Full Text Journal Articles by
Author Anthony Phan


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Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells.

Ilkka Liikanen, Colette Lauhan, Sara Quon, Kyla Omilusik, Anthony T Phan, Laura Barceló Bartrolí, Amir Ferry, John Goulding, Joyce Chen, James P Scott-Browne, Jason T Yustein, Nicole E Scharping, Deborah A Witherden, Ananda W Goldrath,

Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates in patients with solid tumors underscore remaining challenges in realizing the potential of this cellular immunotherapy approach. Promoting CD8+ T cell adaptation to tissue residency represents an underutilized but promising strategy to improve tumor-infiltrating ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(7):]

Cited: 0 times

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cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

David Christian, Thomas Adams, Tony Smith, Lindsey Shallberg, Derek Theisen, Anthony Phan, Mosana Abraha, Joseph Perry, Gordon Ruthel, Joseph Clark, Kenneth Murphy, Ross Kedl, Christopher Hunter,

<h4>ABSTRACT</h4> The omentum in the peritoneal cavity contains fat associated lymphoid clusters (FALCs) whose role in the response to microbial challenge are poorly understood. After intraperitoneal immunization with Toxoplasma gondii , type I dendritic cells (cDC1) were critical to induce innate sources of IFN-γ required to recruit monocytes to the ... Read more >>

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The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.

Longfei Chen, David A Christian, Joshua A Kochanowsky, Anthony T Phan, Joseph T Clark, Shuai Wang, Corbett Berry, Jung Oh, Xiaoguang Chen, David S Roos, Daniel P Beiting, Anita A Koshy, Christopher A Hunter,

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact infection. Here, parasites that inject Cre-recombinase with rhoptry proteins were used to distinguish infected macrophages from those ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2020, 217(3):]

Cited: 9 times

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Initiative to reduce aztreonam use in patients with self-reported penicillin allergy: Effects on clinical outcomes and antibiotic prescribing patterns.

Anthony Phan, Bryan Allen, Kevin Epps, Maryam Alikhil, Katherine Kamataris, Calvin Tucker,

PURPOSE:Evaluation of the clinical impact of a pharmacist led-penicillin allergy assessment initiative to enhance antibiotic selection is reported. METHODS:A retrospective analysis was conducted on patients with a self-reported penicillin allergy (SRPA) at a 529-bed community teaching hospital and compared clinical response rate before and after implementation of a penicillin allergy ... Read more >>

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2018, 75(17 Supplement 3):S58-S62]

Cited: 3 times

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IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors.

Jonathan H DeLong, Aisling O'Hara Hall, Matt Rausch, Devapregasan Moodley, Joseph Perry, Jeongho Park, Anthony T Phan, Daniel P Beiting, Ross M Kedl, Jonathan A Hill, Christopher A Hunter,

Inhibitory receptors (IR) are a diverse group of cell surface molecules that modulate T cell activation, but there are gaps in our knowledge of the cell-extrinsic factors that regulate their expression. The present study found that in vivo overexpression of IL-27 in mice led to increased T cell expression of ... Read more >>

Immunohorizons (ImmunoHorizons)
[2019, 3(1):13-25]

Cited: 13 times

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Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

J Justin Milner, Clara Toma, Bingfei Yu, Kai Zhang, Kyla Omilusik, Anthony T Phan, Dapeng Wang, Adam J Getzler, Toan Nguyen, Shane Crotty, Wei Wang, Matthew E Pipkin, Ananda W Goldrath,

This corrects the article DOI: 10.1038/nature24993. ...

Nature (Nature)
[2018, 554(7692):392]

Cited: 1 time

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An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.

Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson,

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was essential for the effector state in CD8+ T cells. Furthermore, loss of HIF-1α in CD8+ T cells reduced tumor ... Read more >>

Cancer Cell (Cancer cell)
[2017, 32(5):669-683.e5]

Cited: 68 times

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Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity.

Anthony T Phan, Ananda W Goldrath, Christopher K Glass,

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To accommodate increased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferation and effector molecule production. In parallel, activation initiates context-specific gene-expression programs that drive effector functions ... Read more >>

Immunity (Immunity)
[2017, 46(5):714-729]

Cited: 85 times

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Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection.

Anthony T Phan, Andrew L Doedens, Asis Palazon, Petros A Tyrakis, Kitty P Cheung, Randall S Johnson, Ananda W Goldrath,

Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest that subsequent return to reliance on oxidative phosphorylation and increasing spare respiratory capacity are essential for the differentiation of memory CD8<sup>+</sup> T cells. In contrast, we found that constitutive glycolytic metabolism and ... Read more >>

Immunity (Immunity)
[2016, 45(5):1024-1037]

Cited: 59 times

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Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

David Clever, Rahul Roychoudhuri, Michael G Constantinides, Michael H Askenase, Madhusudhanan Sukumar, Christopher A Klebanoff, Robert L Eil, Heather D Hickman, Zhiya Yu, Jenny H Pan, Douglas C Palmer, Anthony T Phan, John Goulding, Luca Gattinoni, Ananda W Goldrath, Yasmine Belkaid, Nicholas P Restifo,

Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase (PHD) proteins is required to maintain local ... Read more >>

Cell (Cell)
[2016, 166(5):1117-1131.e14]

Cited: 73 times

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S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson,

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers, R- and S-2-hydroxyglutarate, are detectible in healthy individuals, yet their physiological function remains elusive. Here we show that 2-hydroxyglutarate accumulates in mouse CD8<sup>+</sup> T cells in ... Read more >>

Nature (Nature)
[2016, 540(7632):236-241]

Cited: 105 times

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Design and fabrication of a three dimensional printable non-assembly articulated hand exoskeleton for rehabilitation.

Lei Cui, Anthony Phan, Garry Allison,

Robotic rehabilitation has proven to be cost-effective in accelerating the rehabilitation process by eliminating the constant need for supervision by a therapist. This work aimed to design and develop a novel three-dimensional (3D) printable non-assembly five-fingered robotic hand exoskeleton for rehabilitation. A single degree-of-freedom (DOF) linkage was designed to actuate ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2015, 2015:4627-4630]

Cited: 1 time

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Hypoxia-inducible factors regulate T cell metabolism and function.

Anthony T Phan, Ananda W Goldrath,

Resolution of infection requires the coordinated response of heterogeneous cell types to a range of physiological and pathological signals to regulate their proliferation, migration, differentiation, and effector functions. One mechanism by which immune cells integrate these signals is through modulating metabolic activity. A well-studied regulator of cellular metabolism is the ... Read more >>

Mol Immunol (Molecular immunology)
[2015, 68(2 Pt C):527-535]

Cited: 17 times

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Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix.

Jonathan P Gumucio, Anthony C Phan, David G Ruehlmann, Andrew C Noah, Christopher L Mendias,

Mechanical loading can increase tendon cross-sectional area (CSA), but the mechanisms by which this occurs are largely unknown. To gain a greater understanding of the cellular mechanisms of adult tendon growth in response to mechanical loading, we used a synergist ablation model whereby a tenectomy of the Achilles tendon was ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2014, 117(11):1287-1291]

Cited: 20 times

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Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear.

Jonathan P Gumucio, Michael A Korn, Anjali L Saripalli, Michael D Flood, Anthony C Phan, Stuart M Roche, Evan B Lynch, Dennis R Claflin, Asheesh Bedi, Christopher L Mendias,

<h4>Background</h4>Rotator cuff tears are one of the most common musculoskeletal complaints and a substantial source of morbidity in elderly patients. Chronic cuff tears are associated with muscle atrophy and an infiltration of fat to the area, a condition known as "fatty degeneration." To improve the treatment of cuff tears in ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2014, 23(1):99-108]

Cited: 47 times

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Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury.

Jonathan P Gumucio, Michael D Flood, Anthony C Phan, Susan V Brooks, Christopher L Mendias,

Transforming growth factor-β (TGF-β) is a proinflammatory cytokine that regulates the response of many tissues following injury. Previous studies in our lab have shown that treating muscles with TGF-β results in a dramatic accumulation of type I collagen, substantial fiber atrophy, and a marked decrease in force production. Because TGF-β ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2013, 115(4):539-545]

Cited: 27 times

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