Full Text Journal Articles by
Author Anne Greenough

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A randomised crossover trial of closed loop automated oxygen control in preterm, ventilated infants.

Sarah Sturrock, Hemant Ambulkar, Emma E Williams, Samantha Sweeney, Nadja F Bednarczuk, Theodore Dassios, Anne Greenough,

AIM:To determine if closed loop automated oxygen control resulted in a reduction in the duration and severity of desaturation episodes and the number of blood gases and chest radiographs in preterm, ventilated infants. METHODS:Infants were studied on two consecutive days for 12 hours on each day. They were randomised to ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial.

Anne Greenough, Fabrice Decobert, David Field, Mikko Hallman, Helmut D Hummler, Baldvin Jonsson, Manuel Sánchez Luna, Bart Van Overmeire, Virgilio P Carnielli, Jim L Potenziano, Jean-Christophe Mercier,

Objectives Most studies of inhaled nitric oxide (iNO) for prevention of bronchopulmonary dysplasia (BPD) in premature infants have focused on short-term mortality and morbidity. Our aim was to determine the long-term effects of iNO. Methods A 7-year follow-up was undertaken of infants entered into a multicenter, double-blind, randomized, placebo-controlled trial ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, :]

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Antenatal and perinatal outcomes of refugees in high income countries.

Sarah Sturrock, Emma Williams, Anne Greenough,

Objectives The World Health Organisation (WHO) has highlighted a marked trend for worse pregnancy-related indicators in migrants, such as maternal and neonatal morbidity and mortality, poor mental health and suboptimal care. The aim of this study was to determine whether such adverse outcomes occurred in refugees who moved to high ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, :]

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Premature infants with patent ductus arteriosus: Postnatal growth according to type of management.

Kunal Babla, Theodore Dassios, Kuberan Pushparajah, Ann Hickey, Anne Greenough,

BACKGROUND:Patent Ductus Arteriosus (PDA) is a common condition, affecting nearly half of infants born before 28 weeks' of gestation, and it has been associated with poor growth. It is not known if different treatment modalities are associated with more profound growth impairment. Our aim was to compare differences in weight ... Read more >>

Pediatr Neonatol (Pediatrics and neonatology)
[2020, :]

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The COVID-19 Early Detection in Doctors and Healthcare Workers (CEDiD) Study: study protocol for a prospective observational trial

Alexander Zargaran, Dina Radenkovic, Chelsea Trengrove, Gill Arbane, Kariem El-Boghdadly, Rocio Teresa Martinez-Nunez, Anne Greenough,

Background: The global COVID-19 pandemic has caused worldwide disruption with its exponential spread mandating national and international lockdown measures. Hospital-associated transmission has been identified as a major factor in the perpetuation of COVID-19, with healthcare workers at high-risk of becoming infected with SARS-CoV-2 and representing important vectors for spread, but ... Read more >>

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Outcomes of the Neonatal Trial of High-Frequency Oscillation at 16 to 19 Years.

Christopher Harris, Alessandra Bisquera, Alan Lunt, Janet L Peacock, Anne Greenough,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 383(7):689-691]

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Response to Hinder et al regarding t-piece resuscitators in the low-compliant newborn lung.

Katie A Hunt, Vadivelam Murthy, Anthony D Milner, Anne Greenough,

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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Anatomical deadspace during resuscitation of infants with congenital diaphragmatic hernia.

Emma E Williams, Theodore Dassios, Vadivelam Murthy, Anne Greenough,

BACKGROUND:Congenital diaphragmatic hernia (CDH) has a high mortality and morbidity related to pulmonary hypoplasia. AIMS:To test the hypothesis that CDH infants who survived would have a greater anatomical deadspace reflecting less severe pulmonary hypoplasia. Furthermore, infants with CDH who had undergone feto-tracheal occlusion (FETO) would have a greater anatomical deadspace. ... Read more >>

Early Hum. Dev. (Early human development)
[2020, 149:105150]

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Postnatal dexamethasone exposure and lung function in adolescents born very prematurely.

Christopher Harris, Alessandra Bisquera, Sanja Zivanovic, Alan Lunt, Sandy Calvert, Neil Marlow, Janet L Peacock, Anne Greenough,

We previously demonstrated corticosteroid administration on the neonatal intensive care unit was associated with reduced lung function at 11 to 14 years of age in children born very prematurely. The objective of this observational study was to assess if lung function remained impaired at 16 to 19 years of age ... Read more >>

PLoS ONE (PloS one)
[2020, 15(8):e0237080]

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Global molecular diversity of RSV - the "INFORM RSV" study.

Annefleur C Langedijk, Robert Jan Lebbink, Christiana Naaktgeboren, Anouk Evers, Marco C Viveen, Anne Greenough, Terho Heikkinen, Renato T Stein, Peter Richmond, Federico Martinón-Torres, Marta Nunes, Mitsuaki Hosoya, Christian Keller, Monika Bauck, Robert Cohen, Jesse Papenburg, Jeffrey Pernica, Marije P Hennus, Hong Jin, David E Tabor, Andrev Tovchigrechko, Alexey Ruzin, Michael E Abram, Deidre Wilkins, Joanne G Wildenbeest, Leyla Kragten-Tabatabaie, Frank E J Coenjaerts, Mark T Esser, Louis J Bont,

BACKGROUND:Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):450]

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Lung function and exercise capacity in prematurely born young people.

Christopher Harris, Alan Lunt, Alessandra Bisquera, Janet Peacock, Anne Greenough,

OBJECTIVES:To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity. WORKING HYPOTHESIS:In the current era, lung function abnormalities would not be associated with exercise intolerance STUDY DESIGN: Follow-up of young people from the United ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Prediction of extubation success using the diaphragmatic electromyograph results in ventilated neonates.

Katie A Hunt, Ian Hunt, Kamal Ali, Theodore Dassios, Anne Greenough,

Objectives Extubation failure is common in infants and associated with complications. Methods A prospective study was undertaken of preterm and term born infants. Diaphragm electromyogram (EMG) was measured transcutaneously for 15-60 min prior to extubation. The EMG results were related to tidal volume (Tve) to calculate the neuroventilatory efficiency (NVE). Receiver ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, 48(6):609-614]

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Volumetric capnography slopes in ventilated term and preterm infants.

Theodore Dassios, Paul Dixon, Emma Williams, Anne Greenough,

OBJECTIVE:To assess whether the slopes of volumetric capnography differ in preterm compared to term-born ventilated newborn infants and whether they are related to gestational age and the duration of ventilation. APPROACH:The slopes of phase II (SII) and III (SIII) of volumetric capnographs were measured in ventilated term and preterm infants ... Read more >>

Physiol Meas (Physiological measurement)
[2020, 41(5):055001]

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Second course of systemic dexamethasone: efficacy and respiratory function changes.

Theodore Dassios, Ourania Kaltsogianni, Anne Greenough,

Background: There is a paucity of data concerning the efficacy of a second course of systemic postnatal corticosteroids resulting in a successful extubation of prematurely-born, ventilated infants and its effect on their respiratory function.Objectives: To determine the efficacy of a second course of systemic dexamethasone in successful extubation of prematurely-born ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-4]

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Assessment of sidestream end-tidal capnography in ventilated infants on the neonatal unit.

Emma Williams, Theodore Dassios, Anne Greenough,

OBJECTIVES:Continuous monitoring of carbon dioxide (CO2 ) levels can be achieved by capnography. Our aims were to compare the performance of a sidestream capnograph with a low dead space and sampling rate to a mainstream device and evaluate whether its results correlated with arterial/capillary CO2 levels in infants with different ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(6):1468-1473]

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Maternal smoking and cannabis use during pregnancy and infant outcomes.

Sarah Sturrock, Emma Williams, Hemant Ambulkar, Theodore Dassios, Anne Greenough,

Background Our aim was to determine the prevalence of tobacco smoking and e-cigarettes and cannabis use during pregnancy, whether these were influenced by ethnicity, and their relationship to perinatal outcomes. Methods A study was carried out in 4465 infants whose mothers delivered during 2017 and 2018. Self-reported maternal smoking, e-cigarette ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, 48(2):168-172]

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Proportional assist ventilation (PAV) versus neurally adjusted ventilator assist (NAVA): effect on oxygenation in infants with evolving or established bronchopulmonary dysplasia.

Katie A Hunt, Theodore Dassios, Anne Greenough,

Both proportional assist ventilation (PAV) and neurally adjusted ventilatory assist (NAVA) provide pressure support synchronised throughout the respiratory cycle proportional to the patient's respiratory demand. Our aim was to compare the effect of these two modes on oxygenation in infants with evolving or established bronchopulmonary dysplasia. Two-hour periods of PAV ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, 179(6):901-908]

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Genetic causes of hypopituitarism.

Katherine Parkin, Ritika Kapoor, Ravindra Bhat, Anne Greenough,

Hypopituitarism in neonates is rare, but has life-threatening complications if untreated. This review describes the features of hypopituitarism and the evidence for which infants in whom a genetic cause should be suspected. Importantly, neonates are often asymptomatic or present with non-specific symptoms. Hypopituitarism can be due to abnormal gland development ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2020, 16(1):27-33]

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European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia.

Liesbeth Duijts, Evelien R van Meel, Laura Moschino, Eugenio Baraldi, Magda Barnhoorn, Wichor M Bramer, Charlotte E Bolton, Jeanette Boyd, Frederik Buchvald, Maria Jesus Del Cerro, Andrew A Colin, Refika Ersu, Anne Greenough, Christiaan Gremmen, Thomas Halvorsen, Juliette Kamphuis, Sailesh Kotecha, Kathleen Rooney-Otero, Sven Schulzke, Andrew Wilson, David Rigau, Rebecca L Morgan, Thomy Tonia, Charles C Roehr, Marielle W Pijnenburg,

This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and who have been discharged from the hospital, or who were >36 weeks of postmenstrual age. The guideline was based on predefined Population, Intervention, Comparison and Outcomes (PICO) questions relevant for clinical care, ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(1):]

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Lung function and respiratory outcomes in teenage boys and girls born very prematurely.

Christopher Harris, Sanja Zivanovic, Alan Lunt, Sandy Calvert, Alessandra Bisquera, Neil Marlow, Janet L Peacock, Anne Greenough,

OBJECTIVES:Male sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood. WORKING HYPOTHESIS:Respiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex. STUDY DESIGN:Analysis of follow-up data. ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(3):682-689]

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Reducing weight and increasing physical activity in people at high risk of cardiovascular disease: a randomised controlled trial comparing the effectiveness of enhanced motivational interviewing intervention with usual care.

Khalida Ismail, Adam Bayley, Katherine Twist, Kurtis Stewart, Katie Ridge, Emma Britneff, Anne Greenough, Mark Ashworth, Jennifer Rundle, Derek G Cook, Peter Whincup, Janet Treasure, Paul McCrone, Kirsty Winkley, Daniel Stahl,

OBJECTIVE:The epidemic of obesity is contributing to the increasing prevalence of people at high risk of cardiovascular disease (CVD), negating the medical advances in reducing CVD mortality. We compared the clinical and cost-effectiveness of an intensive lifestyle intervention consisting of enhanced motivational interviewing in reducing weight and increasing physical activity ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, 106(6):447-454]

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Prolonged ventilation and postnatal growth of preterm infants.

Emma Williams, Theodore Dassios, Kate Arnold, Ann Hickey, Anne Greenough,

Background Extremely premature infants often need invasive respiratory support from birth, but have low nutritional reserves and high metabolic demands. Our aim was to determine if there was a relationship between prolonged ventilation and reduced postnatal growth in such infants. Methods A retrospective, observational study was undertaken. Data from infants ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2019, 48(1):82-86]

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End-tidal carbon dioxide levels during resuscitation and carbon dioxide levels in the immediate neonatal period and intraventricular haemorrhage.

Kentaro Tamura, Emma E Williams, Theodore Dassios, Anoop Pahuja, Katie A Hunt, Vadivelam Murthy, Prashanth Bhat, Ravindra Bhat, Anthony Milner, Anne Greenough,

Abnormal levels of end-tidal carbon dioxide (EtCO2) during resuscitation in the delivery suite are associated with intraventricular haemorrhage (IVH) development. Our aim was to determine whether carbon dioxide (CO2) levels in the first 3 days after birth reflected abnormal EtCO2 levels in the delivery suite, and hence, a prolonged rather ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, 179(4):555-559]

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Core outcomes in neonatology: development of a core outcome set for neonatal research.

James William Harrison Webbe, James M N Duffy, Elsa Afonso, Iyad Al-Muzaffar, Ginny Brunton, Anne Greenough, Nigel J Hall, Marian Knight, Jos M Latour, Caroline Lee-Davey, Neil Marlow, Laura Noakes, Julie Nycyk, Angela Richard-Löndt, Ben Wills-Eve, Neena Modi, Chris Gale,

BACKGROUND:Neonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals. OBJECTIVE:To define a core outcome set (COS) for research involving infants receiving neonatal care in a high-income setting. ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):425-431]

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Foetal lung volumes in pregnant women who deliver very preterm: a pilot study.

Lisa Story, Tong Zhang, Johannes K Steinweg, Jana Hutter, Jacqueline Matthew, Theodore Dassios, Paul T Seed, Dharmintra Pasupathy, Joanna Allsop, Joseph V Hajnal, Anne Greenough, Andrew H Shennan, Mary Rutherford,

BACKGROUND:Infants born preterm are at increased risk of pulmonary morbidity. The contribution of antenatal factors to impairments in lung structure/function has not been fully elucidated. This study aimed to compare standardized lung volumes from foetuses that were delivered <32 weeks' gestation with foetuses that were delivered >37 weeks. METHODS:Fourteen women ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, 87(6):1066-1071]

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