Full Text Journal Articles by
Author Angad Singh

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Possibilities and pitfalls of virtual clinical care: Lessons from developmental paediatrics.

Angad Singh, Mohammad Samad Zubairi,

Child Care Health Dev (Child: care, health and development)
[2021, 47(3):297-299]

Cited: 0 times

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Understanding fish cognition: a review and appraisal of current practices.

Matthew G Salena, Andy J Turko, Angad Singh, Avani Pathak, Emily Hughes, Culum Brown, Sigal Balshine,

With over 30,000 recognized species, fishes exhibit an extraordinary variety of morphological, behavioural, and life-history traits. The field of fish cognition has grown markedly with numerous studies on fish spatial navigation, numeracy, learning, decision-making, and even theory of mind. However, most cognitive research on fishes takes place in a highly ... Read more >>

Anim Cogn (Animal cognition)
[2021, :]

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Nodal yield and topography of nodal metastases from oral cavity squamous cell carcinoma - An audit of 1004 cases undergoing primary surgical resection.

Paromita Roy, Indranil Mallick, Indu Arun, Lateef Zameer, Debdeep Dey, Angad Singh, Sanjoy Chatterjee, Prateek Jain, Kapila Manikantan, Rajeev Sharan, Arun Pattatheyil,

<h4>Objectives</h4>Nodal metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC). Detailed topographic study of metastasis can guide surgical and adjuvant radiation treatment protocols.<h4>Methods</h4>Retrospective analysis of distribution of nodal spread was done by auditing pathology records of 1004 patients who underwent primary surgical management at our center.<h4>Results</h4>The median ... Read more >>

Oral Oncol (Oral oncology)
[2021, 113:105115]

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FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry 'Equivocal' interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center experience.

Angad Singh, Rajiv Kumar, Omshree Shetty, Sangeeta Desai, Swapnil Rane,

<h4>Background</h4>Mutations in ROS1, ALK, and MET genes are targetable alterations in non-small cell lung cancer (NSCLC). They can be evaluated by different techniques, most commonly fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC).<h4>Methods</h4>We explored the prevalence of ROS1, ALK, MET mutations, discuss clinicopathological associations and FISH signal patterns on 413 ... Read more >>

Indian J Cancer (Indian journal of cancer)
[2020, :]

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Unusual presentation of retrocaval ureter with recurrent vomiting: A case report.

Angad Singh, Harjinder Singh,

Retrocaval ureter is a rare congenital anomaly in which the ureter takes an abnormal course from behind the inferior vena cava (IVC). A 26-year-old male was referred to Urology outpatient clinic due to recent finding of right sided hydronephrosis on renal ultrasound and recurrent episodes of vomiting lasting for 2-3 ... Read more >>

Urol Case Rep (Urology case reports)
[2021, 34:101466]

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Hassle Faced with Induced Mania in Elderly Female While Treating for OC Symptoms. A Case Report.

POONAM BHARTI, Angad harshbir singh, Parul Gupta,

<h4>Background: </h4> - Obsessive-compulsive disorder (OCD) is one of the most frequently associated comorbidities in bipolar disorder (BD). While this presents a challenge in understanding the phenomenology and also the treatment aspect of co occurrence of mania with OCD. Case history - The index case is of an elderly female ... Read more >>

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Assessment of quality of sleep and its association with body mass index among medical consultants working in a medical college in northern India.

Manish Bathla, Anshu Goyal, Shazia Anjum, Leezu Bhusri, Angad Harshbir Singh, Parul Gupta,

<h4>Background</h4>Medical specialist/consultants are exposed to various factors such as long duty hours, call duties, academics, meetings and regulation of departmental work which has adversely affected their sleep quality.<h4>Objective</h4>To assess sleep quality and association of body mass index with quality of sleep among medical consultants working in medical college.<h4>Method and tool</h4>This ... Read more >>

Indian J Psychiatry (Indian journal of psychiatry)
[2020, 62(3):306-311]

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A Comparative Study of the Efficacy of Levosulpiride versus Paroxetine in Premature Ejaculation.

Manish Bathla, Shazia Anjum, Angad Harshbir Singh, Vinutha Ramesh, Parul Gupta, Leezu Bhusri,

Background:Premature ejaculation (PME) can be defined as a lack in the normal voluntary control over ejaculation. It is the most common sexual dysfunction encountered by the male populace. In general, these patients presents with distress. Hence, a novel treatment to eliminate their problem is required. Although the role of SSRI ... Read more >>

J Hum Reprod Sci (Journal of human reproductive sciences)
[2020, 13(2):125-132]

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A Nonchordomatous-looking Chordoma: When INI-1 and Radiology Came to the Rescue!!!

Angad Singh, Anirban Das, Argha Chatterjee, Rimpa B Achari, Reghu K S, Paromita Roy,

SMARCB1/integrase interactor (INI)-1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex and acts as a tumor suppressor. INI-1 loss can be easily assessed using immunohistochemistry and is an important diagnostic clue for a histopathologist. Chordoma is a malignant tumor commonly occurring in the sacrococcygeal ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(3):218-219]

Cited: 1 time

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Responding to COVID-19: The UW Medicine Information Technology Services Experience.

Elisha S Grange, Eric J Neil, Michelle Stoffel, Angad P Singh, Ethan Tseng, Kelly Resco-Summers, B Jane Fellner, John B Lynch, Patrick C Mathias, Kristal Mauritz-Miller, Paul R Sutton, Michael G Leu,

<h4>Background</h4>UW Medicine was one of the first health systems to encounter and treat COVID-19 patients in the United States, starting in late February 2020.<h4>Objective</h4>Here we describe the rapid rollout of capabilities by UW Medicine Information Technology Services (ITS) to support our clinical response to the COVID-19 pandemic and provide recommendations ... Read more >>

Appl Clin Inform (Applied clinical informatics)
[2020, 11(2):265-275]

Cited: 18 times

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Acute cutaneous botryomycosis of the hands.

Angad Singh, Courtney Cook, Kaitlyn Kollmann, Anand Rajpara,

Botryomycosis is a rare bacterial infection which is most commonly caused by Staphylococcus aureus. It usually affects the skin but can also involve the viscera. The cutaneous form typically presents as ulcerated plaques or nodules that evolve over months to years to form discharging sinuses. As opposed to the norm ... Read more >>

IDCases (IDCases)
[2020, 19:e00709]

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A community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses.

Theresa A Boyle, Gwendolyn P Quinn, Matthew B Schabath, Teresita Muñoz-Antonia, James J Saller, Luisa F Duarte, Laura S Hair, Jamie K Teer, Derek Y Chiang, Rebecca Leary, Connie C Wong, Alexander Savchenko, Angad P Singh, LaSalette Charette, Kate Mendell, Gullu Gorgun, Scott J Antonia, Alberto A Chiappori, Benjamin C Creelan, Jhanelle E Gray, Eric B Haura,

<h4>Background</h4>For the advancement of cancer research, the collection of tissue specimens from drug-resistant tumors after targeted therapy is crucial. Although patients with lung cancer are often provided targeted therapy, post-therapy specimens are not routinely collected due to the risks of collection, limiting the study of targeted therapy resistance mechanisms. Posthumous ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(1):225-237]

Cited: 2 times

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Germline DICER1-mutant intracranial sarcoma with dual chondroid and spindle cell morphology and pulmonary metastases treated with multimodal therapy.

Anirban Das, Paromita Roy, Sheetal K Modi, Rimpa B Achari, Saugata Sen, Angad Singh, Reghu Sukumaran, Arpita Bhattacharyya,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(7):e27744]

Cited: 0 times

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One in a million

Alexandra Cox-Smith, Angad Singh, Manuel Jasper, Nada El-Hag,

Clin Med (Lond) (Clinical medicine (London, England))
[2019, 19(Suppl 2):19-19]

Cited: 0 times

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A well-differentiated neuroendocrine tumor (Grade I) arising in a tailgut cyst.

Angad Singh, Swapnil Karnik, Bhushan Khedkar, Sanjay Deshmukh, Kedar Deodhar,

Tailgut cysts are rare congenital lesions presenting as retrorectal space masses. They can occur in all age groups. Patients often present with ill-defined nonspecific symptoms and the diagnosis if often delayed. Malignancy arising in a tailgut cyst is an even rarer and unique occurrence. A precise diagnosis can be made ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2019, 15(1):258-260]

Cited: 1 time

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A Rare Pathological Couplet of Colocolic Intussusception Plus Cecal Bascule in a Young Adult: A Case Report.

Auerilius E Hamilton, Angad Singh, Kirk K Austin, JooShik Shin, Jonathan S Hong,

This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. ... Read more >>

Cureus (Cureus)
[2018, 10(10):e3430]

Cited: 0 times

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Lymphoma in Rheumatoid Arthritis - Catastrophic Sequela of a Common Disease.

Swapan Deep Singh Nagpal, Narinder Pal Singh, Pravas Mishra, Angad Singh,

Rheumatoid arthritis (RA) is a common rheumatological condition affecting the joints and has a wide range of extra-articular manifestations. A 69 year old male, known case of rheumatoid arthritis presented to our OPD with right lower limb redness and swelling, and left axillary lymph node swelling. Lymph node biopsy revealed ... Read more >>

J Assoc Physicians India (The Journal of the Association of Physicians of India)
[2018, 66(7):87-89]

Cited: 0 times

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Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers.

Yoon-Sim Yap, Angad P Singh, John H C Lim, Jin-Hee Ahn, Kyung-Hae Jung, Jeongeun Kim, Rebecca A Dent, Raymond C H Ng, Sung-Bae Kim, Derek Y Chiang,

Breast cancer is an increasing problem in Asia, with a higher proportion of premenopausal patients who are at higher risk of recurrence. Targeted sequencing was performed on DNA extracted from primary tumor specimens of 63 premenopausal Asian patients who relapsed after initial diagnosis of non-metastatic breast cancer. The most prevalent ... Read more >>

NPJ Breast Cancer (NPJ breast cancer)
[2018, 4:19]

Cited: 6 times

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Utility of Alternate, Noncentromeric Chromosome 17 Reference Probe for Human Epidermal Growth Factor Receptor Fluorescence In Situ Hybridization Testing in Breast Cancer Cases.

Trupti Pai, Tanuja Shet, Asawari Patil, Omshree Shetty, Angad Singh, Sangeeta B Desai,

Context PathVysion-a US Food and Drug Administration-approved dual-probe human epidermal growth factor receptor ( HER2) fluorescence in situ hybridization (FISH) assay-provides the HER2: CEP17 ratio, a centromeric enumeration probe ratio for determining HER2 status in breast cancers. However, pericentromeric amplifications might then skew the HER2: CEP17 ratio, underestimating the HER2 ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2018, 142(5):626-633]

Cited: 1 time

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Diffuse glioma - Rare homozygous IDH point mutation, is it an oncogenetic mechanism?

Angad Singh, Mamta Gurav, Sandeep Dhanavade, Omshree Shetty, Sridhar Epari,

Isocitrate dehydrogenase (IDH1/IDH2) mutations in gliomas of WHO grade II/III and secondary glioblastoma are almost always heterozygous missense mutations. Here, we report an extremely rare case of homozygous IDH1R132H mutation in a recurrent WHO grade III anaplastic astrocytoma. The authors here also review the relevant literature for the possible metabolic ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2017, 37(6):582-585]

Cited: 1 time

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PureCN: copy number calling and SNV classification using targeted short read sequencing.

Markus Riester, Angad P Singh, A Rose Brannon, Kun Yu, Catarina D Campbell, Derek Y Chiang, Michael P Morrissey,

<h4>Background</h4>Matched sequencing of both tumor and normal tissue is routinely used to classify variants of uncertain significance (VUS) into somatic vs. germline. However, assays used in molecular diagnostics focus on known somatic alterations in cancer genes and often only sequence tumors. Therefore, an algorithm that reliably classifies variants would be ... Read more >>

Source Code Biol Med (Source code for biology and medicine)
[2016, 11:13]

Cited: 27 times

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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.

Steven E Nissen, Neville D Yeomans, Daniel H Solomon, Thomas F Lüscher, Peter Libby, M Elaine Husni, David Y Graham, Jeffrey S Borer, Lisa M Wisniewski, Katherine E Wolski, Qiuqing Wang, Venu Menon, Frank Ruschitzka, Michael Gaffney, Bruce Beckerman, Manuela F Berger, Weihang Bao, A Michael Lincoff, ,

<h4>Background</h4>The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain.<h4>Methods</h4>Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen. The goal of the trial was to assess the noninferiority of celecoxib ... Read more >>

N Engl J Med (The New England journal of medicine)
[2016, 375(26):2519-2529]

Cited: 188 times

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MetaSeq: privacy preserving meta-analysis of sequencing-based association studies.

Angad Pal Singh, Samreen Zafer, Itsik Pe'er,

Human genetics recently transitioned from GWAS to studies based on NGS data. For GWAS, small effects dictated large sample sizes, typically made possible through meta-analysis by exchanging summary statistics across consortia. NGS studies groupwise-test for association of multiple potentially-causal alleles along each gene. They are subject to similar power constraints ... Read more >>

Pac Symp Biocomput (Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing)
[2013, :356-367]

Cited: 1 time

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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Hui Gao, Joshua M Korn, Stéphane Ferretti, John E Monahan, Youzhen Wang, Mallika Singh, Chao Zhang, Christian Schnell, Guizhi Yang, Yun Zhang, O Alejandro Balbin, Stéphanie Barbe, Hongbo Cai, Fergal Casey, Susmita Chatterjee, Derek Y Chiang, Shannon Chuai, Shawn M Cogan, Scott D Collins, Ernesta Dammassa, Nicolas Ebel, Millicent Embry, John Green, Audrey Kauffmann, Colleen Kowal, Rebecca J Leary, Joseph Lehar, Ying Liang, Alice Loo, Edward Lorenzana, E Robert McDonald, Margaret E McLaughlin, Jason Merkin, Ronald Meyer, Tara L Naylor, Montesa Patawaran, Anupama Reddy, Claudia Röelli, David A Ruddy, Fernando Salangsang, Francesca Santacroce, Angad P Singh, Yan Tang, Walter Tinetto, Sonja Tobler, Roberto Velazquez, Kavitha Venkatesan, Fabian Von Arx, Hui Qin Wang, Zongyao Wang, Marion Wiesmann, Daniel Wyss, Fiona Xu, Hans Bitter, Peter Atadja, Emma Lees, Francesco Hofmann, En Li, Nicholas Keen, Robert Cozens, Michael Rugaard Jensen, Nancy K Pryer, Juliet A Williams, William R Sellers,

Profiling candidate therapeutics with limited cancer models during preclinical development hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous patient responses for patient-selection strategies. We established ∼1,000 patient-derived tumor xenograft models (PDXs) with a diverse set of driver mutations. With these PDXs, we performed in vivo compound screens ... Read more >>

Nat Med (Nature medicine)
[2015, 21(11):1318-1325]

Cited: 373 times

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Hyo-eun C Bhang, David A Ruddy, Viveksagar Krishnamurthy Radhakrishna, Justina X Caushi, Rui Zhao, Matthew M Hims, Angad P Singh, Iris Kao, Daniel Rakiec, Pamela Shaw, Marissa Balak, Alina Raza, Elizabeth Ackley, Nicholas Keen, Michael R Schlabach, Michael Palmer, Rebecca J Leary, Derek Y Chiang, William R Sellers, Franziska Michor, Vesselina G Cooke, Joshua M Korn, Frank Stegmeier,

Resistance to cancer therapies presents a significant clinical challenge. Recent studies have revealed intratumoral heterogeneity as a source of therapeutic resistance. However, it is unclear whether resistance is driven predominantly by pre-existing or de novo alterations, in part because of the resolution limits of next-generation sequencing. To address this, we ... Read more >>

Nat Med (Nature medicine)
[2015, 21(5):440-448]

Cited: 157 times

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