Full Text Journal Articles by
Author Anna Maija Tolppanen

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Late-life personality traits, cognitive impairment, and mortality in a population-based cohort.

Elisa Neuvonen, Anette Hall, Anna-Maija Tolppanen, Tiia Ngandu, Minna Rusanen, Tiina Laatikainen, Hilkka Soininen, Miia Kivipelto, Alina Solomon,

OBJECTIVES:We examined longitudinal associations between late-life personality traits and cognitive impairment, dementia, and mortality in the population-based Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Study. METHODS:Anger expression and trait anger (State-Trait Anger Expression Inventory), anxiety (State-Trait Anxiety Inventory), and sense of coherence (Sense of Coherence Scale) were assessed at the ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2020, :]

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Psychotropic Drug-Associated Pneumonia in Older Adults.

Blair Rajamaki, Sirpa Hartikainen, Anna-Maija Tolppanen,

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19-29% among community dwelling older adults. These drugs are often prescribed for off-label use, including neuropsychiatric symptoms. The older adult population also has high rates of pneumonia and some of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):241-261]

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Antiepileptic drug use and mortality among community-dwelling persons with Alzheimer disease.

Tatyana Sarycheva, Piia Lavikainen, Heidi Taipale, Jari Tiihonen, Antti Tanskanen, Sirpa Hartikainen, Anna-Maija Tolppanen,

OBJECTIVE:To evaluate the risk of death in relation to incident antiepileptic drug (AED) use compared with nonuse in people with Alzheimer disease (AD) through the assessment in terms of duration of use, specific drugs, and main causes of death. METHODS:The MEDALZ (Medication Use and Alzheimer Disease) cohort study includes all ... Read more >>

Neurology (Neurology)
[2020, :]

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Incidence of muscle relaxant use in relation to diagnosis of Parkinson's disease.

Anne Paakinaho, Niina Karttunen, Marjaana Koponen, Heidi Taipale, Anna-Maija Tolppanen, Sirpa Hartikainen, Miia Tiihonen,

Background Parkinson's disease is the second most common neurodegenerative disorder. Motor and non-motor symptoms seem to precede the diagnosis of Parkinson's disease. Objective To evaluate the incidence of muscle relaxant use in community-dwelling persons with and without Parkinson's disease from 4 years before to 4 years after the diagnosis of Parkinson's disease. ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2020, 42(2):336-340]

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Metformin and Risk of Alzheimer's Disease Among Community-Dwelling People With Diabetes: A National Case-Control Study.

Janet K Sluggett, Marjaana Koponen, J Simon Bell, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Matti Uusitupa, Anna-Maija Tolppanen, Sirpa Hartikainen,

CONTEXT:Type 2 diabetes has been linked with an increased risk of Alzheimer's disease (AD). Studies on the association between metformin use and AD have reported conflicting results. OBJECTIVE:To investigate whether metformin use modifies the association between diabetes and incident, clinically verified AD. DESIGN:Nested case-control study. SETTING:All community-dwelling people in Finland. ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(4):]

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Opioid Use After Hospital Care due to Hip Fracture Among Community-Dwelling Persons With and Without Alzheimer's Disease.

Eveliina Lintula, Miia Tiihonen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Aleksi Hamina,

BACKGROUND:Hip fractures are common among persons with Alzheimer's disease (AD), but problems in pain assessment may lead to insufficient analgesia after hospitalization. OBJECTIVE:We investigated the prevalence of opioid use in the 6 months after discharge from hospital care due to hip fracture among community-dwellers with and without AD. SETTING AND METHOD:The ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(3):193-203]

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The Risk of Head Injuries Associated With Antipsychotic Use Among Persons With Alzheimer's disease.

Vesa Tapiainen, Piia Lavikainen, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND/OBJECTIVES:Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD). DESIGN:Nationwide register-based cohort study. SETTING:Medication Use and ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2020, 68(3):595-602]

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Asthma and Chronic Obstructive Pulmonary Disease as a Comorbidity and Association with the Choice of Antidementia Medication Among Persons with Alzheimer's Disease.

Pasi Lampela, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale,

BACKGROUND:Asthma and chronic obstructive pulmonary disease (COPD) are common comorbidities in persons with Alzheimer's disease (AD). However, pharmacotherapy of these diseases may have opposite mechanisms of action; anticholinergics in asthma/COPD and acetylcholinesterase inhibitors (AChEI) in AD. OBJECTIVE:To investigate whether existing asthma/COPD affects the choice of AD medication, and the survival ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, 73(3):1243-1251]

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Pelvic organ prolapse surgery and quality of life-a nationwide cohort study.

Nina K Mattsson, Päivi K Karjalainen, Anna-Maija Tolppanen, Anna-Mari Heikkinen, Harri Sintonen, Päivi Härkki, Kari Nieminen, Jyrki Jalkanen,

BACKGROUND:Patient satisfaction and health-related quality of life are nowadays considered as the most important outcomes of pelvic organ prolapse treatment, and large, prospective clinical studies reporting the patient-reported surgical outcomes are needed. OBJECTIVE:To evaluate the effect of female pelvic organ prolapse surgery on health-related quality of life and patient satisfaction ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2019, :]

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Prevalence of cardiovascular drug use before and after diagnosis of Alzheimer's disease.

Mai Vu, Marjaana Koponen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Raimo Kettunen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND:Both cardiovascular diseases and Alzheimer's disease (AD) are common in aging populations. We investigated the prevalence of cardiovascular (CV) drug use in relation to AD diagnosis, and compared the prevalence to a matched cohort without AD. METHODS:Point prevalence of CV drugs was counted every six months, from five years before ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, 300:221-225]

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Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation.

Jari Heiskanen, Juha Hartikainen, Janne Martikainen, Heikki Miettinen, Mikko Hippeläinen, Risto P Roine, Anna-Maija Tolppanen,

AIMS:We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting (CABG)). METHODS:All patients who underwent an elective PCI (N = 1557) or CABG (N = 1768) at the Heart Center, Kuopio University hospital between 2007 and 2014 were ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, 76(1):81-88]

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Accumulation of Hospital Days Among Antipsychotic Initiators With Alzheimer's Disease.

Marjaana Koponen, Piia Lavikainen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

OBJECTIVES:To compare the accumulation of hospital days, a proposed proxy for overall drug safety, between antipsychotic initiators and noninitiators with Alzheimer's disease (AD). DESIGN:Nationwide exposure-matched cohort. SETTING AND PARTICIPANTS:Finnish community dwellers who received an incident AD diagnosis in 2005‒2011 (n = 70,718). For each antipsychotic initiator, 1 noninitiator was matched on age, ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2019, 20(12):1488-1494.e3]

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Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease.

Joosep Kalamägi, Piia Lavikainen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

Objectives: We studied the determinants of high healthcare costs (highest decile of hospital care and medication costs) and cost trajectories among all community-dwellers with clinically verified Alzheimer's disease (AD), diagnosed during 2005-2011 in Finland (N = 70,531). Methods: The analyses were done separately for hospital care costs, medication costs and total healthcare ... Read more >>

Ann. Med. (Annals of medicine)
[2019, 51(5-6):294-305]

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Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

Li-Li Cui, Dominika Golubczyk, Anna-Maija Tolppanen, Johannes Boltze, Jukka Jolkkonen,

Ann. Neurol. (Annals of neurology)
[2019, 86(1):5-16]

Cited: 2 times

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The relationship of defecation symptoms and posterior vaginal wall prolapse in women undergoing pelvic organ prolapse surgery.

Päivi K Karjalainen, Nina K Mattsson, Kari Nieminen, Anna-Maija Tolppanen, Jyrki T Jalkanen,

BACKGROUND:Defecation symptoms are common among women with pelvic organ prolapse. However, the relationship between posterior vaginal wall prolapse and defecation symptoms remains debatable. Even though there is a plausible biomechanical rationale for posterior wall prolapse to cause obstructed defecation, previous studies have drawn contradictory conclusions regarding the association. OBJECTIVE:We aimed ... Read more >>

Am. J. Obstet. Gynecol. (American Journal of Obstetrics and Gynecology)
[2019, 221(5):480.e1-480.e10]

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Incidence of head injury and traumatic brain injury among people with Alzheimer's disease.

Sarianna Ilmaniemi, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND:Injuries caused by falling are a major health concern among older population. For older people, falls are the leading cause of head injuries; especially, persons with cognitive disorders have an increased risk of falling. OBJECTIVE:To compare the incidence of head injury and traumatic brain injury (TBI) among persons with Alzheimer's ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2019, 73(5):451-454]

Cited: 1 time

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Methods of surgery for pelvic organ prolapse in a nationwide cohort (FINPOP 2015).

Nina K Mattsson, Päivi Karjalainen, Anna-Maija Tolppanen, Anna-Mari Heikkinen, Jyrki Jalkanen, Päivi Härkki, Kari Nieminen,

INTRODUCTION:The management of pelvic organ prolapse (POP) varies significantly between countries. The objective of this study was to describe the methods used for POP surgery in Finland and to identify the factors that affect clinicians' choice to use either a native tissue repair (NTR) or a mesh repair method. MATERIAL ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, 98(4):451-459]

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Incident opioid use and risk of hip fracture among persons with Alzheimer disease: a nationwide matched cohort study.

Heidi Taipale, Aleksi Hamina, Niina Karttunen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

The objective of this study was to investigate whether incident opioid use is associated with an increased risk of hip fractures among community-dwelling persons with Alzheimer disease (AD) and to assess the association in terms of duration of use and opioid strength. Among community-dwelling persons with AD diagnosed in 2010 ... Read more >>

Pain (Pain)
[2019, 160(2):417-423]

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Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease.

Piia Lavikainen, Heidi Taipale, Antti Tanskanen, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

OBJECTIVES:To compare the accumulation of hospital days between initiators and noninitiators of antiepileptic drugs (AEDs) among persons with Alzheimer's disease (AD). DESIGN:Exposure-matched cohort study. SETTING AND PARTICIPANTS:Persons newly diagnosed with AD in 2005-2011 (n = 70,718) and initiating AED use identified from Finnish health care registers. For each AED initiator, 1 noninitiator ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2019, 20(6):751-758]

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Hospital-Treated Pneumonia Associated with Opioid Use Among Community Dwellers with Alzheimer's Disease.

Aleksi Hamina, Heidi Taipale, Niina Karttunen, Antti Tanskanen, Jari Tiihonen, Anna-Maija Tolppanen, Sirpa Hartikainen,

BACKGROUND:Pneumonia is a common cause for hospitalization and excess mortality among persons with Alzheimer's disease (AD), but little research exists evaluating drug use as its risk factor. OBJECTIVE:We investigated the association between opioid use and hospital-treated pneumonia among community dwellers with AD. METHODS:This study was part of the Medication use ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2019, 69(3):807-816]

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Concomitant use of benzodiazepines and opioids in community-dwelling older people with or without Alzheimer's disease-A nationwide register-based study in Finland.

Niina Karttunen, Heidi Taipale, Aleksi Hamina, Antti Tanskanen, Jari Tiihonen, Anna-Maija Tolppanen, Sirpa Hartikainen,

OBJECTIVE:The study aims to determine the prevalence of concomitant use of benzodiazepines and opioids among community-dwelling older people with or without Alzheimer's disease (AD). An additional aim was to describe the factors associated with prolonged concomitant use, and the most commonly used combinations of these drugs. METHODS:This study utilized data ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2019, 34(2):280-288]

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Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study.

Heidi Taipale, Pasi Lampela, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen,

BACKGROUND:Antiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia. OBJECTIVES:To investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2019, 68(1):127-136]

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Systemic Estrogen Use and Discontinuation After Alzheimer's Disease Diagnosis in Finland 2005-2012: A Nationwide Exposure-Matched Cohort Study.

Anna-Maija Tolppanen, Miia Tiihonen, Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Jari Tiihonen, Sirpa Hartikainen,

BACKGROUND:It is unknown whether cognitive status or diagnosed cognitive decline affects estrogen use. OBJECTIVES:We assessed how common systemic estrogen use was among community-dwellers with Alzheimer's disease (AD) and a matched comparison cohort without AD. METHODS:This study included an exposure-matched cohort of all Finnish community-dwelling women who received a clinically verified ... Read more >>

Drugs Aging (Drugs & aging)
[2018, 35(11):985-992]

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Duration of new antidepressant use and factors associated with discontinuation among community-dwelling persons with Alzheimer's disease.

Reetta Kettunen, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Marjaana Koponen,

PURPOSE:To study how long antidepressants initiated after diagnoses of Alzheimer's disease (AD) were used and factors associated with discontinuation of use among persons with Alzheimer's disease (AD). In addition, differences in duration of use between the antidepressants groups were compared. METHODS:Register-based Medication use and Alzheimer's disease (MEDALZ) cohort included 70,718 ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2019, 75(3):417-425]

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Is Alzheimer's Disease Associated with Previous Opioid Use?

Heidi Taipale, Aleksi Hamina, Pasi Lampela, Antti Tanskanen, Jari Tiihonen, Niina Karttunen, Anna-Maija Tolppanen, Sirpa Hartikainen,

Objective:We investigated whether opioid use, duration of use, and cumulative dose are associated with an increased risk of Alzheimer's disease (AD). Methods:A Finnish nationwide nested case-control study, MEDALZ, included 70,718 individuals with AD and up to four age-, sex-, and region of residence-matched comparison individuals. The cohort included all Finnish ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2018, 19(11):2115-2121]

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