Full Text Journal Articles by
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Pharmacy Implementation of a New Law Allowing Year-Long Hormonal Contraception Supplies.

Gelareh Nikpour, Antoinette Allen, Sally Rafie, Myung Sim, Radhika Rible, Angela Chen,

BACKGROUND:Prescription hormonal contraceptive methods are vital to prevention of unplanned pregnancies. New legislation among 23 states has expanded access to contraception. In California, a 2017 law requires pharmacists to dispense year-long supplies of contraception and insurance plans to cover it upon patients' request. This study assesses pharmacist knowledge of this ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2020, 8(3):]

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Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation.

Abdulkadir Isidan, Angela M Chen, Kutay Saglam, Sezai Yilmaz, Wenjun Zhang, Ping Li, Burcin Ekser,

Xenotransplantation (ie, cross-species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide. However, despite prolonged survival in preclinical pig-to-nonhuman primate xenotransplantation trials, interspecies coagulation dysregulation remains to be overcome in order to achieve continuous long-term success. Different platelet aggregometry ... Read more >>

Xenotransplantation (Xenotransplantation)
[2020, :e12645]

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Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner.

Jennifer Yeung, Reheman Adili, Adriana Yamaguchi, Cody J Freedman, Angela Chen, Ryan Shami, Aditi Das, Theodore R Holman, Michael Holinstat,

Arterial thrombosis is the underlying cause for a number of cardiovascular-related events. Although dietary supplementation that includes polyunsaturated fatty acids (PUFAs) has been proposed to elicit cardiovascular protection, a mechanism for antithrombotic protection has not been well established. The current study sought to investigate whether an omega-6 essential fatty acid, ... Read more >>

Blood Adv (Blood advances)
[2020, 4(18):4522-4537]

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Morning diurnal preference and food intake: a Mendelian randomization study.

Hassan S Dashti, Angela Chen, Iyas Daghlas, Richa Saxena,

BACKGROUND:Poor dietary choices may underlie known associations between having an evening diurnal preference and cardiometabolic diseases. Assessing causal links between diurnal preference and food intake is now possible in Mendelian randomization (MR) analyses. OBJECTIVES:We aimed to use a 2-sample MR to determine potential causal effects of genetic liability to a ... Read more >>

Am. J. Clin. Nutr. (The American journal of clinical nutrition)
[2020, :]

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Identification of a novel TGFBI gene mutation (p.Serine524Cystine) associated with late-onset recurrent epithelial erosions and Bowman layer opacities.

Angela C Chen, Duangratn Niruthisard, Doug D Chung, Pichaya Chuephanich, Anthony J Aldave,

BACKGROUND:Most transforming growth factor beta-induced (TGFBI) corneal dystrophies are associated with a characteristic phenotype, clinical course, and a conserved mutation in the TGFBI gene. However, we report a novel TGFBI missense mutation associated with a late-onset, variant Bowman layer dystrophy. METHODS:Participants underwent slit-lamp examination and multimodal imaging. Polymerase chain reaction ... Read more >>

Ophthalmic Genet. (Ophthalmic genetics)
[2020, :1-6]

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Quadratus Lumborum 2 Block as the Sole Anesthetic Technique for Open Hernia Repair in Multimorbid Patients.

Julius Balogh, Angela Chen, Tejaswi Marri, Johanna B De Haan, Sara Guzman-Reyes,

Ultrasound-guided quadratus lumborum (QL, QL1-3) blocks have been used extensively for perioperative pain control for patients undergoing abdominal procedures. These blocks provide a more widespread and longer-lasting analgesic effect compared to the transversus abdominis plane (TAP) block. While QL blocks have been used as an adjunct in multimodal postoperative pain ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9697]

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Efficacy of Combined Suprachoroidal Stent and Cataract Surgery in Patients With Glaucoma.

Simon K Law, Diana Salazar, Fei Yu, JoAnn A Giaconi, Angela Chen, Vikas Chopra, Brian Francis, Anne L Coleman, Kenneth Lu, Kouros Nouri-Mahdavi, James Tan, Joseph Caprioli,

PURPOSE:The purpose of this study was to evaluate the efficacy of intraocular pressure (IOP) control after combined CyPass Micro-Stent implantation and cataract surgery (combined surgery). METHODS:All cases of combined surgery performed from February 2017 to July 2018 at Stein and Doheny Eye Institutes were reviewed. The primary outcome was a ... Read more >>

J. Glaucoma (Journal of glaucoma)
[2020, 29(8):627-638]

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An atlas of lamina-associated chromatin across thirteen human cell types reveals cell-type-specific and multiple subtypes of peripheral heterochromatin

Kathleen Keough, Parisha Shah, Nadeera Wickramasinghe, Carolyn Dundes, Angela Chen, Rachel E.A. Salomon, Sean Whalen, Kyle Loh, Nicole Dubois, Katherine Pollard, Rajan Jain,

Abstract Three-dimensional genome organization, specifically organization of heterochromatin at the nuclear periphery, coordinates cell type-specific gene regulation. While defining various histone modifications and chromatin-associated proteins in multiple cell types has provided important insights into epigenetic regulation of gene expression and cellular identity, peripheral heterochromatin has not been mapped comprehensively and ... Read more >>

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Comparison of early visual outcomes following low-energy SMILE, high-energy SMILE, and LASIK for myopia and myopic astigmatism in the United States.

Mitra Nejad, Angela C Chen, Roxana Khorrami, Max Nutkiewicz, D Rex Hamilton,

PURPOSE:To compare uncorrected visual acuities (UDVA) and induced higher-order aberrations (HOAs) in the early postoperative period between low-energy (LE) small incision lenticule extraction (SMILE), high-energy (HE) SMILE and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) procedures. METHODS:Records of patients who underwent SMILE or FS-LASIK were retrospectively reviewed. SMILE patients were ... Read more >>

J Cataract Refract Surg (Journal of cataract and refractive surgery)
[2020, :]

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Long-Term Care, Residential Facilities, and COVID-19: An Overview of Federal and State Policy Responses.

Angela T Chen, Kira L Ryskina, Hye-Young Jung,

The COVID-19 pandemic has disproportionately affected residents and staff at long-term care (LTC) and other residential facilities in the United States. The high morbidity and mortality at these facilities has been attributed to a combination of a particularly vulnerable population and a lack of resources to mitigate the risk. During ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, 21(9):1186-1190]

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COVID-19 vaccine development and a potential nanomaterial path forward.

Matthew D Shin, Sourabh Shukla, Young Hun Chung, Veronique Beiss, Soo Khim Chan, Oscar A Ortega-Rivera, David M Wirth, Angela Chen, Markus Sack, Jonathan K Pokorski, Nicole F Steinmetz,

The COVID-19 pandemic has infected millions of people with no clear signs of abatement owing to the high prevalence, long incubation period and lack of established treatments or vaccines. Vaccines are the most promising solution to mitigate new viral strains. The genome sequence and protein structure of the 2019-novel coronavirus ... Read more >>

Nat Nanotechnol (Nature nanotechnology)
[2020, 15(8):646-655]

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Energy Shortage in Human and Mouse Models of SLC4A11-Associated Corneal Endothelial Dystrophies.

Wenlin Zhang, Ricardo Frausto, Doug D Chung, Christopher G Griffis, Liyo Kao, Angela Chen, Rustam Azimov, Alapakkam P Sampath, Ira Kurtz, Anthony J Aldave,

Purpose:To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the dystrophies associated with SLC4A11 mutations, congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy 4. Methods:Comparative transcriptomic analysis (CTA) was performed in primary human corneal ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2020, 61(8):39]

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Current Status of Ophthalmology Residency Training in China: The Experience From Well-Structured Centers Around the Country.

Ye Elaine Wang, Chuan Zhang, Angela C Chen, Stacy Pineles, Jing Hou,

Chinese ophthalmology residency training is continuously evolving with an emphasis on standardization. In this article, we assess the current status of ophthalmology residency training in China compared with that in the United States through analysis of literature review and onsite data collection. We comprehensively review various aspects of the residency ... Read more >>

Asia Pac J Ophthalmol (Phila) (Asia-Pacific journal of ophthalmology (Philadelphia, Pa.))
[2020, 9(4):369-373]

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Dietary sodium intake and cortisol measurements.

Angela X Chen, Andrea V Haas, Gordon H Williams, Anand Vaidya,

OBJECTIVES:To assess the influence of a dietary sodium intake intervention on cortisol measurements within the general population. DESIGN:Cross-over intervention. PATIENTS:Six hundred thirty adults without known Cushing syndrome, cardiovascular or renal disease completed a restricted dietary sodium diet (10 mmol/d, 230 mg/d) followed by cross-over to a liberalized dietary sodium diet (200 mmol/d, 4600 mg/d). ... Read more >>

Clin. Endocrinol. (Oxf) (Clinical endocrinology)
[2020, :]

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Telehealth in Pediatric Heart Transplant Patients: Exercise, Nutrition, and Parental Imaging.

Angela C Chen, Elif Seda Selamet Tierney,

Telehealth is a promising new tool in medicine that has changed the landscape of medical care. The benefits of telehealth technology are immense, including improved access to care and potential savings in monetary and opportunity costs. Current challenges of incorporating telehealth services into regular clinical care include licensure and regulatory ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2020, 67(4):635-639]

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Complex Abdominal Wound Healing After Multivisceral Retransplant: A Case Report on the Importance of Nutrition.

Angela M Chen, Abdulkadir Isidan, Carlos Vega, Kutay Saglam, Plamen Mihaylov, Jonathan A Fridell, Chandrashekhar A Kubal, Richard S Mangus, Burcin Ekser,

BACKGROUND:Intestinal transplantation (ITx) is performed as an isolated ITx or as a part of multivisceral transplantation for intestinal failure secondary to short gut syndrome, inflammatory bowel disease, trauma, and sequelae of chronic parenteral nutrition dependence. Wound complications after ITx are very common, and abdominal wound closure cannot be immediately achieved ... Read more >>

Transplant. Proc. (Transplantation proceedings)
[2020, :]

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Free, online videos for distance learning in medical genetics.

Sarah Maggipinto, Angela Chen, Dustin Huynh, Olivia Heutlinger, Kimberly Eberenz, Samyukta Mallick, Tanner Marshall, Rishi Desai, Traci A Wolbrink, Philip M Boone,

Eur J Med Genet (European journal of medical genetics)
[2020, 63(9):103983]

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Oxygenation Profiles of Human Blood, Cell Culture Medium, and Water for Perfusion of 3D-Bioprinted Tissues using the FABRICA Bioreactor Platform.

Angela M Chen, Matthew Lashmet, Abdulkadir Isidan, Jane L Sterner, Julia Walsh, Cutter Koehler, Ping Li, Burcin Ekser, Lester Smith,

Persistent and saturated oxygen distribution from perfusion media (i.e., blood, or cell culture media) to cells within cell-dense, metabolically-active biofabricated tissues is required to keep them viable. Improper or poor oxygen supply to cells within the tissue bulk severely limits the tissue culturing potential of many bioreactors. We added an ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7237]

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Exploring Chinese College Students' HPV Awareness, Knowledge, Attitudes, and Intent of HPV Vaccination: a Qualitative Study.

Angela Chia-Chen Chen, Calli Astroth, Elizabeth Reifsnider, Hui Yang, Wenlan Mao, Hong Chen,

Human papillomavirus (HPV) infection is the world's most prevalent sexually transmitted infection and causes cancers. In China, about 47,739 deaths occur annually from HPV-related cervical cancer, and this number continues to increase. HPV vaccines have shown promising results in preventing HPV-associated cancers; however, the vaccination rate in Chinese college students ... Read more >>

J Cancer Educ (Journal of cancer education : the official journal of the American Association for Cancer Education)
[2020, :]

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Comparison of cervical disc arthroplasty and anterior cervical discectomy and fusion for the treatment of cervical disc degenerative diseases on the basis of more than 60 months of follow-up: a systematic review and meta-analysis.

Yijian Zhang, Nanning Lv, Fan He, Bin Pi, Hao Liu, Angela Carley Chen, Huilin Yang, Mingming Liu, Xuesong Zhu,

BACKGROUND:This meta-analysis was designed to investigate the long-term efficacy and safety between cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF) in treating cervical disc degenerative diseases (CDDDs). METHODS:Literature search was performed on Pubmed, Embase, Cochrane Library, and Web of Science before Jan 2019. Surgical details, clinical outcomes, ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):143]

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Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Jiwen Li, Lin Pan, Marlesa Godoy, William Pembroke, Jessica Rexach, Michael Condro, Alvaro Alvarado, Mineli Harteni, Yen-Wei Chen, Linsey Stiles, Angela Chen, Ina Wanner, Xia Yang, Steven Goldman, Daniel Geschwind, Harley Kornblum, Ye Zhang,

Summary Human-mouse differences are a major barrier in translational research. Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. However, the similarities and differences between human and mouse astrocytes are largely unknown. Combining analyses of acutely purified astrocytes, experiments using serum-free cultures of primary astrocytes, and ... Read more >>

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Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes.

Sara Baqar, Yee Wen Kong, Angela X Chen, Christopher O'Callaghan, Richard J MacIsaac, Maree Bouterakos, Gavin W Lambert, George Jerums, Elisabeth E Lambert, Elif I Ekinci,

CONTEXT:Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D). OBJECTIVE:To determine whether sympathetic nervous system (SNS) activation and endothelial dysfunction contribute to these observations, we examined the effect of salt supplementation on these systems in people with T2D with habitual low sodium. We hypothesized that ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(4):]

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Xenotransplantation literature update, January/February 2020.

Angela M Chen, Christopher Burlak,

Xenotransplantation (Xenotransplantation)
[2020, 27(2):e12589]

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Survival and Inactivation by Advanced Oxidative Process of Foodborne Viruses in Model Low-Moisture Foods

Neda Nasheri, Jennifer Harlow, Angela Chen, Forest Dussault, Nathalie Corneau, Sabah Bidawid,

Abstract Enteric viruses, such as human norovirus (NoV) and hepatitis A virus (HAV), are the major causes of foodborne illnesses worldwide. These viruses are shed in high numbers, have low infectious dose, and may remain infectious for weeks in the environment and food. While numerous viral survival studies have been ... Read more >>

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Evaluation of Bead-Based Assays for the Isolation of Foodborne Viruses from Low-Moisture Foods.

Neda Nasheri, Jennifer Harlow, Angela Chen, Nathalie Corneau, Sabah Bidawid,

ABSTRACT:Foodborne viruses such as norovirus and hepatitis A virus (HAV) are highly transmissible, persistent in the environment, and resistant to many conventional inactivation methods. Foods can become contaminated with these viruses either at the source of harvest or during food handling and processing. Multiple lines of evidence suggest that foodborne ... Read more >>

J. Food Prot. (Journal of food protection)
[2020, 83(3):388-396]

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