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Author Andrey Komissarov

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Highly Pathogenic Avian Influenza A(H5N8) Virus Clade 2.3.4.4b, Western Siberia, Russia, 2020.

Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov,

Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2224-2227]

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Spread of endemic SARS-CoV-2 lineages in Russia

Galya Klink, Ksenia Safina, Sofya Garushyants, Mikhail Moldovan, Elena Nabieva, Andrey Komissarov, Dmitry Lioznov, Georgii Bazykin, ,

In 2021, the COVID-19 pandemic is characterized by global spread of several lineages with evidence for increased transmissibility. Russia is among the countries with the highest number of confirmed COVID-19 cases, making it a potential hotspot for emergence of novel variants. Here, we show that among the globally significant variants ... Read more >>

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Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.

Runzhen Zhao, Zhenlei Su, Andrey A Komissarov, Shan-Lu Liu, Guohua Yi, Steven Idell, Michael A Matthay, Hong-Long Ji,

<h4>Background</h4>Dynamic D-dimer level is a key biomarker for the severity and mortality of COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the clinical progression of COVID-19 presents a clinicopathological dilemma challenging intensivists.<h4>Methods</h4>We performed meta-analysis and meta regression to analyze the associations of plasma D-dimer with 106 clinical variables to identify ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:691249]

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Precision targeting of the plasminogen activator inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.

Galina Florova, René A Girard, Ali O Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian J DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas B Cines, Steven Idell, Andrey A Komissarov,

Plasminogen activator inhibitor-1 (PAI-1) is an endogenous irreversible inhibitor of tissue-type (tPA) and urokinase (uPA) plasminogen activators. PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose of tPA and uPA, attenuating the risk of bleeding and other complications. Docking site peptide (DSP) mimics the part of the PAI-1 ... Read more >>

Physiol Rep (Physiological reports)
[2021, 9(9):e14861]

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Antigenic and Genetic Characterization of Swine Influenza Viruses Identified in the European Region of Russia, 2014-2020.

Daria M Danilenko, Andrey B Komissarov, Artem V Fadeev, Mikhail I Bakaev, Anna A Ivanova, Polina A Petrova, Anastasia D Vassilieva, Kseniya S Komissarova, Alyona I Zheltukhina, Nadezhda I Konovalova, Andrey V Vasin,

Pigs have long been recognized as "mixing vessels" in which new viruses are formed by reassortment involving various influenza virus lineages (avian, animal, human). However, surveillance of swine influenza viruses only gained real significance after the 2009 pandemic. A fundamentally important point is the fact that there is still no ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:662028]

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Genomic epidemiology of the early stages of the SARS-CoV-2 outbreak in Russia.

Andrey B Komissarov, Ksenia R Safina, Sofya K Garushyants, Artem V Fadeev, Mariia V Sergeeva, Anna A Ivanova, Daria M Danilenko, Dmitry Lioznov, Olga V Shneider, Nikita Shvyrev, Vadim Spirin, Dmitry Glyzin, Vladimir Shchur, Georgii A Bazykin,

The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):649]

Cited: 5 times

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RNA-Seq transcriptome data of human cells infected with influenza A/Puerto Rico/8/1934 (H1N1) virus.

Evgenii Zhuravlev, Mariia Sergeeva, Sergey Malanin, Rinat Amirkhanov, Dmitriy Semenov, Tatiana Grigoryeva, Andrey Komissarov, Grigory Stepanov,

Human influenza remains a serious public health problem. This data article reports the transcriptome analysis data of human cell lines infected with influenza A/Puerto Rico/8/1934 (H1N1) virus. Mock-infected cells were included as controls. Human embryonic fibroblasts (MRC-5) and immortalized cell lines (A549, HEK293FT, WI-38 VA-13) were selected for RNA sequencing ... Read more >>

Data Brief (Data in brief)
[2020, 33:106604]

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Virological surveillance of influenza viruses in the WHO European Region in 2019/20 - impact of the COVID-19 pandemic.

Angeliki Melidou, Dmitriy Pereyaslov, Olav Hungnes, Katarina Prosenc, Erik Alm, Cornelia Adlhoch, James Fielding, Miriam Sneiderman, Oksana Martinuka, Lucia Pastore Celentano, Richard Pebody, , ,

The COVID-19 pandemic negatively impacted the 2019/20 WHO European Region influenza surveillance. Compared with previous 4-year averages, antigenic and genetic characterisations decreased by 17% (3,140 vs 2,601) and 24% (4,474 vs 3,403). Of subtyped influenza A viruses, 56% (26,477/47,357) were A(H1)pdm09, 44% (20,880/47,357) A(H3). Of characterised B viruses, 98% (4,585/4,679) ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(46):]

Cited: 2 times

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Precision Targeting of the Plasminogen Activator Inhibitor-1 Mechanism Increases Efficacy of Fibrinolytic Therapy in Empyema

Galina Florova, René Girard, Ali Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas Cines, Steven Idell, Andrey Komissarov,

Plasminogen activator inhibitor-1 (PAI-1) is an endogenous irreversible inhibitor of tissue-type (tPA) and urokinase (uPA) plasminogen activators. PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose of tPA and uPA to attenuate the risk of bleeding and other complications. The docking site peptide (DSP) is a part of ... Read more >>

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Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.

Erik Alm, Eeva K Broberg, Thomas Connor, Emma B Hodcroft, Andrey B Komissarov, Sebastian Maurer-Stroh, Angeliki Melidou, Richard A Neher, Áine O'Toole, Dmitriy Pereyaslov, , ,

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(32):]

Cited: 45 times

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Genomic epidemiology of the early stages of SARS-CoV-2 outbreak in Russia

Andrey Komissarov, Ksenia Safina, Sofya Garushyants, Artem Fadeev, Mariia Sergeeva, Anna Ivanova, Daria Danilenko, Dmitry Lioznov, Olga Shneider, Nikita Shvyrev, Vadim Spirin, Dmitry Glyzin, Vladimir Shchur, Georgii Bazykin,

The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has ... Read more >>

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Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018-2019.

Angeliki Melidou, Olav Hungnes, Dmitriy Pereyaslov, Cornelia Adlhoch, Hannah Segaloff, Emmanuel Robesyn, Pasi Penttinen, Sonja J Olsen, ,

<h4>Background</h4>The 2018/2019 influenza season in the WHO European Region was dominated by influenza A (H1N1)pdm09 and (H3N2) viruses, with very few influenza B viruses detected.<h4>Methods</h4>Countries in the European Region reported virus characterization data to The European Surveillance System for weeks 40/2018 to 20/2019. These virus antigenic and genetic characterization and ... Read more >>

Vaccine (Vaccine)
[2020, 38(35):5707-5717]

Cited: 2 times

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Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.

Machteld Sillen, Stephen D Weeks, Xiaohua Zhou, Andrey A Komissarov, Galina Florova, Steven Idell, Sergei V Strelkov, Paul J Declerck,

<h4>Background</h4>Plasminogen activator inhibitor-1 (PAI-1), a key inhibitor of plasminogen activators (PAs) tissue-type PA (tPA) and urokinase-type PA (uPA) plays a crucial role in many (patho)physiological processes (e.g., cardiovascular disease, tissue fibrosis) as well as in many age-related pathologies. Therefore, much effort has been put into the development of small molecule ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, 18(3):681-692]

Cited: 6 times

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Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice.

René A Girard, Prashant S Chauhan, Torry A Tucker, Tim Allen, Jaswinder Kaur, Ann Jeffers, Kathleen Koenig, Galina Florova, Andrey A Komissarov, Tatiana A Gaidenko, Mignote B Chamiso, James Fowler, Danna E Morris, Krishna Sarva, Karan P Singh, Steven Idell, Richard D Idell,

Plasminogen activator inhibitor 1 (PAI-1), which is elevated in numerous disease states, has been implicated as a stress-related protein involved in the pathogenesis of depression. We measured PAI-1 in the plasma of healthy and depressed individuals and assessed plasminogen activator (PA) expression and regulation by PAI-1 in cultured normal human ... Read more >>

Exp Brain Res (Experimental brain research)
[2019, 237(12):3419-3430]

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p62/SQSTM1 expression in canine mammary tumours: Evolutionary notes.

Francesca Mariotti, Gian Enrico Magi, Alessandra Gavazza, Silvia Vincenzetti, Andrey Komissarov, Alex Shneider, Franco Maria Venanzi,

Recent studies highlighted the role of autophagy as a cardinal regulatory system for homeostasis and cancer-related signalling pathways. In this context, the deregulated expression of p62 - Sequestosome1 (p62/SQSTM1) - a protein acting both as an autophagy receptor and signalling hub, has been associated with tumour development and chronic inflammation. ... Read more >>

Vet Comp Oncol (Veterinary and comparative oncology)
[2019, 17(4):570-577]

Cited: 2 times

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Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.

Elena A Prokopyeva, Vsevolod A Zinserling, You-Chan Bae, Yongkuk Kwon, Olga G Kurskaya, Ivan A Sobolev, Peter M Kozhin, Andrey Komissarov, Artem Fadeev, Vladimir Petrov, Alexander M Shestopalov, Kirill A Sharshov,

The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration. We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the ... Read more >>

Interdiscip Perspect Infect Dis (Interdisciplinary perspectives on infectious diseases)
[2019, 2019:4124865]

Cited: 5 times

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Phase 1 trial of intrapleural LTI-01; single chain urokinase in complicated parapneumonic effusions or empyema.

Lutz Beckert, Ben Brockway, Graham Simpson, Anne Marie Southcott, Y C Gary Lee, Najib Rahman, Richard W Light, Steven Shoemaker, John Gillies, Andrey A Komissarov, Galina Florova, Timothy Ochran, William Bradley, Harrison Ndetan, Karan P Singh, Krishna Sarva, Steven Idell,

<h4>Background</h4>Current dosing of intrapleural fibrinolytic therapy (IPFT) in adults with complicated parapneumonic effusion (CPE) / empyema is empiric, as dose-escalation trials have not previously been conducted. We hypothesized that LTI-01 (scuPA), which is relatively resistant to PA inhibitor-1 (PAI-1), would be well-tolerated.<h4>Methods</h4>This was an open-label, dose-escalation trial of LTI-01 IPFT ... Read more >>

JCI Insight (JCI insight)
[2019, 5:]

Cited: 6 times

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Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.

Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A Cox, Marla R Wolfson, Thomas H Shaffer, Robert O Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T Ndetan, Karan P Singh, Steven Idell,

<h4>Background</h4>Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a tissue plasminogen activator; tPA, has been advocated, but airway bleeding is a known and lethal potential complication. We posited that nebulized delivery of single ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2018, 7(1):17]

Cited: 1 time

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Fibrin turnover and pleural organization: bench to bedside.

Andrey A Komissarov, Najib Rahman, Y C Gary Lee, Galina Florova, Sreerama Shetty, Richard Idell, Mitsuo Ikebe, Kumuda Das, Torry A Tucker, Steven Idell,

Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of plasminogen activator inhibitor-1 to the ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 314(5):L757-L768]

Cited: 7 times

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Formulation for a novel inhaled peptide therapeutic for idiopathic pulmonary fibrosis.

Soraya Hengsawas Surasarang, Galina Florova, Andrey A Komissarov, Sreerama Shetty, Steven Idell, Robert O Williams,

A caveolin-1 scaffolding domain, CSP7, is a newly developed peptide for the treatment of idiopathic pulmonary fibrosis. To develop a CSP7 formulation for further use we have obtained, characterized and compared a number of lyophilized formulations of CSP7 trifluoroacetate with DPBS and in combination with excipients (mannitol and lactose at ... Read more >>

Drug Dev Ind Pharm (Drug development and industrial pharmacy)
[2018, 44(2):184-198]

Cited: 1 time

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P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions.

Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B Komissarov, Franco Venanzi, Sergey I Kolesnikov, Albert A Sufianov, Michael Y Sherman, Vladimir L Gabai, Alexander M Shneider,

A high-calorie diet (HCD) induces two mutually exacerbating effects contributing to diet-induced obesity (DIO): impaired glucose metabolism and increased food consumption. A link between the metabolic and behavioral manifestations is not well understood yet. We hypothesized that chronic inflammation induced by HCD plays a key role in linking together the ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(34):56030-56040]

Cited: 1 time

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P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions.

Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B Komissarov, Franco Venanzi, Sergey I Kolesnikov, Albert A Sufianov, Michael Y Sherman, Vladimir L Gabai, Alexander M Shneider,

A high-calorie diet (HCD) induces two mutually exacerbating effects contributing to diet-induced obesity (DIO): impaired glucose metabolism and increased food consumption. A link between the metabolic and behavioral manifestations is not well understood yet. We hypothesized that chronic inflammation induced by HCD plays a key role in linking together the ... Read more >>

Oncotarget (Oncotarget)
[2017, :]

Cited: 4 times

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Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Galina Florova, Ali O Azghani, Sophia Karandashova, Chris Schaefer, Serge V Yarovoi, Paul J Declerck, Douglas B Cines, Steven Idell, Andrey A Komissarov,

Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in tetracycline-induced pleural injury in rabbits. To enhance IPFT with prourokinase (scuPA), two mechanistically distinct approaches to targeting PAI-1 were tested: slowing its reaction with urokinase (uPA) and monoclonal antibody (mAb)-mediated PAI-1 ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 314(1):L54-L68]

Cited: 7 times

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Precision-guided, Personalized Intrapleural Fibrinolytic Therapy for Empyema and Complicated Parapneumonic Pleural Effusions: The Case for the Fibrinolytic Potential.

Steven Idell, Galina Florova, Sreerama Shetty, Torry Tucker, Richard Idell, Kathy Koenig, Ali Azghani, Najib M Rahman, Andrey Komissarov,

Complicated pleural effusions and empyema with loculation and failed drainage are common clinical problems. In adults, intrapleural fibrinolytic therapy is commonly used with variable results and therapy remains empiric. Despite the intrapleural use of various plasminogen activators; fibrinolysins, for about sixty years, there is no clear consensus about which agent ... Read more >>

Clin Pulm Med (Clinical pulmonary medicine)
[2017, 24(4):163-169]

Cited: 7 times

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Development of a realtime RT-PCR assay for the rapid detection of influenza A(H2) viruses.

Andrey Komissarov, Andrey Komissarov, Artem Fadeev, Anna Kosheleva, Kseniya Sintsova, Mikhail Grudinin,

Influenza and other acute respiratory infections are of great concern for public health, causing excessive morbidity and mortality throughout the world. Influenza virus A(H2N2), which caused a pandemic of so called "Asian flu" in 1957 was expelled from the human population by the new pandemic virus subtype H3N2 in 1968, ... Read more >>

Mol Cell Probes (Molecular and cellular probes)
[2017, 35:57-63]

Cited: 1 time

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