Full Text Journal Articles by
Author Antoine D Rolland

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

Cited: 0 times

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Dynamics of the transcriptional landscape during human fetal testis and ovary development.

Estelle Lecluze, Antoine D Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoué, Paul A Fowler, Séverine Mazaud-Guittot, Bernard Jégou, Frédéric Chalmel,

<h4>Study question</h4>Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans?<h4>Summary answer</h4>The characterization of a dynamically regulated protein-coding and non-coding transcriptional landscape in developing human gonads of both sexes highlights a large number of potential key regulators that show ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2020, 35(5):1099-1119]

Cited: 0 times

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Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis.

John E Nielsen, Antoine D Rolland, Ewa Rajpert-De Meyts, Christian Janfelt, Anne Jørgensen, Sofia B Winge, David M Kristensen, Anders Juul, Frédéric Chalmel, Bernard Jégou, Niels E Skakkebaek,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1267]

Cited: 0 times

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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

Erminia Rubino, Melania Cruciani, Nicolas Tchitchek, Anna Le Tortorec, Antoine D Rolland, Önay Veli, Leslie Vallet, Giulia Gaggi, Frédérique Michel, Nathalie Dejucq-Rainsford, Sandra Pellegrini,

Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type, the level of USP18 is a key determinant of the output of IFN-stimulated transcripts. How the ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:627007]

Cited: 1 time

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Characterisation and localisation of the endocannabinoid system components in the adult human testis.

John E Nielsen, Antoine D Rolland, Ewa Rajpert-De Meyts, Christian Janfelt, Anne Jørgensen, Sofia B Winge, David M Kristensen, Anders Juul, Frédéric Chalmel, Bernard Jégou, Niels E Skakkebaek,

Heavy use of cannabis (marijuana) has been associated with decreased semen quality, which may reflect disruption of the endocannabinoid system (ECS) in the male reproductive tract by exogenous cannabinoids. Components of ECS have been previously described in human spermatozoa and in the rodent testis but there is little information on ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12866]

Cited: 7 times

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The ReproGenomics Viewer: a multi-omics and cross-species resource compatible with single-cell studies for the reproductive science community.

Thomas A Darde, Estelle Lecluze, Aurélie Lardenois, Isabelle Stévant, Nathan Alary, Frank Tüttelmann, Olivier Collin, Serge Nef, Bernard Jégou, Antoine D Rolland, Frédéric Chalmel,

<h4>Motivation</h4>Recent advances in transcriptomics have enabled unprecedented insight into gene expression analysis at a single-cell resolution. While it is anticipated that the number of publications based on such technologies will increase in the next decade, there is currently no public resource to centralize and enable scientists to explore single-cell datasets ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2019, 35(17):3133-3139]

Cited: 12 times

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TOXsIgN: a cross-species repository for toxicogenomic signatures.

Thomas A Darde, Pierre Gaudriault, Rémi Beranger, Clément Lancien, Annaëlle Caillarec-Joly, Olivier Sallou, Nathalie Bonvallot, Cécile Chevrier, Séverine Mazaud-Guittot, Bernard Jégou, Olivier Collin, Emmanuelle Becker, Antoine D Rolland, Frédéric Chalmel,

Motivation:At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2018, 34(12):2116-2122]

Cited: 5 times

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New transcriptomic tools to understand testis development and functions.

Estelle Lecluze, Bernard Jégou, Antoine D Rolland, Frédéric Chalmel,

The testis plays a central role in the male reproductive system - secreting several hormones including male steroids and producing male gametes. A complex and coordinated molecular program is required for the proper differentiation of testicular cell types and maintenance of their functions in adulthood. The testicular transcriptome displays the ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2018, 468:47-59]

Cited: 2 times

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Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.

Anne-Sophie Borowiec, Benoit Sion, Frédéric Chalmel, Antoine D Rolland, Loïc Lemonnier, Tatiana De Clerck, Alexandre Bokhobza, Sandra Derouiche, Etienne Dewailly, Christian Slomianny, Claire Mauduit, Mohamed Benahmed, Morad Roudbaraki, Bernard Jégou, Natalia Prevarskaya, Gabriel Bidaux,

Testes of most male mammals present the particularity of being externalized from the body and are consequently slightly cooler than core body temperature (4-8°C below). Although, hypothermia of the testis is known to increase germ cells apoptosis, little is known about the underlying molecular mechanisms, including cold sensors, transduction pathways, ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2016, 30(9):3155-3170]

Cited: 8 times

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Linking transcriptomics and proteomics in spermatogenesis.

Frédéric Chalmel, Antoine D Rolland,

Spermatogenesis is a complex and tightly regulated process leading to the continuous production of male gametes, the spermatozoa. This developmental process requires the sequential and coordinated expression of thousands of genes, including many that are testis-specific. The molecular networks underlying normal and pathological spermatogenesis have been widely investigated in recent ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2015, 150(5):R149-57]

Cited: 18 times

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The ReproGenomics Viewer: an integrative cross-species toolbox for the reproductive science community.

Thomas A Darde, Olivier Sallou, Emmanuelle Becker, Bertrand Evrard, Cyril Monjeaud, Yvan Le Bras, Bernard Jégou, Olivier Collin, Antoine D Rolland, Frédéric Chalmel,

We report the development of the ReproGenomics Viewer (RGV), a multi- and cross-species working environment for the visualization, mining and comparison of published omics data sets for the reproductive science community. The system currently embeds 15 published data sets related to gametogenesis from nine model organisms. Data sets have been ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2015, 43(W1):W109-16]

Cited: 17 times

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Forty-four novel protein-coding loci discovered using a proteomics informed by transcriptomics (PIT) approach in rat male germ cells.

Sophie Chocu, Bertrand Evrard, Régis Lavigne, Antoine D Rolland, Florence Aubry, Bernard Jégou, Frédéric Chalmel, Charles Pineau,

Spermatogenesis is a complex process, dependent upon the successive activation and/or repression of thousands of gene products, and ends with the production of haploid male gametes. RNA sequencing of male germ cells in the rat identified thousands of novel testicular unannotated transcripts (TUTs). Although such RNAs are usually annotated as ... Read more >>

Biol Reprod (Biology of reproduction)
[2014, 91(5):123]

Cited: 13 times

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High-resolution profiling of novel transcribed regions during rat spermatogenesis.

Frédéric Chalmel, Aurélie Lardenois, Bertrand Evrard, Antoine D Rolland, Olivier Sallou, Marie-Charlotte Dumargne, Isabelle Coiffec, Olivier Collin, Michael Primig, Bernard Jégou,

Mammalian spermatogenesis is a complex and highly orchestrated combination of processes in which male germline proliferation and differentiation result in the production of mature spermatozoa. If recent genome-wide studies have contributed to the in-depth analysis of the male germline protein-encoding transcriptome, little effort has yet been devoted to the systematic ... Read more >>

Biol Reprod (Biology of reproduction)
[2014, 91(1):5]

Cited: 24 times

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Profiling of androgen response in rainbow trout pubertal testis: relevance to male gonad development and spermatogenesis.

Antoine D Rolland, Aurélie Lardenois, Anne-Sophie Goupil, Jean-Jacques Lareyre, Rémi Houlgatte, Frédéric Chalmel, Florence Le Gac,

The capacity of testicular somatic cells to promote and sustain germ cell differentiation is largely regulated by sexual steroids and notably androgens. In fish species the importance of androgens is emphasized by their ability to induce sex reversal of the developing fries and to trigger spermatogenesis. Here we studied the ... Read more >>

PLoS One (PloS one)
[2013, 8(1):e53302]

Cited: 19 times

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FSH and LH have common and distinct effects on gene expression in rainbow trout testis.

Elisabeth Sambroni, Antoine D Rolland, Jean-Jacques Lareyre, Florence Le Gac,

The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin involved ... Read more >>

J Mol Endocrinol (Journal of molecular endocrinology)
[2013, 50(1):1-18]

Cited: 27 times

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Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.

Cassy M Spiller, Chun-Wei Feng, Andrew Jackson, Ad J M Gillis, Antoine D Rolland, Leendert H J Looijenga, Peter Koopman, Josephine Bowles,

Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads. In males in particular, the balance between continued proliferation and cell fate commitment is crucial: defects in proliferation result in insufficient spermatogonial stem cells for fertility, but escape ... Read more >>

Development (Development (Cambridge, England))
[2012, 139(22):4123-4132]

Cited: 42 times

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Spermatogenesis in mammals: proteomic insights.

Sophie Chocu, Pierre Calvel, Antoine D Rolland, Charles Pineau,

Spermatogenesis is a highly sophisticated process involved in the transmission of genetic heritage. It includes halving ploidy, repackaging of the chromatin for transport, and the equipment of developing spermatids and eventually spermatozoa with the advanced apparatus (e.g., tightly packed mitochondrial sheat in the mid piece, elongating of the tail, reduction ... Read more >>

Syst Biol Reprod Med (Systems biology in reproductive medicine)
[2012, 58(4):179-190]

Cited: 34 times

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Uncovering gene regulatory networks during mouse fetal germ cell development.

Antoine D Rolland, Kim P Lehmann, Kamin J Johnson, Kevin W Gaido, Peter Koopman,

The commitment of germ cells to either oogenesis or spermatogenesis occurs during fetal gonad development: germ cells enter meiosis or mitotic arrest, depending on whether they reside within an ovary or a testis, respectively. Despite the critical importance of this step for sexual reproduction, gene networks underlying germ cell development ... Read more >>

Biol Reprod (Biology of reproduction)
[2011, 84(4):790-800]

Cited: 14 times

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Expression profiling of rainbow trout testis development identifies evolutionary conserved genes involved in spermatogenesis.

Antoine D Rolland, Jean-Jacques Lareyre, Anne-Sophie Goupil, Jérôme Montfort, Marie-Jo Ricordel, Diane Esquerré, Karine Hugot, Rémi Houlgatte, Fréderic Chalmel, Florence Le Gac,

<h4>Background</h4>Spermatogenesis is a late developmental process that involves a coordinated expression program in germ cells and a permanent communication between the testicular somatic cells and the germ-line. Current knowledge regarding molecular factors driving male germ cell proliferation and differentiation in vertebrates is still limited and mainly based on existing data ... Read more >>

BMC Genomics (BMC genomics)
[2009, 10:546]

Cited: 32 times

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CLPH, a novel casein kinase 2-phosphorylated disordered protein, is specifically associated with postmeiotic germ cells in rat spermatogenesis.

Pierre Calvel, Christine Kervarrec, Régis Lavigne, Virginie Vallet-Erdtmann, Myriam Guerrois, Antoine D Rolland, Frédéric Chalmel, Bernard Jégou, Charles Pineau,

In a recent proteomic study of rat spermatogenesis, we identified CLPH (for Casein-Like PHosphoprotein), a new testis-specific protein expressed exclusively in postmeiotic germ cells. In situ hybridization showed that the CLPH transcript was mainly present in round spermatids, whereas the protein was specifically detected by immunohistochemistry in elongated spermatids and ... Read more >>

J Proteome Res (Journal of proteome research)
[2009, 8(6):2953-2965]

Cited: 8 times

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Testicular development and spermatogenesis: harvesting the postgenomics bounty.

Antoine D Rolland, Bernard Jégou, Charles Pineau,

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2008, 636:16-41]

Cited: 14 times

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The conserved transcriptome in human and rodent male gametogenesis.

Frédéric Chalmel, Antoine D Rolland, Christa Niederhauser-Wiederkehr, Sanny S W Chung, Philippe Demougin, Alexandre Gattiker, James Moore, Jean-Jacques Patard, Debra J Wolgemuth, Bernard Jégou, Michael Primig,

We report a cross-species expression profiling analysis of the human, mouse, and rat male meiotic transcriptional program, using enriched germ cell populations, whole gonads, and high-density oligonucleotide microarrays (GeneChips). Among 35% of the protein-coding genes present in rodent and human genomes that were found to be differentially expressed between germ ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2007, 104(20):8346-8351]

Cited: 165 times

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Two-dimensional fluorescence difference gel electrophoresis analysis of spermatogenesis in the rat.

Antoine D Rolland, Bertrand Evrard, Nathalie Guitton, Régis Lavigne, Pierre Calvel, Morgane Couvet, Bernard Jégou, Charles Pineau,

The molecular mechanisms underlying normal and pathological spermatogenesis remain poorly understood. We compared protein concentrations in different germ cell types to identify those proteins specifically or preferentially expressed at each stage of rat spermatogenesis. Crude cytosolic protein extracts and reversed-phase HPLC prefractionated cytosolic extracts from spermatogonia, pachytene spermatocytes, and early ... Read more >>

J Proteome Res (Journal of proteome research)
[2007, 6(2):683-697]

Cited: 27 times

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Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis.

Emmanuelle Com, Antoine D Rolland, Myriam Guerrois, Florence Aubry, Bernard Jégou, Virginie Vallet-Erdtmann, Charles Pineau,

As part of a program to decipher the rat testicular proteome, we studied spermatogonia and identified numerous proteins including the human homolog of the Minichromosome Maintenance Protein 7 (MCM7). MCM7 has been implicated in DNA replication in various species, but had not been detected in the testis. Here we describe ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2006, 73(7):866-877]

Cited: 14 times

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