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Author Ankit A Desai

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Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.

Xiaoguang Sun, Belinda L Sun, Aleksandra Babicheva, Rebecca Vanderpool, Radu C Oita, Nancy Casanova, Haiyang Tang, Akash Gupta, Heather Lynn, Geetanjali Gupta, Franz Rischard, Saad Sammani, Carrie L Kempf, Liliana Moreno-Vinasco, Mohamed Ahmed, Sara M Camp, Jian Wang, Ankit A Desai, Jason X-J Yuan, Joe G N Garcia,

We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT's (eNAMPT's) role in PAH vascular remodeling. NAMPT transcription and protein expression in human lung endothelial cells were assessed in response to PAH-relevant stimuli (PDGF [platelet-derived growth factor], VEGF [vascular ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2020, 63(1):92-103]

Cited: 0 times

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Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension.

Jason H Karnes, Howard W Wiener, Tae-Hwi Schwantes-An, Balaji Natarajan, Andrew J Sweatt, Abhishek Chaturvedi, Amit Arora, Ken Batai, Vineet Nair, Heidi E Steiner, Jason B Giles, Jeffrey Yu, Maryam Hosseini, Michael W Pauciulo, Katie A Lutz, Anna W Coleman, Jeremy Feldman, Rebecca Vanderpool, Haiyang Tang, Joe G N Garcia, Jason X-J Yuan, Rick Kittles, Vinicio de Jesus Perez, Roham T Zamanian, Franz Rischard, Hemant K Tiwari, William C Nichols, Raymond L Benza, Ankit A Desai,

Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries with genome-wide data and two local cohorts, and further incorporated ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(11):1407-1415]

Cited: 1 time

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Beta-Blocker Dose Stratifies Mortality Risk in a Racially Diverse Heart Failure Population.

Christelle Lteif, Meghan J Arwood, Mayank Kansal, Larisa H Cavallari, Ankit A Desai, Julio D Duarte,

Heart failure (HF) is highly prevalent and a major cause of death in the United States. The effect of HF medications on survival has been predicted by validated models studied in populations predominantly of European descent. This study aimed to identify medications associated with survival in a racially diverse HF ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 75(3):250-258]

Cited: 0 times

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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.

Anna Ulrich, John Wharton, Timothy E Thayer, Emilia M Swietlik, Tufik R Assad, Ankit A Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W Morrell, William C Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C Trembath, Evan L Brittain, Martin R Wilkins, Inga Prokopenko, Christopher J Rhodes, , , ,

Pulmonary arterial hypertension (PAH) is a rare disease that leads to premature death from right heart failure. It is strongly associated with elevated red cell distribution width (RDW), a correlate of several iron status biomarkers. High RDW values can signal early-stage iron deficiency or iron deficiency anaemia. This study investigated ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(2):]

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Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.

Yuqin Chen, Wenju Lu, Kai Yang, Xin Duan, Mengxi Li, Xiuqing Chen, Jie Zhang, Meidan Kuang, Shiyun Liu, Xiongting Wu, Guofa Zou, Chunli Liu, Cheng Hong, Wenjun He, Jing Liao, Chi Hou, Zhe Zhang, Qiuyu Zheng, Jiyuan Chen, Nuofu Zhang, Haiyang Tang, Rebecca R Vanderpool, Ankit A Desai, Franz Rischard, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan, Nanshan Zhong, Jian Wang,

BACKGROUND AND PURPOSE:Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized. TMP has a long history of beneficial effects in the treatment of many cardiovascular diseases. Here we have evaluated the therapeutic effects of TMP on pulmonary ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2020, 177(12):2743-2764]

Cited: 0 times

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American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease.

Robert I Liem, Sophie Lanzkron, Thomas D Coates, Laura DeCastro, Ankit A Desai, Kenneth I Ataga, Robyn T Cohen, Johnson Haynes, Ifeyinwa Osunkwo, Jeffrey D Lebensburger, James P Lash, Theodore Wun, Madeleine Verhovsek, Elodie Ontala, Rae Blaylark, Fares Alahdab, Abdulrahman Katabi, Reem A Mustafa,

BACKGROUND:Prevention and management of end-organ disease represent major challenges facing providers of children and adults with sickle cell disease (SCD). Uncertainty and variability in the screening, diagnosis, and management of cardiopulmonary and renal complications in SCD lead to varying outcomes for affected individuals. OBJECTIVE:These evidence-based guidelines of the American Society ... Read more >>

Blood Adv (Blood advances)
[2019, 3(23):3867-3897]

Cited: 2 times

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End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain.

Ann T Farrell, Julie Panepinto, C Patrick Carroll, Deepika S Darbari, Ankit A Desai, Allison A King, Robert J Adams, Tabitha D Barber, Amanda M Brandow, Michael R DeBaun, Manus J Donahue, Kalpna Gupta, Jane S Hankins, Michelle Kameka, Fenella J Kirkham, Harvey Luksenburg, Shirley Miller, Patricia Ann Oneal, David C Rees, Rosanna Setse, Vivien A Sheehan, John Strouse, Cheryl L Stucky, Ellen M Werner, John C Wood, William T Zempsky,

To address the global burden of sickle cell disease (SCD) and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and patients to develop consensus recommendations for clinical trial end points. ... Read more >>

Blood Adv (Blood advances)
[2019, 3(23):3982-4001]

Cited: 1 time

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End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings.

Ann T Farrell, Julie Panepinto, Ankit A Desai, Adetola A Kassim, Jeffrey Lebensburger, Mark C Walters, Daniel E Bauer, Rae M Blaylark, Donna M DiMichele, Mark T Gladwin, Nancy S Green, Kathryn Hassell, Gregory J Kato, Elizabeth S Klings, Donald B Kohn, Lakshmanan Krishnamurti, Jane Little, Julie Makani, Punam Malik, Patrick T McGann, Caterina Minniti, Claudia R Morris, Isaac Odame, Patricia Ann Oneal, Rosanna Setse, Poornima Sharma, Shalini Shenoy,

To address the global burden of sickle cell disease and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and patients to develop consensus recommendations for clinical trial end points. The ... Read more >>

Blood Adv (Blood advances)
[2019, 3(23):4002-4020]

Cited: 1 time

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Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension.

Ruslan Rafikov, Vineet Nair, Shripad Sinari, Harini Babu, Jennifer C Sullivan, Jason X-J Yuan, Ankit A Desai, Olga Rafikova,

Aims: Pulmonary arterial hypertension (PAH) is a progressive lethal disease with a known gender dimorphism. Female patients are more susceptible to PAH, whereas male patients have a lower survival rate. Initial pulmonary vascular damage plays an important role in PAH pathogenesis. Therefore, this study aimed at investigating the role of ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2019, 31(13):917-932]

Cited: 6 times

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Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.

Evgeny A Zemskov, Qing Lu, Wojciech Ornatowski, Christina N Klinger, Ankit A Desai, Emin Maltepe, Jason X-J Yuan, Ting Wang, Jeffrey R Fineman, Stephen M Black,

Significance: Oxidative stress in the cell is characterized by excessive generation of reactive oxygen species (ROS). Superoxide (O2-) and hydrogen peroxide (H2O2) are the main ROS involved in the regulation of cellular metabolism. As our fundamental understanding of the underlying causes of lung disease has increased it has become evident ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2019, 31(12):819-842]

Cited: 4 times

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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.

Haiyang Tang, Kang Wu, Jian Wang, Sujana Vinjamuri, Yali Gu, Shanshan Song, Ziyi Wang, Qian Zhang, Angela Balistrieri, Ramon J Ayon, Franz Rischard, Rebecca Vanderpool, Jiwang Chen, Guofei Zhou, Ankit A Desai, Stephen M Black, Joe G N Garcia, Jason X-J Yuan, Ayako Makino,

Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension. We identified a differential role of mammalian target of rapamycin (mTOR) complex 1 and complex 2, two ... Read more >>

(JACC. Basic to translational science)
[2018, 3(6):744-762]

Cited: 3 times

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Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension.

Ziyi Wang, Kai Yang, Qiuyu Zheng, Chenting Zhang, Haiyang Tang, Aleksandra Babicheva, Qian Jiang, Meichan Li, Yuqin Chen, Shane G Carr, Kang Wu, Qian Zhang, Angela Balistrieri, Christina Wang, Shanshan Song, Ramon J Ayon, Ankit A Desai, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan, Wenju Lu, Jian Wang,

The tumor-suppressive role of p53, a transcription factor that regulates the expression of many genes, has been linked to cell cycle arrest, apoptosis, and senescence. The noncanonical function or the pathogenic role of p53 has more recently been implicated in pulmonary vascular disease. We previously reported that rapid nuclear accumulation ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2019, 316(1):L216-L228]

Cited: 0 times

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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe G N Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins, , , ,

BACKGROUND:Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes. METHODS:We did two separate genome-wide ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(3):227-238]

Cited: 8 times

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Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.

Olga Rafikova, Elissa R Williams, Matthew L McBride, Marina Zemskova, Anup Srivastava, Vineet Nair, Ankit A Desai, Paul R Langlais, Evgeny Zemskov, Marc Simon, Lawrence J Mandarino, Ruslan Rafikov,

Although hemolytic anemia-associated pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) are more common than the prevalence of idiopathic PAH alone, the role of hemolysis in the development of PAH is poorly characterized. We hypothesized that hemolysis independently contributes to PAH pathogenesis via endothelial barrier dysfunction with resulting perivascular edema ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2018, 59(3):334-345]

Cited: 12 times

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Right ventricular afterload predicts long-term transition from parenteral to oral treprostinil in pulmonary arterial hypertension.

Travis Maestas, Lillian M Hansen, Rebecca R Vanderpool, Ankit A Desai, Sophia Airhart, Shannon M Knapp, Adam Cohen, Jeremy Feldman, Franz P Rischard,

Despite the increasing trends, reports on long-term follow-up are limited on transitioning from parenteral to oral treprostinil therapy in patients with pulmonary arterial hypertension (PAH). We investigated both the effectiveness of parenteral to oral treprostinil transition and the characteristics associated with transition failure over a duration of two years. The ... Read more >>

(Pulmonary circulation)
[2018, 8(4):2045894018797270]

Cited: 1 time

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New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.

Sergey Kurdyukov, Cody A Eccles, Ankit A Desai, Manuel Gonzalez-Garay, Jason X-J Yuan, Joe G N Garcia, Olga Rafikova, Ruslan Rafikov,

Pulmonary Arterial Hypertension (PAH) is a fatal disorder with limited treatment options and reduced life expectancy after diagnosis. Complex genetic backgrounds in PAH complicates identification of causative mutations that is essential for an understanding of the disease diagnostics and etiology especially for idiopathic PAH (iPAH). Hemolysis has been implicated as ... Read more >>

PLoS One (PloS one)
[2018, 13(8):e0203493]

Cited: 2 times

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LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18.

Christine M Gross, Manuela Kellner, Ting Wang, Qing Lu, Xutong Sun, Evgeny A Zemskov, Satish Noonepalle, Archana Kangath, Sanjiv Kumar, Manuel Gonzalez-Garay, Ankit A Desai, Saurabh Aggarwal, Boris Gorshkov, Christina Klinger, Alexander D Verin, John D Catravas, Jeffrey R Jacobson, Jason X-J Yuan, Ruslan Rafikov, Joe G N Garcia, Stephen M Black,

One of the early events in the progression of LPS-mediated acute lung injury in mice is the disruption of the pulmonary endothelial barrier resulting in lung edema. However, the molecular mechanisms by which the endothelial barrier becomes compromised remain unresolved. The SRY (sex-determining region on the Y chromosome)-related high-mobility group ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2018, 58(5):614-624]

Cited: 3 times

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Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung.

Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic,

BACKGROUND:Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated the effects of chronic inhibition of mitochondrial function ... Read more >>

Respir. Res. (Respiratory research)
[2018, 19(1):69]

Cited: 7 times

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Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients.

Julio D Duarte, Mayank Kansal, Ankit A Desai, Katherine Riden, Meghan J Arwood, Alex A Yacob, Thomas D Stamos, Larisa H Cavallari, Roham T Zamanian, Sanjiv J Shah, Roberto F Machado,

The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role of NOS in HF-PH. DNA samples ... Read more >>

Pulm Circ (Pulmonary circulation)
[2018, 8(2):2045894018773049]

Cited: 2 times

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Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension.

Morgan E Whitaker, Vineet Nair, Shripad Sinari, Parinita A Dherange, Balaji Natarajan, Lindsey Trutter, Evan L Brittain, Anna R Hemnes, Eric D Austin, Kumar Patel, Stephen M Black, Joe G N Garcia, Jason X Yuan Md PhD, Rebecca R Vanderpool, Franz Rischard, Ayako Makino, Edward J Bedrick, Ankit A Desai,

BACKGROUND:Diabetes mellitus is associated with left ventricular hypertrophy and dysfunction. Parallel studies have also reported associations between diabetes mellitus and right ventricular dysfunction and reduced survival in patients with pulmonary arterial hypertension. However, the impact of diabetes mellitus on the pulmonary vasculature has not been well characterized. We hypothesized that ... Read more >>

Am J Med (The American journal of medicine)
[2018, 131(6):702.e7-702.e13]

Cited: 5 times

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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.

Andrea L Casillas, Rachel K Toth, Alva G Sainz, Neha Singh, Ankit A Desai, Andrew S Kraft, Noel A Warfel,

Purpose: Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their expression increases in hypoxia. The goal of this study was to determine whether targeting hypoxia-induced PIM kinase expression is effective in combination with VEGF-targeting agents. The rationale ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(1):169-180]

Cited: 8 times

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Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.

Haiyang Tang, Aleksandra Babicheva, Kimberly M McDermott, Yali Gu, Ramon J Ayon, Shanshan Song, Ziyi Wang, Akash Gupta, Tong Zhou, Xutong Sun, Swetaleena Dash, Zilu Wang, Angela Balistrieri, Qiuyu Zheng, Arlette G Cordery, Ankit A Desai, Franz Rischard, Zain Khalpey, Jian Wang, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan,

Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary vascular resistance in patients with idiopathic pulmonary arterial hypertension (IPAH). Here we report that increased hypoxia-inducible factor 2α (HIF-2α) in lung vascular endothelial cells (LVECs) under normoxic conditions is involved in ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2018, 314(2):L256-L275]

Cited: 22 times

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How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension.

Rebecca R Vanderpool, Ankit A Desai, Shannon M Knapp, Marc A Simon, Aiden Abidov, Jason X-J Yuan, Joe G N Garcia, Lillian M Hansen, Steven R Knoper, Robert Naeije, Franz P Rischard,

Eur Respir J (The European respiratory journal)
[2017, 50(2):]

Cited: 7 times

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Association of circulating transcriptomic profiles with mortality in sickle cell disease.

Ankit A Desai, Zhengdeng Lei, Neil Bahroos, Mark Maienschein-Cline, Santosh L Saraf, Xu Zhang, Binal N Shah, Seyed M Nouraie, Taimur Abbasi, Amit R Patel, Roberto M Lang, Yves Lussier, Joe G N Garcia, Victor R Gordeuk, Roberto F Machado,

Sickle cell disease (SCD) complications are associated with increased morbidity and risk of mortality. We sought to identify a circulating transcriptomic profile predictive of these poor outcomes in SCD. Training and testing cohorts consisting of adult patients with SCD were recruited and prospectively followed. A pathway-based signature derived from grouping ... Read more >>

Blood (Blood)
[2017, 129(22):3009-3016]

Cited: 6 times

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Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis.

Katherine M Marsh, Alice S Ferng, Tia Pilikian, Ankit A Desai, Ryan Avery, Mark Friedman, Isabel Oliva, Clint Jokerst, David Schipper, Zain Khalpey,

Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2017, 12(1):6]

Cited: 0 times

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