Full Text Journal Articles by
Author Angela Berg

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Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany.

Florens Lohrmann, Angela Berg, Esther Wicker, Anita Imm, Gérard Krause, Katharina Zürn, Reinhard Berner, Markus Hufnagel, Fabian Lander,

For neonates, group B Streptococcus is life threatening. Current prevention strategies remain insufficient, especially for cases of late-onset sepsis, where intrapartum antibiotic prophylaxis has demonstrated no benefit. One promising approach is the vaccination of pregnant women, which offers protective immunity via transplacental transmission of neutralizing antibodies. Our nationwide, prospective surveillance ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):76-82]

Cited: 0 times

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ATP Inhibits the Transcription Factor STAT5b.

Angela Berg, Bianca Sperl, Thorsten Berg,

Although naturally occurring low-molecular-weight compounds have many known roles within the cell, these do not usually involve the direct inhibition of protein-protein interactions. Based on the results of high-throughput screening of a library of bioactive compounds and neurotransmitters, we report here that the four nucleoside triphosphates ATP, GTP, CTP and ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2019, 20(17):2227-2231]

Cited: 4 times

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The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a.

Julian Gräb, Angela Berg, Linda Blechschmidt, Barbara Klüver, Stefan Rubner, Darwin Y Fu, Jens Meiler, Martin Gräber, Thorsten Berg,

STAT family proteins are important mediators of cell signaling and represent therapeutic targets for the treatment of human diseases. Most STAT inhibitors target the protein-protein interaction domain, the SH2 domain, but specificity for a single STAT protein is often limited. Recently, we developed catechol bisphosphates as the first inhibitors of ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2019, 14(4):796-805]

Cited: 4 times

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A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening.

Sara Abdelfatah, Angela Berg, Madeleine Böckers, Thomas Efferth,

Polo-like kinase 1 (PLK1), a member of the Polo-like kinase family, plays an important regulatory role in mitosis and cell cycle progression. PLK1 overexpression is correlated with tumourigenesis and poor prognosis in cancer patients. Therefore, the identification of novel compounds that inhibit PLK1 would provide attractive therapeutic approaches. Although some ... Read more >>

J Adv Res (Journal of advanced research)
[2019, 16:145-156]

Cited: 1 time

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A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b.

Angela Berg, Thorsten Berg,

The transcription factor STAT5a is a potential target for tumor therapy. We present a fluorescence polarization-based, high-throughput screen of chemical libraries containing natural products and known bioactive molecules, for the identification of small-molecule inhibitors of the STAT5a SH2 domain. This screen identified suramin, a drug used to treat African trypanosomiasis, ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2017, 27(15):3349-3352]

Cited: 4 times

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Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.

Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Berg,

Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications of a chromone-based inhibitor of the Src homology 2 (SH2) ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):17390]

Cited: 5 times

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Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b.

Nagarajan Elumalai, Angela Berg, Stefan Rubner, Linda Blechschmidt, Chen Song, Kalaiselvi Natarajan, Jörg Matysik, Thorsten Berg,

The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain. Here, we demonstrate STAT5b binding of catechol bisphosphate by solid-state nuclear magnetic resonance, and report on rational optimization of Stafib-1 ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):819]

Cited: 17 times

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Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.

Angela Berg, Thorsten Berg,

Polo-like kinase 1 (Plk1), a key player in mitosis, is overexpressed in a wide range of tumor types and has been validated as a target for tumor therapy. In addition to its N-terminal kinase domain, Plk1 harbors a C-terminal protein-protein interaction domain, referred to as the polo-box domain (PBD). Because the ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2016, 17(8):650-656]

Cited: 7 times

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Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.

Nagarajan Elumalai, Angela Berg, Stefan Rubner, Thorsten Berg,

Design approaches for inhibitors of protein-protein interactions are rare, but highly sought after. Here, we report that O-phosphorylation of simple derivatives of the natural products dihydrocapsaicin and N-vanillylnonanamide leads to inhibitors of the SH2 domain of the transcription factor STAT5b. The most potent molecule is obtained from dihydrocapsaicin in only ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2015, 10(12):2884-2890]

Cited: 10 times

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Nanomolar inhibitors of the transcription factor STAT5b with high selectivity over STAT5a.

Nagarajan Elumalai, Angela Berg, Kalaiselvi Natarajan, Andrej Scharow, Thorsten Berg,

Src homology 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer-relevant transcription factors STAT5a and STAT5b are particularly challenging small-molecule targets because their SH2 domains are 93% identical on ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2015, 54(16):4758-4763]

Cited: 21 times

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World Health Organization position on breastfeeding.

M Shirley Gross, Angela Berg,

Can Fam Physician (Canadian family physician Medecin de famille canadien)
[2012, 58(3):253]

Cited: 0 times

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Inconsistency in breastfeeding guidelines.

M Shirley Gross, Angela Berg,

Can Fam Physician (Canadian family physician Medecin de famille canadien)
[2011, 57(4):412]

Cited: 0 times

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Read the fine print.

M Shirley Gross, Angela Berg,

Can Fam Physician (Canadian family physician Medecin de famille canadien)
[2011, 57(4):412]

Cited: 0 times

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Wing and body kinematics of takeoff and landing flight in the pigeon (Columba livia).

Angela M Berg, Andrew A Biewener,

Takeoff and landing are critical phases in a flight. To better understand the functional importance of the kinematic adjustments birds use to execute these flight modes, we studied the wing and body movements of pigeons (Columba livia) during short-distance free-flights between two perches. The greatest accelerations were observed during the ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2010, 213(Pt 10):1651-1658]

Cited: 18 times

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Kinematics and power requirements of ascending and descending flight in the pigeon (Columba livia).

Angela M Berg, Andrew A Biewener,

Ascending or descending locomotion involves a change in potential energy (PE) and a corresponding change in power requirement. We sought to test whether the mechanical power required for steady ascending or descending flight is a simple sum of the power required for level flight and the power necessary for potential ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2008, 211(Pt 7):1120-1130]

Cited: 11 times

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