Full Text Journal Articles by
Author Anna Casu

Advertisement

Find full text journal articles








Pharmacological therapies to address obesity in type 1 diabetes.

Anna Casu, Anika Bilal, Richard E Pratley, ,

PURPOSE OF REVIEW:Obesity is increasing in prevalence among patients with type 1 diabetes (T1D) and is associated with insulin resistance and increased cardiovascular risk. The management of obesity in this population is complicated by defects in pancreatic islet hormone secretion and the effects of exogenous insulin treatment. Here, we review ... Read more >>

Curr Opin Endocrinol Diabetes Obes (Current opinion in endocrinology, diabetes, and obesity)
[2020, 27(4):194-206]

Cited: 0 times

View full text PDF listing >>



Carnosine protects pancreatic beta cells and islets against oxidative stress damage.

Vitale Miceli, Mariangela Pampalone, Giovanna Frazziano, Giuseppe Grasso, Enrico Rizzarelli, Camillo Ricordi, Anna Casu, Gioacchin Iannolo, Pier Giulio Conaldi,

Islet transplantation is a valid therapeutic option for type 1 diabetes treatment. However, in this procedure one of the major problems is the oxidative stress produced during pancreatic islet isolation. The aim of our study was to evaluate potential protective effects of L-carnosine and its isomer D-carnosine against oxidative stress. ... Read more >>

Mol. Cell. Endocrinol. (Molecular and cellular endocrinology)
[2018, 474:105-118]

Cited: 3 times

View full text PDF listing >>



Advertisement

Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development.

Maria Acevedo-Calado, Eddie A James, Michael P Morran, Susan L Pietropaolo, Qin Ouyang, David Arribas-Layton, Marco Songini, Marco Liguori, Anna Casu, Richard J Auchus, Shuai Huang, Liping Yu, Aaron Michels, Roberto Gianani, Massimo Pietropaolo,

OBJECTIVE:The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new antigenic determinants in the neuroendocrine autoantigen IA-2 (ICA512) and assess whether circulating autoantibodies directed to new IA-2 epitopes identify autoimmune diabetes ... Read more >>

Diabetes Care (Diabetes care)
[2017, 40(4):561-568]

Cited: 8 times

View full text PDF listing >>



ISMETT: An International Collaboration on Organ Transplantation.

Giovan B Vizzini, Salvatore Gruttadauria, Marco Spada, Alessandro Bertani, Tullio Bertani, Anna Casu, Giuseppe Raffa, Sergio Sciacca, Gabriele Di Gesaro, Michele Pilato, Lavinia De Monte, Patrizio Vitulo, Angelo Luca, Antonio Arcadipane, Bruno Gridelli,

The Institute of the Mediterranean for Transplantation and High Specialty Therapies (ISMETT) is a multi-organ transplant and high specialty center located in Palermo, Italy and managed by the University of Pittsburgh Medical Center. Clinical transplant activity started in 1999 and, herein, we illustrate the outcomes achieved over the past 15 ... Read more >>

Clin Transpl (Clinical transplants)
[2015, 31:87-99]

Cited: 0 times

View full text PDF listing >>



Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial.

Mikael Knip, Hans K Åkerblom, Dorothy Becker, Hans-Michael Dosch, John Dupre, William Fraser, Neville Howard, Jorma Ilonen, Jeffrey P Krischer, Olga Kordonouri, Margaret L Lawson, Jerry P Palmer, Erkki Savilahti, Outi Vaarala, Suvi M Virtanen, ,

The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas do not contain intact proteins.To test the hypothesis ... Read more >>

JAMA (JAMA)
[2014, 311(22):2279-2287]

Cited: 63 times

View full text PDF listing >>



Clinical islet xenotransplantation: how close are we?

Dirk J van der Windt, Rita Bottino, Goutham Kumar, Martin Wijkstrom, Hidetaka Hara, Mohamed Ezzelarab, Burcin Ekser, Carol Phelps, Noriko Murase, Anna Casu, David Ayares, Fadi G Lakkis, Massimo Trucco, David K C Cooper,

Diabetes (Diabetes)
[2012, 61(12):3046-3055]

Cited: 62 times

View full text PDF listing >>



Growth differences between North American and European children at risk for type 1 diabetes.

Anita M Nucci, Dorothy J Becker, Suvi M Virtanen, David Cuthbertson, Barney Softness, Celine Huot, Renata Wasikowa, Hans Michael Dosch, Hans K Akerblom, Mikael Knip, ,

To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D.Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2012, 13(5):425-431]

Cited: 0 times

View full text PDF listing >>



Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.

Michael P Morran, Anna Casu, Vincent C Arena, Susan Pietropaolo, Ying-Jian Zhang, Leslie S Satin, Patrick Nelson, Gilbert S Omenn, Massimo Trucco, Dorothy J Becker, Massimo Pietropaolo,

The objective of this study was to determine whether antigenic determinants localized within the extracellular domain of the neuroendocrine autoantigen tyrosine phosphatase-like protein IA-2 are targets of humoral responses in type 1 diabetes (T1DM). Previous studies indicated that the immunodominant region of IA-2 is localized within its intracellular domain (IA-2ic; ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(6):2528-2537]

Cited: 21 times

View full text PDF listing >>



Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.

Anna Casu, Gabriel J Echeverri, Rita Bottino, Dirk J van der Windt, Jing He, Burcin Ekser, Suyapa Ball, David Ayares, David K C Cooper,

BACKGROUND:Xenotransplantation of porcine islets could be a valuable alternative to the shortage of human islets for transplantation. To overcome the immunological obstacle of antibody-mediated rejection, pigs homozygous for alpha1,3-galactosyltransferase gene knock-out (GT-KO) have been produced. The effect of this mutation on glucose metabolism is unknown. METHODS:Glucose, insulin, C-peptide and glucagon ... Read more >>

Xenotransplantation (Xenotransplantation)
[2010, 17(2):131-139]

Cited: 17 times

View full text PDF listing >>



The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial.

David K C Cooper, Anna Casu,

Pre-clinical efficacy and complication data required to justify a porcine islet transplantation clinical trial have been considered. To be relevant to clinical islet transplantation, pre-clinical data should be obtained in a pig-to-diabetic non-human primate (NHP) model. In view of the difficulties of maintaining immunosuppressed NHPs for long periods of time, ... Read more >>

Xenotransplantation (Xenotransplantation)
[2009, 16(4):229-238]

Cited: 39 times

View full text PDF listing >>



Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation.

Rita Bottino, Angela Criscimanna, Anna Casu, Jing He, Dirk J Van der Windt, William A Rudert, Carla Giordano, Massimo Trucco,

OBJECTIVE: To describe the ability of nonhuman primate endocrine pancreata to reestablish endogenous insulin production after chemical beta-cell destruction. RESEARCH DESIGN AND METHODS: Eleven monkeys (Macaca fascicularis) were rendered diabetic with streptozotocin. Eight diabetic monkeys received intraportal porcine islet transplantation. RESULTS: Two monkeys transplanted after 75 days of type 1 ... Read more >>

Diabetes (Diabetes)
[2009, 58(2):442-447]

Cited: 18 times

View full text PDF listing >>



Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.

Dirk J van der Windt, Rita Bottino, Anna Casu, Nathalie Campanile, David K C Cooper,

Islets isolated from multiple pancreas donors are often necessary to achieve euglycemia in type 1 diabetic patients treated by islet allotransplantation. This increases the burden on the limited pool of donor organs. After infusion into the portal vein, a substantial percentage of islets are lost in the immediate post-transplant period ... Read more >>

Xenotransplantation (Xenotransplantation)
[2007, 14(4):288-297]

Cited: 91 times

View full text PDF listing >>



Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - case history and review of the literature.

Nathalie Campanile, Pleunie P P M Rood, Peter Yeh, Anna Casu, Rita Bottino, David K C Cooper,

We report a streptozotocin-induced diabetic cynomolgus monkey that developed acute gastric dilatation within the first week after intraportal porcine islet transplantation. The monkey presented with increasing anorexia and somnolence, associated with persistent metabolic acidosis. On physical examination, a diffuse mass was palpable in the abdomen. Because of its deteriorating clinical ... Read more >>

Xenotransplantation (Xenotransplantation)
[2007, 14(3):265-270]

Cited: 6 times

View full text PDF listing >>



A look to the future: prediction, prevention, and cure including islet transplantation and stem cell therapy.

Anna Casu, Massimo Trucco, Massimo Pietropaolo,

Type 1 diabetes mellitus (T1DM) is characterized by the almost complete absence of insulin secretion, which is secondary to an autoimmune destruction or dysfunction of the insulin-producing cells of the pancreatic islets of Langerhans. Because T1DM is an autoimmune disease with a long preclinical course, the predictive testing of individuals ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2005, 52(6):1779-1804]

Cited: 3 times

View full text PDF listing >>



Epidemiology of childhood diabetes.

Marco Songini, Anna Casu,

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2005, 76 Suppl 3:19-25]

Cited: 3 times

View full text PDF listing >>



Effect of a load of Vitamin A after acute thioacetamide intoxication on dolichol, dolichol isoprenoids and retinol content in isolated rat liver cells.

Anna M Bassi, Claudio Canepa, Giuseppe Maloberti, Anna Casu, Giorgio Nanni,

This study examines how treatment with a single dose of thioacetamide, a known experimental hepatotoxin, alters the content of dolichol, dolichol isoprene units and retinol in isolated rat parenchymal and non-parenchymal liver cells at different times and when the animals are supplemented with Vitamin A. Thioacetamide (300 mg/kg i.p.) was ... Read more >>

Toxicology (Toxicology)
[2004, 199(2-3):97-107]

Cited: 3 times

View full text PDF listing >>



Seasonality of month of birth of children and adolescents with type 1 diabetes mellitus in homogenous and heterogeneous populations.

Zvi Laron, Hadas Lewy, Igor Wilderman, Anna Casu, Jinny Willis, Maria Jose Redondo, Ingrid Libman, Neil White, Maria Craig,

BACKGROUND: Type 1 childhood-onset diabetes mellitus has a multifactorial origin involving an interplay between genetic and environmental factors. We have previously shown that many children who subsequently develop T1DM have a different seasonality of birth than the total live births of the same population, supporting the hypothesis that perinatal viral ... Read more >>

Isr. Med. Assoc. J. (The Israel Medical Association journal : IMAJ)
[2005, 7(6):381-384]

Cited: 17 times

View full text PDF listing >>



Chronic high doses of thioacetamide followed by vitamin A modify dolichol, dolichol isoprenoids, and retinol content in rat liver cells.

Anna Maria Bassi, Anna Casu, Claudio Canepa, Giuseppe Maloberti, Giorgio Nanni,

Our line of researches follows the hypothesis that dolichol and retinol metabolism might be interrelated and involved in liver fibrosis. To this end, in this study rats were subjected to chronic treatment with thioacetamide (TAA) (300 mg/L liquid diet) for 1 and 2 months and, after liver damage had occurred, ... Read more >>

Drug Chem Toxicol (Drug and chemical toxicology)
[2005, 28(1):91-104]

Cited: 1 time

View full text PDF listing >>



Association of thioacetamide and ethanol treatment: dolichol and retinol in isolated rat liver cells.

Anna Maria Bassi, Damiano Cottalasso, Claudio Canepa, Giuseppe Maloberti, Anna Casu, Giorgio Nanni,

Our aim was to study the distribution of dolichol, dolichol isoprenoids, and retinol in hepatocytes, Kupffer, sinusoidal endothelial and two subfractions of hepatic stellate cells, --Ito-1 and Ito-2--, after chronic treatment of rats for 2 and 4 months with a low dosage of thioacetamide associated with ethanol. Each type of ... Read more >>

Drug Chem Toxicol (Drug and chemical toxicology)
[2004, 27(1):55-67]

Cited: 3 times

View full text PDF listing >>



Type 1 diabetes among sardinian children is increasing: the Sardinian diabetes register for children aged 0-14 years (1989-1999).

Anna Casu, Cristiana Pascutto, Luisa Bernardinelli, Marco Songini,

OBJECTIVE:The Sardinian type 1 diabetes register represented the basis to determine the most recent trends and the age distribution of type 1 diabetes incidence among Sardinians <15 years of age during 1989-1999. Part of the data (1989-1998) has been already published by the EURODIAB Group with a lower completeness of ... Read more >>

Diabetes Care (Diabetes care)
[2004, 27(7):1623-1629]

Cited: 44 times

View full text PDF listing >>



Bayesian approach to study the temporal trend and the geographical variation in the risk of type 1 diabetes. The Sardinian Conscript Type 1 Diabetes Registry.

Anna Casu, Cristiana Pascutto, Luisa Bernardinelli, Marco Songini, ,

BACKGROUND: A previous analysis of the Sardinian Conscript Type 1 Diabetes Registry indicated an abrupt increase in the risk for type 1 diabetes (T1D) among Sardinian male cohorts starting from the 1946 one. OBJECTIVE: The aim of this study was to update the point prevalence of T1D among Sardinian male ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2004, 5(1):32-38]

Cited: 7 times

View full text PDF listing >>



Chronic ethanol treatment: dolichol and retinol distribution in isolated rat liver cells.

Damiano Cottalasso, Anna Maria Bassi, Claudio Canepa, Giuseppe Maloberti, Anna Casu, Giorgio Nanni,

The aim of this study was to use chronic ethanol intoxication for 2 and 4 months as a means of studying the distribution of dolichol and retinol in isolated rat liver parenchymal cells, Kupffer cells, sinusoidal endothelial cells, and two subfractions of hepatic stellate cells: Ito 1 and Ito 2. ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2003, 34(3):337-344]

Cited: 8 times

View full text PDF listing >>



Dolichol content in isolated sinusoidal liver cells after in vivo chronic treatment with thioacetamide.

Giorgio Nanni, Federica Majorani, Anna Maria Bassi, Claudio Canepa, Giuseppe Maloberti, Anna Casu,

The content of dolichol, an isoprenoid present in all biological membranes, was determined in isolated sinusoidal liver cells after treatment of rats for 2 and 4 months with a low dosage of the hepatotoxin thioacetamide. The significant decrease in dolichol observed in hepatocytes after 2 months might be explained by ... Read more >>

Exp. Toxicol. Pathol. (Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie)
[2002, 54(1):43-50]

Cited: 3 times

View full text PDF listing >>





Advertisement

Disclaimer
1.6289 s