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Author Anne Greenough

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Global molecular diversity of RSV - the "INFORM RSV" study.

Annefleur C Langedijk, Robert Jan Lebbink, Christiana Naaktgeboren, Anouk Evers, Marco C Viveen, Anne Greenough, Terho Heikkinen, Renato T Stein, Peter Richmond, Federico Martinón-Torres, Marta Nunes, Mitsuaki Hosoya, Christian Keller, Monika Bauck, Robert Cohen, Jesse Papenburg, Jeffrey Pernica, Marije P Hennus, Hong Jin, David E Tabor, Andrev Tovchigrechko, Alexey Ruzin, Michael E Abram, Deidre Wilkins, Joanne G Wildenbeest, Leyla Kragten-Tabatabaie, Frank E J Coenjaerts, Mark T Esser, Louis J Bont,

BACKGROUND:Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ... Read more >>

BMC Infect. Dis. (BMC Infectious Diseases)
[2020, 20(1):450]

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Lung function and exercise capacity in prematurely born young people.

Christopher Harris, Alan Lunt, Alessandra Bisquera, Janet Peacock, Anne Greenough,

OBJECTIVES:To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity. WORKING HYPOTHESIS:In the current era, lung function abnormalities would not be associated with exercise intolerance STUDY DESIGN: Follow-up of young people from the United ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Prediction of extubation success using the diaphragmatic electromyograph results in ventilated neonates.

Katie A Hunt, Ian Hunt, Kamal Ali, Theodore Dassios, Anne Greenough,

Objectives Extubation failure is common in infants and associated with complications. Methods A prospective study was undertaken of preterm and term born infants. Diaphragm electromyogram (EMG) was measured transcutaneously for 15-60 min prior to extubation. The EMG results were related to tidal volume (Tve) to calculate the neuroventilatory efficiency (NVE). Receiver ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, :]

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Volumetric capnography slopes in ventilated term and preterm infants.

Theodore Dassios, Paul Dixon, Emma Williams, Anne Greenough,

OBJECTIVE:To assess whether the slopes of volumetric capnography differ in preterm compared to term-born ventilated newborn infants and whether they are related to gestational age and the duration of ventilation. APPROACH:The slopes of phase II (SII) and III (SIII) of volumetric capnographs were measured in ventilated term and preterm infants ... Read more >>

Physiol Meas (Physiological measurement)
[2020, 41(5):055001]

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Second course of systemic dexamethasone: efficacy and respiratory function changes.

Theodore Dassios, Ourania Kaltsogianni, Anne Greenough,

Background: There is a paucity of data concerning the efficacy of a second course of systemic postnatal corticosteroids resulting in a successful extubation of prematurely-born, ventilated infants and its effect on their respiratory function.Objectives: To determine the efficacy of a second course of systemic dexamethasone in successful extubation of prematurely-born ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-4]

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Assessment of sidestream end-tidal capnography in ventilated infants on the neonatal unit.

Emma Williams, Theodore Dassios, Anne Greenough,

OBJECTIVES:Continuous monitoring of carbon dioxide (CO2 ) levels can be achieved by capnography. Our aims were to compare the performance of a sidestream capnograph with a low dead space and sampling rate to a mainstream device and evaluate whether its results correlated with arterial/capillary CO2 levels in infants with different ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(6):1468-1473]

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Maternal smoking and cannabis use during pregnancy and infant outcomes.

Sarah Sturrock, Emma Williams, Hemant Ambulkar, Theodore Dassios, Anne Greenough,

Background Our aim was to determine the prevalence of tobacco smoking and e-cigarettes and cannabis use during pregnancy, whether these were influenced by ethnicity, and their relationship to perinatal outcomes. Methods A study was carried out in 4465 infants whose mothers delivered during 2017 and 2018. Self-reported maternal smoking, e-cigarette ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, 48(2):168-172]

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Proportional assist ventilation (PAV) versus neurally adjusted ventilator assist (NAVA): effect on oxygenation in infants with evolving or established bronchopulmonary dysplasia.

Katie A Hunt, Theodore Dassios, Anne Greenough,

Both proportional assist ventilation (PAV) and neurally adjusted ventilatory assist (NAVA) provide pressure support synchronised throughout the respiratory cycle proportional to the patient's respiratory demand. Our aim was to compare the effect of these two modes on oxygenation in infants with evolving or established bronchopulmonary dysplasia. Two-hour periods of PAV ... Read more >>

Eur. J. Pediatr. (European Journal of Pediatrics)
[2020, 179(6):901-908]

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Genetic causes of hypopituitarism.

Katherine Parkin, Ritika Kapoor, Ravindra Bhat, Anne Greenough,

Hypopituitarism in neonates is rare, but has life-threatening complications if untreated. This review describes the features of hypopituitarism and the evidence for which infants in whom a genetic cause should be suspected. Importantly, neonates are often asymptomatic or present with non-specific symptoms. Hypopituitarism can be due to abnormal gland development ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2020, 16(1):27-33]

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European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia.

Liesbeth Duijts, Evelien R van Meel, Laura Moschino, Eugenio Baraldi, Magda Barnhoorn, Wichor M Bramer, Charlotte E Bolton, Jeanette Boyd, Frederik Buchvald, Maria Jesus Del Cerro, Andrew A Colin, Refika Ersu, Anne Greenough, Christiaan Gremmen, Thomas Halvorsen, Juliette Kamphuis, Sailesh Kotecha, Kathleen Rooney-Otero, Sven Schulzke, Andrew Wilson, David Rigau, Rebecca L Morgan, Thomy Tonia, Charles C Roehr, Marielle W Pijnenburg,

This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and who have been discharged from the hospital, or who were >36 weeks of postmenstrual age. The guideline was based on predefined Population, Intervention, Comparison and Outcomes (PICO) questions relevant for clinical care, ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(1):]

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Lung function and respiratory outcomes in teenage boys and girls born very prematurely.

Christopher Harris, Sanja Zivanovic, Alan Lunt, Sandy Calvert, Alessandra Bisquera, Neil Marlow, Janet L Peacock, Anne Greenough,

OBJECTIVES:Male sex in prematurely born infants has been associated with worse respiratory outcomes in early childhood. WORKING HYPOTHESIS:Respiratory outcomes at 11 to 14 years of age in children born very prematurely and routinely exposed to antenatal corticosteroids and postnatal surfactant would differ according to sex. STUDY DESIGN:Analysis of follow-up data. ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(3):682-689]

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Reducing weight and increasing physical activity in people at high risk of cardiovascular disease: a randomised controlled trial comparing the effectiveness of enhanced motivational interviewing intervention with usual care.

Khalida Ismail, Adam Bayley, Katherine Twist, Kurtis Stewart, Katie Ridge, Emma Britneff, Anne Greenough, Mark Ashworth, Jennifer Rundle, Derek G Cook, Peter Whincup, Janet Treasure, Paul McCrone, Kirsty Winkley, Daniel Stahl,

OBJECTIVE:The epidemic of obesity is contributing to the increasing prevalence of people at high risk of cardiovascular disease (CVD), negating the medical advances in reducing CVD mortality. We compared the clinical and cost-effectiveness of an intensive lifestyle intervention consisting of enhanced motivational interviewing in reducing weight and increasing physical activity ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, 106(6):447-454]

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Prolonged ventilation and postnatal growth of preterm infants.

Emma Williams, Theodore Dassios, Kate Arnold, Ann Hickey, Anne Greenough,

Background Extremely premature infants often need invasive respiratory support from birth, but have low nutritional reserves and high metabolic demands. Our aim was to determine if there was a relationship between prolonged ventilation and reduced postnatal growth in such infants. Methods A retrospective, observational study was undertaken. Data from infants ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2019, 48(1):82-86]

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End-tidal carbon dioxide levels during resuscitation and carbon dioxide levels in the immediate neonatal period and intraventricular haemorrhage.

Kentaro Tamura, Emma E Williams, Theodore Dassios, Anoop Pahuja, Katie A Hunt, Vadivelam Murthy, Prashanth Bhat, Ravindra Bhat, Anthony Milner, Anne Greenough,

Abnormal levels of end-tidal carbon dioxide (EtCO2) during resuscitation in the delivery suite are associated with intraventricular haemorrhage (IVH) development. Our aim was to determine whether carbon dioxide (CO2) levels in the first 3 days after birth reflected abnormal EtCO2 levels in the delivery suite, and hence, a prolonged rather ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, 179(4):555-559]

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Foetal lung volumes in pregnant women who deliver very preterm: a pilot study.

Lisa Story, Tong Zhang, Johannes K Steinweg, Jana Hutter, Jacqueline Matthew, Theodore Dassios, Paul T Seed, Dharmintra Pasupathy, Joanna Allsop, Joseph V Hajnal, Anne Greenough, Andrew H Shennan, Mary Rutherford,

BACKGROUND:Infants born preterm are at increased risk of pulmonary morbidity. The contribution of antenatal factors to impairments in lung structure/function has not been fully elucidated. This study aimed to compare standardized lung volumes from foetuses that were delivered <32 weeks' gestation with foetuses that were delivered >37 weeks. METHODS:Fourteen women ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, 87(6):1066-1071]

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Core outcomes in neonatology: development of a core outcome set for neonatal research.

James William Harrison Webbe, James M N Duffy, Elsa Afonso, Iyad Al-Muzaffar, Ginny Brunton, Anne Greenough, Nigel J Hall, Marian Knight, Jos M Latour, Caroline Lee-Davey, Neil Marlow, Laura Noakes, Julie Nycyk, Angela Richard-Löndt, Ben Wills-Eve, Neena Modi, Chris Gale,

BACKGROUND:Neonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals. OBJECTIVE:To define a core outcome set (COS) for research involving infants receiving neonatal care in a high-income setting. ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):425-431]

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Enhanced motivational interviewing for reducing weight and increasing physical activity in adults with high cardiovascular risk: the MOVE IT three-arm RCT.

Khalida Ismail, Daniel Stahl, Adam Bayley, Katherine Twist, Kurtis Stewart, Katie Ridge, Emma Britneff, Mark Ashworth, Nicole de Zoysa, Jennifer Rundle, Derek Cook, Peter Whincup, Janet Treasure, Paul McCrone, Anne Greenough, Kirsty Winkley,

BACKGROUND:Motivational interviewing (MI) enhanced with behaviour change techniques (BCTs) and deployed by health trainers targeting multiple risk factors for cardiovascular disease (CVD) may be more effective than interventions targeting a single risk factor. OBJECTIVES:The clinical effectiveness and cost-effectiveness of an enhanced lifestyle motivational interviewing intervention for patients at high risk ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2019, 23(69):1-144]

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Closed loop automated oxygen control in neonates-A review.

Sarah Sturrock, Emma Williams, Theodore Dassios, Anne Greenough,

AIM:Neonates frequently require supplementary oxygen but may develop complications if the oxygen saturation is outside the target range. This review aimed to determine whether the algorithms used in closed loop automated oxygen control systems influenced their efficacy and whether use of the systems reduced relevant, long-term neonatal complications. METHODS:A literature ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(5):914-922]

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Electrical activity of the diaphragm following a loading dose of caffeine citrate in ventilated preterm infants.

Emma E Williams, Katie A Hunt, Janathan Jeyakara, Raghavendra Subba-Rao, Theodore Dassios, Anne Greenough,

BACKGROUND:Administration of caffeine citrate can facilitate extubation. Our aim was to determine whether a loading dose of caffeine citrate given to ventilated, preterm infants affected the diaphragm electrical activity. METHODS:Infants <34 weeks of gestational age were recruited if requiring mechanical ventilation and prescribed a loading dose of caffeine citrate. Surface ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, 87(4):740-744]

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The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia.

Suzan Cochius-den Otter, Thomas Schaible, Anne Greenough, Arno van Heijst, Neil Patel, Karel Allegaert, Joost van Rosmalen, Dick Tibboel, ,

INTRODUCTION:Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on 'trial and error'. Inhaled nitric oxide (iNO) is often the drug ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e032122]

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Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.

A Parker Ruhl, S Christy Sadreameli, Julian L Allen, Debra P Bennett, Andrew D Campbell, Thomas D Coates, Dapa A Diallo, Joshua J Field, Elizabeth K Fiorino, Mark T Gladwin, Jeffrey A Glassberg, Victor R Gordeuk, Leroy M Graham, Anne Greenough, Jo Howard, Gregory J Kato, Jennifer Knight-Madden, Benjamin T Kopp, Anastassios C Koumbourlis, Sophie M Lanzkron, Robert I Liem, Roberto F Machado, Alem Mehari, Claudia R Morris, Folasade O Ogunlesi, Carol L Rosen, Kim Smith-Whitley, Danna Tauber, Nancy Terry, Swee Lay Thein, Elliott Vichinsky, Nargues A Weir, Robyn T Cohen, Elizabeth S Klings,

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and encompass acute and chronic disease. The understanding of the natural history of pulmonary complications of SCD is limited, no specific therapies exist, and these complications are a primary cause of morbidity and mortality.Methods: We gathered a multidisciplinary group of ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2019, 16(9):e17-e32]

Cited: 2 times

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Chronology and Determinants of Respiratory Function Changes Following Administration of Systemic Postnatal Corticosteroids in Extremely Preterm Infants.

Theodore Dassios, Ourania Kaltsogianni, Ann Hickey, Ravindra Bhat, Anne Greenough,

OBJECTIVE:To describe the effect of systemic corticosteroids administered to treat evolving bronchopulmonary dysplasia on oxygen diffusion and ventilation efficiency. STUDY DESIGN:This was a retrospective cohort study of ventilated infants who received a 9-day course of dexamethasone in a tertiary neonatal unit. We calculated the transcutaneous oxygen saturation-to-fraction of inspired oxygen ... Read more >>

J. Pediatr. (The Journal of Pediatrics)
[2019, 215:17-23]

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Participant retention in follow-up studies of prematurely born children.

Victoria MacBean, Simon B Drysdale, Sanja Zivanovic, Janet L Peacock, Anne Greenough,

BACKGROUND:Follow-up studies of infants born prematurely are essential to understand the long-term consequences of preterm birth and the efficacy of interventions delivered in the neonatal period. Retention of participants for follow-up studies, however, is challenging, with attrition rates of up to 70%. Our aim was to examine retention rates in ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):1233]

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Tidal Volumes and Outcome of Extubation in Mechanically Ventilated Premature Infants.

Theodore Dassios, Emma Williams, Hemant Ambulkar, Sandeep Shetty, Ann Hickey, Anne Greenough,

OBJECTIVES:To compare the adjusted and unadjusted-for-weight tidal volume (VT) in ventilated prematurely born infants who were successfully extubated compared with the ones who failed extubation and explore the ability of VT to predict successful extubation. STUDY DESIGN:This is a two-center, prospective, observational, cohort study of ventilated infants born <32 weeks ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, 37(2):204-209]

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Educational pathways in Paediatric Virology: Pros and cons.

Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Demetrios A Spandidos,

Exp Ther Med (Experimental and therapeutic medicine)
[2019, 18(4):3260-3262]

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