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Author Anna Maija Tolppanen

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Does Recent Hospitalization Increase Antipsychotic Initiation Among Community Dwellers With Alzheimer's Disease?

Anna Hakala, Anna-Maija Tolppanen, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Sirpa Hartikainen, Miia Tiihonen,

<h4>Objectives</h4>Antipsychotics are often prescribed to persons with cognitive impairment in the hospital, but it is not known whether recent hospital care increases the risk of antipsychotic initiation in community dwellers with Alzheimer's disease (AD). We studied whether hospital care during the previous 2 weeks is associated with antipsychotic initiation in persons ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2021, :]

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Coronary Revascularization and Postoperative Outcomes In People With And Without Alzheimer's Disease.

Mai Vu, Marjaana Koponen, Heidi Taipale, Raimo Kettunen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<h4>Background</h4>Little is known on the incidence and postoperative outcomes of revascularizations according to electivity in persons with Alzheimer's disease (AD).<h4>Methods</h4>The Medication Use and Alzheimer's disease (MEDALZ) cohort includes 70718 community dwellers diagnosed with incident AD during 2005-2011 in Finland. For each person with AD, 1-4 age-, sex- and hospital district-matched ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, :]

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Complications of Pelvic Organ Prolapse Surgery in the 2015 Finnish Pelvic Organ Prolapse Surgery Survey Study.

Olga Wihersaari, Päivi Karjalainen, Anna-Maija Tolppanen, Nina Mattsson, Jyrki Jalkanen, Kari Nieminen,

<h4>Objective</h4>To describe the major complications of pelvic organ prolapse (POP) surgery in Finland.<h4>Methods</h4>The Finnish Pelvic Organ Prolapse Surgery Survey 2015 study is a prospective cohort of POP surgeries performed in Finland in 2015. Perioperative, postoperative, and late complications during 1 year of follow-up were compared among native tissue repair, transvaginal ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2020, 136(6):1135-1144]

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Increased Risk of Parkinson's Disease in Patients With Schizophrenia Spectrum Disorders.

Tomi Kuusimäki, Haidar Al-Abdulrasul, Samu Kurki, Jarmo Hietala, Sirpa Hartikainen, Marjaana Koponen, Anna-Maija Tolppanen, Valtteri Kaasinen,

<h4>Background</h4>PD comorbid with schizophrenia has been considered rare because these diseases associate with opposite alterations in the brain dopamine system. The objective of this study was to investigate the risk of PD after a diagnosis of a schizophrenia spectrum disorder.<h4>Methods</h4>Regionally, this was a retrospective record-based case-control study. The cohort included ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, :]

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Length of Hospital Stay for Hip Fracture and 30-Day Mortality in People With Alzheimer's Disease: A Cohort Study in Finland.

Piia Lavikainen, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND:Persons with Alzheimer's disease (AD) are at higher risk of hip fractures (HFs) than general older population and have worse prognosis after HF. Hospital stays after HF have shortened along time. We investigated the association between length of hospital stay after HF and mortality after discharge among persons with AD. ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2020, 75(11):2184-2192]

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Causes of death in a nationwide cohort of community-dwellers with Alzheimer's disease.

Anna-Maija Tolppanen, Heidi Taipale, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen,

<h4>Background</h4>Alzheimer's disease (AD) is related to higher mortality but it is not entirely evident which causes of death explain this. The objective of this study was to assess the causes of death in a nationwide cohort of clinically verified AD cases and compare the causes to a matched comparison cohort ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):441]

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Minimal important difference and patient acceptable symptom state for PFDI-20 and POPDI-6 in POP surgery.

Päivi K Karjalainen, Nina K Mattsson, Jyrki T Jalkanen, Kari Nieminen, Anna-Maija Tolppanen,

<h4>Introduction and hypothesis</h4>Patient-reported outcome measures are fundamental tools when assessing effectiveness of treatments. The challenge lies in the interpretation: which magnitude of change in score is meaningful for the patients? The minimal important difference (MID) is defined as the smallest difference in score that patients perceive as important. The Patient ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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Application of Healthcare 'Big Data' in CNS Drug Research: The Example of the Neurological and mental health Global Epidemiology Network (NeuroGEN).

Jenni Ilomäki, J Simon Bell, Adrienne Y L Chan, Anna-Maija Tolppanen, Hao Luo, Li Wei, Edward Chia-Cheng Lai, Ju-Young Shin, Giorgia De Paoli, Romin Pajouheshnia, Frederick K Ho, Lorenna Reynolds, Kui Kai Lau, Stephen Crystal, Wallis C Y Lau, Kenneth K C Man, Ruth Brauer, Esther W Chan, Chin-Yao Shen, Ju Hwan Kim, Terry Y S Lum, Sirpa Hartikainen, Marjaana Koponen, Evelien Rooke, Marloes Bazelier, Olaf Klungel, Soko Setoguchi, Jill P Pell, Sharon Cook, Ian C K Wong,

Neurological and psychiatric (mental health) disorders have a large impact on health burden globally. Cognitive disorders (including dementia) and stroke are leading causes of disability. Mental health disorders, including depression, contribute up to one-third of total years lived with disability. The Neurological and mental health Global Epidemiology Network (NeuroGEN) is ... Read more >>

CNS Drugs (CNS drugs)
[2020, 34(9):897-913]

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Agreement between patient global impression scale of improvement, pelvic floor distress inventory and 15D in measuring the outcome of pelvic organ prolapse surgery.

Nina K Mattsson, Päivi Karjalainen, Anna-Mari Heikkinen, Kari Nieminen, Jyrki Jalkanen, Anna-Maija Tolppanen,

<h4>Aims</h4>To evaluate the correlation between three commonly used patient-reported outcome measures, two generic and one condition-specific instrument, in assessing the change in health-related quality of life following pelvic organ prolapse surgery.<h4>Methods</h4>The generic health-related quality of life measure 15-dimensional instrument (15D), Patient Global Impression of Improvement (PGI-I), and prolapse-specific Pelvic Floor ... Read more >>

Neurourol Urodyn (Neurourology and urodynamics)
[2020, 39(8):2171-2178]

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Length of hospital stay after hip fracture and readmission rates of persons with and without Alzheimer's disease: a matched cohort study.

Blair Rajamaki, Marjaana Koponen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<h4>Background</h4>Hospital length of stays (LOS) for incident of hip fracture are decreasing, but it is unknown if these changes have negative impacts on vulnerable older patient populations, like those with Alzheimer's disease (AD). We aimed to assess if persons with and without AD have different hospital LOS for hip fracture, ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):214]

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Psychotropic Drug-Associated Pneumonia in Older Adults.

Blair Rajamaki, Sirpa Hartikainen, Anna-Maija Tolppanen,

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19-29% among community dwelling older adults. These drugs are often prescribed for off-label use, including neuropsychiatric symptoms. The older adult population also has high rates of pneumonia and some of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):241-261]

Cited: 1 time

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Late-life personality traits, cognitive impairment, and mortality in a population-based cohort.

Elisa Neuvonen, Anette Hall, Anna-Maija Tolppanen, Tiia Ngandu, Minna Rusanen, Tiina Laatikainen, Hilkka Soininen, Miia Kivipelto, Alina Solomon,

OBJECTIVES:We examined longitudinal associations between late-life personality traits and cognitive impairment, dementia, and mortality in the population-based Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Study. METHODS:Anger expression and trait anger (State-Trait Anger Expression Inventory), anxiety (State-Trait Anxiety Inventory), and sense of coherence (Sense of Coherence Scale) were assessed at the ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2020, 35(9):989-999]

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Incidence of muscle relaxant use in relation to diagnosis of Parkinson's disease.

Anne Paakinaho, Niina Karttunen, Marjaana Koponen, Heidi Taipale, Anna-Maija Tolppanen, Sirpa Hartikainen, Miia Tiihonen,

Background Parkinson's disease is the second most common neurodegenerative disorder. Motor and non-motor symptoms seem to precede the diagnosis of Parkinson's disease. Objective To evaluate the incidence of muscle relaxant use in community-dwelling persons with and without Parkinson's disease from 4 years before to 4 years after the diagnosis of Parkinson's disease. ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2020, 42(2):336-340]

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Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer disease.

Tatyana Sarycheva, Piia Lavikainen, Heidi Taipale, Jari Tiihonen, Antti Tanskanen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<h4>Objective</h4>To evaluate the risk of death in relation to incident antiepileptic drug (AED) use compared with nonuse in people with Alzheimer disease (AD) through the assessment in terms of duration of use, specific drugs, and main causes of death.<h4>Methods</h4>The MEDALZ (Medication Use and Alzheimer Disease) cohort study includes all Finnish ... Read more >>

Neurology (Neurology)
[2020, 94(20):e2099-e2108]

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Metformin and Risk of Alzheimer's Disease Among Community-Dwelling People With Diabetes: A National Case-Control Study.

Janet K Sluggett, Marjaana Koponen, J Simon Bell, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Matti Uusitupa, Anna-Maija Tolppanen, Sirpa Hartikainen,

<h4>Context</h4>Type 2 diabetes has been linked with an increased risk of Alzheimer's disease (AD). Studies on the association between metformin use and AD have reported conflicting results.<h4>Objective</h4>To investigate whether metformin use modifies the association between diabetes and incident, clinically verified AD.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>All community-dwelling people in Finland.<h4>Participants</h4>Cases were all community-dwelling ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(4):]

Cited: 3 times

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Opioid Use After Hospital Care due to Hip Fracture Among Community-Dwelling Persons With and Without Alzheimer's Disease.

Eveliina Lintula, Miia Tiihonen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Aleksi Hamina,

<h4>Background</h4>Hip fractures are common among persons with Alzheimer's disease (AD), but problems in pain assessment may lead to insufficient analgesia after hospitalization.<h4>Objective</h4>We investigated the prevalence of opioid use in the 6 months after discharge from hospital care due to hip fracture among community-dwellers with and without AD.<h4>Setting and method</h4>The Medication use ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(3):193-203]

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The Risk of Head Injuries Associated With Antipsychotic Use Among Persons With Alzheimer's disease.

Vesa Tapiainen, Piia Lavikainen, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<h4>Background/objectives</h4>Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD).<h4>Design</h4>Nationwide register-based cohort study.<h4>Setting</h4>Medication Use and Alzheimer's Disease ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2020, 68(3):595-602]

Cited: 2 times

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Asthma and Chronic Obstructive Pulmonary Disease as a Comorbidity and Association with the Choice of Antidementia Medication Among Persons with Alzheimer's Disease.

Pasi Lampela, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale,

BACKGROUND:Asthma and chronic obstructive pulmonary disease (COPD) are common comorbidities in persons with Alzheimer's disease (AD). However, pharmacotherapy of these diseases may have opposite mechanisms of action; anticholinergics in asthma/COPD and acetylcholinesterase inhibitors (AChEI) in AD. OBJECTIVE:To investigate whether existing asthma/COPD affects the choice of AD medication, and the survival ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, 73(3):1243-1251]

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Pelvic organ prolapse surgery and quality of life-a nationwide cohort study.

Nina K Mattsson, Päivi K Karjalainen, Anna-Maija Tolppanen, Anna-Mari Heikkinen, Harri Sintonen, Päivi Härkki, Kari Nieminen, Jyrki Jalkanen,

BACKGROUND:Patient satisfaction and health-related quality of life are nowadays considered as the most important outcomes of pelvic organ prolapse treatment, and large, prospective clinical studies reporting the patient-reported surgical outcomes are needed. OBJECTIVE:To evaluate the effect of female pelvic organ prolapse surgery on health-related quality of life and patient satisfaction ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, 222(6):588.e1-588.e10]

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Prevalence of cardiovascular drug use before and after diagnosis of Alzheimer's disease.

Mai Vu, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Raimo Kettunen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND:Both cardiovascular diseases and Alzheimer's disease (AD) are common in aging populations. We investigated the prevalence of cardiovascular (CV) drug use in relation to AD diagnosis, and compared the prevalence to a matched cohort without AD. METHODS:Point prevalence of CV drugs was counted every six months, from five years before ... Read more >>

Int J Cardiol (International journal of cardiology)
[2020, 300:221-225]

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Accumulation of Hospital Days Among Antipsychotic Initiators With Alzheimer's Disease.

Marjaana Koponen, Piia Lavikainen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<h4>Objectives</h4>To compare the accumulation of hospital days, a proposed proxy for overall drug safety, between antipsychotic initiators and noninitiators with Alzheimer's disease (AD).<h4>Design</h4>Nationwide exposure-matched cohort.<h4>Setting and participants</h4>Finnish community dwellers who received an incident AD diagnosis in 2005‒2011 (n = 70,718). For each antipsychotic initiator, 1 noninitiator was matched on age, sex, and ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2019, 20(12):1488-1494.e3]

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Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation.

Jari Heiskanen, Juha Hartikainen, Janne Martikainen, Heikki Miettinen, Mikko Hippeläinen, Risto P Roine, Anna-Maija Tolppanen,

<h4>Aims</h4>We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting (CABG)).<h4>Methods</h4>All patients who underwent an elective PCI (N = 1557) or CABG (N = 1768) at the Heart Center, Kuopio University hospital between 2007 and 2014 were included. ... Read more >>

Eur J Clin Pharmacol (European journal of clinical pharmacology)
[2020, 76(1):81-88]

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Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease.

Joosep Kalamägi, Piia Lavikainen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

<b>Objectives:</b> We studied the determinants of high healthcare costs (highest decile of hospital care and medication costs) and cost trajectories among all community-dwellers with clinically verified Alzheimer's disease (AD), diagnosed during 2005-2011 in Finland (<i>N</i> = 70,531). <b>Methods:</b> The analyses were done separately for hospital care costs, medication costs and total healthcare ... Read more >>

Ann Med (Annals of medicine)
[2019, 51(5-6):294-305]

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Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

Li-Li Cui, Dominika Golubczyk, Anna-Maija Tolppanen, Johannes Boltze, Jukka Jolkkonen,

Ann Neurol (Annals of neurology)
[2019, 86(1):5-16]

Cited: 10 times

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The relationship of defecation symptoms and posterior vaginal wall prolapse in women undergoing pelvic organ prolapse surgery.

Päivi K Karjalainen, Nina K Mattsson, Kari Nieminen, Anna-Maija Tolppanen, Jyrki T Jalkanen,

<h4>Background</h4>Defecation symptoms are common among women with pelvic organ prolapse. However, the relationship between posterior vaginal wall prolapse and defecation symptoms remains debatable. Even though there is a plausible biomechanical rationale for posterior wall prolapse to cause obstructed defecation, previous studies have drawn contradictory conclusions regarding the association.<h4>Objective</h4>We aimed to ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2019, 221(5):480.e1-480.e10]

Cited: 0 times

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