Full Text Journal Articles by
Author Annemie L M Boehmer

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Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

Nienke J Vet, Brenda C M de Winter, Muriel Koninckx, Shelley A Boeschoten, Annemie L M Boehmer, Jacintha T Verhallen, Frans B Plötz, Anja A Vaessen-Verberne, Bart C H van der Nagel, Catherijne A J Knibbe, Corinne M P Buysse, Saskia N de Wildt, Birgit C P Koch, Matthijs de Hoog,

BACKGROUND:Intravenous salbutamol is used to treat children with refractory status asthmaticus, however insufficient pharmacokinetic data are available to guide initial and subsequent dosing recommendations for its intravenous use. The pharmacologic activity of salbutamol resides predominantly in the (R)-enantiomer, with little or no activity and even concerns of adverse reactions attributed ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2020, 59(2):257-264]

Cited: 0 times

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A Loading Dose of IV Salbutamol in an Adolescent with Severe Acute Asthma and Cardiac Arrest.

Shelley A Boeschoten, Ruben S van der Crabben, Annemie L M Boehmer, Matthijs de Hoog, Corinne M P Buysse,

Severe acute asthma (SAA) can lead to respiratory failure and can be fatal. For rational use of intravenous (IV) bronchodilators, evidence regarding the pharmacokinetics and pharmacodynamics is lacking in children. The use of a loading dose IV salbutamol is not mentioned in any international guideline, and its use varies greatly ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2019, 2019:5057390]

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Episodic viral wheeze and multiple-trigger wheeze in preschool children are neither distinct nor constant patterns. A prospective multicenter cohort study in secondary care.

Maud J A Raaymakers, Paul L P Brand, Anneke M Landstra, Marianne L Brouwer, Walter A F Balemans, Laetitia E M Niers, Peter J F M Merkus, Annemie L M Boehmer, Jan A J W Kluytmans, Johan C de Jongste, Marielle W H Pijnenburg, Anja A P H Vaessen-Verberne,

OBJECTIVES:To evaluate whether episodic viral wheeze (EVW) and multiple-trigger wheeze (MTW) are clinically distinguishable and stable preschool wheezing phenotypes. METHODS:Children of age 1 to 4 year with recurrent, pediatrician-confirmed wheeze were recruited from secondary care; 189 were included. Respiratory and viral upper respiratory tract infection (URTI) symptoms were recorded weekly ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(9):1439-1446]

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Children with severe acute asthma admitted to Dutch PICUs: A changing landscape.

Shelley A Boeschoten, Corinne M P Buysse, Peter J F M Merkus, Jacob M C van Wijngaarden, Sabien G J Heisterkamp, Johan C de Jongste, Joost van Rosmalen, Suzan C M Cochius-den Otter, Annemie L M Boehmer, Matthijs de Hoog, ,

The number of children requiring pediatric intensive care unit (PICU) admission for severe acute asthma (SAA) around the world has increased. OBJECTIVES:We investigated whether this trend in SAA PICU admissions is present in the Netherlands. METHODS:A multicenter retrospective cohort study across all tertiary care PICUs in the Netherlands. Inclusion criteria ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2018, 53(7):857-865]

Cited: 1 time

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Online asthma management for children is cost-effective.

Lara S van den Wijngaart, Wietske Kievit, Jolt Roukema, Annemie L M Boehmer, Marianne L Brouwer, Cindy A C Hugen, Laetitia E M Niers, Arwen J Sprij, Eleonora R V M Rikkers-Mutsaerts, Bart L Rottier, Chris M Verhaak, Mariëlle W Pijnenburg, Peter J F M Merkus,

Eur. Respir. J. (The European respiratory journal)
[2017, 50(4):]

Cited: 2 times

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A virtual asthma clinic for children: fewer routine outpatient visits, same asthma control.

Lara S van den Wijngaart, Jolt Roukema, Annemie L M Boehmer, Marianne L Brouwer, Cindy A C Hugen, Laetitia E M Niers, Arwen J Sprij, Eleonora R V M Rikkers-Mutsaerts, Bart L Rottier, A Rogier T Donders, Chris M Verhaak, Mariëlle W Pijnenburg, Peter J F M Merkus,

eHealth is an appealing medium to improve healthcare and its value (in addition to standard care) has been assessed in previous studies. We aimed to assess whether an eHealth intervention could improve asthma control while reducing 50% of routine outpatient visits.In a multicentre, randomised controlled trial with a 16-month follow-up, ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2017, 50(4):]

Cited: 1 time

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The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial.

Jasmijn Teunissen, Anne H J Hochs, Anja Vaessen-Verberne, Annemie L M Boehmer, Carien C J M Smeets, Hein Brackel, René van Gent, Judith Wesseling, Danielle Logtens-Stevens, Ronald de Moor, Philippe P R Rosias, Steph Potgieter, Marianne R Faber, Han J E Hendriks, Maryska L G Janssen-Heijnen, Bettina F Loza,

Bronchiolitis is a common disorder in young children that often results in hospitalisation. Except for a possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy is available. This study investigated the efficacy of nebulised 3% and 6% hypertonic saline compared with 0.9% hypertonic saline in children hospitalised with ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2014, 44(4):913-921]

Cited: 21 times

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Risk factors for pediatric intensive care admission in children with acute asthma.

Gerbrich E van den Bosch, Peter J F M Merkus, Corinne M P Buysse, Annemie L M Boehmer, Anja A P H Vaessen-Verberne, Leonieke N van Veen, Wim C J Hop, Matthijs de Hoog,

INTRODUCTION: Severe acute asthma in children is associated with substantial morbidity and may require pediatric ICU (PICU) admission. The aim of the study was to determine risk factors for PICU admission. METHODS: The study used a retrospective multicenter case-control design. The cases included children admitted to the PICU because ... Read more >>

Respir Care (Respiratory care)
[2012, 57(9):1391-1397]

Cited: 11 times

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Paediatric asthma: everything that seemed to be certain no longer is.

Annemie L M Boehmer,

'Paediatric asthma: everything that seemed to be certain no longer is', holds the promise of leaving you with more questions than answers at the end of this review of paediatric asthma 2008-2009. This has often been true for asthma research, in particular over the past few years. Research with direct ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2010, 11(3):185-190]

Cited: 2 times

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Asthma therapy for children under 5 years of age.

Annemie L M Boehmer, Peter J F M Merkus,

PURPOSE OF REVIEW:The evidence for effectiveness of currently used asthma medication for wheeze in young children is reviewed. RECENT FINDINGS:The management of the infant and preschool child with wheezing is complicated by the uncertainty with respect to the aetiology. Difficulties in defining phenotypes and objective outcome parameters combined with the ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2006, 12(1):34-41]

Cited: 9 times

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Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.

Erica L T Van Den Akker, Jan W Koper, Annemie L M Boehmer, Axel P N Themmen, Miriam Verhoef-Post, Marianna A Timmerman, Barto J Otten, Stenvert L S Drop, Frank H De Jong,

The microsomal enzyme cytochrome P450c17 is an important regulator of steroidogenesis. The enzyme has two functions: 17alpha-hydroxylase and 17,20-lyase activities. These functions determine the ability of adrenal glands and gonads to synthesize 17alpha-hydroxylated glucocorticoids (17alpha-hydroxylase activity) and/or sex steroids (17,20-lyase activity). Both enzyme functions depend on correct steroid binding, but ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2002, 87(12):5714-5721]

Cited: 33 times

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