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Reducing the Burden of Anemia and Neural Tube Defects in Low- and Middle-Income Countries: An Analysis to Identify Countries with an Immediate Potential to Benefit from Large-Scale Mandatory Fortification of Wheat Flour and Rice.

Vijaya Kancherla, Manpreet Chadha, Laura Rowe, Andrew Thompson, Sakshi Jain, Dylan Walters, Homero Martinez,

Using a predetermined set of criteria, including burden of anemia and neural tube defects (NTDs) and an enabling environment for large-scale fortification, this paper identifies 18 low- and middle-income countries with the highest and most immediate potential for large-scale wheat flour and/or rice fortification in terms of health impact and ... Read more >>

Nutrients (Nutrients)
[2021, 13(1):]

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Opposing associations of depression with sexual behaviour: implications for epidemiological investigation among gay, bisexual and other men who have sex with men.

Ada R Miltz, Alison J Rodger, Andrew N Phillips, Janey Sewell, Simon Edwards, Sris Allan, Lorraine Sherr, Anne M Johnson, William J Burman, Fiona C Lampe, ,

<h4>Objective</h4>The aim of this report is to investigate the nature of the relationship between depression and condomless sex (CLS) among gay, bisexual and other men who have sex with men (GBMSM).<h4>Methods</h4>Data are from the Antiretrovirals, Sexual Transmission Risk and Attitude (ASTRA) study of people living with HIV and attending one ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2021, :]

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The association between migrant status and transition in an ultra-high risk for psychosis population.

Brian O'Donoghue, Hellen Geros, Holly Sizer, Jean Addington, G Paul Amminger, Carrie E Beaden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Jessica A Hartmann, Ian B Hickie, Helga K Ising, Suzie Lavoie, Ashleigh Lin, Connie Markulev, Daniel H Mathalon, Thomas H McGlashan, Nathan G Mifsud, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Diana O Perkins, Anita Riecher-Rössler, Miriam R Schäfer, Monika Schlögelhofer, Larry J Seidman, Stephan Smesny, Andrew Thompson, Ming T Tsuang, Mark van der Gaag, Swapna Verma, Elaine F Walker, Stephen J Wood, Scott W Woods, Hok Pan Yuen, Alison Ruth Yung, Patrick D McGorry, Barnaby Nelson,

<h4>Purpose</h4>Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.<h4>Methods</h4>Hazard ratios for the risk of ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2021, :]

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"Girls Aren't Meant to Exercise": Perceived Influences on Physical Activity among Adolescent Girls-The HERizon Project.

Emma S Cowley, Paula M Watson, Lawrence Foweather, Sarahjane Belton, Andrew Thompson, Dick Thijssen, Anton J M Wagenmakers,

<h4>Background</h4>Adolescent girls are less active than boys, with approximately 10% of girls in Ireland and the United Kingdom meeting the minimum recommended daily physical activity (PA) guidelines. This study investigated factors perceived to influence PA among adolescent girls from low socioeconomic areas in order to inform the design of a ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2021, 8(1):]

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Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.

John B Whitfield, Steven Masson, Suthat Liangpunsakul, Sebastian Mueller, Guruprasad P Aithal, Florian Eyer, Dermot Gleeson, Andrew Thompson, Felix Stickel, Michael Soyka, Beat Muellhaupt, Ann K Daly, Heather J Cordell, Tatiana Foroud, Lawrence Lumeng, Munir Pirmohamed, Bertrand Nalpas, Jean-Marc Jacquet, Romain Moirand, Pierre Nahon, Sylvie Naveau, Pascal Perney, Paul S Haber, Helmut K Seitz, Christopher P Day, Philippe Mathurin, Timothy R Morgan, Devanshi Seth, ,

<h4>Introduction</h4>Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk.<h4>Methods</h4>We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(1):106-115]

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Overproduction of ABA in rootstocks alleviates salinity stress in tomato shoots

Cristina Martínez Andújar, Ascensión Martínez-Pérez, Alfonso Albacete Moreno, Purificación Martínez-Melgarejo, Ian Dodd, Andrew Thompson, Almudena Ferrández-Ayela, Jose Manuel Perez-Perez, Miriam Gifford, Francisco P, rez Alfocea,

To determine whether root-supplied ABA alleviates saline stress, tomato (Solanum lycopersicum L. cv. Sugar Drop) was grafted onto two independent lines overexpressing the SlNCED1 (9-cis-epoxycarotenoid dioxygenase) gene (NCED OE) and wild type rootstocks. After 200 days of salinity irrigation (EC = 3.5 dS m-1), plants with NCED OE rootstocks had ... Read more >>

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Testing the Independent and Joint Contribution of Exposure to Neurodevelopmental Adversity and Childhood Trauma to Risk of Psychotic Experiences in Adulthood.

Yiwen Liu, Marina Mendonça, Mary Cannon, Peter B Jones, Glyn Lewis, Andrew Thompson, Stanley Zammit, Dieter Wolke,

Exposure to neurodevelopmental adversity and childhood trauma are both independently associated with psychosis. However, there is little research on the mechanism underlying their relationship with each other. The current study investigated both the independent and joint effects of neurodevelopmental adversity and childhood trauma to better understand the etiology of psychosis. ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, :]

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Adults' experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies.

Gregg Harry Rawlings, Nigel Beail, Iain Armstrong, Robin Condliffe, David G Kiely, Ian Sabroe, Andrew R Thompson,

<h4>Objectives</h4>Pulmonary hypertension is a life-shortening disease that has a considerable impact on quality of life. Improving our understanding of how individuals are affected and cope with the disease will help to improve services and outcomes. This review synthesises the published qualitative research that has listened to adults discuss their experiences ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e041428]

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Monitoring Neuromuscular Performance in Military Personnel.

Justin J Merrigan, Jason D Stone, Andrew G Thompson, W Guy Hornsby, Joshua A Hagen,

A necessarily high standard for physical readiness in tactical environments is often accompanied by high incidences of injury due to overaccumulations of neuromuscular fatigue (NMF). To account for instances of overtraining stimulated by NMF, close monitoring of neuromuscular performance is warranted. Previously validated tests, such as the countermovement jump, are ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(23):]

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Participatory approaches, local stakeholders and cultural relevance facilitate an impactful community-based project in Uganda.

James O'Donovan, Andrew Thompson, Christina Stiles, Japheth A Opintan, Ken Kabali, Ian Willis, Mwebe Edward Mutimba, Elizabeth Nalweyiso, Henry Mugabi, David P Kateete, Matthew Ameniko, George Govina, Rachel Weberman, Edward O'Neil, Niall Winters, Ankur Mutreja,

Sanitation is a major global challenge that is often addressed at national and international levels, while community opinions and beliefs are neglected. To promote water, sanitation and hygiene (WASH) we organized a cross-cultural knowledge exchange workshop to assess participatory methods for engaging local stakeholders. The workshop included 22 participants from ... Read more >>

Health Promot Int (Health promotion international)
[2020, 35(6):1353-1368]

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How frequently should paediatric cardiopulmonary resuscitation skills be taught?

Melissa Mulholland, Seana Molloy, Patricia Coulter, Dara O'Donoghue, Thomas Bourke, Andrew Thompson,

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Cellular and molecular mechanisms of frontal bone development in spotted gar (Lepisosteus oculatus)

Alyssa Enny, Andrew Thompson, Brett Racicot, Ingo Braasch, Tetsuya Nakamura,

<h4>Background</h4> The molecular mechanisms initiating vertebrate cranial dermal bone formation is a conundrum in evolutionary and developmental biology. Decades of studies have determined the developmental processes of cranial dermal bones in various vertebrate species, finding possible inducers of dermal bone. However, the evolutionarily derived characters of current experimental model organisms ... Read more >>

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A common complaint… a rare disease!

Mary-Beth Toner, Seana Molloy, Peter Mallett, Andrew Thompson, Lynne Speirs,

A 2-year-old previously well child presented to the emergency department with temperatures and lethargy. He was pale and looked unwell. He received a fluid bolus and was commenced on intravenous ceftriaxone. Pus was discharging from his left ear with postauricular swelling and erythema. Given clinical concerns, urgent neuroimaging was arranged. ... Read more >>

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, :]

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Adaptation of Influenza Viruses to Human Airway Receptors.

Andrew J Thompson, James C Paulson,

Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses. ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, :]

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Development of novel clinical examination scales for the measurement of disease severity in Creutzfeldt-Jakob disease

Akin Nihat, Tze How Mok, Hans Odd, Andrew Thompson, Diana Caine, Kirsty McNiven, Veronica O’Donnell, Selam Tesfamichael, Peter Rudge, John Collinge, Simon Mead,

<h4>Objective</h4> Sporadic Creutzfeldt-Jakob disease (sCJD) causes rapidly-progressive dementia and complex abnormalities of motor systems with striking phenotypic heterogeneity, but no tools are available for the clinician to determine disease severity from bedside cognitive and neurological assessments. We used a robust statistical methodology and routinely-collected examination data to develop and validate ... Read more >>

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COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning

, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Melissa Bobby, Juliane Brun, BVNBS Sarma, Mark Calmiano, Anna Carbery, Emma Cattermole, John Chodera, Austin Clyde, Joseph Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter Eastman, Noam Erez, Michael Fairhead, Daren Fearon, Oleg Fedorov, Matteo Ferla, Holly Foster, Richard Foster, Ronen Gabizon, Paul Gehrtz, Carina Gileadi, Charline Giroud, William Glass, Robert Glen, Itai Glinert, Marian Gorichko, Tyler Gorrie-Stone, Edward Griffen, Jag Heer, Michelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, Tobias John, Anastassia Kantsadi, Peter Kenny, John Kiappes, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha Albert Lee, Bruce Lefker, Haim Levy, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika Malla, Tatiana Matviiuk, Willam McCorkindale, Sharon Melamed, Oleg Michurin, Halina Mikolajek, Aaron Morris, Garrett Morris, Melody Jane Morwitzer, Demetri Moustakas, Jose Brandao Neto, Vladas Oleinikovas, Gijs Overheul, David Owen, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimir Psenak, Reut Puni, Victor Rangel, Rambabu Reddi, St Patrick Reid, Efrat Resnick, Matthew Robinson, Ralph Robinson, Dominic Rufa, Christopher Schofield, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Assa Sittner, Rachael Skyner, Adam Smalley, Mihaela Smilova, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Andrew Thompson, Warren Thompson, Susana Tomasio, Anthony Tumber, Ioannis Vakonakis, Ronald van Rij, Finny Varghese, Mariana Vaschetto, Einat Vitner, Vincent Voelz, Annette von Delft, Frank von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann,

Herein we provide a living summary of the data generated during the COVID Moonshot project focused on the development of SARS-CoV-2 main protease (Mpro) inhibitors. Our approach uniquely combines crowdsourced medicinal chemistry insights with high throughput crystallography, exascale computational chemistry infrastructure for simulations, and machine learning in triaging designs and ... Read more >>

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Rectal Spacer Usage with Proton Radiation Therapy for Prostate Cancer.

Andrew B Thompson, Daniel A Hamstra,

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 108(3):644-648]

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The genome of the bowfin (Amia calva) illuminates the developmental evolution of ray-finned fishes

Andrew Thompson, Michael Hawkins, Elise Parey, Dustin Wcisel, Tatsuya Ota, Kazuhiko Kawasaki, Emily Funk, Mauricio Losilla, Olivia Fitch, Qiaowei Pan, Romain Feron, Marine Milhes, Brett Racicot, Kevin Childs, Quenton Fontenot, Allyse Ferrara, Solomon David, Amy McCune, Alex Dornburg, Jeffrey Yoder, Yann Guiguen, Hugues Roest Crollius, Camille Berthelot, Matthew Harris, Ingo Braasch,

The bowfin fish ( Amia calva ) diverged before the genome duplication in teleost fishes, and its archetypical body plan and slow rate of molecular evolution make it a key species for genomic exploration as a basal representative of the neopterygian fishes. To investigate the evolution and development of ray-finned ... Read more >>

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Higher-Order Assessment in Gross Anatomy: A Comparison of Performance on Higher- Versus Lower-Order Anatomy Questions between Undergraduate and First-Year Medical Students.

Andrew R Thompson, Bruce F Giffin,

Gross anatomy is considered by many the backbone of medical education. While learning anatomy has a reputation of requiring mainly rote memorization, modern day anatomy education often involves instruction and assessment at cognitive levels that foster higher-order thinking. In many instances, these higher-order anatomical concepts are taught to graduate students ... Read more >>

Anat Sci Educ (Anatomical sciences education)
[2020, :]

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Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.

Agila Kumari Pragasam, Derek Pickard, Vanessa Wong, Gordon Dougan, Gagandeep Kang, Andrew Thompson, Jacob John, Veeraraghavan Balaji, Ankur Mutreja,

BACKGROUND:Typhoid fever caused by Salmonella Typhi is a major public health concern in low-/middle-income countries. A recent study of 1900 global S. Typhi indicated that South Asia might be the site of the original emergence of the most successful and hypervirulent clone belonging to the 4.3.1 genotype. However, this study ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(8):1856-1863]

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Responses of ichthyoplankton assemblages to the recent marine heatwave and previous climate fluctuations in several Northeast Pacific marine ecosystems.

Jens M Nielsen, Lauren A Rogers, Richard D Brodeur, Andrew R Thompson, Toby D Auth, Alison L Deary, Janet T Duffy-Anderson, Moira Galbraith, J Anthony Koslow, R Ian Perry,

The effects of climate warming on ecosystem dynamics are widespread throughout the world's oceans. In the Northeast Pacific, large-scale climate patterns such as the El Niño/Southern Oscillation and Pacific Decadal Oscillation, and recently unprecedented warm ocean conditions from 2014 to 2016, referred to as a marine heatwave (MHW), resulted in ... Read more >>

Glob Chang Biol (Global change biology)
[2020, :]

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Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?

Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate L E P Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz,

<h4>Background</h4>Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra-high risk" (UHR). This study investigated whether the effects of various forms of childhood trauma on transition to psychosis are mediated by cortical thickness and surface area abnormalities.<h4>Methods</h4>This prospective study used data from 62 UHR ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, 224:116-125]

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Relationship Between Sedentary Behavior and Physical Activity at Work and Cognition and Mood.

Sophie E Carter, Richard Draijer, Andrew Thompson, Dick H J Thijssen, Nicola D Hopkins,

<h4>Background</h4>Sedentary behavior is negatively associated with cognition and mood. Adults often engage in high levels of sedentary behavior at work through sitting, which may impact productivity. Consequently, replacing sitting with standing and physical activity (PA) is recommended. However, the associations between sitting, standing, and PA at work and cognition and ... Read more >>

J Phys Act Health (Journal of physical activity & health)
[2020, :1-13]

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Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.

Andrew M Thompson, Patrick D O'Connor, Andrew J Marshall, Vanessa Yardley, Louis Maes, Suman Gupta, Delphine Launay, Stephanie Braillard, Eric Chatelain, Baojie Wan, Scott G Franzblau, Zhenkun Ma, Christopher B Cooper, William A Denny,

Previous investigation of the potent antileishmanial properties of antitubercular 7-substituted 2-nitroimidazo[2,1-b][1,3]oxazines with biaryl side chains led to our development of a new clinical candidate for visceral leishmaniasis (DNDI-0690). Within a collaborative backup program, a racemic monoaryl lead (3) possessing comparable activity in mice but a greater hERG liability formed the ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 209:112914]

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Should vitamin D supplementation routinely be prescribed to children receiving antiepileptic medication?

Maura Scott, Neil Corrigan, Thomas Bourke, Andrew Thompson, Peter Mallett,

Arch Dis Child (Archives of disease in childhood)
[2021, 106(1):90-92]

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