Full Text Journal Articles by
Author Annette S Kim

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JAK2 Rearrangements Are a Recurrent Alteration in CD30+ Systemic T-Cell Lymphomas With Anaplastic Morphology.

Megan J Fitzpatrick, Lucas R Massoth, Chelsea Marcus, Jo-Anne Vergilio, Eric Severson, Daniel Duncan, Shakti H Ramkissoon, Robert P Hasserjian, Annette S Kim, Aliyah R Sohani, Erik A Williams, Valentina Nardi,

Peripheral T-cell lymphoma (PTCL) comprises a heterogenous group of rare mature T-cell neoplasms. While some PTCL subtypes are well-characterized by histology, immunophenotype, and recurrent molecular alterations, others remain incompletely defined. In particular, the distinction between CD30+ PTCL, not otherwise specified and anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma can ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):895-904]

Cited: 0 times

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NPM1-mutant acute myeloid leukemia relapsing as acute lymphoblastic leukemia with clonal persistence of IDH1 mutation.

Hari S Raman, Vignesh Shanmugam, Jingwei Li, David P Steensma, Annette S Kim, Marlise R Luskin,

Leuk Lymphoma (Leukemia & lymphoma)
[2021, 62(7):1790-1792]

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Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium.

Yana Pikman, Sarah K Tasian, Maria Luisa Sulis, Kristen Stevenson, Traci M Blonquist, Beth Apsel Winger, Todd M Cooper, Melinda Pauly, Kelly W Maloney, Michael J Burke, Patrick A Brown, Nathan Gossai, Jennifer L McNeer, Neerav N Shukla, Peter D Cole, Justine M Kahn, Jing Chen, Matthew J Barth, Jeffrey A Magee, Lisa Gennarini, Asmani A Adhav, Catherine M Clinton, Nicole Ocasio-Martinez, Giacomo Gotti, Yuting Li, Shan Lin, Alma Imamovic, Cristina E Tognon, Tasleema Patel, Haley L Faust, Cristina F Contreras, Anjali Cremer, Wilian A Cortopassi, Diego Garrido Ruiz, Matthew P Jacobson, Neekesh V Dharia, Angela Su, Amanda L Robichaud, Amy Saur Conway, Katherine Tarlock, Elliot Stieglitz, Andrew E Place, Alexandre Puissant, Stephen P Hunger, Annette S Kim, Neal I Lindeman, Lia Gore, Katherine A Janeway, Lewis B Silverman, Jeffrey W Tyner, Marian H Harris, Mignon L Loh, Kimberly Stegmaier,

Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. ... Read more >>

Cancer Discov (Cancer discovery)
[2021, 11(6):1424-1439]

Cited: 1 time

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Characteristic nuclear membrane ALK reactivity in chronic myelomonocytic leukemia with RANBP2-ALK fusion.

Christopher B Hergott, Paola Dal Cin, Jason L Hornick, Eric S Winer, Ruben D Carrasco, Annette S Kim,

Am J Hematol (American journal of hematology)
[2021, :]

Cited: 0 times

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Clinical Significance of CBC and WBC Morphology in the Diagnosis and Clinical Course of COVID-19 Infection.

Olga Pozdnyakova, Nathan T Connell, Elisabeth M Battinelli, Jean M Connors, Geoffrey Fell, Annette S Kim,

<h4>Objectives</h4>To investigate the clinical significance of numeric and morphologic peripheral blood (PB) changes in coronavirus disease 2019 (COVID-19)-positive patients in predicting the outcome, as well as to compare these changes between critically ill COVID-19-positive and COVID-19-negative patients.<h4>Methods</h4>The study included 90 COVID-19-positive (51 intensive care unit [ICU] and 39 non-ICU) patients ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2021, 155(3):364-375]

Cited: 2 times

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An Overview of Characteristics of Clinical Next-Generation Sequencing-Based Testing for Hematologic Malignancies.

Bing M Zhang, Alissa Keegan, Peng Li, Neal I Lindeman, Rakesh Nagarajan, Mark J Routbort, Patricia Vasalos, Annette S Kim, Jason D Merker,

<h4>Context.—</h4>With the increasing integration of molecular alterations into the evaluation of hematologic malignancies (HM), somatic mutation profiling by next-generation sequencing (NGS) has become a common clinical testing strategy. Limited data are available about the characteristics of these assays.<h4>Objective.—</h4>To describe assay characteristics, specimen requirements, and reporting practices for NGS-based HM testing ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2021, :]

Cited: 0 times

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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.

Shruti Bhatt, Marissa S Pioso, Elyse Anne Olesinski, Binyam Yilma, Jeremy A Ryan, Thelma Mashaka, Buon Leutz, Sophia Adamia, Haoling Zhu, Yanan Kuang, Abhishek Mogili, Abner Louissaint, Stephan R Bohl, Annette S Kim, Anita K Mehta, Sneha Sanghavi, Youzhen Wang, Erick Morris, Ensar Halilovic, Cloud P Paweletz, David M Weinstock, Jacqueline S Garcia, Anthony Letai,

Acquired resistance to BH3 mimetic antagonists of BCL-2 and MCL-1 is an important clinical problem. Using acute myelogenous leukemia (AML) patient-derived xenograft (PDX) models of acquired resistance to BCL-2 (venetoclax) and MCL-1 (S63845) antagonists, we identify common principles of resistance and persistent vulnerabilities to overcome resistance. BH3 mimetic resistance is ... Read more >>

Cancer Cell (Cancer cell)
[2020, 38(6):872-890.e6]

Cited: 1 time

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Mutational analysis of hematologic neoplasms in 164 paired peripheral blood and bone marrow samples by next-generation sequencing.

Fabienne Lucas, Phillip D Michaels, Dahai Wang, Annette S Kim,

Blood Adv (Blood advances)
[2020, 4(18):4362-4365]

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Targeted Informatics for Optimal Detection, Characterization, and Quantification of FLT3 Internal Tandem Duplications Across Multiple Next-Generation Sequencing Platforms.

Harrison K Tsai, Diane G Brackett, David Szeto, Ryan Frazier, Allison MacLeay, Phani Davineni, Danielle K Manning, Elizabeth Garcia, Neal I Lindeman, Long P Le, Jochen K Lennerz, Christopher J Gibson, R Coleman Lindsley, Annette S Kim, Valentina Nardi,

Assessment of internal tandem duplications in FLT3 (FLT3-ITDs) and their allelic ratio (AR) is recommended by clinical guidelines for diagnostic workup of acute myeloid leukemia and traditionally performed through capillary electrophoresis (CE). Although significant progress has been made integrating FLT3-ITD detection within contemporary next-generation sequencing (NGS) panels, AR estimation is ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2020, 22(9):1162-1178]

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Molecular/Cytogenetic Education for Hematopathology Fellows.

Rose C Beck, Annette S Kim, Rashmi S Goswami, Olga K Weinberg, Cecilia C S Yeung, Mark D Ewalt,

OBJECTIVES:At a discussion on molecular/cytogenetic education for hematopathology fellows at the 2018 Society for Hematopathology Program Directors Meeting, consensus was that fellows should understand basic principles and indications for and limitations of molecular/cytogenetic testing used in routine practice. Fellows should also be adept at integrating results of such testing for ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2020, 154(2):149-177]

Cited: 1 time

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Evidence for separate transformation to acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm from a shared ancestral hematopoietic clone.

Marlise R Luskin, Annette S Kim, Sanjay S Patel, Kyle Wright, Nicole R LeBoeuf, Andrew A Lane,

Leuk Lymphoma (Leukemia & lymphoma)
[2020, 61(9):2258-2261]

Cited: 1 time

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Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next Generation Sequencing-Based Hematologic Malignancy Assays With Survey Material-Specific Differences in Variant Frequencies.

Alissa Keegan, Julia A Bridge, Neal I Lindeman, Thomas A Long, Jason D Merker, Joel T Moncur, Nathan D Montgomery, Rakesh Nagarajan, Paul G Rothberg, Mark J Routbort, Patricia Vasalos, Rena Xian, Annette S Kim,

CONTEXT.—:As laboratories increasingly turn from single-analyte testing in hematologic malignancies to next-generation sequencing-based panel testing, there is a corresponding need for proficiency testing to ensure adequate performance of these next-generation sequencing assays for optimal patient care. OBJECTIVE.—:To report the performance of laboratories on proficiency testing from the first 4 College ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2020, :]

Cited: 1 time

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Detection of the KITD816V mutation in myelodysplastic and/or myeloproliferative neoplasms and acute myeloid leukemia with myelodysplasia-related changes predicts concurrent systemic mastocytosis.

Jeffrey W Craig, Robert P Hasserjian, Annette S Kim, Jon C Aster, Geraldine S Pinkus, Jason L Hornick, David P Steensma, R Coleman Lindsley, Daniel J DeAngelo, Elizabeth A Morgan,

Greater than 90% of cases of systemic mastocytosis (SM) harbor pathogenic KIT mutations, particularly KIT<sup>D816V</sup>. Prognostically-significant pathogenic KIT mutations also occur in 30-40% of core binding factor-associated acute myeloid leukemia (CBF-AML), but are uncommonly associated with concurrent SM. By comparison, the occurrence of SM in other myeloid neoplasms bearing pathogenic ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(6):1135-1145]

Cited: 3 times

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Clinical utility of targeted next-generation sequencing-based screening of peripheral blood in the evaluation of cytopenias.

Vignesh Shanmugam, Aric Parnes, Rajeshwari Kalyanaraman, Elizabeth A Morgan, Annette S Kim,

Blood (Blood)
[2019, 134(24):2222-2225]

Cited: 1 time

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Li-Fraumeni syndrome presenting as precursor B lymphoblastic leukemia mimicking intravascular large B-cell lymphoma.

Sameer S Khatri, Annette S Kim,

Blood (Blood)
[2019, 134(12):993]

Cited: 0 times

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Molecular and Cytogenetic Education in Hematopathology Fellowship.

Lorinda A Soma, Alexandra E Kovach, Alexa J Siddon, Rose Beck, Sarah E Gibson, Steven H Swerdlow, Annette S Kim, David Wu, Dan Jones, James R Cook, Sonam Prakash, Flavia Rosado, Genevieve Crane, Kyle Bradley, Olga K Weinberg, Rachel L Sargent,

<h4>Objectives</h4>Given the increased complexity of molecular and cytogenetic testing (MOL-CG), the Society for Hematopathology Education Committee (SH-EC) was interested in determining what the current expectations are for MOL-CG education in hematopathology (HP) fellowship training.<h4>Methods</h4>The SH-EC sent a questionnaire to HP fellowship program directors (HP-PDs) covering MOL-CG training curricula, test menus, ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2019, 152(4):438-445]

Cited: 0 times

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Bad to the Bone.

Jennifer L Crombie, Ramkumar Venkateswaran, Annette S Kim, Anand Vaidya, David C Fisher,

N Engl J Med (The New England journal of medicine)
[2019, 381(4):e9]

Cited: 0 times

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Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the BRAF, EGFR, and KRAS Genes: A Study of the College of American Pathologists Molecular Oncology Committee.

Joel T Moncur, Angela N Bartley, Julia A Bridge, Suzanne Kamel-Reid, Alexander J Lazar, Neal I Lindeman, Thomas A Long, Jason D Merker, Alex J Rai, David L Rimm, Paul G Rothberg, Patricia Vasalos, Annette S Kim,

<h4>Context.—</h4>The performance of laboratory testing has recently come under increased scrutiny as part of important and ongoing debates on regulation and reimbursement. To address this critical issue, this study compares the performance of assay methods, using either commercial kits or assays designed and implemented by single laboratories ("home brews"), including ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2019, 143(10):1203-1211]

Cited: 1 time

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Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples.

Lea F Surrey, Fredrick D Oakley, Jason D Merker, Thomas A Long, Patricia Vasalos, Joel T Moncur, Annette S Kim,

<h4>Context.—</h4>There has been a rapid expansion of next-generation sequencing (NGS)-based assays for the detection of somatic variants in solid tumors. However, limited data are available regarding the comparative performance of NGS and non-NGS assays using standardized samples across a large number of laboratories.<h4>Objective.—</h4>To compare the performance of NGS and non-NGS ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2019, 143(8):980-984]

Cited: 1 time

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Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy.

Adam J Olszewski, Anna D Chorzalska, Annette S Kim, Peter J Quesenberry, Mary L Lopresti, Mary A Fenton, John L Reagan, James N Butera, Ilyas Sahin, Celine Hamel, Jordan Robison, Max Petersen, Patrycja M Dubielecka,

Br J Haematol (British journal of haematology)
[2019, 186(3):e31-e35]

Cited: 2 times

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Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays.

Jason D Merker, Kelly Devereaux, A John Iafrate, Suzanne Kamel-Reid, Annette S Kim, Joel T Moncur, Stephen B Montgomery, Rakesh Nagarajan, Bryce P Portier, Mark J Routbort, Craig Smail, Lea F Surrey, Patricia Vasalos, Alexander J Lazar, Neal I Lindeman,

<h4>Context.—</h4>Next-generation sequencing-based assays are being increasingly used in the clinical setting for the detection of somatic variants in solid tumors, but limited data are available regarding the interlaboratory performance of these assays.<h4>Objective.—</h4>To examine proficiency testing data from the initial College of American Pathologists (CAP) Next-Generation Sequencing Solid Tumor survey to ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2019, 143(4):463-471]

Cited: 6 times

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Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology.

Rebecca F McClure, Mark D Ewalt, Jennifer Crow, Robyn L Temple-Smolkin, Mrudula Pullambhatla, Rachel Sargent, Annette S Kim,

To address the clinical relevance of small DNA variants in chronic myeloid neoplasms (CMNs), an Association for Molecular Pathology Working Group comprehensively reviewed published literature, summarized key findings that support clinical utility, and defined critical gene inclusions for high-throughput sequencing testing panels. This review highlights the biological complexity of CMNs ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2018, 20(6):717-737]

Cited: 9 times

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Many faces of the same myeloid neoplasm: a case of leukaemia cutis with mixed histiocytic and Langerhans cell differentiation.

Vignesh Shanmugam, Elizabeth A Morgan, Daniel J DeAngelo, Annette S Kim,

J Clin Pathol (Journal of clinical pathology)
[2019, 72(1):93-96]

Cited: 1 time

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Comparison of Laboratory-Developed Tests and FDA-Approved Assays for BRAF, EGFR, and KRAS Testing.

Annette S Kim, Angela N Bartley, Julia A Bridge, Suzanne Kamel-Reid, Alexander J Lazar, Neal I Lindeman, Thomas A Long, Jason D Merker, Alex J Rai, David L Rimm, Paul G Rothberg, Patricia Vasalos, Joel T Moncur,

Importance:The debate about the role of the Food and Drug Administration (FDA) in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. This study provides data comparing the performance of LDTs and FDA-approved companion diagnostics (FDA-CDs) in proficiency testing (PT) provided ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, 4(6):838-841]

Cited: 7 times

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Limited Utility of Fluorescence In Situ Hybridization for Recurrent Abnormalities in Acute Myeloid Leukemia at Diagnosis and Follow-up.

Ferrin C Wheeler, Annette S Kim, Claudio A Mosse, Aaron C Shaver, Ashwini Yenamandra, Adam C Seegmiller,

Objectives:Acute myeloid leukemia (AML) is classified in part by recurrent cytogenetic abnormalities, often detected by both fluorescent in situ hybridization (FISH) and karyotype. The goal of this study was to assess the utility of FISH and karyotyping at diagnosis and follow-up. Methods:Adult AML samples at diagnosis or follow-up with karyotype ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2018, 149(5):418-424]

Cited: 0 times

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