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Monitoring bronchoalveolar lavage with electrical impedance tomography: first experience in a patient with COVID-19.

Yingyun Fu, Rongrong Zou, Shouhong Wang, Junmin Wen, Lei Rong, Ming Tang, Baojun Yu, Fulan Cen, Zhanqi Zhao, Inez Frerichs, Andy Adler, Yingxia Liu, Lei Liu,

Patients with the novel coronavirus disease (COVID-19) often have airways secretions that severely compromise ventilation. This study investigates electrical impedance tomography (EIT) monitoring of a therapeutic bronchoalveolar lavage (BAL) in a patient with COVID-19. A patient with COVID-19 developed acute respiratory distress syndrome requiring mechanical ventilation. He received regional BAL ... Read more >>

Physiol Meas (Physiological measurement)
[2020, :]

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Beneficial techniques for spatio-temporal imaging in electrical impedance tomography.

Alistair Boyle, Kirill Aristovich, Andy Adler,

OBJECTIVE:Electrical impedance tomography (EIT) typically reconstructs individual images from electrical voltage measurements at pairs of electrodes due to current driven through other electrode pairs on a body. EIT images have low spatial resolution, but excellent temporal resolution. There are four methods for integrating temporal data into an EIT reconstruction: filtering ... Read more >>

Physiol Meas (Physiological measurement)
[2020, 41(6):064003]

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Unravelling the complexities of the first breaths of life

David Tingay, Olivia Farrell, Jessica Thomson, Elizabeth Perkins, Prue Pereira-Fantini, Andreas Waldmann, Christoph Rueegger, Peter Davis, Andy Adler, Inez Frerichs,

Background: The transition to air-breathing at birth is a seminal, but poorly understood, respiratory event common to all humans. The objectives of this prospective, observational study were to describe the spatiotemporal gas flow, aeration and ventilation patterns occurring within the lung in neonates during successful respiratory transition. Methods: Electrical impedance ... Read more >>

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Thoracic EIT in 3D: experiences and recommendations.

Bartłomiej Grychtol, Johannes Peter Schramel, Fabian Braun, Thomas Riedel, Ulrike Auer, Martina Mosing, Christina Braun, Andreas D Waldmann, Stephan H Böhm, Andy Adler,

OBJECTIVE:In EIT applications to the thorax, a single electrode plane has typically been used to reconstruct a transverse 2D 'slice'. However, such images can be misleading as EIT is sensitive to contrasts above and below the electrode plane, and ventilation and aeration inhomogeneities can be distributed in complex ways. Using ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(7):074006]

Cited: 1 time

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Electrical impedance tomography identifies a distinct change in regional phase angle delay pattern in ventilation filling immediately prior to a spontaneous pneumothorax.

Martijn Miedema, Andy Adler, Karen E McCall, Elizabeth J Perkins, Anton H van Kaam, David G Tingay,

Pneumothoraxes are common in preterm infants and are a major cause of morbidity. Early detection and treatment of pneumothoraxes are vital to minimize further respiratory compromise. Electrical impedance tomography (EIT) has been suggested as a method of rapidly detecting pneumothoraxes at the bedside. Our objective was to define the EIT-derived ... Read more >>

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2019, 127(3):707-712]

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Left atrial imaging and registration of fibrosis with conduction voltages using LGE-MRI and electroanatomical mapping.

Jinny Lee, Rebecca E Thornhill, Pablo Nery, Robert deKemp, Elena Peña, David Birnie, Andy Adler, Eranga Ukwatta,

BACKGROUND AND PURPOSE:Abnormal electrical conduction and excitability associated with fibrosis in the left atrium (LA) may serve as a substrate for atrial fibrillation (AF). Electroanatomical voltage mapping systems (EAMs) have become a dominant facilitator to treat AF with catheter ablation assisted by additional diagnostic imaging modalities. Importantly, AF has been ... Read more >>

Comput. Biol. Med. (Computers in biology and medicine)
[2019, 111:103341]

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Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model.

Symon Stowe, Alistair Boyle, Michaël Sage, Wendy See, Jean-Paul Praud, Étienne Fortin-Pellerin, Andy Adler,

OBJECTIVE:Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(5):054002]

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Detection of pulmonary oedema by electrical impedance tomography: validation of previously proposed approaches in a clinical setting.

Zhanqi Zhao, Hongli He, Jingying Luo, Andy Adler, Xiaoqin Zhang, Rongan Liu, Yunping Lan, Sen Lu, Xiaoxiu Luo, Yu Lei, Inez Frerichs, Xiaobo Huang, Knut Möller,

OBJECTIVE:The aim of the present study was to evaluate two previously proposed approaches based on electrical impedance tomography (EIT) to assess pulmonary oedema at the bedside. APPROACH:Fourteen patients with acute respiratory distress syndrome were included and examined prospectively. Patients were rotated laterally along their longitudinal axis from supine to 45-degree ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(5):054008]

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Evaluation of the signal quality of wrist-based photoplethysmography.

Nikhilesh Pradhan, Sreeraman Rajan, Andy Adler,

OBJECTIVE:Wearable devices with embedded photoplethysmography (PPG) sensors enable continuous monitoring of cardiovascular activity, allowing for the detection cardiovascular problems, such as arrhythmias. However, the quality of wrist-based PPG is highly variable, and is subject to artifacts from motion and other interferences. The goal of this paper is to evaluate the ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(6):065008]

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Electrical Impedance Tomography Can Identify Ventilation and Perfusion Defects: A Neonatal Case.

David G Tingay, Andreas D Waldmann, Inéz Frerichs, Sarath Ranganathan, Andy Adler,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 199(3):384-386]

Cited: 2 times

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Perflubron Distribution During Transition From Gas to Total Liquid Ventilation.

Michaël Sage, Symon Stowe, Andy Adler, Claudia Forand-Choinière, Mathieu Nadeau, Claire Berger, Sofia Marouan, Philippe Micheau, Renaud Tissier, Jean-Paul Praud, Étienne Fortin-Pellerin,

Total liquid ventilation (TLV) using perfluorocarbons has shown promising results for the management of neonatal respiratory distress. However, one important safety consideration for TLV is a better understanding of the early events during the transition to TLV, especially regarding the fate of residual air in the non-dependent-lung regions. Our objective ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:1723]

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Wearable Sensors for Frequency-Multiplexed EIT and Multilead ECG Data Acquisition.

Michael Rapin, Fabian Braun, Andy Adler, Josias Wacker, Inez Frerichs, Barbara Vogt, Olivier Chetelat,

This paper presents a wearable sensor architecture for frequency-multiplexed electrical impedance tomography (EIT) and synchronous multilead electrocardiogram (ECG) data acquisition. The system is based on a novel electronic sensing architecture, called cooperative sensors, that significantly reduces the cabling complexity and enables flexible EIT stimulation and measurement patterns. The cooperative-sensor architecture ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2019, 66(3):810-820]

Cited: 1 time

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Accuracy and reliability of noninvasive stroke volume monitoring via ECG-gated 3D electrical impedance tomography in healthy volunteers.

Fabian Braun, Martin Proença, Andy Adler, Thomas Riedel, Jean-Philippe Thiran, Josep Solà,

Cardiac output (CO) and stroke volume (SV) are parameters of key clinical interest. Many techniques exist to measure CO and SV, but are either invasive or insufficiently accurate in clinical settings. Electrical impedance tomography (EIT) has been suggested as a noninvasive measure of SV, but inconsistent results have been reported. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(1):e0191870]

Cited: 4 times

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Limitations and challenges of EIT-based monitoring of stroke volume and pulmonary artery pressure.

Fabian Braun, Martin Proença, Mathieu Lemay, Mattia Bertschi, Andy Adler, Jean-Philippe Thiran, Josep Solà,

OBJECTIVE:Electrical impedance tomography (EIT) shows potential for radiation-free and noninvasive hemodynamic monitoring. However, many factors degrade the accuracy and repeatability of these measurements. Our goal is to estimate the impact of this variability on the EIT-based monitoring of two important central hemodynamic parameters: stroke volume (SV) and pulmonary artery pressure ... Read more >>

Physiol Meas (Physiological measurement)
[2018, 39(1):014003]

Cited: 2 times

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RCVS and BVA are not to blame.

Andy Adler,

Vet. Rec. (The Veterinary record)
[2018, 182(13):385]

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Electrical Impedance Tomography: Tissue Properties to Image Measures.

Andy Adler, Alistair Boyle,

Electrical impedance tomography (EIT) uses electrical stimulation and measurement at the body surface to image the electrical properties of internal tissues. It has the advantage of noninvasiveness and high temporal resolution but suffers from poor spatial resolution and sensitivity to electrode movement and contact quality. EIT can be useful to ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2017, 64(11):2494-2504]

Cited: 13 times

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Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.

Karen E McCall, Andreas D Waldmann, Prue Pereira-Fantini, Regina Oakley, Martijn Miedema, Elizabeth J Perkins, Peter G Davis, Peter A Dargaville, Stephan H Böhm, Raffaele Dellacà, Magdy Sourial, Emanuela Zannin, Anushi E Rajapaksa, Andre Tan, Andy Adler, Inéz Frerichs, David G Tingay,

BackgroundCurrent sustained lung inflation (SI) approaches use uniform pressures and durations. We hypothesized that gestational-age-related mechanical and developmental differences would affect the time required to achieve optimal lung aeration, and resultant lung volumes, during SI delivery at birth in lambs.Methods49 lambs, in five cohorts between 118 and 139 days of ... Read more >>

Pediatr. Res. (Pediatric research)
[2017, 82(4):712-720]

Cited: 4 times

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Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET.

Adrian F Ocneanu, Robert A deKemp, Jennifer M Renaud, Andy Adler, Rob S B Beanlands, Ran Klein,

Purpose. Myocardial blood flow (MBF) quantification with 82Rb positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic 82Rb PET, ... Read more >>

Comput Math Methods Med (Computational and Mathematical Methods in Medicine)
[2017, 2017:6810626]

Cited: 1 time

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A Versatile Noise Performance Metric for Electrical Impedance Tomography Algorithms.

Fabian Braun, Martin Proenca, Josep Sola, Jean-Philippe Thiran, Andy Adler,

Electrical impedance tomography (EIT) is an emerging technology for real-time monitoring of patients under mechanical ventilation. EIT has the potential to offer continuous medical monitoring while being noninvasive, radiation free, and low cost. Due to their ill-posedness, image reconstruction typically uses regularization, which implies a hyperparameter controlling the tradeoff between ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2017, 64(10):2321-2330]

Cited: 3 times

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Lobe based image reconstruction in Electrical Impedance Tomography.

Benjamin Schullcke, Bo Gong, Sabine Krueger-Ziolek, Merryn Tawhai, Andy Adler, Ullrich Mueller-Lisse, Knut Moeller,

Electrical Impedance Tomography (EIT) is an imaging modality used to generate two-dimensional cross-sectional images representing impedance change in the thorax. The impedance of lung tissue changes with change in air content of the lungs; hence, EIT can be used to examine regional lung ventilation in patients with abnormal lungs. In ... Read more >>

Med Phys (Medical physics)
[2017, 44(2):426-436]

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Effectiveness of individualized lung recruitment strategies at birth: an experimental study in preterm lambs.

David G Tingay, Anushi Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele L Dellaca, Elizabeth J Perkins, Cornelis E E Zonneveld, Andy Adler, Don Black, Inéz Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G Davis,

Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung while aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume response and a dynamic tidal positive end-expiratory pressure (PEEP) (open lung volume, OLV) strategy that both enhance this process. ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2017, 312(1):L32-L41]

Cited: 5 times

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Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group.

Inéz Frerichs, Marcelo B P Amato, Anton H van Kaam, David G Tingay, Zhanqi Zhao, Bartłomiej Grychtol, Marc Bodenstein, Hervé Gagnon, Stephan H Böhm, Eckhard Teschner, Ola Stenqvist, Tommaso Mauri, Vinicius Torsani, Luigi Camporota, Andreas Schibler, Gerhard K Wolf, Diederik Gommers, Steffen Leonhardt, Andy Adler, ,

Electrical impedance tomography (EIT) has undergone 30 years of development. Functional chest examinations with this technology are considered clinically relevant, especially for monitoring regional lung ventilation in mechanically ventilated patients and for regional pulmonary function testing in patients with chronic lung diseases. As EIT becomes an established medical technology, it requires ... Read more >>

Thorax (Thorax)
[2017, 72(1):83-93]

Cited: 94 times

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Electrical impedance tomography in 3D using two electrode planes: characterization and evaluation.

Justin Wagenaar, Andy Adler,

Electrical impedance tomography (EIT) uses body surface electrical stimulation and measurements to create conductivity images; it shows promise as a non-invasive technology to monitor the distribution of lung ventilation. Most applications of EIT have placed electrodes in a 2D ring around the thorax, and thus produced 2D cross-sectional images. These ... Read more >>

Physiol Meas (Physiological measurement)
[2016, 37(6):922-937]

Cited: 1 time

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3D EIT image reconstruction with GREIT.

Bartłomiej Grychtol, Beat Müller, Andy Adler,

Most applications of thoracic EIT use a single plane of electrodes on the chest from which a transverse image 'slice' is calculated. However, interpretation of EIT images is made difficult by the large region above and below the electrode plane to which EIT is sensitive. Volumetric EIT images using two ... Read more >>

Physiol Meas (Physiological measurement)
[2016, 37(6):785-800]

Cited: 7 times

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Non-invasive monitoring of pulmonary artery pressure from timing information by EIT: experimental evaluation during induced hypoxia.

Martin Proença, Fabian Braun, Josep Solà, Andy Adler, Mathieu Lemay, Jean-Philippe Thiran, Stefano F Rimoldi,

Monitoring of pulmonary artery pressure (PAP) in pulmonary hypertensive patients is currently limited to invasive solutions. We investigate a novel non-invasive approach for continuous monitoring of PAP, based on electrical impedance tomography (EIT), a safe, low-cost and non-invasive imaging technology. EIT recordings were performed in three healthy subjects undergoing hypoxia-induced ... Read more >>

Physiol Meas (Physiological measurement)
[2016, 37(6):713-726]

Cited: 7 times

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