Full Text Journal Articles by
Author Anjana Pillai

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The effect of COVID-19 on liver transplantation: impact, practice patterns, therapeutics, and next steps.

Alan L Hutchison, Anjana Pillai,

<h4>Purpose of review</h4>To assess the impact of coronavirus disease 2019 (COVID-19) and the pandemic on liver transplant candidates, recipients, and donors, and review guidelines and recommendations for integrating COVID-19 therapies into current practice.<h4>Recent findings</h4>COVID-19 has high morbidity and mortality for transplant candidates; interestingly, posttransplant comorbidities play a larger role than ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):339-345]

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Empiric use of anticoagulation in hospitalized patients with COVID-19: a propensity score-matched study of risks and benefits.

Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, J Daniel Kelly, Vidya Menon,

<h4>Background</h4>Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in a large ... Read more >>

Biomark Res (Biomarker research)
[2021, 9(1):29]

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Patient Preferences for Hepatocellular Carcinoma Surveillance Parameters.

Sean A Woolen, Amit G Singal, Matthew S Davenport, Jonathan P Troost, Shokoufeh Khalatbari, Sukul Mittal, Sehar Siddiqui, Austin Fobar, Jason Morris, Mobolaji Odewole, Elliot B Tapper, Anjana Pillai, Neehar D Parikh,

<h4>Background and aims</h4>Professional societies recommend abdominal ultrasound (US) with or without alpha fetoprotein (AFP) for hepatocellular cancer (HCC) surveillance; however, there are several emerging surveillance modalities, including abbreviated MRI and blood-based biomarker panels. Most studies have focused on provider perspectives for surveillance logistics, but few have assessed patient preferences. We ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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High Initial Titres of Anti-Spike Antibodies following SARS-CoV-2 Infection is Associated with Faster Decay Rates at Four Months Follow-Up

Vidya Menon, Masood Shariff, Victor Perez Gutierrez, Juan Carreño, Bo Yu, Muzamil Jawed, Marcia Gossai, Elisenda Valdez, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Florian Krammer,

<h4>Background</h4> Dynamics of humoral immune responses to SARS-CoV-2 antigens following infection suggests an initial decay of antibody followed by subsequent stabilization. We aim to understand the longitudinal humoral responses to SARS-CoV-2 nucleocapsid (N) protein and spike (S) protein and to evaluate their correlation to clinical symptoms among healthcare workers (HCW). ... Read more >>

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Empiric use of Anticoagulation in Hospitalized Patients with COVID-19: A Propensity Score-Matched Study of Risks and Benefits

Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, Daniel Kelly, Vidya Menon,

<h4>Background: </h4> Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in ... Read more >>

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Living-Donor Liver Transplantation in the United States: Evolution of Frequency, Outcomes, Center Volumes and Factors Associated with Outcomes.

Thomas G Cotter, Mohamad Minhem, Jennifer Wang, Thoetchai Peeraphatdit, Fares Ayoub, Anjana Pillai, Roberto Hernandez-Alejandro, Diego di Sabato, Michael Charlton,

<h4>Background</h4>Recent modifications in organ allocation policies and increases in chronic liver diseases may have resulted in important changes in living donor liver transplantation (LDLT) in the US. We examined the trends, outcomes and factors associated with outcomes in adult LDLT.<h4>Methods</h4>UNOS data on 2566 adult LDLT recipients from 01/01/2010 through 12/31/2019 ... Read more >>

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, :]

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Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma.

Gabriella Aitcheson, Anjana Pillai, Bassam Dahman, Binu V John,

<h4>Purpose of review</h4>This paper aims to summarize the data of recently completed and key ongoing clinical trials of systemic agents for advanced hepatocellular carcinoma (aHCC). In particular, the review focuses on ongoing checkpoint inhibitor combination trials and promising studies combining tyrosine kinase inhibitors with checkpoint inhibitors.<h4>Recent findings</h4>The recently approved combination ... Read more >>

Curr Hepatol Rep (Current hepatology reports)
[2021, :1-11]

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Empiric use of anticoagulation in hospitalized patients with COVID-19: a propensity score-matched study of risks and benefits

Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, J. Daniel Kelly, Vidya Menon,

<h4>Background</h4> Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in a ... Read more >>

Biomark Res (Biomarker research)
[2021, 9(1):]

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CON: Liver Transplant Should Not Be Performed in Patients With Acute Alcoholic Hepatitis.

Parita Patel, Jennifer Wang, Anjana Pillai,

Clin Liver Dis (Hoboken) (Clinical liver disease)
[2020, 16(5):182-185]

Cited: 0 times

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Locoregional Therapies for Hepatocellular Carcinoma: What Has Changed in the Past Ten Years?

Anjana A Pillai, Meera Ramanathan, Laura Kulik,

The evolution of locoregional therapies in the last decade has been refined with improved patient selection and a development of a more personalized approach. In doing so, there has been associated improved outcomes and less toxicity. With the rapidly changing landscape of systemic therapy, the role of locoregional therapies alone ... Read more >>

Clin Liver Dis (Clinics in liver disease)
[2020, 24(4):681-700]

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Integrating Genomics Into Clinical Practice in Hepatocellular Carcinoma: The Challenges Ahead.

Anjana Pillai, Joseph Ahn, Laura Kulik,

The incidence and mortality related to hepatocellular carcinoma (HCC) continue to increase in the United States, with most patients presenting at advanced stages where curative therapy and long-term survival is unlikely. Fortunately, significant progress has been made in identifying the landscape of HCC mutations due to advances in whole genome ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(12):1960-1969]

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Liver transplantation for alcoholic hepatitis in the United States: Excellent outcomes with profound temporal and geographic variation in frequency.

Thomas G Cotter, Burhaneddin Sandıkçı, Sonali Paul, Anuhya Gampa, Jennifer Wang, Helen Te, Anjana Pillai, Kapuluru G Reddy, Diego di Sabato, Ester C Little, Vinay Sundaram, John Fung, Michael R Lucey, Michael Charlton,

Medical-refractory severe alcoholic hepatitis (AH) has a high mortality. The national frequency, longer term outcomes and regional practices of AH liver transplantation (LT) in the United States are not well described, despite the increasing mortality from alcohol-associated liver disease. We analyzed the trends in frequency and outcomes of UNOS data ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(3):1039-1055]

Cited: 1 time

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SARS-CoV-2 seroprevalence among health care workers in a New York City hospital: A cross-sectional analysis during the COVID-19 pandemic.

Usha Venugopal, Nargis Jilani, Sami Rabah, Masood A Shariff, Muzamil Jawed, Astrid Mendez Batres, Muhamed Abubacker, Sharika Menon, Anjana Pillai, Nehad Shabarek, Moiz Kasubhai, Vihren Dimitrov, Vidya Menon,

<h4>Background</h4>New York City (NYC) has endured the greatest burden of COVID-19 infections in the US. Health inequities in South Bronx predisposed this community to a large number of infectious cases, hospitalizations, and mortality. Health care workers (HCWs) are at a high risk of exposure to the infection. This study aims ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 102:63-69]

Cited: 9 times

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Provider Attitudes Toward Risk-Based Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis in the United States.

Nicole J Kim, Karine Rozenberg-Ben-Dror, David A Jacob, Nicole Rich, Amit G Singal, Elizabeth S Aby, Ju Dong Yang, Veronica Nguyen, Anjana Pillai, Michael Fuchs, Andrew M Moon, Hersh Shroff, Parul D Agarwal, Ponni Perumalswami, Shaun Chandna, Kali Zhou, Yuval A Patel, Nyan L Latt, Robert Wong, Andres Duarte-Rojo, Christina C Lindenmeyer, Catherine Frenette, Jin Ge, Neil Mehta, Francis Yao, Jihane N Benhammou, Patricia P Bloom, Michael Leise, Hyun-Seok Kim, Cynthia Levy, Abbey Barnard, Mandana Khalili, George N Ioannou,

<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) surveillance rates are suboptimal in clinical practice. We aimed to elicit providers' opinions on the following aspects of HCC surveillance: preferred strategies, barriers and facilitators, and the impact of a patient's HCC risk on the choice of surveillance modality.<h4>Methods</h4>We conducted a web-based survey among gastroenterology ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, :]

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Lymphoepithelioma-Like Carcinomas: A Rare Variant of Cholangiocarcinoma.

Austin Lin, Lindsay Alpert, John Hart, Christopher Chapman, Anjana A Pillai,

Hepatology (Hepatology (Baltimore, Md.))
[2020, 72(1):353-355]

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Positron Emission Tomography With Computed Tomography as a Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma: Ready for Prime Time?

Neehar Parikh, Anjana Pillai,

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2020, 26(6):746-747]

Cited: 0 times

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Hepatocellular Carcinoma Surveillance and Staging

Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai,

Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related death in the United States and has one of fastest increasing incidence rates among all solid tumors. Surveillance (or screening) for HCC is recommended for patients with cirrhosis and subgroups of patients with chronic hepatitis B using ultrasound and a ... Read more >>

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Transsplenic portal vein recanalization and direct intrahepatic portosystemic shunt placement to optimize liver transplantation.

Osman Ahmed, Abhijit L Salaskar, Steven Zangan, Anjana Pillai, Talia Baker,

BACKGROUND:Percutaneous trans-splenic portal vein recanalization (PVR) has been reported for facilitation of transjugular intrahepatic portosystemic shunts (TIPS), however has not been applied to patients undergoing direct intrahepatic portosystemic shunt (DIPS). We report the utilization of trans-splenic-PVR with DIPS creation in a patient with chronic portal and hepatic vein occlusions undergoing ... Read more >>

CVIR Endovasc (CVIR endovascular)
[2020, 3(1):5]

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Liver transplantation for hepatocellular carcinoma: Management after the transplant.

Elizabeth C Verna, Yuval A Patel, Avin Aggarwal, Archita P Desai, Catherine Frenette, Anjana A Pillai, Reena Salgia, Anil Seetharam, Pratima Sharma, Courtney Sherman, Georgios Tsoulfas, Francis Y Yao,

Hepatocellular carcinoma (HCC) is an increasingly common indication for liver transplantation (LT) in the United States and in many parts of the world. In the last decade, significant work has been done to better understand how to risk stratify LT candidates for recurrence of HCC following transplant using a combination ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(2):333-347]

Cited: 8 times

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Consult for Portal Vein Thrombosis.

Thomas G Cotter, Anjana A Pillai,

Clin Liver Dis (Hoboken) (Clinical liver disease)
[2019, 14(2):74-77]

Cited: 2 times

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Provider Attitudes and Practice Patterns for Direct-Acting Antiviral Therapy for Patients With Hepatocellular Carcinoma.

Nicole E Rich, Ju Dong Yang, Ponni V Perumalswami, Naim Alkhouri, Whitney Jackson, Neehar D Parikh, Neil Mehta, Reena Salgia, Andres Duarte-Rojo, Laura Kulik, Mina Rakoski, Adnan Said, Omobonike Oloruntoba, George N Ioannou, Maarouf A Hoteit, Andrew M Moon, Amol S Rangnekar, Sheila L Eswaran, Elizabeth Zheng, Janice H Jou, James Hanje, Anjana Pillai, Ruben Hernaez, Robert Wong, Steven Scaglione, Hrishikesh Samant, Devika Kapuria, Shaun Chandna, Russell Rosenblatt, Veeral Ajmera, Catherine T Frenette, Sanjaya K Satapathy, Parvez Mantry, Prasun Jalal, Binu V John, Oren K Fix, Michael Leise, Christina C Lindenmeyer, Avegail Flores, Nayan Patel, Z Gordon Jiang, Nyan Latt, Renumathy Dhanasekaran, Mobolaji Odewole, Sofia Kagan, Jorge A Marrero, Amit G Singal,

<h4>Background & aims</h4>Direct-acting antivirals (DAAs) are effective against hepatitis C virus and sustained virologic response is associated with reduced incidence of hepatocellular carcinoma (HCC). However, there is controversy over the use of DAAs in patients with active or treated HCC and uncertainty about optimal management of these patients. We aimed ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(4):974-983]

Cited: 4 times

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Approach to Evaluation of Multiple Liver Lesions-Reply.

Adam Mikolajczyk, Lindsay Yassan, Anjana Pillai,

JAMA (JAMA)
[2019, 321(20):2031-2032]

Cited: 0 times

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Liver Allocation Policies in the USA: Past, Present, and the Future.

Anjana Pillai, Thomas Couri, Michael Charlton,

Identifying the optimal allocation policy with regard to hepatocellular carcinoma has been a persistent and evolving challenge. The current criteria for LT for HCC endorsed by the United Network of Organ Sharing (UNOS) are based on the Milan Criteria: a solitary tumor < 5 cm, or maximum of three tumors ≤ 3 cm each, ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2019, 64(4):985-992]

Cited: 2 times

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Goals and targets for personalized therapy for HCC.

Thomas Couri, Anjana Pillai,

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and its incidence continues to rise. While cirrhosis underlies most cases of HCC, many molecular pathways are implicated in HCC carcinogenesis, including the TERT promoter mutation, Wnt/β-catenin, P53, Akt/mTOR, vascular endothelial growth factor receptor (VEGFR), and endothelial growth ... Read more >>

Hepatol Int (Hepatology international)
[2019, 13(2):125-137]

Cited: 37 times

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A Patient With an Elevated α-Fetoprotein Level and Liver Masses.

Adam E Mikolajczyk, Lindsay J Yassan, Anjana A Pillai,

JAMA (JAMA)
[2019, 321(1):97-98]

Cited: 2 times

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