Full Text Journal Articles by
Author Antonio A Freitas

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Microbiota stimulation generates LCMV-specific memory CD8+ T cells in SPF mice and determines their TCR repertoire during LCMV infection.

Pedro Gonçalves, Sary El Daker, Florence Vasseur, Nicolas Serafini, Annick Lim, Orly Azogui, Helene Decaluwe, Delphine Guy-Grand, Antonio A Freitas, James P Di Santo, Benedita Rocha,

Both mouse and human harbour memory phenotype CD8+ T cells specific for antigens in hosts that have not been previously exposed to these antigens. The origin and the nature of the stimuli responsible for generation of CD44hi CD8+ T cells in specific pathogen-free (SPF) mice remain controversial. It is known ... Read more >>

Mol. Immunol. (Molecular immunology)
[2020, 124:125-141]

Cited: 0 times

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Maria de Sousa, (1939-2020).

Antonio A Freitas, Benedita Rocha,

Eur. J. Immunol. (European journal of immunology)
[2020, 50(6):768-769]

Cited: 0 times

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The S(c)ensory Immune System Theory.

Henrique Veiga-Fernandes, António A Freitas,

Viewpoints on the immune system have evolved across different paradigms, including the clonal selection theory, the idiotypic network, and the danger and tolerance models. Herein, we propose that in multicellular organisms, where panoplies of cells from different germ layers interact and immune cells are constantly generated, the behavior of the ... Read more >>

Trends Immunol. (Trends in immunology)
[2017, 38(10):777-788]

Cited: 3 times

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Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool.

Marie Anson, Inês Amado, Marie-Pierre Mailhé, Emmanuel Donnadieu, Sylvie Garcia, François Huetz, Antonio A Freitas,

We investigated the ability of monoclonal B cells to restore primary and secondary T-cell dependent antibody responses in adoptive immune-deficient hosts. Priming induced B cell activation and expansion, AID expression, antibody production and the generation of IgM+IgG- and IgM-IgG+ antigen-experienced B-cell subsets that persisted in the lymphopenic environment by cell ... Read more >>

PLoS ONE (PloS one)
[2016, 11(11):e0167003]

Cited: 2 times

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IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.

Milena J Tosiek, Laurence Fiette, Sary El Daker, Gérard Eberl, Antonio A Freitas,

The ability of CD4+ T cells to change their phenotype and to specialize into different functional subsets may enhance the risk of autoimmune diseases. Here we investigate how a pleiotropic cytokine interleukin (IL)-15 may modify the functional commitment of CD4+ T cells expressing the lineage-associated transcription factors: forkhead box P3 ... Read more >>

Nat Commun (Nature communications)
[2016, 7:10888]

Cited: 20 times

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microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells.

Antoine Marcais, Rory Blevins, Johannes Graumann, Amelie Feytout, Gopuraja Dharmalingam, Thomas Carroll, Inês F Amado, Ludovica Bruno, Keunwook Lee, Thierry Walzer, Matthias Mann, Antonio A Freitas, Mark Boothby, Amanda G Fisher, Matthias Merkenschlager,

T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state of anergy. Here, we ask whether microRNAs affect the interpretation of TCR signaling. We find that Dicer-deficient CD4 T cells fail to correctly discriminate between activating and anergy-inducing stimuli and produce IL-2 in ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2014, 211(11):2281-2295]

Cited: 25 times

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Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice.

Malika Serra-Hassoun, Maryline Bourgine, Michele Boniotto, Julien Berges, Francina Langa, Marie-Louise Michel, Antonio A Freitas, Sylvie Garcia,

We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following injection of human ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2014, 193(3):1504-1511]

Cited: 2 times

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A mathematical perspective on CD4(+) T cell quorum-sensing.

Joseph Reynolds, Inês F Amado, Antonio A Freitas, Grant Lythe, Carmen Molina-París,

We analyse a mathematical model of the peripheral CD4(+) T cell population, based on a quorum-sensing mechanism, by which an optimum number of regulatory T cells can be established and maintained. We divide the population of a single T cell receptor specificity into four pools: naive, IL-2 producing, IL-2 non-producing, ... Read more >>

J. Theor. Biol. (Journal of theoretical biology)
[2014, 347:160-175]

Cited: 3 times

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Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.

Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schönefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel H D Gray, Adrian Liston,

Foxp3⁺ regulatory T (Treg) cells are a crucial immunosuppressive population of CD4⁺ T cells, yet the homeostatic processes and survival programs that maintain the Treg cell pool are poorly understood. Here we report that peripheral Treg cells markedly alter their proliferative and apoptotic rates to rapidly restore numerical deficit through ... Read more >>

Nat. Immunol. (Nature immunology)
[2013, 14(9):959-965]

Cited: 111 times

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IL-2 coordinates IL-2-producing and regulatory T cell interplay.

Inês F Amado, Julien Berges, Rita J Luther, Marie-Pierre Mailhé, Sylvie Garcia, Antonio Bandeira, Casey Weaver, Adrian Liston, Antonio A Freitas,

Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)-producing CD4(+) T cell (IL-2p) pool using ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2013, 210(12):2707-2720]

Cited: 35 times

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Origin, trafficking, and intraepithelial fate of gut-tropic T cells.

Delphine Guy-Grand, Pierre Vassalli, Gerard Eberl, Pablo Pereira, Odile Burlen-Defranoux, Fabrice Lemaitre, James P Di Santo, Antonio A Freitas, Ana Cumano, Antonio Bandeira,

The small intestine epithelium (SI-Ep) harbors millions of unconventional (γδ and CD4(-) CD8(-) NK1.1(-) TCRαβ) and conventional (CD8αβ and CD4) T cells, designated intraepithelial lymphocytes (IELs). Here, we identified the circulating pool of SI-Ep-tropic T cells and studied their capacity to colonize the SI-Ep under steady-state conditions in SPF mice. ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2013, 210(9):1839-1854]

Cited: 33 times

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Quorum sensing contributes to activated IgM-secreting B cell homeostasis.

Caroline Montaudouin, Marie Anson, Yi Hao, Susanne V Duncker, Tahia Fernandez, Emmanuelle Gaudin, Michael Ehrenstein, William G Kerr, Jean-Hervé Colle, Pierre Bruhns, Marc Daëron, António A Freitas,

Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into immune-deficient hosts, B lymphocytes expand poorly, but fully reconstitute the pool of natural IgM-secreting cells ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2013, 190(1):106-114]

Cited: 18 times

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Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.

Afonso R M Almeida, Inês F Amado, Joseph Reynolds, Julien Berges, Grant Lythe, Carmen Molina-París, Antonio A Freitas,

Homeostasis of lymphocyte numbers is believed to be due to competition between cellular populations for a common niche of restricted size, defined by the combination of interactions and trophic factors required for cell survival. Here we propose a new mechanism: homeostasis of lymphocyte numbers could also be achieved by the ... Read more >>

Front Immunol (Frontiers in immunology)
[2012, 3:125]

Cited: 34 times

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Humanized mice: current states and perspectives.

Sylvie Garcia, Antonio A Freitas,

The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation ... Read more >>

Immunol. Lett. (Immunology letters)
[2012, 146(1-2):1-7]

Cited: 19 times

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Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools.

Bruno Zaragoza, César Evaristo, Adrien Kissenpfennig, Valentina Libri, Bernard Malissen, Benedita Rocha, António A Freitas, Afonso R M Almeida,

We here describe novel aspects of CD8(+) and CD4(+) T cell subset interactions that may be clinically relevant and provide new tools for regulating the reconstitution of the peripheral CD8(+) T cell pools in immune-deficient states. We show that the reconstitution capacity of transferred isolated naïve CD8(+) T cells and ... Read more >>

PLoS ONE (PloS one)
[2011, 6(3):e17423]

Cited: 6 times

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Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.

Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat, Maria-Encarnita Mariotti-Ferrandiz, Anne Louise, Adrien Six, Antonio A Freitas, Sylvie Garcia,

Recombination activating gene (RAG)-deficient TCR (T Cell Receptor) Tg (transgenic) mice are routinely used as sources of monoclonal T cells. We found that after the transfer of T cells from a RAG-2-deficient 5CC7 TCR Tg mice into allogeneic hosts we recovered a population of T cells expressing diverse alphabeta-TCRs. In ... Read more >>

PLoS ONE (PloS one)
[2010, 5(4):e10238]

Cited: 6 times

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CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism.

Ana Inés Lalanne, Ignacio Moraga, Yi Hao, João Pedro Pereira, Nuno L Alves, Nicholas D Huntington, Antonio A Freitas, Ana Cumano, Paulo Vieira,

TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2010, 184(10):5678-5685]

Cited: 9 times

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The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.

Catarina Leitão, António A Freitas, Sylvie Garcia,

Survival of peripheral CD8(+) T cells requires TCR interactions with peptide-MHC complexes (p-MHC). In the adult mouse, in the presence of homeostatic mechanisms that strictly control T cell numbers, it is likely that diverse T cell clones may compete for shared patterns of p-MHC. In the present study, we investigate ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2009, 182(9):5232-5239]

Cited: 9 times

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Homeostasis of naive T cells: the Foxo that fixes.

Antonio A Freitas, Benedita Rocha,

Nat. Immunol. (Nature immunology)
[2009, 10(2):133-134]

Cited: 7 times

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Wild-derived mouse strains, a valuable model to study B cell responses.

Aude Thiriot, Anne-Marie Drapier, Sylvie Mémet, Catherine Fitting, Aude Sturny-Leclere, Jean-Marc Cavaillon, Pierre-André Cazenave, Antonio A Freitas, Dominique Rueff-Juy,

In the present report, we revisited the B cell responsiveness of 7 wild-derived mouse strains to various toll-like receptor ligands (TLR-L). We found that 2 of them, namely PWK and STF presented profound defects in B cell proliferative responses to most of the TLR-L. Yet, their macrophage responses were largely ... Read more >>

Mol. Immunol. (Molecular immunology)
[2009, 46(4):601-612]

Cited: 4 times

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Peritoneal B-cell subsets in the genus Mus: their role in innate immunity.

Aude Thiriot, Antonio A Freitas, Dominique Rueff-Juy,

In this review, we demonstrate that wild-derived mouse strains (wild-DMS) represent a useful tool for dissecting the immune system. We confirm and extend the notion that we and others have previously advanced, which is that common laboratory mice are not fully representative of the whole genus Mus. We illustrate how ... Read more >>

Crit. Rev. Immunol. (Critical reviews in immunology)
[2008, 28(4):341-361]

Cited: 0 times

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TLR-activated B cells suppress T cell-mediated autoimmunity.

Vicky Lampropoulou, Kai Hoehlig, Toralf Roch, Patricia Neves, Elisabeth Calderón Gómez, Claire H Sweenie, Yi Hao, Antonio A Freitas, Ulrich Steinhoff, Stephen M Anderton, Simon Fillatreau,

TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2008, 180(7):4763-4773]

Cited: 216 times

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Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6.

Vanesa Sanchez-Guajardo, Corinne Tanchot, John T O'Malley, Mark H Kaplan, Sylvie Garcia, Antonio A Freitas,

The factors that induce Foxp3 expression and regulatory T (Treg) cell development remain unknown. In this study, we investigated the role of STAT4 and STAT6 in agonist-driven generation of Ag-specific Foxp3-expressing Treg cells. Our findings indicate that fully efficient induction of Foxp3 expression and development of Ag-specific Treg cells requires ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2007, 178(12):7550-7556]

Cited: 13 times

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The clone size of peripheral CD8 T cells is regulated by TCR promiscuity.

Yi Hao, Nicolas Legrand, Antonio A Freitas,

Positive selection in the thymus and peripheral T cell survival depend on T cell receptor (TCR)-major histocompatibility complex (MHC) interactions, but it is not yet clear if both events follow exactly the same rules. We studied peripheral T cell survival and clone sizes in conditions of progressive reduction of restricting ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2006, 203(7):1643-1649]

Cited: 30 times

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Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.

Afonso R M Almeida, Bruno Zaragoza, Antonio A Freitas,

To fulfill its mission, the immune system must maintain a complete set of different cellular subpopulations that play specific roles in immune responses. We have investigated the mechanisms regulating CD4+CD25+ regulatory T (Treg) cell homeostasis. We show that the expression of the high-affinity IL-2Ralpha endows these cells with the capacity ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2006, 177(1):192-200]

Cited: 70 times

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