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Bloodstream infections in hospitalized patients before and during the COVID-19 surge in a community hospital in the South Bronx.

Afsheen Afzal, Victor Perez Gutierrez, Edgar Gomez, Aye Myat Mon, Carolina Moreira Sarmiento, Amna Khalid, Svetlana Polishchuk, Mohannad Al-Khateeb, Boyana Yankulova, Mubarak Yusuf, Yinelka Silverio de Castro, Anjana Pillai, Usha Venugopal, Addi Feinstein, Alexander LaFortune, Daniel Sittler, Karen Hennessy, Vidya Menon,

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 116:43-46]

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The Systemic Inflammatory Response Identifies Patients with Adverse Clinical Outcome from Immunotherapy in Hepatocellular Carcinoma.

Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J Pinato,

Systemic inflammation is a hallmark of cancer, and it has a pivotal role in hepatocellular carcinoma (HCC) development and progression. We conducted a retrospective study including 362 patients receiving immune check-point inhibitors (ICIs) across three continents, evaluating the influence of neutrophiles to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR), ... Read more >>

Cancers (Basel) (Cancers)
[2021, 14(1):]

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Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial.

Meagan P O'Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Bret J Musser, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Elizabeth R Brown, Ingeborg Heirman, John D Davis, Kenneth C Turner, Divya Ramesh, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Yunji Kim, Lisa A Purcell, Alina Baum, Christos A Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A Thomas DiCioccio, Gregory P Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, David M Weinreich, ,

<h4>Importance</h4>Easy-to-administer anti-SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage.<h4>Objective</h4>To evaluate the effect of combination subcutaneous casirivimab and imdevimab on progression from early asymptomatic SARS-CoV-2 infection to symptomatic COVID-19.<h4>Design, setting, and participants</h4>Randomized, double-blind, placebo-controlled, phase 3 trial of close household ... Read more >>

JAMA (JAMA)
[2022, :]

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201. Comparison of Bloodstream Infections Between Hospitalized Patients with and without COVID-19 Infection During the First Wave of the COVID-19 Pandemic in a Community Hospital in South Bronx: An Observational Study

Afsheen Afzal, Edgar Gomez, Victor Perez Guttierrez, Aye Myat Mon, Carolina Moreira Sarmiento, Amna Khalid, svetlana Polishchuk, Mohannad Al-Khateeb Al-Khateeb, Mubarak Yusuf, Boyana Yankulova, Yinelka Silverio De Castro, Anjana Pillai, Usha Venugopal, Addi Feinstein, Alexander LaFortune, Daniel Sittler, Karen Hennessey, Vidya Menon,

Abstract <h4>Background</h4> Comparative data on bloodstream infections (BSI) in hospitalized patients with and without SARS-CoV2 positive test is lacking. <h4>Methods</h4> A retrospective observational study comparing (BSI) with and without COVID-19 infection was performed was performed from Jan1- May 1, 2020. Patient demographics, clinical microbiological characteristics of infections, therapeutic interventions and ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):208-209]

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The New Era of Liver Transplantation for Cholangiocarcinoma: No Longer Just a 1-Man Show.

Nirmal Desai, Anjana A Pillai,

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, :]

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Longitudinal humoral antibody response to SARS-CoV-2 infection among healthcare workers in a New York City hospital.

Vidya Menon, Masood A Shariff, Victor Perez Gutierrez, Juan M Carreño, Bo Yu, Muzamil Jawed, Marcia Gossai, Elisenda Valdez, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Florian Krammer,

<h4>Objective</h4>Dynamics of humoral immune responses to SARS-CoV-2 antigens following infection suggest an initial decay of antibody followed by subsequent stabilisation. We aim to understand the longitudinal humoral responses to SARS-CoV-2 nucleocapsid (N) protein and spike (S) protein and to evaluate their correlation to clinical symptoms among healthcare workers (HCWs).<h4>Design</h4>A prospective ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e051045]

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Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma.

Petros Fessas, Muntaha Naeem, Matthias Pinter, Thomas U Marron, David Szafron, Lorenz Balcar, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Pei-Chang Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I Abugabal, Tiziana Pressiani, Nicola Personeni, Naoshi Nishida, Masatoshi Kudo, Ahmed Kaseb, Yi-Hsiang Huang, Celina Ang, Anjana Pillai, Lorenza Rimassa, Abdul Rafeh Naqash, Elad Sharon, Alessio Cortellini, David J Pinato,

<h4>Background and rationale</h4>Immune checkpoint inhibitor (ICI) therapy is an expanding therapeutic option for hepatocellular carcinoma (HCC). Antibiotics (ATB) taken prior to or early during ICI therapy can impact immunotherapy efficacy across indications; however, the effect of ATB is undefined in HCC.<h4>Methods</h4>In a large international cohort of 450 ICI recipients from ... Read more >>

Liver Cancer (Liver cancer)
[2021, 10(6):583-592]

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208. Comparison of Bloodstream Infections in Hospitalized Patients Before and During the COVID-19 Surge in a Community Hospital in the South Bronx: An Observational Study

Afsheen Afzal, Edgar Gomez, Victor Perez Guttierrez, Aye Myat Mon, Carolina Moreira Sarmiento, Amna Khalid, svetlana Polishchuk, Mohannad Al-Khateeb Al-Khateeb, Boyana Yankulova, Mubarak Yusuf, Yinelka Silverio De Castro, Anjana Pillai, Usha Venugopal, Addi Feinstein, Alexander LaFortune, Daniel Sittler, Karen Hennessey, Vidya Menon,

Abstract <h4>Background</h4> There is a paucity of data of bloodstream infections (BSI) before and during the COVID-19 pandemic. The aim of our study was to compare the incidence and characteristics of blood stream infections (BSI) in hospitalized patients before and during the surge of COVID-19 pandemic in a community hospital ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):S212-S213]

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REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19.

David M Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Jing Xiao, Andrea T Hooper, Jennifer D Hamilton, Bret J Musser, Diana Rofail, Mohamed Hussein, Joseph Im, Dominique Y Atmodjo, Christina Perry, Cynthia Pan, Adnan Mahmood, Romana Hosain, John D Davis, Kenneth C Turner, Alina Baum, Christos A Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Lilia Roque-Guerrero, Gerard Acloque, Hessam Aazami, Kevin Cannon, J Abraham Simón-Campos, Joseph A Bocchini, Bari Kowal, A Thomas DiCioccio, Yuhwen Soo, Gregory P Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, ,

<h4>Background</h4>In the phase 1-2 portion of an adaptive trial, REGEN-COV, a combination of the monoclonal antibodies casirivimab and imdevimab, reduced the viral load and number of medical visits in patients with coronavirus disease 2019 (Covid-19). REGEN-COV has activity in vitro against current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(23):e81]

Cited: 5 times

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590. Persisting COVID-19 vaccination hesitancy in the South Bronx

Danelly Gomez D' Aza, Masood A Shariff, Israel Duran Santibanez, Raquel Horowitz, Hina Asad, Dennis Mensah, Lara Rabiee, Anjana Pillai, Vipul Shah, Vidya Menon,

Abstract <h4>Background</h4> Minority groups have the lowest vaccination rates when compared to the overall population. We aim to study the attitudes and perceptions of COVID-19 vaccination, about six months after vaccine rollout in the South Bronx. <h4>Methods</h4> Cross-sectional anonymized online survey evaluating knowledge, attitude and perception about COVID-19 vaccination using ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(Suppl 1):S397-S398]

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How to Navigate National Societal Organizations for Leadership Development and Academic Promotion: A Guide for Trainees and Young Faculty.

Elizabeth S Aby, Michael Kriss, David T Rubin, Anjana Pillai,

Gastroenterology (Gastroenterology)
[2021, 161(5):1361-1365]

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Twenty Years of Radiation Therapy of Unresectable Intrahepatic Cholangiocarinoma: Internal or External? A Systematic Review and Meta-Analysis.

Qian Yu, Chenyu Liu, Anjana Pillai, Osman Ahmed,

<h4>Purpose</h4>Both external beam radiation therapy (EBRT) and selective-internal radiation therapy (SIRT) are implemented to treat unresectable intrahepatic cholangiocarcinoma (iCCA). The present study aimed to evaluate the efficacy of EBRT and SIRT in managing iCCA through a systematic review and meta-analysis.<h4>Methods</h4>PubMed and Cochrane database were queried to search for studies published ... Read more >>

Liver Cancer (Liver cancer)
[2021, 10(5):433-450]

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Treatment-related toxicity and improved outcome from immunotherapy in hepatocellular cancer: Evidence from an FDA pooled analysis of landmark clinical trials with validation from routine practice.

David J Pinato, Thomas U Marron, Pallavi Shruti Mishra-Kalyani, Yutao Gong, Guo Wei, David Szafron, Elad Sharon, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Abdul R Naqash, Thoetchai Peeraphatdit, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Chieh J Lee, Pei-Chang Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I Abugabal, Tiziana Pressiani, Nicola Personeni, Antonio D'Alessio, Ahmed O Kaseb, Yi-Hsiang Huang, Celina Ang, Julie Schneider, Anjana Pillai, Lorenza Rimassa, Kirsten B Goldberg, Richard Pazdur, Marc Theoret, Steven Lemery, 'Lola Fashoyin-Aje, Alessio Cortellini, Lorraine Pelosof,

<h4>Purpose</h4>The development of treatment-related adverse events (trAE) correlates favorably with clinical outcomes in multiple studies of patients receiving immune checkpoint inhibitors (ICI); however, this relationship is undefined in patients with hepatocellular carcinoma (HCC).<h4>Patients and methods</h4>We derived a cohort of 406 patients with unresectable/advanced HCC receiving ICI therapy as part of ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 157:140-152]

Cited: 3 times

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Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19.

Meagan P O'Brien, Eduardo Forleo-Neto, Bret J Musser, Flonza Isa, Kuo-Chen Chan, Neena Sarkar, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Peijie Hou, Ingeborg Heirman, John D Davis, Kenneth C Turner, Divya Ramesh, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Yunji Kim, Lisa A Purcell, Alina Baum, Christos A Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A Thomas DiCioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, David M Weinreich, ,

<h4>Background</h4>REGEN-COV (previously known as REGN-COV2), a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the risk of hospitalization or death among high-risk persons with coronavirus disease 2019 (Covid-19). Whether subcutaneous REGEN-COV prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent Covid-19 in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(13):1184-1195]

Cited: 37 times

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Recent Advances in Hepatocellular Carcinoma Treatment.

Neehar D Parikh, Anjana Pillai,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(10):2020-2024]

Cited: 0 times

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Living Donor Liver Transplantation in the United States: Evolution of Frequency, Outcomes, Center Volumes, and Factors Associated With Outcomes.

Thomas G Cotter, Mohamad Minhem, Jennifer Wang, Thoetchai Peeraphatdit, Fares Ayoub, Anjana Pillai, Roberto Hernandez-Alejandro, Diego di Sabato, Michael Charlton,

Recent modifications in organ allocation policies and increases in chronic liver diseases may have resulted in important changes in living donor liver transplantation (LDLT) in the United States. We examined the trends, outcomes, and factors associated with outcomes in adult LDLT. United Network for Organ Sharing data on 2566 adult ... Read more >>

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, 27(7):1019-1031]

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Knowledge, Attitudes and Perceptions of COVID-19 Vaccination among Healthcare Workers of an Inner-City Hospital in New York.

Federico Ciardi, Vidya Menon, Jamie L Jensen, Masood A Shariff, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Balavenkatesh Kanna, Brian D Poole,

<b>Introduction:</b> New York City is one of the areas most affected by the COVID-19 pandemic in the United States. Healthcare workers are among those at high risk of contracting the virus, and a vital source of information and trust in vaccines to the community. <b>Methods:</b> This study was conducted about ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(5):]

Cited: 3 times

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Liver Transplantation Services During the Time of COVID-19.

Parita Patel, Anjana Pillai,

The coronavirus disease 2019 (COVID-19) is associated with high morbidity and mortality, prompting overwhelmed hospital systems to reallocate resources to those stricken with the disease. In response, many liver transplantation programs unexpectedly came to an abrupt halt, significantly affecting the lives of living donors and recipients around the world. As ... Read more >>

J Clin Transl Hepatol (Journal of clinical and translational hepatology)
[2021, 9(4):587-591]

Cited: 0 times

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The effect of COVID-19 on liver transplantation: impact, practice patterns, therapeutics, and next steps.

Alan L Hutchison, Anjana Pillai,

<h4>Purpose of review</h4>To assess the impact of coronavirus disease 2019 (COVID-19) and the pandemic on liver transplant candidates, recipients, and donors, and review guidelines and recommendations for integrating COVID-19 therapies into current practice.<h4>Recent findings</h4>COVID-19 has high morbidity and mortality for transplant candidates; interestingly, posttransplant comorbidities play a larger role than ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):339-345]

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Systemic Therapy for Hepatocellular Carcinoma.

Jennifer Wang, Anjana Pillai,

Clin Liver Dis (Hoboken) (Clinical liver disease)
[2021, 17(5):337-340]

Cited: 0 times

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Empiric use of anticoagulation in hospitalized patients with COVID-19: a propensity score-matched study of risks and benefits.

Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, J Daniel Kelly, Vidya Menon,

<h4>Background</h4>Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in a large ... Read more >>

Biomark Res (Biomarker research)
[2021, 9(1):29]

Cited: 2 times

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High Initial Titres of Anti-Spike Antibodies following SARS-CoV-2 Infection is Associated with Faster Decay Rates at Four Months Follow-Up

Vidya Menon, Masood Shariff, Victor Perez Gutierrez, Juan Carreño, Bo Yu, Muzamil Jawed, Marcia Gossai, Elisenda Valdez, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Florian Krammer,

<h4>Background</h4> Dynamics of humoral immune responses to SARS-CoV-2 antigens following infection suggests an initial decay of antibody followed by subsequent stabilization. We aim to understand the longitudinal humoral responses to SARS-CoV-2 nucleocapsid (N) protein and spike (S) protein and to evaluate their correlation to clinical symptoms among healthcare workers (HCW). ... Read more >>

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Empiric use of Anticoagulation in Hospitalized Patients with COVID-19: A Propensity Score-Matched Study of Risks and Benefits

Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, Daniel Kelly, Vidya Menon,

<h4>Background: </h4> Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in ... Read more >>

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Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma.

Gabriella Aitcheson, Anjana Pillai, Bassam Dahman, Binu V John,

<h4>Purpose of review</h4>This paper aims to summarize the data of recently completed and key ongoing clinical trials of systemic agents for advanced hepatocellular carcinoma (aHCC). In particular, the review focuses on ongoing checkpoint inhibitor combination trials and promising studies combining tyrosine kinase inhibitors with checkpoint inhibitors.<h4>Recent findings</h4>The recently approved combination ... Read more >>

Curr Hepatol Rep (Current hepatology reports)
[2021, :1-11]

Cited: 2 times

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Patient Preferences for Hepatocellular Carcinoma Surveillance Parameters.

Sean A Woolen, Amit G Singal, Matthew S Davenport, Jonathan P Troost, Shokoufeh Khalatbari, Sukul Mittal, Sehar Siddiqui, Austin Fobar, Jason Morris, Mobolaji Odewole, Elliot B Tapper, Anjana Pillai, Neehar D Parikh,

<h4>Background and aims</h4>Professional societies recommend abdominal ultrasound (US) with or without alpha fetoprotein (AFP) for hepatocellular cancer (HCC) surveillance; however, there are several emerging surveillance modalities, including abbreviated MRI and blood-based biomarker panels. Most studies have focused on provider perspectives for surveillance logistics, but few have assessed patient preferences. We ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2022, 20(1):204-215.e6]

Cited: 1 time

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