonio Marchini,

The rat parvovirus H-1 (H-1PV) attracts high attention as an anticancer agent, because it is not pathogenic for humans and has oncotropic and oncosuppressive properties. The viral nonstructural NS1 protein is thought to mediate H-1PV cytotoxicity, but its exact contribution to this process remains undefined. In this study, we analyzed ... Read more >>

J. Virol. (Journal of virology)
[2010, 84(12):5909-5922]

Cited: 42 times

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Sodium butyrate with UCN-01 has marked antitumour activity against cervical cancer cells.

Anne-Zélie Decrion-Barthod, Matthieu Bosset, Marie-Laure Plissonnier, Antonio Marchini, Magalie Nicolier, Sophie Launay, Jean-Luc Prétet, Jean Rommelaere, Christiane Mougin,

AIM: The effect of combining sodium butyrate (NaB), a histone deacetylase inhibitor, and 7-hydroxy-staurosporine (UCN-01) on cytotoxicity in human cervical carcinoma cells was evaluated. MATERIALS AND METHODS: HeLa and CaSki cells were treated using NaB alone or in combination with staurosporine (STS) or its analog UCN-01. Cytotoxicity was determined by ... Read more >>

Anticancer Res. (Anticancer research)
[2010, 30(10):4049-4061]

Cited: 4 times

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BNP is a transcriptional target of the short stature homeobox gene SHOX.

Antonio Marchini, Beate Häcker, Tiina Marttila, Volker Hesse, Joyce Emons, Birgit Weiss, Marcel Karperien, Gudrun Rappold,

Short stature due to SHOX deficiency represents a common congenital form of growth failure and is involved in the aetiology of 'idiopathic' short stature and the growth deficits and skeletal anomalies in Leri-Weill, Langer and Turner syndromes. Although much is known on the clinical and molecular aspects of SHOX haploinsufficiency, ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2007, 16(24):3081-3087]

Cited: 23 times

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SHOX at a glance: from gene to protein.

Antonio Marchini, Gudrun Rappold, Katja U Schneider,

The Short Stature Homeobox-containing Gene SHOX was identified as the genetic cause of the short stature phenotype in patients with Turner Syndrome and in certain patients with idiopathic short stature. Shortly after, SHOX mutations were also associated with the growth failure and skeletal deformities seen in patients with Léri - ... Read more >>

Arch. Physiol. Biochem. (Archives of physiology and biochemistry)
[2007, 113(3):116-123]

Cited: 18 times

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Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.

Antonio Marchini, Laurent Daeffler, Tiina Marttila, Katja U Schneider, Rüdiger J Blaschke, Martina Schnölzer, Jean Rommelaere, Gudrun Rappold,

Mutations within the homeobox SHOX gene have been associated with short stature and the skeletal deformities found in Léri-Weill, Turner and Langer syndromes implying an involvement of SHOX in growth and bone formation. Despite its clinical significance, the precise role of SHOX and the mechanisms that modulate its functions remain ... Read more >>

J. Mol. Biol. (Journal of molecular biology)
[2006, 355(3):590-603]

Cited: 6 times

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Alteration of DNA binding, dimerization, and nuclear translocation of SHOX homeodomain mutations identified in idiopathic short stature and Leri-Weill dyschondrosteosis.

Katja U Schneider, Antonio Marchini, Nitin Sabherwal, Ralph Röth, Beate Niesler, Tiina Marttila, Rüdiger J Blaschke, Margaret Lawson, Miroslav Dumic, Gudrun Rappold,

Haploinsufficiency of the short stature homeobox gene SHOX has been found in patients with idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). In addition to complete gene deletions and nonsense mutations, several missense mutations have been identified in both patient groups, leading to amino acid substitutions in the SHOX protein. ... Read more >>

Hum. Mutat. (Human mutation)
[2005, 26(1):44-52]

Cited: 20 times

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High levels of the mitochondrial large ribosomal subunit protein 40 prevent loss of mitochondrial DNA in null mmf1 Saccharomyces cerevisiae cells.

Rosita Accardi, Ellinor Oxelmark, Nicolas Jauniaux, Vito de Pinto, Antonio Marchini, Massimo Tommasino,

Members of the YERO57c/YJGFc/UK114 protein family have been identified in bacteria and eukaryotes. The budding yeast Saccharomyces cerevisiae contains two different proteins of this family, Hmf1p and Mmf1p. We have previously shown that Mmf1p is a mitochondrial protein functionally related to its human homologue and able to influence the maintenance ... Read more >>

Yeast (Yeast (Chichester, England))
[2004, 21(7):539-548]

Cited: 8 times

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Impairment of SHOX nuclear localization as a cause for Léri-Weill syndrome.

Nitin Sabherwal, Katja U Schneider, Rüdiger J Blaschke, Antonio Marchini, Gudrun Rappold,

We report the characterization of the nuclear localization signal (NLS) of the short stature homeobox gene SHOX. Mutations within the SHOX gene cause Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LD) as well as idiopathic short stature (ISS). Furthermore, haploinsufficiency of SHOX has also been implicated in Turner syndrome. SHOX ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2004, 117(Pt 14):3041-3048]

Cited: 16 times

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The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.

Antonio Marchini, Tiina Marttila, Anja Winter, Sandra Caldeira, Ilaria Malanchi, Rüdiger J Blaschke, Beate Häcker, Ercole Rao, Marcel Karperien, Jan M Wit, Wiltrud Richter, Massimo Tommasino, Gudrun A Rappold,

Mutations in the homeobox gene SHOX cause growth retardation and the skeletal abnormalities associated with Léri-Weill, Langer, and Turner syndromes. Little is known about the mechanism underlying these SHOX-related inherited disorders of bone formation. Here we demonstrate that SHOX expression in osteogenic stable cell lines, primary oral fibroblasts, and primary ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(35):37103-37114]

Cited: 51 times

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Transcriptional and translational regulation of the Leri-Weill and Turner syndrome homeobox gene SHOX.

Rudiger J Blaschke, Christine Töpfer, Antonio Marchini, Herbert Steinbeisser, Johannes W G Janssen, Gudrun A Rappold,

Regulation of gene expression is particularly important for gene dosage-dependent diseases and the phenomenon of clinical heterogeneity frequently associated with these phenotypes. We here report on the combined transcriptional and translational regulatory mechanisms controlling the expression of the Léri-Weill and Turner syndrome gene SHOX. We define an alternative promotor within ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2003, 278(48):47820-47826]

Cited: 33 times

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Schizosaccharomyces pombe Pmf1p is structurally and functionally related to Mmf1p of Saccharomyces cerevisiae.

Antonio Marchini, Rosita Accardi, Ilaria Malanchi, Evi Schyr, Ellinor Oxelmark, Vito De Pinto, Jean-Claude Jauniaux, Kinsey Maundrell, Massimo Tommasino,

A novel family of small proteins, termed p14.5 or YERO57c/YJGFc, has been identified. Independent studies indicate that p14.5 family members are multifunctional proteins involved in several pathways, e.g. regulation of translation or activation of the protease mu-calpain. We have previously shown that Mmf1p, a p14.5 of the budding yeast Saccharomyces ... Read more >>

Yeast (Yeast (Chichester, England))
[2002, 19(8):703-711]

Cited: 5 times

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