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Author Anna L David

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Mesenchymal Stem Cell Therapy for Osteogenesis Imperfecta.

Cecilia Götherström, Anna L David, Lilian Walther-Jallow, Eva Åström, Magnus Westgren,

The aim of this study was to provide a brief overview on the background and rationale on treating fetuses and children suffering from osteogenesis imperfecta (OI) with mesenchymal stem cells (MSCs). MSCs ability to migrate, engraft, and differentiate into bone cells and to act via paracrine effects on the recipient's ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2021, 64(4):898-903]

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What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review.

Nada Mufti, Adalina Sacco, Michael Aertsen, Fred Ushakov, Sebastian Ourselin, Dominic Thomson, Jan Deprest, Andrew Melbourne, Anna L David,

<h4>Purpose</h4>Open spina bifida (OSB) encompasses a wide spectrum of intracranial abnormalities. With foetal surgery as a new treatment option, robust intracranial imaging is important for comprehensive preoperative evaluation and prognostication. We aimed to determine the incidence of infratentorial and supratentorial findings detected by magnetic resonance imaging (MRI) alone and MRI ... Read more >>

Neuroradiology (Neuroradiology)
[2021, :]

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Interleukin-1 receptor antagonist, mode of analgesia and risk of Caesarean delivery after onset of labour: a Mendelian randomisation analysis.

Gareth L Ackland, Stefan Van Duijvenboden, Tom E F Abbott, Ana Gutierrez Del Arroyo, Matthew J Wilson, Anna L David, ,

<h4>Background</h4>Lower circulating levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) are associated with intrapartum inflammation and epidural analgesia-related maternal fever, both of which increase the rate of obstetric interventions. We hypothesised that genetic variants determining IL-1ra levels would be associated with Caesarean delivery rates after the onset of labour.<h4>Methods</h4>We ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Deep Learning for Instrumented Ultrasonic Tracking: From synthetic training data to in vivo application.

Efthymios Maneas, Andreas Hauptmann, Erwin J Alles, Wenfeng Xia, Tom Vercauteren, Sebastien Ourselin, Anna L David, Simon Arridge, Adrien E Desjardins,

Instrumented ultrasonic tracking is used to improve needle localisation during ultrasound guidance of minimally-invasive percutaneous procedures. Here, it is implemented with transmitted ultrasound pulses from a clinical ultrasound imaging probe that are detected by a fibre-optic hydrophone integrated into a needle. The detected transmissions are then reconstructed to form the ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2021, PP:]

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Super-resolution Reconstruction MRI Application in Fetal Neck Masses and Congenital High Airway Obstruction Syndrome.

Nada Mufti, Michael Ebner, Premal Patel, Michael Aertsen, Trevor Gaunt, Paul D Humphries, Fonteini Emmananouella Bredaki, Richard Hewitt, Colin Butler, Magdalena Sokolska, Giles S Kendall, David Atkinson, Tom Vercauteren, Sebastien Ourselin, Pranav P Pandya, Jan Deprest, Andrew Melbourne, Anna L David,

<h4>Objective</h4>Reliable airway patency diagnosis in fetal tracheolaryngeal obstruction is crucial to select and plan ex utero intrapartum treatment (EXIT) surgery. We compared the clinical utility of magnetic resonance imaging (MRI) super-resolution reconstruction (SRR) of the trachea, which can mitigate unpredictable fetal motion effects, with standard 2-dimensional (2D) MRI for airway ... Read more >>

OTO Open (OTO open)
[2021, 5(4):2473974X211055372]

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Development of standard definitions and grading for Maternal and Fetal Adverse Event Terminology.

Rebecca N Spencer, Kurt Hecher, Gill Norman, Karel Marsal, Jan Deprest, Alan Flake, Francesc Figueras, Christoph Lees, Steve Thornton, Kathleen Beach, Marcy Powell, Fatima Crispi, Anke Diemert, Neil Marlow, Donald M Peebles, Magnus Westgren, Helena Gardiner, Eduard Gratacos, Jana Brodszki, Albert Batista, Helen Turier, Mehali Patel, Beverley Power, James Power, Gillian Yaz, Anna L David,

<h4>Objective</h4>Adverse event (AE) monitoring is central to assessing therapeutic safety. The lack of a comprehensive framework to define and grade maternal and fetal AEs in pregnancy trials severely limits understanding risks in pregnant women. We created AE terminology to improve safety monitoring for developing pregnancy drugs, devices and interventions.<h4>Method</h4>Existing severity ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2021, :]

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Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Kathleen A Boyd, Robert Heggie, Lisa Wotherspoon, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben W Mol, Richard D Riley, Jane E Norman, John Norrie,

<h4>Background</h4>Timely interventions in women presenting with preterm labour can substantially improve health outcomes for preterm babies. However, establishing such a diagnosis is very challenging, as signs and symptoms of preterm labour are common and can be nonspecific. We aimed to develop and externally validate a risk prediction model using concentration ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(7):e1003686]

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Prenatal transplantation of human amniotic fluid stem cell could improve clinical outcome of type III spinal muscular atrophy in mice.

Steven W Shaw, Shao-Yu Peng, Ching-Chung Liang, Tzu-Yi Lin, Po-Jen Cheng, T'sang-T'ang Hsieh, Hao-Yu Chuang, Paolo De Coppi, Anna L David,

Spinal muscular atrophy (SMA) is a single gene disorder affecting motor function in uterus. Amniotic fluid is an alternative source of stem cell to ameliorate SMA. Therefore, this study aims to examine the therapeutic potential of Human amniotic fluid stem cell (hAFSC) for SMA. Our SMA model mice were generated ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9158]

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Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta.

Yada Kunpalin, Jan Deprest, Ioannis Papastefanou, Emma Bredaki, Adalina Sacco, Francesca Russo, Jute Richter, Katrien Jansen, Sebastien Ourselin, Paolo De Coppi, Anna L David, Fred Ushakov, Luc De Catte,

<h4>Objective</h4>To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation.<h4>Methods</h4>This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2021, 41(8):957-964]

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Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.

Nada Mufti, Michael Aertsen, Michael Ebner, Lucas Fidon, Premal Patel, Muhamad Bin Abdul Rahman, Yannick Brackenier, Gregor Ekart, Virginia Fernandez, Tom Vercauteren, Sebastien Ourselin, Dominic Thomson, Luc De Catte, Philippe Demaerel, Jan Deprest, Anna L David, Andrew Melbourne,

<h4>Purpose</h4>A retrospective study was performed to study the effect of fetal surgery on brain development measured by MRI in fetuses with myelomeningocele (MMC).<h4>Methods</h4>MRI scans of 12 MMC fetuses before and after surgery were compared to 24 age-matched controls without central nervous system abnormalities. An automated super-resolution reconstruction technique generated isotropic ... Read more >>

Neuroradiology (Neuroradiology)
[2021, 63(10):1721-1734]

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Myocardial Viability Imaging using Manganese-Enhanced MRI in the First Hours after Myocardial Infarction.

Nur Hayati Jasmin, May Zaw Thin, Robert D Johnson, Laurence H Jackson, Thomas A Roberts, Anna L David, Mark F Lythgoe, Philip C Yang, Sean M Davidson, Patrizia Camelliti, Daniel J Stuckey,

Early measurements of tissue viability after myocardial infarction (MI) are essential for accurate diagnosis and treatment planning but are challenging to obtain. Here, manganese, a calcium analogue and clinically approved magnetic resonance imaging (MRI) contrast agent, is used as an imaging biomarker of myocardial viability in the first hours after ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2021, 8(11):e2003987]

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Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents.

Lina Antounians, Vincenzo D Catania, Louise Montalva, Benjamin D Liu, Huayun Hou, Cadia Chan, Andreea C Matei, Areti Tzanetakis, Bo Li, Rebeca L Figueira, Karina M da Costa, Amy P Wong, Robert Mitchell, Anna L David, Ketan Patel, Paolo De Coppi, Lourenço Sbragia, Michael D Wilson, Janet Rossant, Augusto Zani,

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by decreased lung growth and maturation. The most common birth defect found in babies with pulmonary hypoplasia is congenital diaphragmatic hernia (CDH). Despite research and clinical advances, babies with CDH still have high morbidity and mortality rates, which are directly ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(590):]

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Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.

Monika Byrne, Rosalind Aughwane, Joanna L James, J Ciaran Hutchinson, Owen J Arthurs, Neil J Sebire, Sebastien Ourselin, Anna L David, Andrew Melbourne, Alys R Clark,

A well-functioning placenta is critical for healthy fetal development, as the placenta brings fetal blood in close contact with nutrient rich maternal blood, enabling exchange of nutrients and waste between mother and fetus. The feto-placental circulation forms a complex branching structure, providing blood to fetal capillaries, which must receive sufficient ... Read more >>

J Theor Biol (Journal of theoretical biology)
[2021, 517:110630]

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Ethical and Regulatory Considerations of Placental Therapeutics.

Anna L David,

<h4>Purpose</h4>Placental therapeutics aim to treat placental disease; however, ethical and regulatory issues should be considered if the drug also potentially affects the fetus. Drugs that might transfer or edit genes carry a specific challenge because currently fetal gene editing and fetal gene therapy are considered unethical.<h4>Methods</h4>This article reviews the literature ... Read more >>

Clin Ther (Clinical therapeutics)
[2021, 43(2):297-307]

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Consent in pregnancy - an observational study of ante-natal care in the context of Montgomery: all about risk?

Jacqueline A Nicholls, Anna L David, Joseph Iskaros, Dimitrios Siassakos, Anne Lanceley,

<h4>Background</h4>How to best support pregnant women in making truly autonomous decisions which accord with current consent law is poorly understood and problematic for them and their healthcare professionals. This observational study examined a range of ante-natal consultations where consent for an intervention took place to determine key themes during the ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):102]

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Magnetic resonance imaging of placentome development in the pregnant Ewe.

Dimitra Flouri, Jack R T Darby, Stacey L Holman, Sunthara R Perumal, Anna L David, Janna L Morrison, Andrew Melbourne,

<h4>Introduction</h4>Novel imaging measurements of placental development are difficult to validate due to the invasive nature of gold-standard procedures. Animal studies have been important in validation of magnetic resonance imaging (MRI) measurements in invasive preclinical studies, as they allow for controlled experiments and analysis of multiple time-points during pregnancy. This study ... Read more >>

Placenta (Placenta)
[2021, 105:61-69]

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Maternal and infant morbidity following birth before 27 weeks of gestation: a single centre study.

Andrei S Morgan, Saadia Waheed, Shivani Gajree, Neil Marlow, Anna L David,

Delivery at extreme preterm gestational ages (GA) [Formula: see text] weeks is challenging with limited evidence often focused only on neonatal outcomes. We reviewed management and short term maternal, fetal and neonatal outcomes of births for 132 women (22 + 0 to 26 + 6 weeks' GA) with a live ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):288]

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Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.

Yada Kunpalin, Sindhu Subramaniam, Silvia Perin, Mattia F M Gerli, Jan Bosteels, Sebastien Ourselin, Jan Deprest, Paolo De Coppi, Anna L David,

<h4>Objective</h4>We performed a systematic review to summarize the efficacy and safety of in utero stem cells application in preclinical models with myelomeningocele (MMC).<h4>Methods</h4>The study was registered with PROSPERO (CRD42019160399). We searched MEDLINE, Embase, Web of Science, Scopus and CENTRAL for publications articles on stem cell therapy in animal fetuses with ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2021, 41(3):283-300]

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The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: an MRI study.

Sophie Couper, Alys Clark, John M D Thompson, Dimitra Flouri, Rosalind Aughwane, Anna L David, Andrew Melbourne, Ali Mirjalili, Peter R Stone,

<h4>Key points</h4>Maternal supine sleep position in late pregnancy is associated with an increased risk of stillbirth. Maternal supine position in late pregnancy reduces maternal cardiac output and uterine blood flow. Using MRI, this study shows that compared to the left lateral position, maternal supine position in late pregnancy is associated ... Read more >>

J Physiol (The Journal of physiology)
[2021, 599(6):1901-1915]

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The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs.

Federica Michielin, Giovanni G Giobbe, Camilla Luni, Qianjiang Hu, Ida Maroni, Michael R Orford, Anna Manfredi, Lucio Di Filippo, Anna L David, Davide Cacchiarelli, Paolo De Coppi, Simon Eaton, Nicola Elvassore,

The specification of the hepatic identity during human liver development is strictly controlled by extrinsic signals, yet it is still not clear how cells respond to these exogenous signals by activating secretory cascades, which are extremely relevant, especially in 3D self-organizing systems. Here, we investigate how the proteins secreted by ... Read more >>

Cell Rep (Cell reports)
[2020, 33(9):108453]

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CRAFT (Cerclage after full dilatation caesarean section): protocol of a mixed methods study investigating the role of previous in-labour caesarean section in preterm birth risk.

Naomi Carlisle, Agnieszka Glazewska-Hallin, Lisa Story, Jenny Carter, Paul T Seed, Natalie Suff, Lucie Giblin, Jana Hutter, Raffaele Napolitano, Mary Rutherford, Daniel C Alexander, Nigel Simpson, Amrita Banerjee, Anna L David, Andrew H Shennan,

<h4>Background</h4>Full dilatation caesarean sections are associated with recurrent early spontaneous preterm birth and late miscarriage. The risk following first stage caesarean sections, are less well defined, but appears to be increased in late-first stage of labour. The mechanism for this increased risk of late miscarriage and early spontaneous preterm birth ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):698]

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Dimensionless squared jerk: An objective differential to assess experienced and novice probe movement in obstetric ultrasound.

Brian P Dromey, Shahanaz Ahmed, Francisco Vasconcelos, Evangelos Mazomenos, Yada Kunpalin, Sebastien Ourselin, Jan Deprest, Anna L David, Danail Stoyanov, Donald M Peebles,

<h4>Objective</h4>Widely accepted, validated and objective measures of ultrasound competency have not been established for clinical practice. Outcomes of training curricula are often based on arbitrary thresholds, such as the number of clinical cases completed. We aimed to define metrics against which competency could be measured.<h4>Method</h4>We undertook a prospective, observational study ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2021, 41(2):271-277]

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Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency.

Carlo Rossi, Mark Lees, Vedanta Mehta, Tommi Heikura, John Martin, Ian Zachary, Rebecca Spencer, Donald M Peebles, Robert Shaw, Minna Karhinen, Seppo Yla-Herttuala, Anna L David,

Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency is a major cause. Transduction of uterine arteries in normal or FGR sheep and guinea pigs using an adenovirus ... Read more >>

Hum Gene Ther (Human gene therapy)
[2020, 31(21-22):1190-1202]

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Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense.

David W Barrett, Babatunde O Okesola, Eleni Costa, Christopher Thrasivoulou, David L Becker, Alvaro Mata, Jan A Deprest, Anna L David, Tina T Chowdhury,

<h4>Objective</h4>We examined whether peptide amphiphiles functionalised with adhesive, migratory or regenerative sequences could be combined with amniotic fluid (AF) to form plugs that repair fetal membrane (FM) defects after trauma and co-culture with connexin 43 (Cx43) antisense.<h4>Methods</h4>We assessed interactions between peptide amphiphiles and AF and examined the plugs in FM ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2021, 41(1):89-99]

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Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress.

Janna L Morrison, Oyekoya T Ayonrinde, Alison S Care, Geoffrey D Clarke, Jack R T Darby, Anna L David, Justin M Dean, Stuart B Hooper, Marcus J Kitchen, Christopher K Macgowan, Andrew Melbourne, Erin V McGillick, Charles A McKenzie, Navin Michael, Nuruddin Mohammed, Suresh Anand Sadananthan, Eric Schrauben, Timothy R H Regnault, S Sendhil Velan,

Advanced imaging techniques are enhancing research capacity focussed on the developmental origins of adult health and disease (DOHaD) hypothesis, and consequently increasing awareness of future health risks across various subareas of DOHaD research themes. Understanding how these advanced imaging techniques in animal models and human population studies can be both ... Read more >>

J Dev Orig Health Dis (Journal of developmental origins of health and disease)
[2021, 12(2):153-167]

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